Abstract：
PURPOSE:To determine whether glaucoma patients exhibit an abnormal melatonin concentration in aqueous humor. DESIGN:Case-controlled study, laboratory investigation. METHODS:Aqueous humor and plasma samples of 28 patients with primary open-angle glaucoma and 31 nonglaucoma control patients were collected during surgery, and additional plasma samples were taken the night preceding surgery. Melatonin concentrations were determined using direct radioimmunoassay. RESULTS:This study shows detectable concentrations of melatonin in the aqueous humor of healthy humans (45% of subjects) and of glaucoma patients (36% of subjects) sampled in the morning, with similar levels of aqueous humor melatonin concentrations in both groups (6.4 +/- 9.3 standard deviation (SD) pg/ml and 3.6 +/- 1.9 pg/ml, respectively). We find no significant association between the severity of glaucoma and melatonin levels in aqueous humor or in plasma. CONCLUSIONS:Moderate and severe glaucoma does not appear to be associated with abnormal melatonin concentrations in aqueous humor, at least during the morning sampling period assayed in this study.
journal_name
Am J Ophthalmoljournal_title
American journal of ophthalmologyauthors
Chiquet C,Claustrat B,Thuret G,Brun J,Cooper HM,Denis Pdoi
10.1016/j.ajo.2006.03.040subject
Has Abstractpub_date
2006-08-01 00:00:00pages
325-327.e1issue
2eissn
0002-9394issn
1879-1891pii
S0002-9394(06)00424-7journal_volume
142pub_type
杂志文章abstract：PURPOSE:To describe the genetic and phenotypic characteristics of a cohort of patients with PROM1 variants. DESIGN:Case-case study. METHODS:We screened a cohort of 2216 families with inherited retinal dystrophies using classical molecular techniques and next-generation sequencing approaches. The clinical histories of...
journal_title：American journal of ophthalmology
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journal_title：American journal of ophthalmology
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journal_title：American journal of ophthalmology
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journal_title：American journal of ophthalmology
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journal_title：American journal of ophthalmology
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journal_title：American journal of ophthalmology
pub_type： 杂志文章
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更新日期：2015-06-01 00:00:00
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journal_title：American journal of ophthalmology
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journal_title：American journal of ophthalmology
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journal_title：American journal of ophthalmology
pub_type： 杂志文章
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journal_title：American journal of ophthalmology
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更新日期：1999-04-01 00:00:00
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journal_title：American journal of ophthalmology
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更新日期：2020-10-01 00:00:00
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journal_title：American journal of ophthalmology
pub_type： 杂志文章
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更新日期：2001-12-01 00:00:00
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journal_title：American journal of ophthalmology
pub_type： 杂志文章,评审
doi：10.1016/j.ajo.2012.06.006
更新日期：2012-12-01 00:00:00
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journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(79)90199-5
更新日期：1979-01-01 00:00:00
abstract：PURPOSE:To report the association of Marcus Gunn jaw-winking phenomenon and pseudo inferior oblique overaction. METHODS:Case report. RESULTS:A 21-year-old woman presented with right eyelid elevation on the chewing movement since infancy. Examination showed that both Marcus Gunn jaw-winking phenomenon and pseudo infer...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
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更新日期：2001-01-01 00:00:00
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journal_title：American journal of ophthalmology
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journal_title：American journal of ophthalmology
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更新日期：2021-01-22 00:00:00
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pub_type： 杂志文章,多中心研究,随机对照试验
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更新日期：2016-03-01 00:00:00
abstract：PURPOSE:To report the response of acute Behçet retinitis to high-dose corticosteroids. METHOD:Case report. A 58-year-old man with Behçet disease and severe bilateral glaucoma experienced a sudden decrease of visual acuity to counting fingers in his (better-seeing) left eye. Examination disclosed hypopyon uveitis and a...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
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更新日期：1998-03-01 00:00:00
abstract：PURPOSE:To describe the incidence rates of visual loss and ocular complications in patients with retinal vasculitis (RV). DESIGN:Retrospective cohort study. METHODS:Clinical data were collected for 96 patients (175 eyes) diagnosed with RV from 2003 to 2013. Main outcome measures included rates of visual loss and ocul...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
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更新日期：2017-07-01 00:00:00
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journal_title：American journal of ophthalmology
pub_type： 杂志文章
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更新日期：2003-12-01 00:00:00
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journal_title：American journal of ophthalmology
pub_type： 杂志文章
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更新日期：1976-10-01 00:00:00
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journal_title：American journal of ophthalmology
pub_type： 杂志文章
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更新日期：2020-09-01 00:00:00
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journal_title：American journal of ophthalmology
pub_type： 杂志文章
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更新日期：2008-08-01 00:00:00
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journal_title：American journal of ophthalmology
pub_type： 杂志文章
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更新日期：1996-11-01 00:00:00
abstract：:Surgical treatments of macular holes have become increasingly effective in inducing resolution of the cuff of surrounding subretinal fluid, resulting in increased vision in many patients. However, for many conditions that mimic a macular hole, either surgery is not indicated or different surgical manipulations are nec...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
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更新日期：1994-06-15 00:00:00
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journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(88)90364-9
更新日期：1988-09-15 00:00:00
