Abstract：
:We believe axoplasmic transport alteration is the anatomic substrate for formation of drusen of the optic disk. In familial cases the cause of axoplasmic transport alteration may be related to the presence of a genetically determined, small, crowded optic nerve head. We believe these congenitally elevated nerve heads evolve over a period of many years through stages of atrophy and drusen formation. Vascular malformations in the familial cases are primarily developmental; however, secondary vascular alterations may occur as the drusen enlarge. In retinitis pigmentosa the drusen may be caused by diminished production of axoplasmic material by the ganglion cell. Chronic alterations in axonal transport from any cause produce aggregates of swollen nerve fibers. These give a yellow-white appearance to the disk tissue and account for the yellow, filled-in appearance of the disk in patients with drusen, chronic atrophic papilledema, melanocytomas, and, in part, for the waxy yellow appearance of the disk in retinitis pigmentosa.
journal_name
Am J Ophthalmoljournal_title
American journal of ophthalmologyauthors
Spencer WHdoi
10.1016/s0002-9394(14)76658-9subject
Has Abstractpub_date
1978-01-01 00:00:00pages
1-12issue
1eissn
0002-9394issn
1879-1891pii
S0002-9394(14)76658-9journal_volume
85pub_type
杂志文章abstract：PURPOSE:To study the effects of age, sex, intraocular pressure (IOP), corneal thickness, axial length (AXL), disc area, and the signal strength of the scan on optical coherence tomography (OCT) parameters of normal subjects in the L V Prasad Eye Institute-Glaucoma Epidemiological and Molecular Genetic Study (LVPEI-GLEA...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2020.11.015
更新日期：2020-12-08 00:00:00
abstract：PURPOSE:To evaluate the efficacy of autologous plasmin (AP)-assisted vitrectomy for stage 5 retinopathy of prematurity (ROP). DESIGN:Interventional case series. METHODS:Six consecutive eyes of four children with stage 5 ROP were treated. The patients' ages at the surgery ranged from five to eight months after birth. ...
journal_title：American journal of ophthalmology
pub_type： 临床试验,杂志文章
doi：10.1016/j.ajo.2007.03.020
更新日期：2007-07-01 00:00:00
abstract：PURPOSE:To compare the late complications in the Ahmed Baerveldt Comparison Study during 5 years of follow-up. DESIGN:Multicenter, prospective randomized clinical trial. METHODS:setting: Sixteen international clinical centers. STUDY POPULATION:Two hundred seventy-six subjects aged 18-85 years with previous intraocul...
journal_title：American journal of ophthalmology
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.ajo.2015.11.023
更新日期：2016-03-01 00:00:00
abstract：:Because determination of the differential light threshold of a visual field is a psychophysiologic test, the results can be subject to variation. This scatter measured during a single examination is usually called the short-term fluctuation. Increases of the short-term fluctuation were thought to occur primarily in ab...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(89)90667-3
更新日期：1989-04-15 00:00:00
abstract：:Fifty-five patients with primary open-angle glaucoma and early glaucomatous damage who had medical therapy and laser trabeculoplasty were followed up for four to 11 years or until progressive glaucomatous damage was documented. Factors associated with the stability or progression of glaucoma were evaluated. Eyes with ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)76896-5
更新日期：1991-01-15 00:00:00
abstract：PURPOSE:To determine if asymmetry in thickness of the retinal nerve fiber layer (RNFL), ganglion cell layer, ganglion cell complex, and total retina between upper and lower macula halves can predict glaucoma. DESIGN:Retrospective case-control series. METHODS:One hundred twenty-two eyes of 122 patients (30 normal eyes...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2014.08.040
更新日期：2014-12-01 00:00:00
abstract：:In August 1989, the Tokyo Metropolitan Government officially began a vision screening program for children aged 3 years 1 month. A 1988 pilot study of 1,303 children this age disclosed five cases (0.38%) of amblyopia. The home vision test, which uses picture cards of familiar figures, proved to be an efficient and ine...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)71851-3
更新日期：1992-10-15 00:00:00
abstract：:Induced prolonged complementary chromatopsia in four subjects (two men, 26 and 34 years old, and two women, 34 and 45 years old) was documented by abnormal responses to pseudoisochromatic color plates 30 minutes after cessation of monochrome video display terminal use. This phenomenon was unrelated to preexisting colo...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(84)90694-9
更新日期：1984-12-15 00:00:00
abstract：:A consecutive group of 67 patients (70 eyes) with senile cataract underwent extracapsular cataract extraction and implantation of a Shearing posterior chamber intraocular lens. After two years of follow-up, there was an 11% +/- 2% decrease in central cell density (P less than .001), a 20% +/- 2% decrease in superior c...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(83)90068-5
更新日期：1983-06-01 00:00:00
abstract：PURPOSE:To describe a case of Langerhans cell histiocytosis (LCH) that involved the anterior uveal tract. DESIGN:Interventional case report. METHODS:A retrospective review was conducted on a patient with iris nodules and anterior uveitis in the setting of LCH. Visual acuity and clinical findings that were noted on sl...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2005.06.059
更新日期：2005-12-01 00:00:00
abstract：PURPOSE:To study the effect of higher-order aberrations (HOAs) on visual function in keratoconus with a rigid gas permeable (RGP) contact lens (CLs). DESIGN:Retrospective nonrandomized study. METHODS:Thirteen eyes of 10 subjects with keratoconus who wore a RGP CLs (KC-RGP group), 15 eyes of nine normal subjects (norm...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2007.08.004
更新日期：2007-12-01 00:00:00
abstract：:We examined the ability of hypothermic infusion fluid to reduce the risk of light damage to the retina from the intraocular fiberoptic probe during vitreous surgery. Following vitrectomy, we exposed the retina of rabbits to light from an intraocular fiberoptic probe during infusion of fluid at body temperature (39 C) ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(86)90073-5
更新日期：1986-10-15 00:00:00
abstract：PURPOSE:To report a case series of contact lens-related corneal ulcers in compliant patients with no apparent predisposing factors. DESIGN:Retrospective case series. METHODS:Charts of 70 patients with contact lens-related corneal ulcers from July 1999 to June 2002 were reviewed. Lens care hygiene and method of disinf...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(03)00722-0
更新日期：2004-01-01 00:00:00
abstract：:We studied four patients with anisocoria and the pigmentary dispersion syndrome. In all patients, the larger pupil was on the side of the greater iris transillumination. The amount of anisocoria was between 0.5 and 1.5 mm and was the same in both the light and dark. There was no blepharoptosis, and all pupils dilated ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)77063-1
更新日期：1990-12-15 00:00:00
abstract：:We assessed 81 patients in four groups (normal, low- and high-risk ocular hypertension, and early glaucoma) with the standard Octopus G1 central visual field program in addition to two quantitative programs, PFN (peripheral field-nasal) and PFT (peripheral field-temporal), designed for this study to test the nasal and...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(88)90831-8
更新日期：1988-08-15 00:00:00
abstract：:A survey in Arkansas of 14 cases of ocular injuries caused by the explosion of Class C fireworks showed significant, and possibly permanent, visual loss in five men. The most common injuries, corneal abrasion and hyphema, occurred in nine male patients with no residual ocular damage. ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(75)90621-2
更新日期：1975-03-01 00:00:00
abstract：PURPOSE:Intraindividual comparison of tilt and decentration of three-piece foldable intraocular lenses (IOLs) with 6-mm optics and different edge design and material. DESIGN:Prospective randomized study. METHODS:Twenty-five patients with senile cataract (group I) received a foldable silicone, sharp optic edge IOL in ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.ajo.2005.07.026
更新日期：2005-12-01 00:00:00
abstract：PURPOSE:To assess retinal nerve fiber layer (RNFL) and macular thickness using optical coherence tomography (OCT) on HIV-infected patients without ocular manifestations and to correlate these findings with frequency-doubling technology perimetry (FDT). DESIGN:Cross-sectional study. METHODS:setting: Single center. stu...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2009.11.026
更新日期：2010-04-01 00:00:00
abstract：PURPOSE:To describe the ultrasound biomicroscopic features of eyes with aniridia. DESIGN:Observational case series. METHODS:Nineteen eyes of 10 patients with aniridia (six males and four females) ranging in age from 3 months to 53 years (21.0 +/- 16.4, mean +/- SD), and 50 normal subjects (30 men and 20 women) rangin...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2003.12.014
更新日期：2004-05-01 00:00:00
abstract：PURPOSE:To compare retinal nerve fiber layer (RNFL) thickness measurements between 3 different spectral-domain optical coherence tomography (SD-OCT) instruments (Spectralis; Heidelberg Engineering; Cirrus; Carl Zeiss Meditec; RTVue; Optovue, Inc) and one time-domain OCT (Stratus; Carl Zeiss Meditec). DESIGN:Prospectiv...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2010.06.024
更新日期：2010-12-01 00:00:00
abstract：PURPOSE:Anterior segment optical coherence tomography (AS-OCT) provides an objective imaging modality for visually identifying anterior segment structures. An automated detection system could assist ophthalmologists in interpreting AS-OCT images for the presence of angle closure. DESIGN:Development of an artificial in...
journal_title：American journal of ophthalmology
pub_type： 杂志文章,多中心研究
doi：10.1016/j.ajo.2019.02.028
更新日期：2019-07-01 00:00:00
abstract：PURPOSE:To determine the repeatability of automated retinal and choroidal thickness measurements with swept-source optical coherence tomography (SS OCT) and the frequency and type of scan artifacts. DESIGN:Prospective evaluation of new diagnostic technology. METHODS:Thirty healthy subjects were recruited prospectivel...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2014.02.008
更新日期：2014-05-01 00:00:00
abstract：:The in vivo sites of the blood-aqueous barrier were determined in five animal species, using acriflavine neutral (224 mol. wt.), ultrafreezing and drying, fluorescence microscopy, and fluorometry. Not toxic, acriflavine had specific in vivo affinity for nuclear DNA and RNA, produced intense fluorescence, and did not p...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(75)90405-5
更新日期：1975-10-01 00:00:00
abstract：PURPOSE:To quantify ocular higher-order aberrations (HOAs) in eyes with supernormal vision, that is, natural uncorrected visual acuity (UCVA) > or = 20/15, to analyze the correlation between ocular HOAs and age in these eyes, and to investigate the correlation of HOAs between right and left eyes. DESIGN:Observational ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2004.08.035
更新日期：2005-02-01 00:00:00
abstract：PURPOSE:To determine if adequate intraocular levels of methotrexate are achieved after intravenous administration. METHODS:After intravenous administration, methotrexate levels were determined in the serum, the anterior chamber, and the cerebrospinal fluids of a patient with recurrent ocular lymphoma. A fluorescence p...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)70444-1
更新日期：1996-04-01 00:00:00
abstract：:Sixty-five patients less than 10 years of age had cataract surgery on 99 eyes. The visual prognosis depended on the cataract type and whether the treatment was undertaken during the critical period for development of the fixation reflex. All patients received the same surgical technique, aggressive optical correction,...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(82)90237-9
更新日期：1982-10-01 00:00:00
abstract：PURPOSE:To determine the pattern of agreement of retinal nerve fiber layer (RNFL) defects between fellow eyes of glaucoma patients measured with optical coherence tomography (OCT). DESIGN:Observational, cross-sectional study. METHODS:Seventy-seven glaucoma patients (154 eyes) underwent OCT (Stratus) imaging with the ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2009.02.009
更新日期：2009-07-01 00:00:00
abstract：PURPOSE:To evaluate the efficacy of transconjunctival Müller muscle recession and graded levator disinsertion for eyelid retraction in patients with thyroid-related orbitopathy (TRO). DESIGN:Retrospective consecutive case series. METHODS:Medical record review of 78 TRO patients (107 eyelids) who underwent surgery for...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2005.02.034
更新日期：2005-07-01 00:00:00
abstract：PURPOSE:To report a model of choroidal neovascularization feeder vessels that reconciles current histologic, angiographic, and clinical data, and to report experimental studies that investigate the potential of indocyanine-green-dye-enhanced photocoagulation to improve feeder-vessel treatment. METHODS:A model of choro...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(99)00411-0
更新日期：2000-04-01 00:00:00
abstract：PURPOSE:To measure the area of the optic nerve subarachnoid space (ONSASA) in patients with normal tension glaucoma (NTG), primary open-angle glaucoma (POAG), and controls and examine its association with relevant ocular and systemic parameters. DESIGN:Cross-sectional study. METHODS:The study included 40 patients wit...
journal_title：American journal of ophthalmology
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.ajo.2017.11.024
更新日期：2018-02-01 00:00:00
