Abstract:
PURPOSE:Assessment of anterior segment-optical coherence tomography angiography (AS-OCTA) to determine severity of corneal neovascularization (CoNV). DESIGN:Retrospective, cross-sectional, single-center study. METHODS:Patients of various CoNV etiologies were selected and classified into mild, moderate, and severe. Their AS-OCTA images were measured for CoNV anterior limit, CoNV posterior limit, CoNV thickness, CoNV depth%, CoNV vessel density, CoNV area, and CoNV volume. Further, AS-OCTA parameters were correlated to clinical parameters, such as classification, a numerical severity scale, vascular clock hours, and best-corrected visual acuity (BCVA). RESULTS:A total of 19 mild, 10 moderate, and 6 severe CoNV eyes were included with no significant age-gender differences. CoNV depth% and volume increased from mild to moderate (9.3 ± 1.1% to 17.7 ± 3.3%, P = .030, and 0.2 ± 0.1 mm3 to 1.0 ± 0.3 mm3, P = .025, respectively) and from moderate to severe CoNV (44.6 ± 5.3%, P < .001, and 2.0 ± 0.3 mm3, P = .014, respectively). CoNV area and posterior limit increased from mild to moderate (1.7 ± 0.3 mm2 to 4.6 ± 0.7 mm2, P = .001, and 217.7 ± 16.8 μm to 349.1 ± 54.9 μm, P = .048, respectively), not from moderate to severe (P = .999 and P = .403, respectively). CoNV thickness increased from moderate to severe (218.2 ± 46.6 μm to 340.2 ± 8.7 μm, P = .020), but not from mild to moderate. CoNV area and volume showed good correlations to CoNV staging (r = 0.703 and r = 0.771, respectively; P < .001) and severity scale (r = 0.794 and r = 0.712, respectively; P < .001). CoNV area showed good correlation to clock hours (r = 0.749, P < .001). CoNV depth and volume showed good correlation to BCVA (r = 0.744 and r = 0.722, respectively; P < .001). CoNV anterior limit and vessel density showed no significant correlations (P ≥ .05). CONCLUSIONS:Severe CoNV shows greater CoNV posterior limit, thickness, depth%, area, and volume on AS-OCTA compared to mild. CoNV volume and depth strongly correlate to BCVA. AS-OCTA provides novel, quantitative, and noninvasive parameters for assessing CoNV severity.
journal_name
Am J Ophthalmoljournal_title
American journal of ophthalmologyauthors
Binotti WW,Koseoglu ND,Nosé RM,Kenyon KR,Hamrah Pdoi
10.1016/j.ajo.2020.08.023subject
Has Abstractpub_date
2020-08-18 00:00:00pages
206-217eissn
0002-9394issn
1879-1891pii
S0002-9394(20)30452-9journal_volume
222pub_type
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journal_title:American journal of ophthalmology
pub_type: 杂志文章
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journal_title:American journal of ophthalmology
pub_type: 杂志文章,多中心研究
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journal_title:American journal of ophthalmology
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journal_title:American journal of ophthalmology
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更新日期:2019-08-01 00:00:00
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更新日期:2002-05-01 00:00:00
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更新日期:1986-08-15 00:00:00
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更新日期:1998-04-01 00:00:00
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更新日期:2020-09-01 00:00:00
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更新日期:2011-02-01 00:00:00
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journal_title:American journal of ophthalmology
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更新日期:1996-05-01 00:00:00