Abstract：
PURPOSE:To evaluate clinically a recently developed confocal scanning laser ophthalmoscope for simultaneous fluorescein and indocyanine green angiography. METHODS:After comprehensive ophthalmic examination, including stereoscopic biomicroscopy, and after color fundus photographs, simultaneous confocal scanning laser fluorescein and indocyanine green angiography was performed after injection of 500 mg of fluorescein and 25 mg of indocyanine green mixed in one syringe using the Heidelberg Retina Angiograph. An argon laser beam (488 nm) and a diode laser beam (795 nm) from an external source were delivered by single-mode fibers. Emission was recorded between 500 and 700 nm and above 810 nm, respectively. Digital images were displayed simultaneously on a monitor during angiography. RESULTS:Two hundred twenty simultaneous fluorescein and indocyanine green angiograms were obtained in 193 consecutive patients with various diagnoses, including exudative age-related macular degeneration with occult and classic choroidal neovascularization. Simultaneous angiography with both dyes gave high-contrast images during all phases of the angiography, which allowed for accurate correlation of fluorescein and indocyanine green angiographic findings and correct comparison of the transit of both dyes through the retinal and choroidal circulation. Corresponding display of quasisimultaneous frames facilitated interpretation of the angiograms. CONCLUSIONS:Confocal laser scanning angiography allows for quasisimultaneous fluorescein and indocyanine green angiography. The investigation is possible at low retinal irradiance and offers high-contrast digital images. Compared with consecutive angiographic investigations using both dyes, simultaneous angiography is less time consuming, requires only one injection, and, because quasisimultaneous frames are obtained, facilitates interpretation of the angiograms.
journal_name
Am J Ophthalmoljournal_title
American journal of ophthalmologyauthors
Holz FG,Bellmann C,Rohrschneider K,Burk RO,Völcker HEdoi
10.1016/s0002-9394(99)80095-6subject
Has Abstractpub_date
1998-02-01 00:00:00pages
227-36issue
2eissn
0002-9394issn
1879-1891pii
S0002-9394(99)80095-6journal_volume
125pub_type
杂志文章abstract：:We undertook an in vitro investigation of the role of the design of the eyedrop dispenser in bacterial contamination. The nozzle tips of pipette and squeeze bottles containing Fluress (pH 5.0) were inoculated with 10 microliter of an ocular isolate of Pseudomonas aeruginosa (5.5 X 10(5) bacteria/ml). Cultures of singl...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(84)90238-1
更新日期：1984-11-01 00:00:00
abstract：PURPOSE:To correlate the histologic and clinical classification of type 1 (subretinal pigment epithelium) and type 2 (subsensory retina) choroidal neovascularization. METHODS:Ten eyes of 10 patients with surgically excised choroidal neovascularization that were routinely processed and could be histologically classifie...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(98)00145-7
更新日期：1998-07-01 00:00:00
abstract：PURPOSE:To investigate the relationship between intraretinal macular hemorrhage and visual acuity outcomes in eyes with central retinal vein occlusion or hemiretinal vein occlusion managed with aflibercept, bevacizumab, or observation. DESIGN:Retrospective analysis of data from 2 randomized clinical trials. METHODS:A...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2020.08.030
更新日期：2020-08-20 00:00:00
abstract：PURPOSE:To provide evidence that corticosteroid-induced ocular hypertension has a genetic component. DESIGN:Evidence-based perspective. METHODS:We conducted a comprehensive literature search for studies exploring genetic influences on intraocular pressure responses to corticosteroid treatment. RESULTS:Studies demons...
journal_title：American journal of ophthalmology
pub_type： 杂志文章,评审
doi：10.1016/j.ajo.2019.02.001
更新日期：2019-06-01 00:00:00
abstract：PURPOSE:To report a child with the mitochondrial cytopathy of Pearson syndrome and zonular cataract. METHOD:Case report. We describe a 6-year-old boy with Pearson syndrome. RESULTS:At age 3 years, the boy developed secondary strabismus caused by bilateral zonular cataract. Subsequently, he underwent successful bilate...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(99)80105-6
更新日期：1998-02-01 00:00:00
abstract：:In this prospective evaluation of the reliability and efficiency of an optimized visual field screening protocol for glaucoma, we tested 145 eyes (73 patients) with increased intraocular pressures to determine the location of early glaucomatous visual field defects. The field examination, which was used as a control, ...
journal_title：American journal of ophthalmology
pub_type： 临床试验,杂志文章
doi：
更新日期：1981-10-01 00:00:00
abstract：PURPOSE:To report the clinical and histopathologic features of orbital hemangiopericytoma. METHOD:We review the clinical and histopathologic features in seven patients. RESULTS:Ultrasonography, computed tomography, and magnetic resonance imaging defined the location and extent of the tumor in each patient but did not...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)70904-3
更新日期：1997-11-01 00:00:00
abstract：PURPOSE:To study the effect of higher-order aberrations (HOAs) on visual function in keratoconus with a rigid gas permeable (RGP) contact lens (CLs). DESIGN:Retrospective nonrandomized study. METHODS:Thirteen eyes of 10 subjects with keratoconus who wore a RGP CLs (KC-RGP group), 15 eyes of nine normal subjects (norm...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2007.08.004
更新日期：2007-12-01 00:00:00
abstract：PURPOSE:To evaluate the involvement of the anterior ocular segment in Harada disease. METHODS:In a prospective study, ultrasound biomicroscopy was performed in 18 consecutive eyes of nine patients with Harada disease in its acute phase before and after onset of systemic corticosteroid therapy. Examination was repeated...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(98)00033-6
更新日期：1998-05-01 00:00:00
abstract：:A 70-year-old man had unilateral congestion of the right upper eyelid, which contained a nodular mass. A biopsy was performed, and histologic, immunocytochemical, and ultrastructural studies disclosed a pseudoneoplastic proliferation of endothelial cells and pericytes in a region containing clumps of bacteria. This co...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)72894-6
更新日期：1994-08-15 00:00:00
abstract：PURPOSE/METHODS:We observed a clinicopathologic correlation of a case of adenocarcinoma of the retinal pigment epithelium. RESULTS/CONCLUSIONS:The ultrasonographic findings of this tumor demonstrated a collar button profile with high internal reflectivity. The ultrasonographic characteristics in this case reflected th...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)73887-5
更新日期：1995-02-01 00:00:00
abstract：PURPOSE:To assess whether successful surgical intervention for intermittent exotropia, or the timing of intervention, has any effect on the development of mental illness. DESIGN:Retrospective, observational case series. METHODS:All patients (<19 years of age) diagnosed with intermittent exotropia in Olmsted County, M...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2014.06.008
更新日期：2014-10-01 00:00:00
abstract：PURPOSE:To report the clinicopathologic findings in patient with optic nerve sheath hemangiopericytoma. DESIGN:Clinicopathologic report. METHODS:The clinical, histologic, and immunohistochemical findings of a patient with optic nerve sheath hemangiopericytoma were reviewed. RESULTS:An excisional biopsy of an optic n...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2006.11.046
更新日期：2007-05-01 00:00:00
abstract：:The haptic of a semiflexible anterior chamber intraocular lens (Kelman Quadraflex) broke inside the eye of a 70-year-old man. No history of major eye or head trauma could be elicited from the patient. Clinical manifestations included inferior corneal edema progressing toward the optical axis resulting from a free-floa...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(85)90226-0
更新日期：1985-02-15 00:00:00
abstract：:We conducted a two-part study to determine whether any positive association between the use of allopurinol and the development of cataracts could be demonstrated. Study 1 included 251 Boston-area patients hospitalized for cataract and 753 matched controls. Two cataract patients were regular allopurinol users as compar...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(84)90328-3
更新日期：1984-09-15 00:00:00
abstract：PURPOSE:To evaluate the outcome of intravitreal injection of aflibercept in cases with exudative age-related macular degeneration, (AMD) resistant to injections of bevacizumab or ranibizumab. DESIGN:Retrospective observational case series. METHODS:A retrospective chart review at a single institution was conducted to ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2013.02.017
更新日期：2013-07-01 00:00:00
abstract：PURPOSE:To determine the long-term outcome of glaucoma filtration surgery in preserving vision. Visual loss from progressive glaucomatous damage and from complications of surgery, both short and long term, were included. METHODS:A retrospective, community-based, longitudinal study of residents of Olmsted County, Minne...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(01)00923-0
更新日期：2001-07-01 00:00:00
abstract：PURPOSE:To review the progress and challenges in obtaining accurate corneal power measurements for intraocular lens (IOL) calculations. DESIGN:Personal perspective, review of literature, case presentations, and personal data. METHODS:Through literature review findings, case presentations, and data from the author's c...
journal_title：American journal of ophthalmology
pub_type：
doi：10.1016/j.ajo.2016.08.020
更新日期：2016-11-01 00:00:00
abstract：PURPOSE:To examine acquired pit of the optic nerve as a risk factor for progression of glaucoma. METHODS:In a retrospective longitudinal study, 25 open-angle glaucoma patients with acquired pit of the optic nerve were compared with a group of 24 open-angle glaucoma patients without acquired pit of the optic nerve. The...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(99)80185-8
更新日期：1998-04-01 00:00:00
abstract：PURPOSE:To determine whether glaucoma patients exhibit an abnormal melatonin concentration in aqueous humor. DESIGN:Case-controlled study, laboratory investigation. METHODS:Aqueous humor and plasma samples of 28 patients with primary open-angle glaucoma and 31 nonglaucoma control patients were collected during surger...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2006.03.040
更新日期：2006-08-01 00:00:00
abstract：PURPOSE:To report a patient with persistent subepithelial corneal opacities 18 months after adenoviral keratoconjunctivitis who underwent photorefractive keratectomy for the correction of myopia. METHODS:Case report, review of medical literature, and slit-lamp photography. RESULTS:The patient underwent photorefractiv...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(98)00224-4
更新日期：1998-12-01 00:00:00
abstract：:In four patients, we repaired leaking blebs by using a new technique of excision of the cystic bleb and replacement with free conjunctival autograft. The leaks were repaired successfully, and bleb function was maintained in all four patients. This technique should be considered when surgical management of a leaking bl...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)70060-1
更新日期：1994-05-15 00:00:00
abstract：:Patients with chronic forms of blepharochalasis often develop eyelid deformities characterized by blepharoptosis and prolapse of the orbital fat and lacrimal gland. Some individuals have an acquired form of blepharophimosis, secondary to the dehiscence of the canthal tendons. In this late stage of the condition, the t...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(85)90009-1
更新日期：1985-04-15 00:00:00
abstract：:We conducted electrophysiologic tests of the toxic effects of fluorouracil on 26 albino rabbit eyes. Fluorouracil concentrations of 10(-7) g/ml, 10(-6) g/ml, and 10(-5) g/ml produced no significant changes in the b-wave amplitudes of the electroretinogram. A concentration of 10(-4) g/ml, however, reduced the b-wave am...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)73422-1
更新日期：1983-11-01 00:00:00
abstract：:Eight patients with manifest latent nystagmus, as noted by ocular movement recordings, were examined for nystagmus reduction after surgical or optical treatment. Seven of the patients had strabismus. Five patients underwent strabismus surgery, had no tropia postoperatively, and the manifest latent nystagmus converted ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)76985-5
更新日期：1990-08-15 00:00:00
abstract：PURPOSE:To identify the frequency of recently acquired vs chronic systemic Toxoplasma gondii infections in patients with ocular toxoplasmosis. METHODS:Serum samples from 22 patients with primary ocular toxoplasmosis (not from scars) and 42 patients with recurrent ocular toxoplasmosis were tested for the presence of an...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(99)00266-4
更新日期：1999-10-01 00:00:00
abstract：:We used fluorophotometry and pachymetry to examine the longer-term (more than three months) postoperative effects in the anterior segment of extracapsular lens extraction with and without posterior chamber intraocular lens implantation. Fluorophotometry was performed after oral administration of fluorescein solution (...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)76090-8
更新日期：1984-02-01 00:00:00
abstract：:A 26-year-old woman experienced bilateral hearing loss, progressive nasal obstruction, and rhinorrhea. Examination disclosed a retropharyngeal mass. A needle biopsy specimen of the mass showed that it was a chordoma. The patient underwent surgery to remove the mass and received a postoperative course of radioactive co...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)75899-4
更新日期：1981-07-01 00:00:00
abstract：:Long-term medical therapy and laser trabeculoplasty have been implicated as risk factors in the outcome of glaucoma filtration surgery. A retrospective analysis was performed of patients undergoing primary trabeculectomy during three key periods: before use of beta-blockers and laser trabeculoplasty (1975 and 1976), a...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)73068-5
更新日期：1994-02-15 00:00:00
abstract：PURPOSE:To determine the haptic position in transsclerally sutured posterior chamber lenses. METHODS:Fifty eyes with transsclerally sutured posterior chamber lenses were evaluated gonioscopically to determine the superior haptic position using previous peripheral iridectomies. RESULTS:The superior haptic of the trans...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)70146-1
更新日期：1997-03-01 00:00:00
