Abstract:
PURPOSE:To determine the relationship between quantitative nerve fiber layer measurements and visual field testing in patients with large cup-to-disk ratios. METHODS:Seventy-six patients with vertical cup-to-disk ratios by contour of at least 0.8 on stereoscopic photographs and 50 normal subjects were included. One eye was randomly selected for study. All patients underwent standard achromatic automated perimetry, short-wavelength automated perimetry, and retinal nerve fiber layer measurements with scanning laser polarimetry. Analysis of variance was used to evaluate differences between the subject groups. Significance of pairwise comparisons was determined using the Tukey-Kramer multiple comparison test. RESULTS:Statistically significant differences in nerve fiber layer measurements between patients with large cup-to-disk ratios and both abnormal standard achromatic automated perimetry and short-wavelength automated perimetry (n = 22) and patients with large cup-to-disk ratios and both normal standard achromatic automated perimetry and short-wavelength automated perimetry (n = 42) were found for superior nasal ratio, maximum modulation, ellipse modulation, and the linear discriminant function (Tukey-Kramer less than.05). There was no significant difference in patients with abnormal short-wavelength automated perimetry only (n = 9) as compared with patients with both normal standard achromatic automated perimetry and short-wavelength automated perimetry and patients with both abnormal standard achromatic automated perimetry and short-wavelength automated perimetry. Statistically significant differences between the normal subjects and patients with large cup-to-disk ratios and both abnormal standard achromatic automated perimetry and short-wavelength automated perimetry were found for all retinal nerve fiber layer parameters, with the exception of symmetry, superior ratio, and inferior ratio. CONCLUSION:Our results show considerable overlap in nerve fiber layer measurements in eyes with large cup-to-disk ratio and abnormal visual fields as compared with eyes with large cup-to-disk ratios and normal visual fields. This may limit the clinical usefulness of scanning laser polarimetry for detection of early glaucoma in patients with large cup-to-disk ratios. Longitudinal studies are needed to determine if patients with large cup-to-disk ratios with normal standard achromatic automated perimetry and abnormal short-wavelength automated perimetry subsequently develop standard achromatic automated perimetry defects and if scanning laser polarimetry can concurrently detect progression of nerve fiber layer damage.
journal_name
Am J Ophthalmoljournal_title
American journal of ophthalmologyauthors
Tannenbaum DP,Zangwill LM,Bowd C,Sample PA,Weinreb RNdoi
10.1016/s0002-9394(01)01107-2subject
Has Abstractpub_date
2001-10-01 00:00:00pages
501-6issue
4eissn
0002-9394issn
1879-1891pii
S0002939401011072journal_volume
132pub_type
临床试验,杂志文章,随机对照试验abstract:PURPOSE/METHODS:Central retinal artery occlusion occurs infrequently in children. We treated a child with central retinal artery occlusion before a systemic disease was discovered. RESULTS/CONCLUSION:Vision improved after paracentesis and anticoagulation. Systemic T-cell lymphoma was subsequently diagnosed. In contras...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(14)73772-9
更新日期:1995-07-01 00:00:00
abstract::Beta-aminopropionitrile, an inhibitor of collagen cross-linking, effectively limited the degree of posttraumatic vitreous proliferation in rabbits three weeks after double perforating injury. Light microscopic examination of the sites of perforating injury after five weeks showed minimal intravitreal fibrous prolifera...
journal_title:American journal of ophthalmology
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abstract:PURPOSE:To determine the effects of a second fluocinolone implant inserted in eyes with uveitis in which recurrent inflammation developed after the original implant was placed. DESIGN:Prospective, interventional trial. METHODS:Study subjects comprised all consecutive patients with noninfectious posterior uveitis who ...
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abstract:PURPOSE:To characterize the locations, circumstances, and outcomes of falls in patients with varying degrees of glaucoma. DESIGN:Prospective cohort study. METHODS:Patients with suspected or diagnosed glaucoma completed monthly calendars reporting falls. After each fall, a 30-item questionnaire was administered to det...
journal_title:American journal of ophthalmology
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abstract:PURPOSE:To determine whether central fusion and distance stereoacuity are useful as objective measures in assessing the need for and success of surgery for intermittent exotropia (X[T]). METHODS:A prospective, institutional, clinical trial was conducted of 26 consecutive patients with X(T) who were undergoing strabism...
journal_title:American journal of ophthalmology
pub_type: 临床试验,杂志文章
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abstract::Benign lateral rectus palsy developed in two adults, a 62-year-old man and a 56-year-old woman. Both were hospitalized because of headache and diplopia. Extensive laboratory and neurologic testing showed no abnormalities except leukopenia (the white blood cell count was 2,600 cells/mm3 in one patient and 3,100 cells/m...
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abstract::In two patients, a 55-year-old man and a 49-year-old man, who had fungal keratitis initially undiagnosed by corneal scrapings the condition was successfully diagnosed by corneal biopsy. We compared corneal biopsy specimens and corneal scraping in the diagnosis of keratomycosis in rabbits with experimental bilateral fu...
journal_title:American journal of ophthalmology
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abstract:PURPOSE:To investigate whether the statin class of drugs reduces the risk of cataract extraction. DESIGN:Case-control study. METHOD:setting: Kaiser Permanente Southern California, which provides prepaid healthcare for 3.2 million residents by 6000 physicians. patient population: Eligible patients were those who had 5...
journal_title:American journal of ophthalmology
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journal_title:American journal of ophthalmology
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更新日期:1995-03-01 00:00:00
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journal_title:American journal of ophthalmology
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更新日期:2004-01-01 00:00:00
abstract::We implanted nine intraocular lenses for the aphakic correction of congenital monocular cataracts in eight children (eight eyes). During follow-up periods ranging from 18 to 50 months in six children, there were no major complications connected to the surgery. Parental cooperation with treatment for amblyopia was sati...
journal_title:American journal of ophthalmology
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abstract:PURPOSE:To characterize spontaneous dislocation of the fluocinolone acetonide sustained release implant (Retisert; Bausch & Lomb) drug pellet from its strut. DESIGN:Retrospective, observational case series. METHODS:The medical records of 224 patients in whom 407 fluocinolone acetonide implants were placed by either o...
journal_title:American journal of ophthalmology
pub_type: 杂志文章,多中心研究
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更新日期:2015-05-01 00:00:00
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journal_title:American journal of ophthalmology
pub_type: 杂志文章
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更新日期:2012-02-01 00:00:00
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更新日期:2020-03-01 00:00:00
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journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(03)00465-3
更新日期:2003-11-01 00:00:00
abstract::In 98 patients, 112 eyes with chronic closed-angle or combined glaucoma were operated on using filtering iridocycloretraction, including preparation of two limbal-based scleral strips that were introduced through scleral incisions into the anterior chamber and the supraciliary space. The intraocular pressure was contr...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
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更新日期:1985-03-15 00:00:00
abstract:PURPOSE:To report a rare case of craniodiaphysial dysplasia (CDD) that resulted in a profound loss of vision in both eyes. DESIGN:Observational case report. METHODS:A 2-year-old girl presented with midfacial anomaly. Marked thickening and sclerosis in the calvaria and facial bones were detected on the plain x-rays, w...
journal_title:American journal of ophthalmology
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doi:10.1016/j.ajo.2005.08.071
更新日期:2006-02-01 00:00:00
abstract:PURPOSE:To describe and quantify the appearance of the optic disk in patients with advanced age-related macular degeneration (ARMD). DESIGN:Retrospective comparative study. METHODS:A total of 316 charts were reviewed. From these, 45 subjects with advanced ARMD (defined as geographic atrophy or disciform scar) in at l...
journal_title:American journal of ophthalmology
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journal_title:American journal of ophthalmology
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journal_title:American journal of ophthalmology
pub_type: 杂志文章
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journal_title:American journal of ophthalmology
pub_type: 杂志文章,meta分析,评审
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更新日期:2015-07-01 00:00:00
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journal_title:American journal of ophthalmology
pub_type: 杂志文章
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更新日期:1977-02-01 00:00:00
abstract::Amyloid fibrils occurring in primary and myeloma-associated (AL), secondary (AA), and certain neuropathic hereditary forms of systemic amyloidosis can be distinguished biochemically or immunohistologically as being composed of immunoglobulin light chain, protein AA, or prealbumin respectively. All types of systemic an...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
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更新日期:1984-08-15 00:00:00
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journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(14)72676-5
更新日期:1995-10-01 00:00:00
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journal_title:American journal of ophthalmology
pub_type: 杂志文章
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更新日期:2003-10-01 00:00:00
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journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2018.12.024
更新日期:2019-04-01 00:00:00
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journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(14)72158-0
更新日期:1995-09-01 00:00:00
abstract::The noninvasive laser Doppler technique was used to study retinal circulatory characteristics in five patients who underwent uncomplicated scleral buckling procedures. In each patient, the systolic/diastolic variation of the red blood cell speed in the retinal arteries (flow pulsatility ratio) was lower in the eye tha...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/0002-9394(83)90012-0
更新日期:1983-02-01 00:00:00
abstract:PURPOSE:To describe optical coherence tomographic (OCT) angiography findings in chronic central serous chorioretinopathy (CSC), and to characterize their OCT B-scans by means of the split-spectrum amplitude-decorrelation angiography algorithm. DESIGN:Evaluation of an imaging technique in a cohort of patients. METHODS...
journal_title:American journal of ophthalmology
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更新日期:2015-09-01 00:00:00