Abstract：
PURPOSE:To evaluate the outcome of intravitreal injection of aflibercept in cases with exudative age-related macular degeneration, (AMD) resistant to injections of bevacizumab or ranibizumab. DESIGN:Retrospective observational case series. METHODS:A retrospective chart review at a single institution was conducted to identify patients with exudative AMD and choroidal neovascularization (CNV) in 1 or both eyes resistant to treatment with ranibizumab or bevacizumab who were switched to treatment with at least 3 monthly injections of aflibercept. In total, 36 eyes from 31 patients were included. The demographic data, visual acuities, central macular thickness on optical coherence tomography (OCT), complications, and number of injections were reviewed. RESULTS:The mean patient age was 79 years (range 60-88). There were 13 male and 18 female patients. The number of prior injections with either bevacizumab or ranibizumab ranged from 6-74. After 3 monthly injections of aflibercept, there was a reduction of either subretinal or intraretinal fluid in 18 of 36 (50.0%) of the treated eyes; the amount of fluid remained stable in 15 eyes (41.7%) and worsened in 3 eyes (8.3%). A significant average decrease was observed for the central macular thickness after 3 injections of 65 μm (P = 2.9 × 10(-6)), with no significant change in visual acuity. CONCLUSIONS:Aflibercept therapy appears to be beneficial in a subset of patients with neovascular age-related macular degeneration who exhibit recurrent or resistant intraretinal or subretinal fluid following multiple injections with either bevacizumab or ranibizumab.
journal_name
Am J Ophthalmoljournal_title
American journal of ophthalmologyauthors
Bakall B,Folk JC,Boldt HC,Sohn EH,Stone EM,Russell SR,Mahajan VBdoi
10.1016/j.ajo.2013.02.017subject
Has Abstractpub_date
2013-07-01 00:00:00pages
15-22.e1issue
1eissn
0002-9394issn
1879-1891pii
S0002-9394(13)00144-Xjournal_volume
156pub_type
杂志文章abstract：:We modified trabeculo-iridocyclosclerectomy in a technique for en bloc excision of anterior uveal tumor. A trabeculectomy-type of approach was used, which allowed excision of a rectangular block of sclera, cornea, and trabeculum with attached uveal tissue containing the tumor. ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(79)90657-3
更新日期：1979-09-01 00:00:00
abstract：PURPOSE:To determine the efficacy of internal limiting membrane (ILM) peeling during vitrectomy for rhegmatogenous retinal detachment (RRD) regarding post-vitrectomy epiretinal membrane (ERM) development and visual outcomes. DESIGN:Retrospective, interventional, comparative case series. METHODS:Setting: Institutional...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2016.08.015
更新日期：2016-11-01 00:00:00
abstract：:Subconjunctival 5-fluorouracil has been an effective adjunct in glaucoma filtering surgery. We investigated the effectiveness of 5-fluorouracil in primary trabeculectomy combined with phacoemulsification and posterior chamber intraocular lens implantation (glaucoma triple procedure). Seventy-four patients were enrolle...
journal_title：American journal of ophthalmology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0002-9394(14)73202-7
更新日期：1993-11-15 00:00:00
abstract：PURPOSE:To compare the in vitro toxicity of brilliant blue G (BBG), indocyanine green (ICG), Trypan blue (TB), and Evans blue (EB) in a human retinal pigment epithelial cell line (ARPE-19) and a murine retinal ganglion/Muller glial (RGC) primary cell culture. DESIGN:In vitro cell biology experimental study. METHODS:T...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2008.08.031
更新日期：2009-02-01 00:00:00
abstract：PURPOSE:To identify any temporal trends in the diagnosis of plus disease in retinopathy of prematurity (ROP) by experts. DESIGN:Reliability analysis. METHODS:ROP experts were recruited in 2007 and 2016 to classify 34 wide-field fundus images of ROP as plus, pre-plus, or normal, coded as "3," "2," and "1," respectivel...
journal_title：American journal of ophthalmology
pub_type： 杂志文章,多中心研究
doi：10.1016/j.ajo.2016.12.025
更新日期：2017-04-01 00:00:00
abstract：:We studied four patients who, having received postoperative 5-fluorouracil after glaucoma filtering operations, developed serious corneal complications. All four patients had preexisting corneal abnormalities including keratoconjunctivitis sicca, exposure keratopathy, and bullous keratopathy. All of the patients devel...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)74224-2
更新日期：1987-02-15 00:00:00
abstract：PURPOSE:To identify the frequency of recently acquired vs chronic systemic Toxoplasma gondii infections in patients with ocular toxoplasmosis. METHODS:Serum samples from 22 patients with primary ocular toxoplasmosis (not from scars) and 42 patients with recurrent ocular toxoplasmosis were tested for the presence of an...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(99)00266-4
更新日期：1999-10-01 00:00:00
abstract：PURPOSE:In juvenile X-linked retinoschisis (XLRS), fluorescein angiography is usually unremarkable and contributes poorly to the diagnosis. However, indocyanine green (ICG) angiography features in eyes that are affected with XLRS were not yet described. DESIGN:Retrospective observational case series. METHODS:A comple...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2005.03.051
更新日期：2005-09-01 00:00:00
abstract：PURPOSE:To evaluate the effect of macular reticular pseudodrusen on retinal function using multiple imaging methods. DESIGN:Prospective cross-sectional study. METHODS:Thirteen eyes with reticular pseudodrusen, but without any other macular abnormality or glaucoma, and 20 normal eyes were evaluated. All subjects under...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2013.06.036
更新日期：2013-12-01 00:00:00
abstract：PURPOSE:To investigate the fundus autofluorescence (FAF) imaging findings in patients with serous and drusenoid pigment epithelial detachment (PED) associated with age-related macular degeneration (AMD). DESIGN:Observational case series. METHODS:Fourteen eyes of 13 consecutive patients with serous (n = 10) and drusen...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2005.07.037
更新日期：2005-12-01 00:00:00
abstract：PURPOSE:To report a case of chronic recurrent varicella virus epithelial keratitis in a child. DESIGN:Case report. METHODS:Clinical examination and polymerase chain reaction analysis of corneal epithelium. RESULTS:A 10-year-old healthy child developed chronic recurrent varicella virus keratitis with pseudodendrites ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2004.12.014
更新日期：2005-06-01 00:00:00
abstract：:Graft edema developed after removal of continuous monofilament sutures in six eyes of six patients in whom no wound dehiscence occurred. All sutures were removed at least one year after penetrating keratoplasty, and graft edema was noted one day after suture removal. In all cases, partial or total resolution of graft ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(79)90461-6
更新日期：1979-08-01 00:00:00
abstract：PURPOSE:To identify the genetic defect and present the ocular and extraocular findings in a large pedigree of predominantly ocular Stickler syndrome. DESIGN:Observational case series. METHODS:An eight-generation pedigree with hereditary retinal detachments was retrospectively and prospectively studied. Clinical infor...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(02)01646-x
更新日期：2002-11-01 00:00:00
abstract：:Rabbit eyes in which vitrectomy was performed underwent three hours of hypothermic perfusion with either 22 C or 2 C lactated Ringer's solution. Clinical, electroretinographic, fluorescein angiographic, histologic, and ultrastructural examinations were performed. No changes were noted in eyes cooled with 22 C fluid. R...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)74615-x
更新日期：1990-04-15 00:00:00
abstract：PURPOSE:To determine whether cataract in patients with atopic dermatitis is associated with higher levels of aqueous flare or cells. METHODS:In a prospective study, 35 consecutive patients examined during a 6-month period at the atopic dermatitis service in a university hospital underwent standardized ophthalmologic e...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)71641-1
更新日期：1997-07-01 00:00:00
abstract：PURPOSE:To objectively quantify choroidal thickness and choroidal volume using fully automated choroidal segmentation software applied to images obtained from enhanced depth imaging spectral-domain optical coherence tomography (EDI SD OCT) in a population-based study; and evaluate the ocular and systemic determinants o...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2014.10.034
更新日期：2015-02-01 00:00:00
abstract：PURPOSE:To report long-term clinical outcomes of deep anterior lamellar keratoplasty (DALK) in patients with keratoconus. DESIGN:Retrospective noncomparative interventional study. METHODS:setting: Single center. patients: Total of 158 eyes/150 consecutive patients with keratoconus with postoperative follow-up time eq...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2014.11.033
更新日期：2015-03-01 00:00:00
abstract：:We studied four patients with anisocoria and the pigmentary dispersion syndrome. In all patients, the larger pupil was on the side of the greater iris transillumination. The amount of anisocoria was between 0.5 and 1.5 mm and was the same in both the light and dark. There was no blepharoptosis, and all pupils dilated ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)77063-1
更新日期：1990-12-15 00:00:00
abstract：PURPOSE:To study the effects of age, sex, intraocular pressure (IOP), corneal thickness, axial length (AXL), disc area, and the signal strength of the scan on optical coherence tomography (OCT) parameters of normal subjects in the L V Prasad Eye Institute-Glaucoma Epidemiological and Molecular Genetic Study (LVPEI-GLEA...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
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更新日期：2020-12-08 00:00:00
abstract：PURPOSE:To report histopathologic confirmation of the internal limiting membrane (ILM) using triamcinolone acetonide (TA). DESIGN:Interventional case report. METHODS:One eye of one patient who underwent macular hole repair using TA suspension to help visualize the internal limiting membrane (ILM). The specimen was se...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2004.04.025
更新日期：2004-10-01 00:00:00
abstract：PURPOSE:To assess the optic nerve head (ONH) by optical coherence tomography (OCT), confocal scanning laser ophthalmoscopy (CSLO), and the retinal nerve fiber layer (RNFL) by OCT and scanning laser polarimetry (GDx) in highly myopic subjects. DESIGN:Observational cross-sectional study. METHODS:Thirty-five eyes of hig...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2006.05.022
更新日期：2006-11-01 00:00:00
abstract：PURPOSE:To evaluate the outcome of surgeries for macular holes using trypan blue to facilitate delamination of the internal limiting membrane. DESIGN:A retrospective series of 18 patients. METHOD:All patients underwent a three-port pars plana vitrectomy with internal limiting membrane delamination using trypan blue 0...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(02)02239-0
更新日期：2003-06-01 00:00:00
abstract：PURPOSE:To evaluate the efficacy and safety of transpupillary thermotherapy (TTT) for subfoveal neovascularization (SRNVM) in patients with group 2A Idiopathic Juxtafoveolar Telangiectasis (IJFT). DESIGN:Nonrandomized interventional case series. METHODS:We performed TTT for subfoveal SRNVM in 14 eyes of 13 patients w...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2004.01.047
更新日期：2004-07-01 00:00:00
abstract：PURPOSE:To develop a rapid, sensitive, and specific laboratory assay based on the polymerase chain reaction for the diagnosis of varicella-zoster virus retinitis in patients with acquired immunodeficiency syndrome (AIDS). METHODS:We developed and tested a polymerase chain reaction-based assay for the detection of vari...
journal_title：American journal of ophthalmology
pub_type： 临床试验,杂志文章
doi：10.1016/s0002-9394(14)71031-1
更新日期：1997-02-01 00:00:00
abstract：:Nonaccommodative convergence excess is a condition in which a patient has orthotropia or a small-angle esophoria or esotropia at distance and a large-angle esotropia at near, not significantly reduced by the addition of spherical plus lenses. The AC/A ratio, determined with the gradient method, is normal or subnormal....
journal_title：American journal of ophthalmology
pub_type： 杂志文章
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更新日期：1986-01-15 00:00:00
abstract：PURPOSE:To determine whether glaucoma patients exhibit an abnormal melatonin concentration in aqueous humor. DESIGN:Case-controlled study, laboratory investigation. METHODS:Aqueous humor and plasma samples of 28 patients with primary open-angle glaucoma and 31 nonglaucoma control patients were collected during surger...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2006.03.040
更新日期：2006-08-01 00:00:00
abstract：PURPOSE:To describe the clinical presentation and histologic findings in a patient with metastatic mesothelioma presenting to the ophthalmologist with nonaxial proptosis. DESIGN:Case report. METHODS:A 55-year-old man presented with a short history of progressive ocular discomfort and vertical diplopia. Clinical exami...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2003.12.012
更新日期：2004-05-01 00:00:00
abstract：:A microsurgical modification of the Rizzuti scleral fixation forceps for corneal and cataract surgery employs Bonn 0.12-mm teeth on an angled handle with an appropriate curve between the teeth to fix the tissue more adequately to allow accurate placement of sutures. ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(76)90077-5
更新日期：1976-12-01 00:00:00
abstract：:We studied the clinical and microscopic appearances of the optic nerve head in squirrel monkeys with optic nerve degeneration produced by optic nerve transection at the orbital apex. The ophthalmoscopic development of optic disk pallor coincided with the loss of nerve fiber bundles and the rearrangement of the remaini...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(77)90138-6
更新日期：1977-05-01 00:00:00
abstract：PURPOSE:To present a case of choroidal neovascularization associated with sympathetic ophthalmia successfully treated with photocoagulation. DESIGN:Interventional case report. METHODS:A 41-year-old man with a history of penetrating injury right eye, as well as sympathetic ophthalmia left eye, developed a classic chor...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
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更新日期：2001-10-01 00:00:00
