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Treatment of bilateral refractive amblyopia in children three to less than 10 years of age.

Abstract：

PURPOSE:To determine the amount and time course of binocular visual acuity improvement during treatment of bilateral refractive amblyopia in children three to less than 10 years of age. DESIGN:Prospective, multicenter, noncomparative intervention. METHODS:One hundred and thirteen children (mean age, 5.1 years) with previously untreated bilateral refractive amblyopia were enrolled at 27 community- and university-based sites and were provided with optimal spectacle correction. Bilateral refractive amblyopia was defined as 20/40 to 20/400 best-corrected binocular visual acuity in the presence of 4.00 diopters (D) or more of hypermetropia by spherical equivalent, 2.00 D or more of astigmatism, or both in each eye. Best-corrected binocular and monocular visual acuities were measured at baseline and at five, 13, 26, and 52 weeks. The primary study outcome was binocular acuity at one year. RESULTS:Mean binocular visual acuity improved from 0.50 logarithm of the minimum angle of resolution (logMAR) units (20/63) at baseline to 0.11 logMAR units (20/25) at one year (mean improvement, 3.9 lines; 95% confidence interval [CI], 3.5 to 4.2). Mean improvement at one year for the 84 children with baseline binocular acuity of 20/40 to 20/80 was 3.4 lines (95% CI, 3.2 to 3.7) and for the 16 children with baseline binocular acuity of 20/100 to 20/320 was 6.3 lines (95% CI, 5.1 to 7.5). The cumulative probability of binocular visual acuity of 20/25 or better was 21% at five weeks, 46% at 13 weeks, 59% at 26 weeks, and 74% at 52 weeks. CONCLUSIONS:Treatment of bilateral refractive amblyopia with spectacle correction improves binocular visual acuity in children three to less than 10 years of age, with most improving to 20/25 or better within one year.

journal_name

Am J Ophthalmol

journal_title

American journal of ophthalmology

authors

Wallace DK,Chandler DL,Beck RW,Arnold RW,Bacal DA,Birch EE,Felius J,Frazier M,Holmes JM,Hoover D,Klimek DA,Lorenzana I,Quinn GE,Repka MX,Suh DW,Tamkins S,Pediatric Eye Disease Investigator Group.

doi

10.1016/j.ajo.2007.05.040

subject

Has Abstract

pub_date

2007-10-01 00:00:00

pages

487-96

issue

eissn

0002-9394

issn

1879-1891

pii

S0002-9394(07)00525-9

journal_volume

144

pub_type

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Treatment of bilateral refractive amblyopia in children three to less than 10 years of age.