Abstract：
PURPOSE:To identify any temporal trends in the diagnosis of plus disease in retinopathy of prematurity (ROP) by experts. DESIGN:Reliability analysis. METHODS:ROP experts were recruited in 2007 and 2016 to classify 34 wide-field fundus images of ROP as plus, pre-plus, or normal, coded as "3," "2," and "1," respectively, in the database. The main outcome was the average calculated score for each image in each cohort. Secondary outcomes included correlation on the relative ordering of the images in 2016 vs 2007, interexpert agreement, and intraexpert agreement. RESULTS:The average score for each image was higher for 30 of 34 (88%) images in 2016 compared with 2007, influenced by fewer images classified as normal (P < .01), a similar number of pre-plus (P = .52), and more classified as plus (P < .01). The mean weighted kappa values in 2006 were 0.36 (range 0.21-0.60), compared with 0.22 (range 0-0.40) in 2016. There was good correlation between rankings of disease severity between the 2 cohorts (Spearman rank correlation ρ = 0.94), indicating near-perfect agreement on relative disease severity. CONCLUSIONS:Despite good agreement between cohorts on relative disease severity ranking, the higher average score and classifications for each image demonstrate that experts are diagnosing pre-plus and plus disease at earlier stages of disease severity in 2016, compared with 2007. This has implications for patient care, research, and teaching, and additional studies are needed to better understand this temporal trend in image-based plus disease diagnosis.
journal_name
Am J Ophthalmoljournal_title
American journal of ophthalmologyauthors
Moleta C,Campbell JP,Kalpathy-Cramer J,Chan RVP,Ostmo S,Jonas K,Chiang MF,Imaging & Informatics in ROP Research Consortium.doi
10.1016/j.ajo.2016.12.025subject
Has Abstractpub_date
2017-04-01 00:00:00pages
70-76eissn
0002-9394issn
1879-1891pii
S0002-9394(17)30001-6journal_volume
176pub_type
杂志文章,多中心研究abstract：PURPOSE:To evaluate the natural history and ophthalmologic morbidity of Mycoplasma pneumoniae-induced rash and mucositis (MIRM) and propose a treatment algorithm. DESIGN:Retrospective, interventional case series. METHODS:Retrospective chart review of all MIRM patients examined by the department of ophthalmology at a ...
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