Abstract：
PURPOSE:To assess retinal nerve fiber layer (RNFL) and macular thickness using optical coherence tomography (OCT) on HIV-infected patients without ocular manifestations and to correlate these findings with frequency-doubling technology perimetry (FDT). DESIGN:Cross-sectional study. METHODS:setting: Single center. study population: Seventy-three patients (146 eyes) with clinically normal examination classified in 3 groups: group A, HIV-infected patients with CD4 count <100 cells/mm(3) for at least 6 months; group B, HIV-infected patients with CD4 count >100 cells/mm(3) since diagnosis; and group C, HIV-negative control subjects. observation procedures: Fast RNFL and fast macula scan strategies on Stratus OCT and Humphrey Matrix 24-2 full-threshold program. main outcome measures: OCT RNFL and macular thicknesses and FDT indices (mean deviation [MD], pattern standard deviation [PSD], and glaucoma hemifield test [GHT]). RESULTS:Group A had a significantly thinner average RNFL, temporal outer macula, and inferior outer macula thicknesses when compared to groups B and C (P < .05). Statistically significant differences were observed in the FDT MD between groups A and C (P = .034) and in PSD in group A compared to groups B and C (P = .011). Eyes of HIV patients with GHT and PSD results outside normal confidence limits had thinner average RNFL thickness measures than eyes with results within normal limits in the same group of patients (P < .05). CONCLUSIONS:HIV-infected patients with low CD4 count have a significant RNFL and macular thinning. Functional loss detected by FDT is related to RNFL thinning in HIV-infected patients.
journal_name
Am J Ophthalmoljournal_title
American journal of ophthalmologyauthors
Faria E Arantes TE,Garcia CR,Mello PA,Muccioli Cdoi
10.1016/j.ajo.2009.11.026subject
Has Abstractpub_date
2010-04-01 00:00:00pages
571-576.e2issue
4eissn
0002-9394issn
1879-1891pii
S0002-9394(09)00890-3journal_volume
149pub_type
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journal_title：American journal of ophthalmology
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更新日期：1995-02-01 00:00:00
