Abstract：
PURPOSE:To estimate incidence of age-related macular degeneration (AMD) by subtype in American whites aged ≥50 years. DESIGN:Systematic review and meta-analysis. METHODS: SETTING:Prospective cohort studies of AMD incidence in populations of white European ancestry published in MEDLINE, EMBASE, and Web of Science. STUDY POPULATION:Fourteen publications in 10 populations that examined AMD incident cases were identified. OBSERVATION PROCEDURE:Data on age-sex-specific incidence of late AMD, geographic atrophy (GA) and neovascular AMD (NVAMD), year of recruitment, AMD grading method, and continent were extracted. MAIN OUTCOME MEASURE(S):Annual incidence of late AMD, GA, and NVAMD by age-sex in American whites aged ≥50 years from a Bayesian meta-analysis of incidence studies was compared with incidence extrapolated from published prevalence estimates. RESULTS:Incidence rates from the review agreed with those derived from prevalence, but the latter were based on more data, especially at older ages and by AMD subtypes. Annual incidence (estimated from prevalence) of late AMD in American whites was 3.5 per 1000 aged ≥50 years (95% credible interval 2.5, 4.7 per 1000), equivalent to 293 000 new cases in American whites per year (95% credible interval 207 000, 400 000). Incidence rates approximately quadrupled per decade in age. Annual incidence GA rates were 1.9 per 1000 aged ≥50 years, NVAMD rates were 1.8 per 1000. Late AMD incidence was 38% higher in women vs men (95% credible interval 6%, 82%). CONCLUSIONS:Estimating AMD incidence from prevalence allows better characterization at older ages and by AMD subtype where longitudinal data from incidence studies are limited.
journal_name
Am J Ophthalmoljournal_title
American journal of ophthalmologyauthors
Rudnicka AR,Kapetanakis VV,Jarrar Z,Wathern AK,Wormald R,Fletcher AE,Cook DG,Owen CGdoi
10.1016/j.ajo.2015.04.003subject
Has Abstractpub_date
2015-07-01 00:00:00pages
85-93.e3issue
1eissn
0002-9394issn
1879-1891pii
S0002-9394(15)00191-9journal_volume
160pub_type
杂志文章,meta分析,评审abstract：:A retrospective study of patients who underwent keratoplasty for keratoconus was done in 100 consecutive cases, of which 50 were penetrating keratoplasty procedures, and 50 were lamellar keratoplasty procedures. Each case was done by the same surgeon in both series. Criteria for patient selection were essentially the ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(78)90126-5
更新日期：1978-12-01 00:00:00
abstract：PURPOSE:To evaluate qualitatively the structural characteristics and the associated features that antedate the occurrence of a disk hemorrhage in patients with glaucoma. METHODS:Retrospective observational case series. A total of 4018 pairs of stereoscopic optic disk images obtained over 15 years were reviewed. All ey...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(01)01009-1
更新日期：2001-09-01 00:00:00
abstract：PURPOSE:To report microvascular retinopathy after percutaneous transluminal coronary angioplasty and stent insertion for acute myocardial infarction. DESIGN:Observational case series. METHODS:Retrospective review of seven patients with a retinal microangiopathy following coronary catheterization, angioplasty, and ste...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(03)00267-8
更新日期：2003-09-01 00:00:00
abstract：:A graft of hard palate mucosa is a satisfactory substitute for the posterior lamella of tarsus and conjunctiva in eyelid reconstruction. The graft may be harvested after administration of local anesthesia in adults, provides structural support as well as a mucosal surface, and contracts minimally. The palatal donor si...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(89)90257-2
更新日期：1989-06-15 00:00:00
abstract：PURPOSE:To compare tear film thickness between normal subjects and aqueous tear deficiency dry eye patients by tear interferometry. DESIGN:Prospective case-control study. METHODS:Central precorneal tear film thickness was measured noninvasively using an interference thin-film thickness measurement device (Quore MSPA1...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2010.07.019
更新日期：2011-01-01 00:00:00
abstract：PURPOSE:To assess whether alcohol consumption is associated with the long-term incidence of cataract or cataract surgery. DESIGN:Population-based prospective cohort study. METHODS:A total of 3654 persons aged 49+ years were examined at baseline and 2564 were re-examined after 5 and/or 10 years. Lens photographs were ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2010.04.020
更新日期：2010-09-01 00:00:00
abstract：PURPOSE:To report the efficacy and safety of outpatient fluid-gas exchange for open macular hole after primary vitrectomy. DESIGN:Retrospective interventional case series. METHODS:setting: Institutional. patients: Thirty-six patients with primary failed closure or reopened holes after primary vitrectomy. intervention...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2013.03.031
更新日期：2013-08-01 00:00:00
abstract：PURPOSE:To determine photoreceptor oxidative stress and damage in sympathetic ophthalmia (SO). DESIGN:Immunohistologic study. METHODS:Eight formalin-fixed and paraffin-embedded human globes with typical histologic features of SO and five age-matched globes without intraocular inflammation (controls) were retrieved fr...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2008.03.026
更新日期：2008-12-01 00:00:00
abstract：PURPOSE:An association of glaucoma and sleep apnea syndrome (SAS) has been widely reported. We investigated the largest group of patients with SAS thus far to determine the prevalence of glaucoma among these patients. DESIGN:Cross-sectional study. METHODS:An institutional study. STUDY POPULATION:A total of 228 patie...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(03)00709-8
更新日期：2003-12-01 00:00:00
abstract：PURPOSE:To describe intentional placement of intraocular lens haptics in the ciliary sulcus of patients with uveitis who are at high risk for postoperative posterior synechiae and lens dislocation. METHODS:We reviewed our experience with 16 eyes of 12 patients with uveitis who underwent cataract surgery with ciliary s...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(99)00140-3
更新日期：1999-07-01 00:00:00
abstract：:We have developed a new model of retinal neovascularization in the rabbit. After intravitreal autotransplantation of 250,000 tissue-cultured skin fibroblasts, we observed strand formation in the midvitreous cavity. These strands grew toward the vascularized part of the retina and attached to it. Once the attachment wa...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)75913-6
更新日期：1981-07-01 00:00:00
abstract：PURPOSE:To report the cases of four patients with hepatitis C virus infection who experienced clinical features that are virtually identical to Vogt-Koyanagi-Harada disease (VKH). DESIGN:Retrospective observational case series. METHODS:Medical records of patients who were referred between January and December 2003 we...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2005.06.020
更新日期：2005-11-01 00:00:00
abstract：PURPOSE:To report a case of pityriasis rubra pilaris (PRP)-induced bilateral lower eyelid cicatricial ectropion that resolved with systemic low-dose methotrexate. DESIGN:Observational case report. METHODS:A retrospective case review of a patient with cicatricial ectropion caused by PRP. RESULTS:A 82-year-old female ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2006.11.038
更新日期：2007-04-01 00:00:00
abstract：PURPOSE:This study sought to investigate retinal function in patients with noninfectious uveitis by using full-field electroretinography (ERG) and correlate the ERG to disease duration and severity of inflammation. DESIGN:Prospective cohort study. METHODS:Patients (n = 200) with noninfectious uveitis and a disease du...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2019.05.028
更新日期：2019-11-01 00:00:00
abstract：PURPOSE:To describe the immune alterations associated with age-related macular degeneration (AMD); and, based on these findings, to offer an approach to possibly prevent the expression of late disease. DESIGN:Perspective. METHODS:Review of the existing literature dealing with epidemiology, models, and immunologic fin...
journal_title：American journal of ophthalmology
pub_type： 杂志文章,评审
doi：10.1016/j.ajo.2014.03.014
更新日期：2014-07-01 00:00:00
abstract：PURPOSE:To evaluate the repeatability of an extensive number of relevant indices with the Pentacam HR in keratoconus of varying severity and normal eyes. DESIGN:Reliability analysis. METHODS:This study was performed at Antwerp University Hospital, Belgium, and enrolled 20 healthy volunteers (20 eyes) and 69 patients ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2020.06.013
更新日期：2020-11-01 00:00:00
abstract：:A 35-year-old woman with Engelmann's disease and systemic lupus erythematosus developed spontaneous luxation of the globe and glaucoma. Radiological studies demonstrated increased sclerosis of the orbital bones and decreased orbital volumes, the probable cause of the luxation and the glaucoma. The glaucoma was control...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(77)90917-5
更新日期：1977-06-01 00:00:00
abstract：:A 26-year-old woman experienced bilateral hearing loss, progressive nasal obstruction, and rhinorrhea. Examination disclosed a retropharyngeal mass. A needle biopsy specimen of the mass showed that it was a chordoma. The patient underwent surgery to remove the mass and received a postoperative course of radioactive co...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)75899-4
更新日期：1981-07-01 00:00:00
abstract：PURPOSE:To evaluate the effects of a dexamethasone intravitreous drug delivery system (dexamethasone DDS) in patients with persistent macular edema (ME) resulting from uveitis or Irvine-Gass syndrome. DESIGN:Randomized, prospective, single-masked, controlled trial. METHODS:Three hundred and fifteen patients with pers...
journal_title：American journal of ophthalmology
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.ajo.2008.12.033
更新日期：2009-06-01 00:00:00
abstract：PURPOSE:To examine changes of select reduction-oxidation (redox) sensitive proteins from human donor retinal pigment epithelium (RPE) at four stages of age-related macular degeneration (AMD). DESIGN:Experimental study. METHODS:Human donor eyes were obtained from the Minnesota Lions Eye Bank and graded using the Minne...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2006.12.006
更新日期：2007-04-01 00:00:00
abstract：PURPOSE:To evaluate multifocal electroretinography (mfERG) as a screening test for detecting hydroxychloroquine and chloroquine toxicity. DESIGN:Diagnostic accuracy study. METHODS:Patients referred to the University of Ottawa for hydroxychloroquine or chloroquine retinopathy screening during 2011-2014 underwent 10-2 ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2019.04.025
更新日期：2019-10-01 00:00:00
abstract：PURPOSE:To determine novel diagnostic parameters for keratoconus, and to assess the correlation between anterior and posterior corneal surfaces based on vectorial astigmatism analyses. DESIGN:Retrospective case-control study. METHODS:Six hundred and ninety-eight eyes of 698 patients were enrolled in the study. Health...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2016.04.008
更新日期：2016-07-01 00:00:00
abstract：PURPOSE:To demonstrate techniques of iris reconstruction (pupilloplasty) at the time of penetrating keratoplasty (PKP) for a variety of pupil abnormalities, and to evaluate the effect of pupilloplasty on graft survival and visual outcome. DESIGN:Case-control study. METHODS:Thirty-five cases (combined PKP and pupillop...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2007.10.006
更新日期：2008-02-01 00:00:00
abstract：PURPOSE:To report atypical kerato-conjunctivitis as a manifestation of Hodgkin disease. METHODS:Case report. RESULTS:A 19-year old woman presented with conjunctival nodules and corneal infiltrates. Diffuse lymph node enlargement occurred, but not in the preauricular or submandibular areas. Extensive microbiologic exa...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(00)00895-3
更新日期：2001-06-01 00:00:00
abstract：:We perfused enucleated human eyes via the anterior chamber by the constant pressure technique. Infusion of human serum into the anterior chamber of enucleated human eyes for 30 minutes at 23 mm Hg pressure induced a 42% decrease in facility of outflow, which was not relieved by irrigation of the anterior chamber with ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(78)90023-5
更新日期：1978-07-01 00:00:00
abstract：:The extent of visual function loss from nuclear cataractous change can be estimated by observing the extinction of blue light compared to white light as a function of sagittal lens depth in standard slit lamps. Apparent extinction (loss of transmissivity) of 50% or more of the depth of the lens in blue light of maxima...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(81)90057-x
更新日期：1981-05-01 00:00:00
abstract：PURPOSE:To report an HIV-negative lymphoma patient who developed progressive outer retinal necrosis syndrome and who had a good visual outcome after treatment with two-drug antiviral therapy and intravenous immunoglobulin. METHODS:Case report. RESULTS:A 43-year-old man with small lymphocytic lymphoma was diagnosed wi...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(00)00951-x
更新日期：2001-07-01 00:00:00
abstract：:A 33-year-old man had a sudden onset of night blindness 3 1/2 years after intestinal bypass surgery for morbid obesity. Ocular examination disclosed a probable Bitot's spot and electrophysiologic testing showed markedly impaired dark adaptation and subnormal electroretinography. After therapy with orally administered ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(80)90164-6
更新日期：1980-06-01 00:00:00
abstract：:We conducted a two-part study to determine whether any positive association between the use of allopurinol and the development of cataracts could be demonstrated. Study 1 included 251 Boston-area patients hospitalized for cataract and 753 matched controls. Two cataract patients were regular allopurinol users as compar...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(84)90328-3
更新日期：1984-09-15 00:00:00
abstract：PURPOSE:We sought to understand better the efficacy and risks of local therapies (direct placement of drug into the eye) for the treatment of cytomegalovirus retinopathy. This understanding can be used to design rational treatment regimens, to formulate indications for use of local therapy, and to establish criteria fo...
journal_title：American journal of ophthalmology
pub_type： 杂志文章,评审
doi：10.1016/s0002-9394(14)72168-3
更新日期：1995-09-01 00:00:00
