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Risk factors for blindness in children with primary congenital glaucoma - follow-up of a registry cohort.

Abstract：

PURPOSE:The aim of this study was to evaluate the baseline features associated with blindness in a cohort of children with primary congenital glaucoma (PCG) from a hospital registry. METHODS:Setting: Observational cohort study DESIGN: Retrospective clinical cohort study STUDY POPULATION: The registry included all children who presented to our tertiary care institute between 1995 and 2014 with a diagnosis of childhood glaucoma. OBSERVATION PROCEDURE:Baseline characteristics at initial presentation of children with PCG in the registry who were blind at the last follow-up, were compared with those who were not blind, using bivariate and then multivariate regressions to account for potential confounders. MAIN OUTCOME MEASURES:Blindness was defined as a best corrected visual acuity (BCVA) of 3/60 (20/400) or worse in the better eye at final follow-up. RESULTS:The eligible sample consisted of 196 children with a mean age of 9.54 ± 22.44 months at presentation. After a mean ± SD follow-up of 8.49 ± 3.85 years, 20 (10.2%) children were blind. The baseline demographic factors, IOP, horizontal corneal diameter, spherical equivalent, axial length, and corneal thickness was similar for 'blind' and 'not blind' groups (p>0.05). In the multivariate regression, only the severity of corneal opacification remained significantly (p<0.001) associated with the risk of blindness (OR = 4.05; 95% CI: 1.89-8.85). CONCLUSION:Corneal clouding is a predictor of future blindness in children with PCG. Children with severe corneal clouding may need more aggressive intraocular pressure control, closer follow-up and earlier counselling.

journal_name

Am J Ophthalmol

journal_title

American journal of ophthalmology

authors

Alshigari R,Freidi A,Souru C,Edward DP,Malik R

doi

10.1016/j.ajo.2020.12.014

subject

Has Abstract

pub_date

2020-12-21 00:00:00

eissn

0002-9394

issn

1879-1891

pii

S0002-9394(20)30672-3

pub_type

杂志文章

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