Abstract:
PURPOSE:To describe the relationship between the incidence of age-related macular degeneration (AMD) and nonsteroidal anti-inflammatory drug (NSAIDs) use. DESIGN:Prospective cohort study. METHODS:This study consisted of participants in the California Men's Health Study. Those who completed surveys in 2002-2003 and 2006 were included. Men who self-reported use of aspirin, ibuprofen, naproxen, valdecoxib, celecoxib, and/or rofecoxib at least 3 days per week were considered NSAID users. Patients were categorized as non-users, former users, new users, or longer-term users based on survey responses. NSAID use was also categorized by type: any NSAIDs, aspirin, and/or non-aspirin NSAIDs. Age, race/ethnicity, smoking status, education, income, alcohol use, and Charlson comorbidity index score were included in the multivariate analysis as risk factors for AMD. RESULTS:A total of 51 371 men were included. Average follow-up time was 7.4 years. There were 292 (0.6%) and 1536 (3%) cases of exudative and nonexudative AMD, respectively. Longer-term use of any NSAID was associated with lower risk of exudative AMD (hazard ratio [HR] 0.69, 95% confidence interval [CI] 0.50-0.96, P = .029). New users of any NSAIDs (HR = 0.79, 95% CI 0.68-0.93, P = .0039) and aspirin (HR = 0.82, 95% CI 0.70-0.97, P = .018) had a lower risk of nonexudative AMD, although this trend did not persist in longer-term users. The relationship between exudative or nonexudative AMD and the remaining categories of NSAID use were not significant. CONCLUSION:The overall impact of NSAIDs on AMD incidence is small; however, the lower risk of exudative AMD in longer-term NSAID users may point to a protective effect and deserves further study as a possible mechanism to modulate disease risk.
journal_name
Am J Ophthalmoljournal_title
American journal of ophthalmologyauthors
Modjtahedi BS,Fong DS,Jorgenson E,Van Den Eeden SK,Quinn V,Slezak JMdoi
10.1016/j.ajo.2018.01.012subject
Has Abstractpub_date
2018-04-01 00:00:00pages
111-122eissn
0002-9394issn
1879-1891pii
S0002-9394(18)30015-1journal_volume
188pub_type
杂志文章abstract::In several tumors of different organ sites, the amount of DNA in a cell (ploidy) is associated with malignancy. We performed DNA quantitation in 21 choroidal melanomas and compared flow cytometry with image analysis in 11 of these melanomas. We modified our preparation technique to overcome problems with pigment and c...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(14)73592-5
更新日期:1993-03-15 00:00:00
abstract:PURPOSE:To determine the optical coherence tomographic images that are commonly observed in eyes with choroidal osteoma (choroidal ossification). METHODS:Three patients with choroidal osteoma were examined by optical coherence tomography. RESULTS:We found two optical coherence tomographic patterns in the eyes with ch...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(00)00503-1
更新日期:2000-07-01 00:00:00
abstract:PURPOSE:To report the results of a Latin American consensus panel regarding the diagnosis and management of primary open-angle glaucoma and to compare these results with those from a similar panel in the United States. DESIGN:A RAND-like (Research and Development) appropriateness methodology was used to assess glaucom...
journal_title:American journal of ophthalmology
pub_type: 共识发展会议,杂志文章
doi:10.1016/j.ajo.2012.03.015
更新日期:2012-09-01 00:00:00
abstract:PURPOSE:To compare the efficacy and visual results of phacoemulsification vs manual sutureless small-incision extracapsular cataract surgery (SICS) for the treatment of cataracts in Nepal. DESIGN:Prospective, randomized comparison of 108 consecutive patients with visually significant cataracts. METHODS:settings: Outr...
journal_title:American journal of ophthalmology
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.ajo.2006.07.023
更新日期:2007-01-01 00:00:00
abstract::Communication between the retinal and the choroidal circulation occurred in one case of proliferative diabetic retinopathy and one case of Leber's disease (multiple miliary aneurysms) after argon laser photocoagulation treatment to eliminate abnormal retinal vasculature. In both instances rapid-sequence fluorescein an...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/0002-9394(76)90426-8
更新日期:1976-08-01 00:00:00
abstract::Cataract operations may be recommended when retinal disease is suspected but cannot be adequately diagnosed or treated because of lens opacity. We evaluated the outcome of cataract operations performed under those circumstances. We reviewed the records of 119 patients who were examined at the Wilmer Retinal Vascular C...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(14)75793-9
更新日期:1994-10-15 00:00:00
abstract:PURPOSE:To compare the accuracy and speed of using the computerized MatchedFlicker software program (EyeIC Inc, Narberth, Pennsylvania, USA) to evaluate glaucomatous optic disc change against the traditional gold standard of manually examining stereoscopic disc photographs. DESIGN:A prospective evaluation of diagnosti...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2016.03.031
更新日期:2016-07-01 00:00:00
abstract:PURPOSE:To identify any temporal trends in the diagnosis of plus disease in retinopathy of prematurity (ROP) by experts. DESIGN:Reliability analysis. METHODS:ROP experts were recruited in 2007 and 2016 to classify 34 wide-field fundus images of ROP as plus, pre-plus, or normal, coded as "3," "2," and "1," respectivel...
journal_title:American journal of ophthalmology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.ajo.2016.12.025
更新日期:2017-04-01 00:00:00
abstract:PURPOSE:To determine the relationship between eyelid pressure during blinking and the fluorescein staining of the cornea and conjunctiva in dry eye patients. DESIGN:Cross-sectional prospective study. METHODS:The pressure of the upper and lower eyelids was measured with a specially designed blepahro-tensiometer in 130...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2015.06.028
更新日期:2015-10-01 00:00:00
abstract:PURPOSE:To determine whether glaucoma patients exhibit an abnormal melatonin concentration in aqueous humor. DESIGN:Case-controlled study, laboratory investigation. METHODS:Aqueous humor and plasma samples of 28 patients with primary open-angle glaucoma and 31 nonglaucoma control patients were collected during surger...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2006.03.040
更新日期:2006-08-01 00:00:00
abstract:PURPOSE:To determine the incidence of new chorioretinal lesions in children with toxoplasmosis diagnosed after, and therefore not treated during, their first year. DESIGN:Prospective longitudinal cohort study. METHODS:Thirty-eight children were evaluated in Chicago between 1981 and 2005 for new chorioretinal lesions....
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2008.04.033
更新日期:2008-09-01 00:00:00
abstract:PURPOSE:To document clinical features of uveitis in patients with familial juvenile systemic granulomatosis. DESIGN:Retrospective chart review. METHODS:Ophthalmologic examination, medical history, and clinical course in 16 patients from eight families examined at six academic medical centers. RESULTS:Of the 16 patie...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(02)01709-9
更新日期:2002-12-01 00:00:00
abstract:PURPOSE:To evaluate the effects of a dexamethasone intravitreous drug delivery system (dexamethasone DDS) in patients with persistent macular edema (ME) resulting from uveitis or Irvine-Gass syndrome. DESIGN:Randomized, prospective, single-masked, controlled trial. METHODS:Three hundred and fifteen patients with pers...
journal_title:American journal of ophthalmology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.ajo.2008.12.033
更新日期:2009-06-01 00:00:00
abstract:PURPOSE:To implant foldable posterior chamber intraocular lenses in the absence of capsular and zonular support. METHODS:Case reports. In two patients, two eyes with aphakia, lack of capsular or zonular support, and contact lens intolerance underwent the implantation of a silicone and an acrylic foldable posterior cha...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(98)00297-9
更新日期:1999-02-01 00:00:00
abstract:PURPOSE:To evaluate the incidence of adverse events (AEs) in patients who underwent refractive lens exchange. DESIGN:Retrospective case series. METHODS:Setting: Private refractive surgery clinics. Patients/Study Population: Patients who underwent refractive lens exchange between July 1, 2014, and June 30, 2016. Inter...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2019.08.025
更新日期:2019-12-01 00:00:00
abstract::The technique of keratoprosthesis was used in 21 cases of severe and intractable forms of keratopathy during the past 3 1/2 years. The results in terms of visual acuity were satisfactory in more than half the cases. Significant problems that occurred after this procedure included the diagnosis and management of glauc...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/0002-9394(79)90465-3
更新日期:1979-08-01 00:00:00
abstract::Rabbit eyes in which vitrectomy was performed underwent three hours of hypothermic perfusion with either 22 C or 2 C lactated Ringer's solution. Clinical, electroretinographic, fluorescein angiographic, histologic, and ultrastructural examinations were performed. No changes were noted in eyes cooled with 22 C fluid. R...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(14)74615-x
更新日期:1990-04-15 00:00:00
abstract::A graft of hard palate mucosa is a satisfactory substitute for the posterior lamella of tarsus and conjunctiva in eyelid reconstruction. The graft may be harvested after administration of local anesthesia in adults, provides structural support as well as a mucosal surface, and contracts minimally. The palatal donor si...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/0002-9394(89)90257-2
更新日期:1989-06-15 00:00:00
abstract:PURPOSE:To evaluate multifocal electroretinography (mfERG) as a screening test for detecting hydroxychloroquine and chloroquine toxicity. DESIGN:Diagnostic accuracy study. METHODS:Patients referred to the University of Ottawa for hydroxychloroquine or chloroquine retinopathy screening during 2011-2014 underwent 10-2 ...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2019.04.025
更新日期:2019-10-01 00:00:00
abstract:PURPOSE:To report a case of progressive necrotizing fasciitis of the face following acute dacryocystitis. DESIGN:Interventional case report. METHODS:A 60-year-old woman presented with left acute dacryocystitis with abscess formation that had ruptured; a small wound remained. Erythematous swelling of the left eyelid a...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(03)00089-8
更新日期:2003-07-01 00:00:00
abstract:PURPOSE/METHODS:We examined a patient with progressive outer retinal necrosis, which is presumably caused by the varicella-zoster virus in patients with the acquired immunodeficiency syndrome. RESULTS/CONCLUSIONS:The patient was successfully treated with a combination of intravitreal ganciclovir and oral sorivudine. T...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(14)71242-5
更新日期:1995-04-01 00:00:00
abstract::Of 59 patients with traumatic hyphema studied prospectively, 32 received aminocaproic acid, an antifibrinolytic agent, to prevent secondary hemorrhage. The remaining 27 patients received placebo in an identical manner. Of the aminocaproic acid-treated patients, only one (3%) rebled, while nine patients (33%) receiving...
journal_title:American journal of ophthalmology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0002-9394(76)90254-3
更新日期:1976-03-01 00:00:00
abstract:PURPOSE:To compare the late complications in the Ahmed Baerveldt Comparison Study during 5 years of follow-up. DESIGN:Multicenter, prospective randomized clinical trial. METHODS:setting: Sixteen international clinical centers. STUDY POPULATION:Two hundred seventy-six subjects aged 18-85 years with previous intraocul...
journal_title:American journal of ophthalmology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.ajo.2015.11.023
更新日期:2016-03-01 00:00:00
abstract:PURPOSE:To evaluate the retinal toxicity of intravitreal bevacizumab in an animal model. DESIGN:Animal study. METHODS:Bevacizumab was injected into the vitreous of one eye of each of eight Dutch-belted rabbits; the other eye served as a control. Four rabbits received a dose of 1.25 mg/0.05 ml of bevacizumab intravitr...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2006.03.058
更新日期:2006-07-01 00:00:00
abstract:PURPOSE:To report a minimally symptomatic patient with bilateral carcinoid tumors metastatic to the choroid who was followed up for 42 months without any treatment. METHOD:Case report. RESULTS:A 54-year-old white man with a history of bronchial carcinoid tumor had bilateral multiple carcinoid tumors metastatic to the...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(98)00053-1
更新日期:1998-06-01 00:00:00
abstract:PURPOSE:To report a patient with ocular ischemic syndrome due to an internal carotid artery stenosis in whom we confirmed improved retinal blood flow noninvasively after carotid endarterectomy. DESIGN:Observational case report. METHODS:Retinal flowmetry. RESULTS:In a 72-year-old hypertensive man with a transient isc...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(02)01531-3
更新日期:2002-08-01 00:00:00
abstract::We examined 29 patients with homozygous beta thalassemia. The mean age of the patients was 15.6 +/- 8.9 years. Twelve patients (mean age, 02.0 +/- 10.4 years) had one or more ocular abnormalities. Five patients had degeneration of the retinal pigment epithelium, one had lens opacities, two had lens opacities and degen...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/0002-9394(89)90864-7
更新日期:1989-12-15 00:00:00
abstract::Primary oculomotor nerve synkinesis is almost always caused by an intracavernous meningioma or aneurysm. We treated a patient who had signs of primary oculomotor nerve synkinesis from an unruptured extracavernous aneurysm located at the junction of the internal carotid artery and the posterior communicating artery. Th...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(14)72846-6
更新日期:1994-07-15 00:00:00
abstract:PURPOSE:To report angiographically documented cystoid macula edema associated with the use of each of the three newly available ocular hypotensive lipids: unoprostone, travaprost, and bimatoprost. DESIGN:Observational case series. METHODS:Retrospective review of three patients in a clinical practice who had uncontrol...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(01)01411-8
更新日期:2002-03-01 00:00:00
abstract:PURPOSE:To compare the ultrastructural features of excised tissue removed during surgery for idiopathic macular holes with the preoperative stage of the macular hole. METHODS:Twelve consecutive patients with a unilateral idiopathic macular hole underwent vitrectomy with surgical removal of the internal limiting membra...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(14)71965-8
更新日期:1996-07-01 00:00:00