Abstract:
PURPOSE:Anterior segment optical coherence tomography (AS-OCT) provides an objective imaging modality for visually identifying anterior segment structures. An automated detection system could assist ophthalmologists in interpreting AS-OCT images for the presence of angle closure. DESIGN:Development of an artificial intelligence automated detection system for the presence of angle closure. METHODS:A deep learning system for automated angle-closure detection in AS-OCT images was developed, and this was compared with another automated angle-closure detection system based on quantitative features. A total of 4135 Visante AS-OCT images from 2113 subjects (8270 anterior chamber angle images with 7375 open-angle and 895 angle-closure) were examined. The deep learning angle-closure detection system for a 2-class classification problem was tested by 5-fold cross-validation. The deep learning system and the automated angle-closure detection system based on quantitative features were evaluated against clinicians' grading of AS-OCT images as the reference standard. RESULTS:The area under the receiver operating characteristic curve of the system using quantitative features was 0.90 (95% confidence interval [CI] 0.891-0.914) with a sensitivity of 0.79 ± 0.037 and a specificity of 0.87 ± 0.009, while the area under the receiver operating characteristic curve of the deep learning system was 0.96 (95% CI 0.953-0.968) with a sensitivity of 0.90 ± 0.02 and a specificity of 0.92 ± 0.008, against clinicians' grading of AS-OCT images as the reference standard. CONCLUSIONS:The results demonstrate the potential of the deep learning system for angle-closure detection in AS-OCT images.
journal_name
Am J Ophthalmoljournal_title
American journal of ophthalmologyauthors
Fu H,Baskaran M,Xu Y,Lin S,Wong DWK,Liu J,Tun TA,Mahesh M,Perera SA,Aung Tdoi
10.1016/j.ajo.2019.02.028subject
Has Abstractpub_date
2019-07-01 00:00:00pages
37-45eissn
0002-9394issn
1879-1891pii
S0002-9394(19)30087-Xjournal_volume
203pub_type
杂志文章,多中心研究abstract:PURPOSE:To report a case of conjunctival intraepithelial neoplasia presenting as corneal ulcer. METHOD:Case report of a 28-year-old man who presented with sudden onset of pain, redness, and watering in the right eye. Examination of right cornea revealed deep stromal infiltrate inferonasally. Adjacent to the infiltrate...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(99)00286-x
更新日期:2000-01-01 00:00:00
abstract:PURPOSE:To describe a case of severe dry eye syndrome in a child. METHODS:Observational case report. The authors describe a 10-year-old male with severe dry eyes who was profoundly disabled by pain and photophobia despite aggressive conventional therapy. Lacrimal gland histology was consistent with the primary Sjögren...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(01)01182-5
更新日期:2001-12-01 00:00:00
abstract::Six patients (all male, five homosexual and one bisexual, 23 to 48 years old) with the acquired immune deficiency syndrome (AIDS) who had cytomegalovirus retinitis were treated with a new antiviral drug as a part of a prospective open-labeled trial for serious cytomegalovirus infections. The drug, 9-[2-hydroxy-1-(hydr...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/0002-9394(86)90638-0
更新日期:1986-04-15 00:00:00
abstract::Although surgical excision, with or without adjunctive cryotherapy, is an accepted method of managing conjunctival squamous cell carcinoma, histologically verified tumor-free surgical margins cannot be assured by excision alone. We used a tissue conservation method, an adaptation of the Mohs' micrographic technique fo...
journal_title:American journal of ophthalmology
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abstract:PURPOSE:To evaluate whether the full-field flicker test, a psychophysical test employing full-field flickering stimuli to measure temporal contrast sensitivity, can detect glaucomatous optic nerve damage in patients with increased intraocular pressure and glaucomatous optic disk abnormalities but normal visual fields. ...
journal_title:American journal of ophthalmology
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journal_title:American journal of ophthalmology
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abstract:PURPOSE:To evaluate long-term complications related to glaucoma drainage devices in patients undergoing Boston type 1 keratoprosthesis surgery. DESIGN:Retrospective case series. METHODS:All patients who underwent Boston type 1 keratoprosthesis surgery at the University of California, Davis, between 2004 and 2010 were...
journal_title:American journal of ophthalmology
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更新日期:2011-08-01 00:00:00
abstract:PURPOSE:To report the echographic appearance of a scleral fold in hypotony. METHOD:We performed ultrasonography on a patient who, after trabeculectomy with mitomycin C, had an intraocular pressure of 1 mm Hg, an opaque cataract, and suspected hypotonous maculopathy in the left eye. RESULTS:An area of dome-shaped eyew...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
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更新日期:1997-08-01 00:00:00
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journal_title:American journal of ophthalmology
pub_type: 杂志文章
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更新日期:2004-02-01 00:00:00
abstract::Using the Octopus automated perimeter, we conducted visual measurements on four separate occasions during a four-week period in six subjects with normal eyes. In 11 of 12 eyes, we found at least one point at which the threshold for light detection determined for that point showed a variance of more than 4 dB between t...
journal_title:American journal of ophthalmology
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abstract::In the elderly patient with a massive vitreous hemorrhage in one eye and senile macular choroidal degenerative changes in the fellow eye, a hemorrhagic disciform detachment causing this massive vitreous hemorrhage must be considered in the differential diagnosis. Ultrasonography selectively combined with radioactive p...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(14)75023-8
更新日期:1980-10-01 00:00:00
abstract::We reviewed the records of 74 patients with exfoliation syndrome. Patients with exfoliation syndrome represented 12% of the current Glaucoma Clinic population. There were 40 unilateral and 34 bilateral cases. Thirteen percent of the patients who originally had unilateral exfoliation later developed exfoliation in the ...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/0002-9394(80)90054-9
更新日期:1980-04-01 00:00:00
abstract::Retinoic acid 0.1% in arachis oil was applied to one eye and arachis oil alone to the other eye, of each of 19 patients with equivalent degrees of corneal xerophthalmia in the fellow eyes. Even with concomitant systemic vitamin A therapy, topical retinoic acid was associated with more rapid healing of corneal lesions ...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
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更新日期:1983-03-01 00:00:00
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journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(14)76806-0
更新日期:1978-08-01 00:00:00
abstract:PURPOSE:To examine the relationship of choroidal thickness with axial length (AL) and myopia in young adult eyes in the ethnically diverse Correction of Myopia Evaluation Trial (COMET) cohort. DESIGN:Cross-sectional, multicenter study. METHODS:In addition to measures of myopia by cycloplegic autorefraction and AL by ...
journal_title:American journal of ophthalmology
pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2015-07-01 00:00:00
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journal_title:American journal of ophthalmology
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更新日期:2009-08-01 00:00:00
abstract::A controlled chemotherapy trial of trachoma was carried out in a Tunisian oasis among schoolchildren with active disease. We compared 1% tetracycline ointment (79 patients) or 1% rifampicin ointment (76 patients) with 5% boric acid ointment (79 patients). Medications were administered twice daily, six days a week, for...
journal_title:American journal of ophthalmology
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journal_title:American journal of ophthalmology
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journal_title:American journal of ophthalmology
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journal_title:American journal of ophthalmology
pub_type: 杂志文章
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更新日期:1999-07-01 00:00:00
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journal_title:American journal of ophthalmology
pub_type: 杂志文章
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更新日期:1995-04-01 00:00:00
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journal_title:American journal of ophthalmology
pub_type: 临床试验,杂志文章
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更新日期:2006-05-01 00:00:00
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journal_title:American journal of ophthalmology
pub_type: 杂志文章
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更新日期:2012-07-01 00:00:00
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journal_title:American journal of ophthalmology
pub_type: 杂志文章,多中心研究
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更新日期:2018-07-01 00:00:00
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journal_title:American journal of ophthalmology
pub_type: 杂志文章
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更新日期:2009-07-01 00:00:00
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journal_title:American journal of ophthalmology
pub_type: 杂志文章
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更新日期:1980-11-01 00:00:00
abstract::A review of lens implant surgery using different implant styles and both methods of cataract extraction revealed that there is little difference in the final visual acuity regardless of which implant or cataract technique is used. There appears to be a higher rate of cystoid macular edema with the intracapsular techni...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
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更新日期:1979-11-01 00:00:00
abstract:PURPOSE/METHODS:By fundus photography and histopathologic examination, we documented a case of early endogenous Aspergillus endophthalmitis in a 29-year-old man after lung transplantation. RESULTS/CONCLUSIONS:The clinical and histopathologic features of this case are consistent with those of previous case reports of e...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
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更新日期:1995-01-01 00:00:00