Abstract:
PURPOSE:To determine the long-term outcome of glaucoma filtration surgery in preserving vision. Visual loss from progressive glaucomatous damage and from complications of surgery, both short and long term, were included. METHODS:A retrospective, community-based, longitudinal study of residents of Olmsted County, Minnesota, who were newly diagnosed with open-angle glaucoma between 1965 and 1980 and underwent filtration surgery in these or subsequent years through 1998. Intraocular pressure (IOP), visual acuity, visual fields, and progression to legal blindness were monitored. Kaplan-Meier analysis was used to determine the cumulative probabilities of changes in these parameters. RESULTS:73 eyes of 49 patients underwent conventional filtration surgery. Analysis of the first eye having surgery revealed a mean preoperative IOP of 27.6 +/- 8.5 mm dropping to 16.7 +/- 5.6 mm at year one, and remaining in this range throughout follow-up (14.7 +/- 3.0 mm at 10 years; with or without use of medications). The probability of progression to blindness was 46% at 10 years after surgery, as calculated by Kaplan-Meier analysis. Eyes going blind had a postoperative IOP equal to or lower than those not becoming blind (14.0 +/- 4.4 vs. 15.4 +/- 3.0 at postoperative year 10). Eyes going blind had more advanced field loss at the time of surgery, with scotomas above and below the horizontal axis, than eyes not going blind, which had scotomas in only one hemifield. Three patients developed late bleb leaks; two patients developed endophthalmitis. The probability of undergoing cataract surgery was 37% by 10 years postoperatively, which did not differ significantly from the cohort of patients not undergoing surgery at a comparable time point. CONCLUSIONS:Filtration surgery was associated with a 54% probability of preservation of vision from progression to legal blindness at 10 years after surgery. Patients becoming blind had more advanced field loss at the time of surgery; IOP was similar between those going blind and those retaining vision.
journal_name
Am J Ophthalmoljournal_title
American journal of ophthalmologyauthors
Parc CE,Johnson DH,Oliver JE,Hattenhauer MG,Hodge DOdoi
10.1016/s0002-9394(01)00923-0subject
Has Abstractpub_date
2001-07-01 00:00:00pages
27-35issue
1eissn
0002-9394issn
1879-1891pii
S0002939401009230journal_volume
132pub_type
杂志文章abstract:PURPOSE:To report histopathologic confirmation of the internal limiting membrane (ILM) using triamcinolone acetonide (TA). DESIGN:Interventional case report. METHODS:One eye of one patient who underwent macular hole repair using TA suspension to help visualize the internal limiting membrane (ILM). The specimen was se...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2004.04.025
更新日期:2004-10-01 00:00:00
abstract::Two siblings had atrophic maculopathy associated with hereditary ataxia clinically defined as an olivopontocerebellar degeneration. The macular changes were suggestive of an early bull's-eye maculopathy in one case and of a late atrophic stage of bull's-eye maculopathy in the other. This suggests that concentric annul...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(14)75125-6
更新日期:1980-11-01 00:00:00
abstract::The adjunctive use of antimetabolites has revolutionized surgical procedures to correct glaucoma in the past decade. Although much is known about the in vitro and in vivo actions of 5-fluorouracil and mitomycin C, their use in the eye has raised new questions about cellular toxicity. For example, filtering blebs after...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(14)72957-5
更新日期:1994-09-15 00:00:00
abstract::Between September 1978 and December 1985, 450 case reports of serious respiratory and cardiovascular events and 32 case reports of death attributed to ophthalmic timolol were received by the United States Food and Drug Administration and the National Registry of Drug-Induced Ocular Side Effects. Two hundred sixty-seve...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/0002-9394(86)90532-5
更新日期:1986-11-15 00:00:00
abstract::A 4-year-old boy had a case of ischemic infarction of the retina that occurred immediately after percutaneous carotoid angiography via a femoral percutaneous approach. This appears to be the youngest reported patient with this complication. ...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/0002-9394(76)90203-8
更新日期:1976-01-01 00:00:00
abstract:PURPOSE:To evaluate the effects of a dexamethasone intravitreous drug delivery system (dexamethasone DDS) in patients with persistent macular edema (ME) resulting from uveitis or Irvine-Gass syndrome. DESIGN:Randomized, prospective, single-masked, controlled trial. METHODS:Three hundred and fifteen patients with pers...
journal_title:American journal of ophthalmology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.ajo.2008.12.033
更新日期:2009-06-01 00:00:00
abstract:PURPOSE:To compare the nocturnal effects of once-daily timolol and latanoprost on intraocular pressure (IOP) in patients with ocular hypertension or early glaucomatous changes. DESIGN:Prospective, open-label, experimental study with crossover design. METHODS:Eighteen patients with ocular hypertension or early glaucom...
journal_title:American journal of ophthalmology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/j.ajo.2004.04.022
更新日期:2004-09-01 00:00:00
abstract:PURPOSE:To determine the incidence of developing an idiopathic full-thickness macular hole in fellow eyes that have vitreofoveal attachments and perifoveal vitreous detachment in patients with unilateral idiopathic macular hole. DESIGN:Retrospective cross-sectional observational study. METHODS:The fellow eyes of 201 ...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2005.03.070
更新日期:2005-09-01 00:00:00
abstract::Dipivalyl epinephrine, 0.1%, though slightly less effective in decreasing intraocular pressure, showed significantly fewer side effects than epinephrine hydrochloride, 2%. Seventeen patients with symmetrically increased intraocular pressures who completed a six-month double-masked crossover study showed a significant ...
journal_title:American journal of ophthalmology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0002-9394(79)90142-9
更新日期:1979-02-01 00:00:00
abstract::Leber's hereditary optic neuropathy is caused by a single nucleotide change in the mitochondrial deoxyribonucleic acid (mtDNA). Each cell contains thousands of mitochondrial DNA molecules. We demonstrated that in certain isolated instances, the proband and close maternal lineage relatives can have mixtures of mutant a...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(14)72429-8
更新日期:1990-06-15 00:00:00
abstract::A 57-year-old man had a clinically suspected malignant melanoma in his left eye. On microscopic study, the enucleated eye harbored an unusual choroidal tumor that had extended extraocularly. This tumor had been variously interpreted microscopically as an angiosarcoma, an atpical angioma, a glioma, or a neurilemoma. El...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/0002-9394(76)90419-0
更新日期:1976-08-01 00:00:00
abstract:PURPOSE:To report the visual outcome of multiple laser treatments for macular edema attributable to branch retinal vein occlusions (BRVO) and to determine if any prognostic factors exist for improvement. DESIGN:Retrospective chart review. METHODS:A private practice with four vitreoretinal surgeons performed laser tre...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2004.11.011
更新日期:2005-04-01 00:00:00
abstract::Severe retrobulbar hemorrhage may occur as a complication of a retrobulbar injection or from blunt or sharp injury to the orbit during an orbital or periorbital operation. When the patient with a severe retrobulbar hemorrhage does not respond to intermittent ocular massage, or paracentesis, or a lateral canthotomy, pr...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(14)71740-4
更新日期:1993-07-15 00:00:00
abstract::A 65-year-old white man had an unusual disseminated lymphoid tumor that first appeared in the subconjunctival tissues of the right eye. The tumor later appeared in the skin, lymph nodes, and left upper eyelid and orbit. A monoclonal serum IgA spike was present although the urine did not contain Bence Jones proteins. T...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/0002-9394(75)90082-3
更新日期:1975-02-01 00:00:00
abstract::Patients with chronic forms of blepharochalasis often develop eyelid deformities characterized by blepharoptosis and prolapse of the orbital fat and lacrimal gland. Some individuals have an acquired form of blepharophimosis, secondary to the dehiscence of the canthal tendons. In this late stage of the condition, the t...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/0002-9394(85)90009-1
更新日期:1985-04-15 00:00:00
abstract:UNLABELLED:To examine prospectively the efficacy and safety of photorefractive keratectomy and photoastigmatic refractive keratectomy. METHODS:We treated 645 eyes (440 patients) with a VisX Twenty/Twenty excimer laser and followed them up for 12 months. RESULTS:The percentage of eyes with myopia between -5.01 and -10...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(14)70433-7
更新日期:1996-04-01 00:00:00
abstract::A 46-year-old man developed symptoms of a chronic progressive uveitis in his right eye approximately one week after a dental procedure. The patient's intraocular inflammation was not diminished by massive treatment with topical and systemic corticosteroid therapy or intravenously administered adrenocorticotropic hormo...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(14)77101-6
更新日期:1978-05-01 00:00:00
abstract:PURPOSE:To develop a classification and grading system for myopic maculopathy. DESIGN:Development and evaluation of a classification system for myopic maculopathy based on observational case series. METHODS:A comprehensive set of myopic macular lesions was defined via literature review and through consensus meetings ...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2015.01.022
更新日期:2015-05-01 00:00:00
abstract::Long-term medical therapy and laser trabeculoplasty have been implicated as risk factors in the outcome of glaucoma filtration surgery. A retrospective analysis was performed of patients undergoing primary trabeculectomy during three key periods: before use of beta-blockers and laser trabeculoplasty (1975 and 1976), a...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(14)73068-5
更新日期:1994-02-15 00:00:00
abstract:PURPOSE:To compare 1-muscle vs 2-muscle surgery for moderate-angle hyperdeviations owing to presumed unilateral fourth nerve palsy. DESIGN:Retrospective chart review. METHODS:Seventy-three patients (aged 5-86 years) underwent either 1- or 2-muscle surgery at our institution for moderate hyperdeviation owing to presum...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2017.06.030
更新日期:2017-10-01 00:00:00
abstract:PURPOSE:Encapsulation of the Ahmed glaucoma valve (AGV) plate is a common cause for postoperative elevation of intraocular pressure, especially in children. Many reports have described the outcomes of AGV revision in adults. However, the outcomes of AGV revision in children are poorly documented. The aim of this study ...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2017.09.015
更新日期:2017-11-01 00:00:00
abstract:PURPOSE:To report the spontaneous resolution of a traumatic macular hole that was considerably larger than in previously reported cases. DESIGN:Observational case report. METHODS:The clinical and angiographic data of the patient were reviewed. RESULTS:A traumatic 600 x 400 micro macular hole was observed to spontane...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(02)01594-5
更新日期:2002-10-01 00:00:00
abstract:PURPOSE:To evaluate a new computerized segmentation technique for the quantification of intraretinal and subretinal fluid in spectral-domain optical coherence tomography (SD OCT) images of the retina. DESIGN:Prospective, cross-sectional study. METHODS:Thirty-seven B-scan images of 37 patients with exudative age-relat...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2012.07.030
更新日期:2013-02-01 00:00:00
abstract:PURPOSE:To investigate whether use of donors predisposed by corneal collagen cross-linking (CXL) reduced myopic refractive errors for keratoconic eyes after penetrating keratoplasty (PK). DESIGN:Randomized controlled trial. METHODS:One hundred sixteen eyes of 116 patients with keratoconus from Zhongshan Ophthalmic Ce...
journal_title:American journal of ophthalmology
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.ajo.2017.10.003
更新日期:2017-12-01 00:00:00
abstract:PURPOSE:To compare the effect of age, sex and generation on physician practice patterns in Ontario, Canada. DESIGN:Retrospective cohort study. METHODS:Physician and patient data from 1992-2013 were used to calculate the yearly number of physicians, distinct patients seen, patient visits, government payments, physicia...
journal_title:American journal of ophthalmology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.ajo.2019.04.006
更新日期:2019-09-01 00:00:00
abstract::The transmission characteristics of a new filter combination for fluorescein angiography were selected on the basis of in vivo measurements of the excitation and emission spectra of fluorescein dye during its transit in the fundus. This combination of filters was characterized by separation of 530 nm between the spect...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/0002-9394(76)90542-0
更新日期:1976-10-01 00:00:00
abstract::We studied the ultrastructure of the four types of dysplastic rosettes and compared them with retinoblastoma rosettes. Dysplastic rosettes have morphologic characteristics intermediate between the normal photoreceptor layer and retino-blastoma rosettes; Müller cells contribute to the formation of dysplastic but not ne...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(14)77107-7
更新日期:1978-05-01 00:00:00
abstract::We used wide-field color specular microscopy of the human corneal surface to study the morphologic changes that occur under extended-wear contact lenses. There was a shift in the frequency distribution of surface cells by size to larger cells, suggesting a prolonged residence time on the ocular surface. Other abnormal...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/0002-9394(86)90818-4
更新日期:1986-03-15 00:00:00
abstract:OBJECTIVE:To elucidate molecular risk factors for posterior segment uveitis using a functional genomics approach. DESIGN:Genetic association cohort study. METHODS:Setting: Single-center study at an academic referral center. STUDY POPULATION:164 patients with clinically diagnosed uveitis of the posterior segment. MA...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2020.07.021
更新日期:2021-01-01 00:00:00
abstract:PURPOSE:To determine the spectrum of conjunctival flora and the antibiotic susceptibility profiles of patients undergoing cataract surgery at a Midwestern university. DESIGN:Prospective in vitro laboratory investigation of a patient cohort. METHODS:Conjunctival cultures were obtained from patients undergoing cataract...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2012.06.024
更新日期:2013-01-01 00:00:00