Ocular abnormalities in patients with beta thalassemia.

Abstract:

:We examined 29 patients with homozygous beta thalassemia. The mean age of the patients was 15.6 +/- 8.9 years. Twelve patients (mean age, 02.0 +/- 10.4 years) had one or more ocular abnormalities. Five patients had degeneration of the retinal pigment epithelium, one had lens opacities, two had lens opacities and degeneration of the retinal pigment epithelium, one had vascular abnormalities and degeneration of the retinal pigment epithelium, one had angioid streaks, lens opacities, and degeneration of the retinal pigment epithelium, and two had angioid streaks and degeneration of the retinal pigment epithelium. These abnormalities were observed in patients with both forms of beta thalassemia, major and intermedia. The frequency of the ocular abnormalities increased with age. The youngest patient with an ocular abnormality was 6 1/2 years old. There was no correlation between the abnormalities observed and the serum ferritin level, the mean hematocrit value, and the dose of deferoxamine given to the patients.

journal_name

Am J Ophthalmol

authors

Gartaganis S,Ismiridis K,Papageorgiou O,Beratis NG,Papanastasiou D

doi

10.1016/0002-9394(89)90864-7

subject

Has Abstract

pub_date

1989-12-15 00:00:00

pages

699-703

issue

6

eissn

0002-9394

issn

1879-1891

pii

0002-9394(89)90864-7

journal_volume

108

pub_type

杂志文章
  • Anterior chamber depth and complications during cataract surgery in eyes with pseudoexfoliation syndrome.

    abstract:PURPOSE:To look for associations of preoperative A-scan ultrasound ocular dimensions with complications during phacoemulsification in eyes with pseudoexfoliation. METHODS:A total of 174 eyes with pseudoexfoliation of 135 patients undergoing planned cataract surgery were included in a prognostic study based on the revi...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1016/s0002-9394(99)00365-7

    authors: Küchle M,Viestenz A,Martus P,Händel A,Jünemann A,Naumann GO

    更新日期:2000-03-01 00:00:00

  • Novel Parameters to Assess the Severity of Corneal Neovascularization Using Anterior Segment Optical Coherence Tomography Angiography.

    abstract:PURPOSE:Assessment of anterior segment-optical coherence tomography angiography (AS-OCTA) to determine severity of corneal neovascularization (CoNV). DESIGN:Retrospective, cross-sectional, single-center study. METHODS:Patients of various CoNV etiologies were selected and classified into mild, moderate, and severe. Th...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1016/j.ajo.2020.08.023

    authors: Binotti WW,Koseoglu ND,Nosé RM,Kenyon KR,Hamrah P

    更新日期:2020-08-18 00:00:00

  • Evidence for visual compromise in preverbal children with orbital vascular birthmarks.

    abstract:PURPOSE:To learn whether electrophysiological changes indicating amblyopia occur even in the absence of clinically recognizable amblyopia. DESIGN:Prospective study. METHODS:Four consecutive infants between 7 and 19 months of age with unilateral periocular vascular lesions that intermittently obstructed vision in the ...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1016/j.ajo.2008.11.007

    authors: Good WV,Hou C,Frieden IJ,Norcia AM

    更新日期:2009-04-01 00:00:00

  • Bone marrow transplantation retinopathy in the absence of radiation therapy.

    abstract:PURPOSE:To describe a case of bone marrow transplantation retinopathy in a patient in the absence of prior radiation therapy. METHODS:Case report. RESULTS:Bilateral scotomata developed in a 26-year-old woman because of a retinal microvasculopathy two years after receiving an autologous bone marrow transplantation for...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1016/s0002-9394(14)72023-9

    authors: Cunningham ET Jr,Irvine AR,Rugo HS

    更新日期:1996-08-01 00:00:00

  • Pseudotumor cerebri associated with corticosteroid withdrawal in inflammatory bowel disease.

    abstract::We treated two patients with Crohn's disease and one patient with ulcerative colitis who developed headache, papilledema, and intracranial hypertension (pseudotumor cerebri) during corticosteroid withdrawal. One had four separate episodes with corticosteroid withdrawal, which suggested a causal relationship. This asso...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1016/s0002-9394(14)73145-9

    authors: Liu GT,Kay MD,Bienfang DC,Schatz NJ

    更新日期:1994-03-15 00:00:00

  • Rebubbling in Descemet Membrane Endothelial Keratoplasty: Influence of Pressure and Duration of the Intracameral Air Tamponade.

    abstract:PURPOSE:To explore the impact of intracameral air tamponade pressure and duration on graft attachment and rebubbling rates. DESIGN:A prospective, interventional, nonrandomized study. METHODS:setting: Department of Ophthalmology, Charité - Universitätsmedizin Berlin. STUDY POPULATION:One hundred seventeen patients wh...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1016/j.ajo.2017.03.021

    authors: Pilger D,Wilkemeyer I,Schroeter J,Maier AB,Torun N

    更新日期:2017-06-01 00:00:00

  • Corneal higher-order aberrations induced by overnight orthokeratology.

    abstract:PURPOSE:To evaluate corneal higher-order aberrations induced by overnight orthokeratology for myopia. DESIGN:Prospective, noncomparative, consecutive, interventional case series. METHODS:A prospective study was conducted in 64 eyes of 39 patients with overnight orthokeratology for myopia, who were followed up for at ...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1016/j.ajo.2004.10.006

    authors: Hiraoka T,Matsumoto Y,Okamoto F,Yamaguchi T,Hirohara Y,Mihashi T,Oshika T

    更新日期:2005-03-01 00:00:00

  • Long-term visual prognosis of peripheral multifocal chorioretinitis.

    abstract:PURPOSE:To report on the clinical manifestations, complications, and long-term visual prognosis of patients with peripheral multifocal chorioretinitis and to search for predictors for a lower visual outcome. DESIGN:Retrospective consecutive observational case series. METHODS:setting: Institutional. PATIENT POPULATIO...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1016/j.ajo.2015.01.005

    authors: Ossewaarde-van Norel J,Ten Dam-van Loon N,de Boer JH,Rothova A

    更新日期:2015-04-01 00:00:00

  • Retinal nerve fiber layer atrophy is associated with visual field loss over time in glaucoma suspect and glaucomatous eyes.

    abstract:PURPOSE:To compare prospectively detection of progressive retinal nerve fiber layer thickness (RNFL) atrophy identified using time-domain optical coherence tomography with visual field progression using standard automated perimetry in glaucoma suspect and preperimetric glaucoma patients or perimetric glaucoma patients....

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1016/j.ajo.2012.07.005

    authors: Sehi M,Zhang X,Greenfield DS,Chung Y,Wollstein G,Francis BA,Schuman JS,Varma R,Huang D,Advanced Imaging for Glaucoma Study Group.

    更新日期:2013-01-01 00:00:00

  • Prospective comparison of microbial culture and polymerase chain reaction in the diagnosis of corneal ulcer.

    abstract:PURPOSE:To compare polymerase chain reaction (PCR) to microbial culture for the detection and identification of bacterial and fungal pathogens in microbial keratitis. DESIGN:Prospective cohort study. METHODS:A total of 108 consecutive corneal ulcers were cultured and analyzed by PCR using pan-bacterial and pan-fungal...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1016/j.ajo.2008.06.009

    authors: Kim E,Chidambaram JD,Srinivasan M,Lalitha P,Wee D,Lietman TM,Whitcher JP,Van Gelder RN

    更新日期:2008-11-01 00:00:00

  • Accuracy of New Generation Intraocular Lens Calculation Formulas in Vitrectomized Eyes.

    abstract:PURPOSE:To compare the prediction accuracy of new intraocular lens (IOL) calculation formulas (Barrett Universal II [BUII], Emmetropia Verifying Optical [EVO], Kane and Ladas Super formula) and traditional formulas (Haigis, Hoffer Q, Holladay 1, and SRK/T) with Wang-Koch (WK) axial length (AL) adjustment in vitrectomiz...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1016/j.ajo.2020.04.035

    authors: Tan X,Zhang J,Zhu Y,Xu J,Qiu X,Yang G,Liu Z,Luo L,Liu Y

    更新日期:2020-09-01 00:00:00

  • Reimplantation of a fluocinolone acetonide sustained drug delivery implant for chronic uveitis.

    abstract:PURPOSE:To determine the effects of a second fluocinolone implant inserted in eyes with uveitis in which recurrent inflammation developed after the original implant was placed. DESIGN:Prospective, interventional trial. METHODS:Study subjects comprised all consecutive patients with noninfectious posterior uveitis who ...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1016/j.ajo.2007.11.008

    authors: Jaffe GJ

    更新日期:2008-04-01 00:00:00

  • Proliferative diabetic retinopathy in patients with defects of platelet function.

    abstract::A 71-year-old woman had von Willebrand's disease, an inheritable abnormality of platelet activity, and developed diabetic retinal neovascularization. A 59-year-old man had a myeoloproliferative disorder with thrombocythemia but may have had retinal changes before the development of his platelet dysfunction. The occurr...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1016/0002-9394(79)90749-9

    authors: Ho PC,Feman SS,Stein RS,McKee LC

    更新日期:1979-07-01 00:00:00

  • Comparative toxicity of mitomycin C and 5-fluorouracil in vitro.

    abstract::The adjunctive use of antimetabolites has revolutionized surgical procedures to correct glaucoma in the past decade. Although much is known about the in vitro and in vivo actions of 5-fluorouracil and mitomycin C, their use in the eye has raised new questions about cellular toxicity. For example, filtering blebs after...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1016/s0002-9394(14)72957-5

    authors: Smith S,D'Amore PA,Dreyer EB

    更新日期:1994-09-15 00:00:00

  • Simultaneous confocal scanning laser fluorescein and indocyanine green angiography.

    abstract:PURPOSE:To evaluate clinically a recently developed confocal scanning laser ophthalmoscope for simultaneous fluorescein and indocyanine green angiography. METHODS:After comprehensive ophthalmic examination, including stereoscopic biomicroscopy, and after color fundus photographs, simultaneous confocal scanning laser f...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1016/s0002-9394(99)80095-6

    authors: Holz FG,Bellmann C,Rohrschneider K,Burk RO,Völcker HE

    更新日期:1998-02-01 00:00:00

  • Hypertension and lens opacities from the Beaver Dam Eye Study.

    abstract:PURPOSE:To examine the relationship between hypertension and lens opacities, and the use of antihypertensive agents. METHODS:A total of 4,926 adults, 43 to 84 years of age, living in Beaver Dam, Wisconsin, at the time of a private census, were invited to participate in a study that included a medical interview and an ...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1016/s0002-9394(14)70223-5

    authors: Klein BE,Klein R,Jensen SC,Linton KL

    更新日期:1995-05-01 00:00:00

  • Twice-yearly exams unnecessary for patients taking quetiapine.

    abstract:PURPOSE:To determine the necessity for the heightened level of monitoring for cataract development in patients taking quetiapine (Seroquel, AstraZeneca Pharmaceuticals, Wilmington, Delaware) dictated by the Physicians' Desk Reference. Also, to explore the possibility of cataractogenesis because of quetiapine therapy. ...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1016/j.ajo.2004.05.038

    authors: Fraunfelder FW

    更新日期:2004-11-01 00:00:00

  • Can patients guess their intraocular pressure?

    abstract:PURPOSE:To determine whether patients can guess their intraocular pressure (IOP). DESIGN:Patient survey. METHODS:We asked consecutive patients to guess their IOP and then indicate the IOP and the symptoms that allowed them to guess. RESULTS:Of 132 patients, 22 (17%) believed they could guess their IOP, usually based...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1016/S0002-9394(03)00861-4

    authors: Stewart WC,Jackson AL,Jenkins JN

    更新日期:2004-02-01 00:00:00

  • Posterior vitreous detachment and idiopathic preretinal macular gliosis.

    abstract::A prospective study of 78 eyes with idiopathic preretinal macular gliosis disclosed that 74 of the 78 (95%) had posterior vitreous detachments at the time of the initial examination. A second prospective study of 34 eyes with acute posterior vitreous detachment showed preretinal macular gliosis in three eyes (9%) init...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1016/0002-9394(86)90144-3

    authors: Wiznia RA

    更新日期:1986-08-15 00:00:00

  • The effect of an Ahmed glaucoma valve implant on corneal endothelial cell density in children with glaucoma secondary to uveitis.

    abstract:PURPOSE:To assess the effect of Ahmed glaucoma valve implants on corneal endothelial cell density (ECD) in children with uveitic glaucoma. DESIGN:Cross-sectional study. METHODS:setting: Institutional. patientpopulation: Eighty eyes from 42 patients diagnosed with uveitis before the age of 16. Twenty-eight eyes had an...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1016/j.ajo.2012.09.001

    authors: Kalinina Ayuso V,Scheerlinck LM,de Boer JH

    更新日期:2013-03-01 00:00:00

  • Ocular toxoplasmosis in human immunodeficiency virus-infected patients.

    abstract::The files of 45 human immunodeficiency virus-infected patients with ocular toxoplasmosis were reviewed, with a median follow-up of eight months. The condition was unilateral in 37 of the 45 patients (82%) and was bilateral in eight (18%). Inflammation of the anterior chamber and the vitreous was present in 32 of 53 ey...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1016/s0002-9394(14)73975-3

    authors: Cochereau-Massin I,LeHoang P,Lautier-Frau M,Zerdoun E,Zazoun L,Robinet M,Marcel P,Girard B,Katlama C,Leport C

    更新日期:1992-08-15 00:00:00

  • Orbital invasion by an intracranial chordoma.

    abstract::A 26-year-old woman experienced bilateral hearing loss, progressive nasal obstruction, and rhinorrhea. Examination disclosed a retropharyngeal mass. A needle biopsy specimen of the mass showed that it was a chordoma. The patient underwent surgery to remove the mass and received a postoperative course of radioactive co...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1016/s0002-9394(14)75899-4

    authors: Ferry AP,Haddad HM,Goldman JL

    更新日期:1981-07-01 00:00:00

  • Vitrectomy for diabetic traction retinal detachment involving the macula.

    abstract::We analyzed the surgical results for 197 eyes that underwent vitrectomy for diabetic traction detachment of the macula. The retina was successfully reattached in 130 of the 197 cases (66%), although the final level of vision depended on the amount of permanent macular damage from the previous detachment and on the eff...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1016/0002-9394(83)90330-6

    authors: Rice TA,Michels RG,Rice EF

    更新日期:1983-01-01 00:00:00

  • Comparison of the in vitro safety of intraocular dyes using two retinal cell lines: a focus on brilliant blue G and indocyanine green.

    abstract:PURPOSE:To compare the in vitro toxicity of brilliant blue G (BBG), indocyanine green (ICG), Trypan blue (TB), and Evans blue (EB) in a human retinal pigment epithelial cell line (ARPE-19) and a murine retinal ganglion/Muller glial (RGC) primary cell culture. DESIGN:In vitro cell biology experimental study. METHODS:T...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1016/j.ajo.2008.08.031

    authors: Yuen D,Gonder J,Proulx A,Liu H,Hutnik C

    更新日期:2009-02-01 00:00:00

  • Lower eyelid laxity and ocular symptoms.

    abstract::We measured lower eyelid length in 288 healthy subjects to establish a norm and then in 95 patients with complaints of intractable photophobia, foreign-body sensation, chronic tearing, or chronic recurrent conjunctivitis. The difference in length was statistically significant (34.25 +/- 2.43 mm for healthy men vs 36.5...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1016/0002-9394(83)90279-9

    authors: Liu D,Stasior OG

    更新日期:1983-04-01 00:00:00

  • Anti-Vascular Endothelial Growth Factor Treatment for Diabetic Macular Edema in a Real-World Clinical Setting.

    abstract:PURPOSE:To report the long-term outcomes of intravitreal anti-vascular endothelial growth factor (VEGF) treatment for diabetic macular edema (DME) in a real-world clinical setting and to assess the efficacy of subsequent alternative treatments in eyes with suboptimal response to anti-VEGF. DESIGN:Retrospective interve...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1016/j.ajo.2018.08.004

    authors: Maggio E,Sartore M,Attanasio M,Maraone G,Guerriero M,Polito A,Pertile G

    更新日期:2018-11-01 00:00:00

  • Neurologic complications with elevated antibody titer after acute hemorrhagic conjunctivitis.

    abstract::Nine patients with polyradiculomyeloneuropathy after acute hemorrhagic conjunctivitis (AHC) infection were studied serologically. All except one patient had neutralization titers larger than or equal to 1:16 against the prototype J670/71 strain of AHC virus in at least one of their serum samples. The development of a ...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1016/0002-9394(75)90279-2

    authors: Hung TP,Green IJ,Sung SM

    更新日期:1975-11-01 00:00:00

  • Nodular adenomatosis of iris pigment epithelium.

    abstract::A 62-year-old man manifested multiple nodular growths in his left iris and unilateral glaucoma. Detailed clinical and pathologic studies showed that these lesions were adenomas derived from the spurs of Fuchs, Michel, and Grunert in the iris pigment epithelium. We suggest terming this newly described entity nodular ad...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1016/s0002-9394(14)74989-x

    authors: Tso MO,Goldberg MF,Sugar J

    更新日期:1985-07-15 00:00:00

  • Autologous plasmin-assisted vitrectomy for stage 5 retinopathy of prematurity: a preliminary trial.

    abstract:PURPOSE:To evaluate the efficacy of autologous plasmin (AP)-assisted vitrectomy for stage 5 retinopathy of prematurity (ROP). DESIGN:Interventional case series. METHODS:Six consecutive eyes of four children with stage 5 ROP were treated. The patients' ages at the surgery ranged from five to eight months after birth. ...

    journal_title:American journal of ophthalmology

    pub_type: 临床试验,杂志文章

    doi:10.1016/j.ajo.2007.03.020

    authors: Tsukahara Y,Honda S,Imai H,Kondo N,Fujii S,Yokoyama N,Hirata A,Kawaji T,Fukushima M,Tanihara H,Negi A

    更新日期:2007-07-01 00:00:00

  • Diabetic vacuolation of the iris pigment epithelium.

    abstract::In a postmortem study of 57 diabetic patients, 19 of 23 patients with blood glucose levels greater than 200 mg/100 ml in the 72-hour period before death showed the characteristic histologic findings of "lacy" vacuolation of the iris pigment epithelium as well as vacuolation of the renal tubules (Armanni-Ebstein nephro...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1016/0002-9394(75)90749-7

    authors: Smith ME,Glickman P

    更新日期:1975-05-01 00:00:00