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Is early age-related maculopathy related to cognitive function? The Atherosclerosis Risk in Communities Study.

Abstract：

PURPOSE:Age-related maculopathy (ARM) and cognitive impairment are both neurodegenerative disorders associated with aging and have been hypothesized to share common pathogenic pathways. We describe the association between cognitive function and ARM in middle-aged persons. DESIGN:Population-based, cross-sectional study involving participants of the Atherosclerosis Risk in Communities Study, an ongoing cardiovascular investigation of persons 51 to 70 years of age, examined every 3 years between 1987 to 1998. METHODS:At visit three (1993-1995), retinal photographs were obtained and evaluated for ARM using a modification of the Wisconsin ARM Grading System. Cognitive function was assessed using standardized tests (Delayed Word Recall, Digit Symbol, and Word Fluency) at visits two (1990-1992) and four (1996-1998) and averaged for analysis. Severe cognitive impairment was defined as scores falling in the lowest 10th percentile of the population. RESULTS:Data were available in 9286 persons after exclusion of persons with stroke or using antipsychotic medication. After adjusting for age, gender, race, education, diabetes, hypertension, cigarette smoking, and alcohol consumption, persons with severe cognitive impairment based on Word Fluency Test scores were more likely to have early ARM (odds ratio [OR]: 1.6, 95% confidence interval [CI]: 1.1-2.2) and its components, soft drusen (OR: 1.6; 95% CI: 1.1-2.3) and pigmentary abnormality (OR: 1.5; 95% CI: 0.9-2.5) than those without severe impairment. However, severe cognitive impairment in scores of the other two cognitive function tests was not associated with ARM. CONCLUSION:These population-based data suggest a weak association between cognitive function and early ARM in middle-aged persons.

journal_name

Am J Ophthalmol

journal_title

American journal of ophthalmology

authors

Wong TY,Klein R,Nieto FJ,Moraes SA,Mosley TH,Couper DJ,Klein BE,Boland LL,Hubbard LD,Sharrett AR

doi

10.1016/s0002-9394(02)01672-0

subject

Has Abstract

pub_date

2002-12-01 00:00:00

pages

828-35

issue

6

eissn

0002-9394

issn

1879-1891

pii

S0002939402016720

journal_volume

134

pub_type

杂志文章

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