Abstract：
:Multiple endocrine neoplasia type 2b is a syndrome, often familial, characterized by medullary carcinoma of the thyroid gland, pheochromocytoma, and many mucosal neuromas in patients who frequently have a marfanoid habitus. The ophthalmic findings are distinctive and include conjunctival and eyelid neuromas, keratoconjunctivitis sicca, and, most characteristically, greatly thickened corneal nerves. Ocular histopathologic study of a 30-year-old man demonstrated thickened nerves in the ciliary body, iris, and corneoscleral limbal regions. In these regions, the nerves were a mixture of myelinated and unmyelinated fibers. Sections through the thickened corneal nerves, 1.5 mm centrally from the corneoscleral limbus, showed only nonmyelinated nerves associated with Schwann cells. The many axons were normal in appearance but varied in diameter; some were between 0.1 and 0.2 ng and others between 1.0 and 1.4 ng. An unexpected finding was numerous ganglion cells in the ciliary body. The subconjunctival tissue showed neuromas with a minimum of fibrous structure. Sections of the lacrimal gland showed normal glandular tissue.
journal_name
Am J Ophthalmoljournal_title
American journal of ophthalmologyauthors
Riley FC Jr,Robertson DMdoi
10.1016/0002-9394(81)90349-4subject
Has Abstractpub_date
1981-01-01 00:00:00pages
57-64issue
1eissn
0002-9394issn
1879-1891pii
0002-9394(81)90349-4journal_volume
91pub_type
杂志文章abstract：PURPOSE:To examine the occurrence and outcome of methicillin-resistant Staphylococcus aureus ophthalmologic infections in a newborn intensive care unit cohort. DESIGN:Noninterventional case series. METHODS:Over a 13-month period, 29 neonates were colonized with methicillin-resistant S. aureus in a newborn intensive c...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2006.02.019
更新日期：2006-07-01 00:00:00
abstract：PURPOSE:Encapsulation of the Ahmed glaucoma valve (AGV) plate is a common cause for postoperative elevation of intraocular pressure, especially in children. Many reports have described the outcomes of AGV revision in adults. However, the outcomes of AGV revision in children are poorly documented. The aim of this study ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2017.09.015
更新日期：2017-11-01 00:00:00
abstract：PURPOSE:To evaluate changes in postoperative refractive outcomes following combined phacoemulsification and pars plana vitrectomy for rhegmatogenous retinal detachment (RRD) compared with other retinal diseases. DESIGN:Retrospective observational case-control study. METHODS:A total of 55 patients who had combined sur...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2014.04.023
更新日期：2014-08-01 00:00:00
abstract：:We reviewed the results of vitreous surgery in 12 eyes of 12 patients with tractional macular detachment from Toxocara canis. We performed a vitrectomy and membrane peeling in all eyes, with additional scleral buckling in four eyes. After a minimum of six months' follow-up, ten of the 12 eyes (83%) had complete retina...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)73253-2
更新日期：1989-07-15 00:00:00
abstract：:Communication between the retinal and the choroidal circulation occurred in one case of proliferative diabetic retinopathy and one case of Leber's disease (multiple miliary aneurysms) after argon laser photocoagulation treatment to eliminate abnormal retinal vasculature. In both instances rapid-sequence fluorescein an...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(76)90426-8
更新日期：1976-08-01 00:00:00
abstract：:The in vivo sites of the blood-aqueous barrier were determined in five animal species, using acriflavine neutral (224 mol. wt.), ultrafreezing and drying, fluorescence microscopy, and fluorometry. Not toxic, acriflavine had specific in vivo affinity for nuclear DNA and RNA, produced intense fluorescence, and did not p...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(75)90405-5
更新日期：1975-10-01 00:00:00
abstract：PURPOSE:To determine and validate thresholds of anterior chamber angle (ACA) parameters in discriminating open- vs narrow-angle eyes using images from dedicated anterior segment optical coherence tomography (DASOCT). DESIGN:Reliability analysis. METHODS:Eyes imaged by DASOCT and examined with gonioscopy were reviewed...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2016.06.032
更新日期：2016-09-01 00:00:00
abstract：PURPOSE:To study the association between peripheral changes in age-related macular degeneration (AMD) and dark adaptation (DA). DESIGN:Prospective, cross-sectional study. METHODS:We recruited patients with AMD and a control group (>50 years) without any vitreoretinal disease. Ultra-widefield (UWF) pseudocolor and fun...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2018.03.035
更新日期：2018-06-01 00:00:00
abstract：PURPOSE:Current screening of potential corneal donors for human immunodeficiency virus type 1 (HIV-1) involves serologic detection of antibodies to the virus. However, this approach cannot detect infection during the seronegative window period of the disease. We therefore evaluated the polymerase chain reaction (PCR) a...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)72113-0
更新日期：1996-10-01 00:00:00
abstract：:We reviewed the records of 78 patients who underwent 128 surgical procedures for congenital or infantile cataracts before age 30 months for the type and frequency of postoperative complications. The surgeries included 92 limbal lensectomies and anterior vitrectomies, 13 pars plicata lensectomies, 20 aspirations, and t...
journal_title：American journal of ophthalmology
pub_type： 杂志文章,评审
doi：10.1016/0002-9394(89)90007-x
更新日期：1989-08-15 00:00:00
abstract：PURPOSE:To determine the incidence of new chorioretinal lesions in children with toxoplasmosis diagnosed after, and therefore not treated during, their first year. DESIGN:Prospective longitudinal cohort study. METHODS:Thirty-eight children were evaluated in Chicago between 1981 and 2005 for new chorioretinal lesions....
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2008.04.033
更新日期：2008-09-01 00:00:00
abstract：PURPOSE:To critically assess the evidence base regarding outcomes following cataract surgery in uveitic cases. DESIGN:Systematic evidence-based review and meta-analysis. METHODS:A comprehensive search query was performed on MEDLINE, EMBASE, CINHAL, and CENTRAL databases. Relevant publications were identified by revie...
journal_title：American journal of ophthalmology
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.ajo.2014.06.018
更新日期：2014-10-01 00:00:00
abstract：PURPOSE:To describe the relationship between the incidence of age-related macular degeneration (AMD) and nonsteroidal anti-inflammatory drug (NSAIDs) use. DESIGN:Prospective cohort study. METHODS:This study consisted of participants in the California Men's Health Study. Those who completed surveys in 2002-2003 and 20...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2018.01.012
更新日期：2018-04-01 00:00:00
abstract：PURPOSE:To report a case of Bartonella henselae infection. DESIGN:Observational case report. METHODS:Review of the clinical, laboratory, photographic, and angiographic records of a patient with cat scratch disease associated with central retinal artery and vein occlusion, neovascular glaucoma, and severe vision loss....
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(03)00784-0
更新日期：2004-01-01 00:00:00
abstract：PURPOSE:To assess agreement between structural and functional testing in classifying eyes as normal or abnormal and their repeatability on two consecutive visits by means of standard automated perimetry (SAP) and confocal scanning laser ophthalmoscopy. DESIGN:Analysis of selected data obtained from a prospective longi...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2006.04.027
更新日期：2006-09-01 00:00:00
abstract：PURPOSE:Photorefractive keratectomy has the potential to cause transient corneal haze. The purpose of this study was to evaluate the relationship between transient corneal haze as measured by an objective means and high and low contrast visual performance. METHODS:In a prospective study, 44 eyes of 28 patients were ex...
journal_title：American journal of ophthalmology
pub_type： 临床试验,杂志文章
doi：10.1016/s0002-9394(01)01003-0
更新日期：2001-08-01 00:00:00
abstract：PURPOSE:To explore the association between the consumption of fruits and vegetables and the presence of glaucoma. DESIGN:Cross-sectional cohort study. METHODS:In a sample of 1,155 women located in multiple centers in the United States, glaucoma specialists diagnosed glaucoma in at least one eye by assessing optic ner...
journal_title：American journal of ophthalmology
pub_type： 杂志文章,多中心研究
doi：10.1016/j.ajo.2008.01.022
更新日期：2008-06-01 00:00:00
abstract：PURPOSE:This study compared the outcomes after Descemet's membrane endothelial keratoplasty (DMEK) in pseudophakic patients with the outcomes after DMEK combined with cataract surgery (triple-DMEK) in patients with Fuchs' endothelial dystrophy (FED). DESIGN:Retrospective, single-institution, interventional, consecutiv...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2020.05.003
更新日期：2020-10-01 00:00:00
abstract：:Lamellar keratoplasty was done in 18 eyes with keratoconus in an attempt to obtain a more satisfactory postoperative refractive error than that after penetrating keratoplasty. The refractive error after lamellar keratoplasty was better than that after 7.5-mm penetrating keratoplasties, but the vision was not as good. ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(77)90563-3
更新日期：1977-04-01 00:00:00
abstract：:We measured lower eyelid length in 288 healthy subjects to establish a norm and then in 95 patients with complaints of intractable photophobia, foreign-body sensation, chronic tearing, or chronic recurrent conjunctivitis. The difference in length was statistically significant (34.25 +/- 2.43 mm for healthy men vs 36.5...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(83)90279-9
更新日期：1983-04-01 00:00:00
abstract：PURPOSE:Distance stereoacuity is used to monitor deterioration of intermittent exotropia (IXT), but variability of stereoacuity has not been studied rigorously. The purpose of this study was to assess the variability of stereoacuity over one day in children with IXT. DESIGN:Prospective cohort study. METHODS:Twelve ch...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2007.10.028
更新日期：2008-03-01 00:00:00
abstract：PURPOSE:To assess indocyanine green angiography (ICGA) as a method for monitoring autograft perfusion after pterygium excision with limbal-conjunctival autograft transplantation (LCAT) and to compare ICGA with anterior segment fluorescein angiography (ASFA). DESIGN:Nonrandomized prospective interventional case series....
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(02)01834-2
更新日期：2003-01-01 00:00:00
abstract：PURPOSE:The effectiveness of diffusion trace value analysis for non-invasive assessment of retinal ganglion cell (RGC) axonal degeneration at multiple anatomic levels along the human visual pathway under clinical setting was evaluated. DESIGN:Imaging study. METHODS:Ten patients with unilateral chronic optic neuropath...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2006.05.042
更新日期：2006-10-01 00:00:00
abstract：PURPOSE:To report a patient with uveal effusion and intermittent angle-closure glaucoma associated with primary pulmonary hypertension. METHODS:Observational case report. RESULTS:A 78-year-old woman with primary pulmonary hypertension noticed pain and decreased vision in her right eye. Ocular examination disclosed ex...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(02)02090-1
更新日期：2003-05-01 00:00:00
abstract：PURPOSE:To determine whether alterations of p53, a tumor suppressor gene, were present in uveal melanoma, and to characterize further the nature of those changes. METHODS:Immunohistochemical analysis with a monoclonal antibody was used to determine whether alterations of p53 were present in 35 enucleated archival uvea...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)75431-5
更新日期：1996-05-01 00:00:00
abstract：PURPOSE:To assess the effect of Ahmed glaucoma valve implants on corneal endothelial cell density (ECD) in children with uveitic glaucoma. DESIGN:Cross-sectional study. METHODS:setting: Institutional. patientpopulation: Eighty eyes from 42 patients diagnosed with uveitis before the age of 16. Twenty-eight eyes had an...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2012.09.001
更新日期：2013-03-01 00:00:00
abstract：PURPOSE:To highlight the possible role of indocyanine green angiography in predicting future exudative changes in eyes that are candidates for drusen laser treatment. METHODS:In a 56-year-old woman, fluorescein and indocyanine green angiography were performed before drusen laser treatment. RESULTS:The treated eye had...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)70875-x
更新日期：1997-10-01 00:00:00
abstract：:Amyloid was identified by light and electron microscopy within corneal grafts of two male siblings from a family with lattice corneal dystrophy type 1. These deposits indicate a recurrent disease within the donor tissue, and we believe this reflects an infiltration of the grafts by genetically abnormal host corneal fi...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(82)90251-3
更新日期：1982-10-01 00:00:00
abstract：PURPOSE:To report a case of conjunctival-corneal intraepithelial neoplasia (CCIN) in an elderly African American patient treated with topical mitomycin C and the subsequent complication of limbal stem cell deficiency. DESIGN:Interventional case report. METHODS:A 92-year-old African American woman was diagnosed with C...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2003.10.048
更新日期：2004-05-01 00:00:00
abstract：:Using immunohistochemical techniques, we studied ligneous conjunctival lesions from two patients. A significant immune reaction was detected that was characterized by activated T lymphocytes and focal accumulation of plasma cells and B lymphocytes. Immunofluorescent studies demonstrated that IgG was a prominent compon...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(89)90216-x
更新日期：1989-02-15 00:00:00
