Abstract:
:To evaluate the effects of two beta-adrenergic blocking agents on cardiopulmonary function, we investigated two topical ophthalmologic preparations, betaxolol 1% and timolol 0.5%, in nine patients (eight men and one woman, ranging in age from 25 to 69 years) with reactive airway disease. The randomized, double-masked, crossover study used placebo eyedrops as the control, and each drug was tested on separate days. Spirometric measurements, respiratory rate, pulse rate, and blood pressure were observed at frequent intervals for four hours after the test solutions were instilled. At the end of the test, an inhaled beta-adrenergic stimulant (isoproterenol) was administered, and the measurements were repeated. Timolol produced a significant decrease in airflow, measured by forced expiratory volume in one second (FEV1) and the ratio of FEV1 to vital capacity at each observation time beyond 15 minutes. Betaxolol and placebo eyedrops produced no significant change from control values. These results suggested that timolol can adversely affect patients with reactive airway disease. Betaxolol eyedrops, conversely, caused no decrease in airflow in the same patients with proven airway disease.
journal_name
Am J Ophthalmoljournal_title
American journal of ophthalmologyauthors
Schoene RB,Abuan T,Ward RL,Beasley CHdoi
10.1016/0002-9394(84)90450-1subject
Has Abstractpub_date
1984-01-01 00:00:00pages
86-92issue
1eissn
0002-9394issn
1879-1891pii
0002-9394(84)90450-1journal_volume
97pub_type
杂志文章abstract:PURPOSE:To develop a classification and grading system for myopic maculopathy. DESIGN:Development and evaluation of a classification system for myopic maculopathy based on observational case series. METHODS:A comprehensive set of myopic macular lesions was defined via literature review and through consensus meetings ...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2015.01.022
更新日期:2015-05-01 00:00:00
abstract:PURPOSE:To report the clinical outcome in 48 eyes of 48 children who received a Baerveldt glaucoma implant (BGI) for the management of pediatric glaucoma. DESIGN:Retrospective, noncomparative case series. METHODS:The medical records of all patients with pediatric glaucoma who underwent a BGI at two tertiary care refe...
journal_title:American journal of ophthalmology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.ajo.2004.12.028
更新日期:2005-05-01 00:00:00
abstract:PURPOSE:To determine the prognostic factors of long-term visual outcome in birdshot retinochoroidopathy (BRC). METHODS:Design: Retrospective case series. Study Population: Successive HLA-A29+ BRC patients whose latest visit was between May and August 2013 at a single tertiary center (Pitié-Salpétrière Hospital, Paris)...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2016.08.007
更新日期:2016-10-01 00:00:00
abstract:PURPOSE:To determine the amount and time course of binocular visual acuity improvement during treatment of bilateral refractive amblyopia in children three to less than 10 years of age. DESIGN:Prospective, multicenter, noncomparative intervention. METHODS:One hundred and thirteen children (mean age, 5.1 years) with p...
journal_title:American journal of ophthalmology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.ajo.2007.05.040
更新日期:2007-10-01 00:00:00
abstract::We evaluated the reliability of optic disk area and disk rim area measurements obtained with the Humphrey Retinal Analyzer from ten repeat fundus images each of one eye of ten normal subjects and ten subjects with increased intraocular pressure. Variability of rim and disk areas was not significantly different between...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(14)73309-4
更新日期:1989-10-15 00:00:00
abstract:PURPOSE:To report one-year results of the Tube Versus Trabeculectomy (TVT) Study. DESIGN:Multicenter randomized clinical trial. METHODS: SETTING:17 Clinical Centers. STUDY POPULATION:Patients 18 to 85 years of age who had previous trabeculectomy and/or cataract extraction with intraocular lens implantation and unco...
journal_title:American journal of ophthalmology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.ajo.2006.07.020
更新日期:2007-01-01 00:00:00
abstract::Twenty-two fine needle (30 gauge) aspirations were performed in eyes enucleated for the clinical diagnosis of melanoma. Cytologic preparations were evaluated for adequacy of material, and needle tracts were evaluated for tumor implantation. A scleral marking method was used to identify all needle tracts. The number of...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/0002-9394(88)90248-6
更新日期:1988-05-15 00:00:00
abstract::Normal volunteers used 1, 2, and 4% pilocarpine eyedrops, three times daily, or ocular therapeutic systems placed in the conjunctival cul-de-sac to control intraocular pressure. The systems continuously release 20 and 40 mug/hour of pilocarpine for one week. Although the amount of drug delivered to the eye from the o...
journal_title:American journal of ophthalmology
pub_type: 临床试验,杂志文章
doi:10.1016/0002-9394(75)90404-3
更新日期:1975-10-01 00:00:00
abstract:PURPOSE:To measure retinal nerve fiber layer (NFL) thickness in normal subjects and patients with ocular hypertension and examine the relationship between age and normal NFL thickness. METHODS:Nerve fiber layer thickness was determined by scanning laser polarimetry in 210 normal subjects and 100 patients with ocular h...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(14)72013-6
更新日期:1996-08-01 00:00:00
abstract:PURPOSE:To determine whether central fusion and distance stereoacuity are useful as objective measures in assessing the need for and success of surgery for intermittent exotropia (X[T]). METHODS:A prospective, institutional, clinical trial was conducted of 26 consecutive patients with X(T) who were undergoing strabism...
journal_title:American journal of ophthalmology
pub_type: 临床试验,杂志文章
doi:10.1016/s0002-9394(99)00079-3
更新日期:1999-08-01 00:00:00
abstract:OBJECTIVE:To document the clinical presentation, treatment, and visual outcome of sarcoid uveitis and to determine the timing and potential risk factors of sarcoidosis progression to symptomatic systemic disease from the time of sarcoid uveitis diagnosis. DESIGN:Retrospective, interventional case series. METHODS:Subj...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2018.09.013
更新日期:2019-02-01 00:00:00
abstract:PURPOSE:To report a case of Diffuse Subretinal Fibrosis (DSF) syndrome refractory to immunosuppressive therapy who was successfully treated with anti-tumor necrosis factor-alpha (TNF)-alpha monoclonal antibodies infliximab. DESIGN:Interventional case report. METHODS:A 23-year-old male with bilateral choroiditis prese...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2006.10.047
更新日期:2007-03-01 00:00:00
abstract:PURPOSE:To report the spontaneous resolution of a traumatic macular hole that was considerably larger than in previously reported cases. DESIGN:Observational case report. METHODS:The clinical and angiographic data of the patient were reviewed. RESULTS:A traumatic 600 x 400 micro macular hole was observed to spontane...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(02)01594-5
更新日期:2002-10-01 00:00:00
abstract:PURPOSE:To compare the incidence, prevalence, and hazard of nonexudative and exudative age-related macular degeneration (AMD) among different races throughout the United States. DESIGN:Retrospective longitudinal cohort study. METHODS:Billing records of all encounters for 2 259 061 beneficiaries aged ≥40 enrolled in a...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2011.02.004
更新日期:2011-08-01 00:00:00
abstract::We recorded full-field electroretinograms from 47 males and 26 obligate carrier females with choroideremia. All males had responses that were subnormal with delayed cone b-wave implicit times or undetectable. Only four of 26 females had abnormal electroretinographic responses but 25 of 26 were identified by ophthalmos...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/0002-9394(86)90832-9
更新日期:1986-03-15 00:00:00
abstract::Exposure to organic isocyanates in the atmosphere of a polyurethane-foam-producing company resulted in microcystic corneal epithelial edema and conjunctival injection localized primarily in the palpebral fissure. The degree of microcystic edema and decreased visual acuity appeared to be related to location, length of ...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(14)75137-2
更新日期:1980-11-01 00:00:00
abstract:PURPOSE:To implant foldable posterior chamber intraocular lenses in the absence of capsular and zonular support. METHODS:Case reports. In two patients, two eyes with aphakia, lack of capsular or zonular support, and contact lens intolerance underwent the implantation of a silicone and an acrylic foldable posterior cha...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(98)00297-9
更新日期:1999-02-01 00:00:00
abstract::The haptic of a semiflexible anterior chamber intraocular lens (Kelman Quadraflex) broke inside the eye of a 70-year-old man. No history of major eye or head trauma could be elicited from the patient. Clinical manifestations included inferior corneal edema progressing toward the optical axis resulting from a free-floa...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/0002-9394(85)90226-0
更新日期:1985-02-15 00:00:00
abstract:PURPOSE:To determine the relationship between delayed patchy choroidal filling and morphologic and functional outcomes among eyes treated with ranibizumab or bevacizumab. DESIGN:Cohort study. METHODS:Comparison of Age-related Macular Degeneration Treatment Trials participants were assigned randomly to ranibizumab or ...
journal_title:American journal of ophthalmology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.ajo.2014.06.004
更新日期:2014-09-01 00:00:00
abstract:PURPOSE:To perform a comprehensive review and to investigate the presence and role of autoimmune antibodies in 25 cases of acute zonal occult outer retinopathy (AZOOR) identified using the classification originally proposed by J. Donald Gass. DESIGN:Observational case series. METHODS:Setting: Institutional. STUDY PO...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2016.12.001
更新日期:2017-04-01 00:00:00
abstract::We reviewed the records of 78 patients who underwent 128 surgical procedures for congenital or infantile cataracts before age 30 months for the type and frequency of postoperative complications. The surgeries included 92 limbal lensectomies and anterior vitrectomies, 13 pars plicata lensectomies, 20 aspirations, and t...
journal_title:American journal of ophthalmology
pub_type: 杂志文章,评审
doi:10.1016/0002-9394(89)90007-x
更新日期:1989-08-15 00:00:00
abstract:PURPOSE/METHODS:Central retinal artery occlusion occurs infrequently in children. We treated a child with central retinal artery occlusion before a systemic disease was discovered. RESULTS/CONCLUSION:Vision improved after paracentesis and anticoagulation. Systemic T-cell lymphoma was subsequently diagnosed. In contras...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(14)73772-9
更新日期:1995-07-01 00:00:00
abstract::We used contact irradiation with iodine 125 seeds to treat a large, exulcerative, nodular, amelanotic malignant eyelid melanoma with metastasis to the regional lymph nodes in an 80-year-old man. The procedure was similar to iodine 125 plaque irradiation of malignant choroidal melanoma; special equipment, however, was ...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(14)76936-3
更新日期:1990-07-15 00:00:00
abstract:PURPOSE:To study the clinicopathologic features of an untreated macular hole in the right eye and a macular hole in the left eye treated by vitrectomy, application of transforming growth factor-beta 2, and gas tamponade. METHODS:The patient, a 73-year-old man with bilateral macular holes, was studied clinically before...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(14)70382-4
更新日期:1996-12-01 00:00:00
abstract:PURPOSE:We investigated whether opsin mislocalization occurs in photoreceptors in a female carrier of X-linked retinitis pigmentosa with a Gly436Asp mutation in the retinitis pigmentosa GTPase regulator gene (RPGR). DESIGN:Histologic findings in autopsy eyes from a carrier were compared with those from a normal female...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2006.03.061
更新日期:2006-09-01 00:00:00
abstract::A small piece of Ping-Pong ball material fitted to a Burian-Allen contact lens electrode provided a large field of evenly distributed light on the retina that resulted in larger electroretinographic amplitudes and more accurate measurement of b-wave latencies. ...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/0002-9394(75)90148-8
更新日期:1975-08-01 00:00:00
abstract:PURPOSE:To compare tear film thickness between normal subjects and aqueous tear deficiency dry eye patients by tear interferometry. DESIGN:Prospective case-control study. METHODS:Central precorneal tear film thickness was measured noninvasively using an interference thin-film thickness measurement device (Quore MSPA1...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2010.07.019
更新日期:2011-01-01 00:00:00
abstract:PURPOSE:Diseases that involve retinal or choroidal vascular endothelial cells are leading causes of vision loss: age-related macular degeneration, retinal ischemic vasculopathies, and noninfectious posterior uveitis. Proteins differentially expressed by these endothelial cell populations are potential drug targets. We ...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2018.03.020
更新日期:2018-09-01 00:00:00
abstract:PURPOSE:To highlight the possible role of indocyanine green angiography in predicting future exudative changes in eyes that are candidates for drusen laser treatment. METHODS:In a 56-year-old woman, fluorescein and indocyanine green angiography were performed before drusen laser treatment. RESULTS:The treated eye had...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(14)70875-x
更新日期:1997-10-01 00:00:00
abstract::Nonaccommodative convergence excess is a condition in which a patient has orthotropia or a small-angle esophoria or esotropia at distance and a large-angle esotropia at near, not significantly reduced by the addition of spherical plus lenses. The AC/A ratio, determined with the gradient method, is normal or subnormal....
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/0002-9394(86)90466-6
更新日期:1986-01-15 00:00:00