Abstract：
PURPOSE:To measure retinal nerve fiber layer (NFL) thickness in normal subjects and patients with ocular hypertension and examine the relationship between age and normal NFL thickness. METHODS:Nerve fiber layer thickness was determined by scanning laser polarimetry in 210 normal subjects and 100 patients with ocular hypertension. Relative ratios for the superior and inferior NFLs were calculated by dividing the NFL values of the respective regions by the nasal value. RESULTS:Mean superior NFL in normal subjects measured 2.5 (95% confidence interval [CI], 1.3 to 3.7), and mean inferior NFL, 2.4 (95% CI, 1.2 to 3.6). Regression analysis showed a gradual decrease in NFL thickness with increasing age. In the patients with ocular hypertension, mean superior and inferior NFL were significantly lower compared with those of normal subjects: superior, 1.6 (95% CI, 0.4 to 2.8) and inferior, 1.6 (95% CI, 1.0 to 2.2). Of the patients with ocular hypertension, 58 of 100 (58%) had an abnormal NFL parameter. CONCLUSIONS:Normograms we obtained for NFL as determined by scanning laser polarimetry may serve as reference points for future studies. Patients with ocular hypertension had a significantly lower NFL thickness, although there was some overlap in resulting measurements with those of normal subjects. The Nerve Fiber Analyzer may be useful for individual follow-up of people at risk for glaucoma; however, its role as a screening instrument requires further study.
journal_name
Am J Ophthalmoljournal_title
American journal of ophthalmologyauthors
Tjon-Fo-Sang MJ,de Vries J,Lemij HGdoi
10.1016/s0002-9394(14)72013-6subject
Has Abstractpub_date
1996-08-01 00:00:00pages
220-7issue
2eissn
0002-9394issn
1879-1891pii
S0002-9394(14)72013-6journal_volume
122pub_type
杂志文章abstract：:We initiated a pathologic investigation of ocular disease in wallabies. Of 21 animals examined, the eyes were investigated histologically in 11; in four of these animals the brains were also available for section and the sera were investigated in three. In ten animals only sera were received. Histologic studies showed...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(79)90628-7
更新日期：1979-09-01 00:00:00
abstract：:We used a handheld disposable cautery for the diagnostic scraping of corneal ulcers. Sterility of the tip is obtained by activating the unit until the tip reaches a red-hot color and then allowing it to cool. The unit has a sturdy, well-defined tip, and is self-sterilizing, reusable, readily available, and simple to u...
journal_title：American journal of ophthalmology
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doi：10.1016/s0002-9394(14)75086-x
更新日期：1980-07-01 00:00:00
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journal_title：American journal of ophthalmology
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abstract：:We believe axoplasmic transport alteration is the anatomic substrate for formation of drusen of the optic disk. In familial cases the cause of axoplasmic transport alteration may be related to the presence of a genetically determined, small, crowded optic nerve head. We believe these congenitally elevated nerve heads ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)76658-9
更新日期：1978-01-01 00:00:00
abstract：PURPOSE:To evaluate the in vivo durability of the surface and optical properties of the implantable Collamer lens (ICL). DESIGN:Retrospective case series. METHODS:We included patients who developed cataracts after having undergone ICL implantation from March 2003 to May 2014 and underwent ICL explantation followed by...
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journal_title：American journal of ophthalmology
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journal_title：American journal of ophthalmology
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更新日期：1999-01-01 00:00:00
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journal_title：American journal of ophthalmology
pub_type： 杂志文章
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journal_title：American journal of ophthalmology
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更新日期：1980-05-01 00:00:00
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journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2004.03.003
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journal_title：American journal of ophthalmology
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doi：10.1016/s0002-9394(14)73309-4
更新日期：1989-10-15 00:00:00
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journal_title：American journal of ophthalmology
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更新日期：1982-10-01 00:00:00
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journal_title：American journal of ophthalmology
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journal_title：American journal of ophthalmology
pub_type： 杂志文章
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更新日期：1997-12-01 00:00:00
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journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(89)90498-4
更新日期：1989-05-15 00:00:00
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journal_title：American journal of ophthalmology
pub_type： 杂志文章
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更新日期：2014-12-01 00:00:00
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journal_title：American journal of ophthalmology
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doi：10.1016/s0002-9394(14)76806-0
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abstract：PURPOSE:To investigate the value of whole-body positron emission tomography/computed tomography (PET/CT) as a screening tool for patients with uveal metastasis. DESIGN:Retrospective observational case series. METHODS:setting: Clinical practice. study population: Eighteen patients with uveal metastatic tumors were eva...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
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更新日期：2012-04-01 00:00:00
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journal_title：American journal of ophthalmology
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journal_title：American journal of ophthalmology
pub_type： 杂志文章
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更新日期：1992-01-15 00:00:00
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journal_title：American journal of ophthalmology
pub_type： 杂志文章
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更新日期：2011-12-01 00:00:00
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journal_title：American journal of ophthalmology
pub_type： 杂志文章
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更新日期：2001-09-01 00:00:00
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journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)73021-1
更新日期：1994-01-15 00:00:00
abstract：:Fifteen patients with malignant epithelial tumors of the conjunctiva were treated with beta-ray ocular applicators filled with radioactive strontium and yttrium (90Sr/90Y). Histologic examination confirmed the diagnosis. There were ten squamous cell carcinomas, four carcinomas in situ, and one case of epidermidalizati...
journal_title：American journal of ophthalmology
pub_type： 杂志文章,评审
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更新日期：1976-02-01 00:00:00
abstract：:Multiple endocrine neoplasia type 2b is a syndrome, often familial, characterized by medullary carcinoma of the thyroid gland, pheochromocytoma, and many mucosal neuromas in patients who frequently have a marfanoid habitus. The ophthalmic findings are distinctive and include conjunctival and eyelid neuromas, keratocon...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
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更新日期：1981-01-01 00:00:00
abstract：:Six patients (five men and one woman, 19 to 57 years old) with laboratory-proven fungal corneal infections were successfully treated with topical ketoconazole, a synthetic imidazole derivative. No signs of progression of the corneal infection were seen after the antifungal therapy was initiated. The clinical signs of ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
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更新日期：1985-08-15 00:00:00
abstract：PURPOSE:To investigate the genetic findings and phenotypic characters of autosomal dominant optic atrophy (ADOA). DESIGN:Case report and experimental study. METHODS:Molecular genetic analysis and clinical examinations were performed in a Chinese family with ADOA. Mutations in OPA1 were detected by direct sequencing. ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2006.06.049
更新日期：2007-01-01 00:00:00
abstract：PURPOSE:To determine the safety and efficacy of verteporfin photodynamic therapy (PDT) for the treatment of persistent choroidal neovascularization (CNV) previously treated with external beam radiotherapy (EBRT). DESIGN:Retrospective case series. METHODS:Verteporfin PDT was performed on 14 eyes of 13 patients with sy...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2004.09.019
更新日期：2005-03-01 00:00:00
