Leukemic involvement of the optic nerve.

Abstract:

:We studied five cases of leukemia with invasion of the optic disk and optic nerve. Two patients had acute lymphoblastic leukemia and three had acute myelogenous leukemia. All patients received intrathecal injections of chemotherapeutic drugs including methotrexate, cytarabine, and prednisolone. Three patients underwent irradiation therapy of the whole brain and optic nerve. While initial improvement in the ophthalmic abnormalities, such as optic disk edema, flame-shaped retinal hemorrhages, and dilation of the retinal vein, was noted, optic atrophy was later found in all eyes.

journal_name

Am J Ophthalmol

authors

Nikaido H,Mishima H,Ono H,Choshi K,Dohy H

doi

10.1016/0002-9394(88)90013-x

subject

Has Abstract

pub_date

1988-03-15 00:00:00

pages

294-8

issue

3

eissn

0002-9394

issn

1879-1891

pii

0002-9394(88)90013-X

journal_volume

105

pub_type

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