Progressive outer retinal necrosis syndrome in a lymphoma patient with good visual outcome.

Abstract:

PURPOSE:To report an HIV-negative lymphoma patient who developed progressive outer retinal necrosis syndrome and who had a good visual outcome after treatment with two-drug antiviral therapy and intravenous immunoglobulin. METHODS:Case report. RESULTS:A 43-year-old man with small lymphocytic lymphoma was diagnosed with progressive outer retinal necrosis in his left eye. Treatment was initiated with intravenous foscarnet and ganciclovir as well as intravenous gammaglobulin at a dose of 0.5 gm/kg per day for 5 days. On the second hospital day he was started on decadron 4 mg orally four times daily. No further posterior retinitis progression was observed despite severe immunosuppression. Visual acuity remained stable at 20/30 with 10 months' follow-up. CONCLUSIONS:The benefit of using gammaglobulin in progressive outer retinal necrosis is unknown. Given the rapid improvement seen in this patient's retinitis, it may be reasonable to consider the use of gammaglobulin in other cases of infectious retinitis in immunocompromised patients.

journal_name

Am J Ophthalmol

authors

Foster RE,Petersen MR,Neuss MN,Osher RH

doi

10.1016/s0002-9394(00)00951-x

subject

Has Abstract

pub_date

2001-07-01 00:00:00

pages

117-20

issue

1

eissn

0002-9394

issn

1879-1891

pii

S000293940000951X

journal_volume

132

pub_type

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