Abstract：
PURPOSE:To report a case of conjunctival-corneal intraepithelial neoplasia (CCIN) in an elderly African American patient treated with topical mitomycin C and the subsequent complication of limbal stem cell deficiency. DESIGN:Interventional case report. METHODS:A 92-year-old African American woman was diagnosed with CCIN in the right eye. Following incisional biopsy, the patient received five 1-week courses of 0.04% mitomycin C and was followed over a period of 10 months. RESULTS:The CCIN regressed completely following mitomycin C therapy. Three months later, the patient developed recurrent nonhealing epithelial defects in the right cornea. CONCLUSIONS:Conjunctival-corneal intraepithelial neoplasia may occur in the African American population. Although MMC is effective in eradicating CCIN, a limbal stem cell deficiency may complicate the treatment.
journal_name
Am J Ophthalmoljournal_title
American journal of ophthalmologyauthors
Dudney BW,Malecha MAdoi
10.1016/j.ajo.2003.10.048subject
Has Abstractpub_date
2004-05-01 00:00:00pages
950-1issue
5eissn
0002-9394issn
1879-1891pii
S0002939403014119journal_volume
137pub_type
杂志文章abstract：:We studied 216 eyes of 160 patients who underwent combined phacoemulsification and posterior chamber intraocular lens implantation with trabeculectomy. The mean follow-up was 18.7 months, with a minimum follow-up of six months. To assess the safety and efficacy of a recently developed 3-mm incision procedure with fold...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)72258-5
更新日期：1991-02-15 00:00:00
abstract：PURPOSE:To evaluate postoperative corneal deturgescence after Descemet stripping endothelial keratoplasty (DSAEK) using the Visante anterior segment optical coherence tomography (OCT) system (Carl Zeiss Meditec Inc, Dublin, California, USA). DESIGN:Retrospective case series. METHODS:We included 21 eyes (9 males and 1...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2009.01.016
更新日期：2009-07-01 00:00:00
abstract：:We reviewed the records of 1,323 patients with retinoblastoma treated here between 1922 and 1978. Twenty-eight patients underwent bilateral enucleation alone and received no additional treatment for their advanced tumors. Of the 28 patients, 22 (92%) survived. Four patients were lost to follow-up, and two died of meta...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(79)90293-9
更新日期：1979-05-01 00:00:00
abstract：PURPOSE:To assess and compare the frequency of reflex sneezing occurring during periocular anesthetic injections with and without intravenous sedation. DESIGN:Retrospective, comparative case series. METHODS:Seven hundred and twenty-two patients undergoing oculoplastic surgical procedures were included in this study. ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2008.02.013
更新日期：2008-07-01 00:00:00
abstract：PURPOSE:To report a case of nodular scleritis and panuveitis associated with erythema elevatum diutinum, a rare immunocomplex-mediated skin disease. DESIGN:Observational case report. METHODS:A 22-year-old woman who was diagnosed with erythema elevatum diutinum developed nodular scleritis and panuveitis of the right e...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/S0002-9394(03)00907-3
更新日期：2004-02-01 00:00:00
abstract：:Two patients had paresis of the trochlear nerve contralateral to the site of lesions in the brainstem. Both patients had ipsilateral blepharoptosis and miosis suggesting oculosympathetic paresis from involvement of the descending sympathetic tract, adjacent to the fourth cranial nerve nucleus and its fascicles, in the...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(89)90818-0
更新日期：1989-01-15 00:00:00
abstract：:Using immunohistochemical techniques, we studied ligneous conjunctival lesions from two patients. A significant immune reaction was detected that was characterized by activated T lymphocytes and focal accumulation of plasma cells and B lymphocytes. Immunofluorescent studies demonstrated that IgG was a prominent compon...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(89)90216-x
更新日期：1989-02-15 00:00:00
abstract：PURPOSE:Although the association of cystoid macular edema with peripheral choroidal melanoma has been studied previously, the pathogenesis of cystoid macular edema as evaluated by light and electron microscopy remains controversial. We evaluated the cause of cystoid macular edema at the retinal capillary level. METHOD...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)73867-x
更新日期：1995-02-01 00:00:00
abstract：:Subretinal neovascular membranes cause late visual loss and are important determinants of final visual acuity in patients with Vogt-Koyanagi-Harada syndrome. The purpose of this study was to determine the prevalence and risk factors associated with the development of subretinal neovascular membranes in Vogt-Koyanagi-H...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)71280-2
更新日期：1993-08-15 00:00:00
abstract：:Rabbit eyes in which vitrectomy was performed underwent three hours of hypothermic perfusion with either 22 C or 2 C lactated Ringer's solution. Clinical, electroretinographic, fluorescein angiographic, histologic, and ultrastructural examinations were performed. No changes were noted in eyes cooled with 22 C fluid. R...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)74615-x
更新日期：1990-04-15 00:00:00
abstract：PURPOSE:To perform 11- and 2-year health care sector (ophthalmic) and societal cost perspective reference case, cost-utility analyses comparing bevacizumab, ranibizumab, and aflibercept monotherapies for neovascular age-related macular degeneration (NVAMD). DESIGN:Cost-utility analysis. METHODS:The authors performed ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2020.05.029
更新日期：2020-10-01 00:00:00
abstract：PURPOSE:An association between multiple sclerosis during childhood and uveitis is exceptionally rare. This is a report of a female patient who presented at the age of 8 years with bilateral intermediate uveitis and whose final diagnosis of multiple sclerosis was made at age 21 years. DESIGN:Case report. METHOD:Retros...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(02)01702-6
更新日期：2003-06-01 00:00:00
abstract：:Confirmation of iodine-125 plaque position was determined with a modified fiberoptic light pipe that directed light at right angles to the long axis of the fiberoptic pipe. While the examiner observed the interior of the eye with indirect ophthalmoscopy, the point source of light from the fiberoptic light pipe was mov...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)74171-6
更新日期：1987-01-15 00:00:00
abstract：:A 56-year-old woman presented with the typical findings of cicatricial pemphigoid: vesicular lesions of the mucous membranes and skin. Ocular involvement included symblepharon and dryness. A regimen of 80 mg of oral trimcinolone per day healed the lesions of the skin and mucous membrane. The patient received three inj...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(75)90081-1
更新日期：1975-02-01 00:00:00
abstract：PURPOSE:To report a case of migration of liquid silicone into the upper eyelid. DESIGN:Interventional case report. METHODS:A 32-year-old woman had an injection of liquid silicone into the subcutaneous tissue of the forehead. She developed a cystic mass in the upper eyelid 2 days postinjection. An excisional biopsy wa...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(03)00465-3
更新日期：2003-11-01 00:00:00
abstract：:Lacrimal tissue and accessory lacrimal tissue from seven autopsy cases, lacrimal tissue from three patients undergoing orbital exploration, and biopsy specimens from conjunctiva of 14 subjects were examined for the presence and distribution of secretory component by three anti-secretory-component antisera. Secretory c...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(80)90004-5
更新日期：1980-03-01 00:00:00
abstract：PURPOSE:To compare measurements of anterior chamber depth (ACD) and corneal curvature obtained with the Pentacam to other commonly used devices. DESIGN:Prospective, nonrandomized clinical trial. METHODS:Measurements of ACD and keratometry were prospectively obtained in 22 eyes of 11 subjects with the Pentacam compare...
journal_title：American journal of ophthalmology
pub_type： 临床试验,杂志文章
doi：10.1016/j.ajo.2006.08.031
更新日期：2007-01-01 00:00:00
abstract：PURPOSE:To evaluate the mechanism of spontaneous resolution of foveal detachments and idiopathic macular breaks. METHODS:We reviewed the records of 139 consecutive eyes (94 patients) with either a foveal detachment or a macular break in patients who were examined between 1989 and 1992. There were 26 men and 68 women (...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)72730-8
更新日期：1995-12-01 00:00:00
abstract：:Self-inflicted mutilation of the eyes is an uncommon but fairly distinct entity. Patients are typically young men; they often have criminal records and histories of drug abuse. Underlying schizophrenia is a common feature. The patients frequently suffer from castration fears, oedipal conflicts, repressed homosexual im...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(81)90070-2
更新日期：1981-05-01 00:00:00
abstract：PURPOSE:beta-Adrenergic blocking drugs lower intraocular pressure. The question of whether these drugs also alter, either directly or indirectly, orbital hemodynamics is potentially of great importance for patients with normal-tension glaucoma who may have some degree of reversible vasospasm. METHODS:We compared the e...
journal_title：American journal of ophthalmology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0002-9394(14)72604-2
更新日期：1995-08-01 00:00:00
abstract：PURPOSE:To describe the incidence of vision loss and of ocular complications attributable to birdshot retinochoroidopathy and to describe the association between therapy and the incidence thereof. DESIGN:Retrospective cohort study. METHODS: SETTING:Single-center, academic practice. STUDY POPULATION:Forty patients w...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2005.01.035
更新日期：2005-07-01 00:00:00
abstract：:A consecutive group of 67 patients (70 eyes) with senile cataract underwent extracapsular cataract extraction and implantation of a Shearing posterior chamber intraocular lens. After two years of follow-up, there was an 11% +/- 2% decrease in central cell density (P less than .001), a 20% +/- 2% decrease in superior c...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(83)90068-5
更新日期：1983-06-01 00:00:00
abstract：PURPOSE:To report a case of peripheral retinal nonperfusion and chronic myeloid leukemia in a 23-year-old woman. DESIGN:Observational case report. METHODS:A complete ophthalmic and systemic evaluation was performed. RESULTS:Ophthalmic examination revealed peripheral retinal nonperfusion with retinal neovascularizati...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(02)01956-6
更新日期：2003-03-01 00:00:00
abstract：:Four patients, two men 25 and 43 years old and two women 20 and 40 years old, had complete monocular temporal hemianopsias, suggesting that it may be a more common functional deficit than has been recognized. The initial symptoms were visual loss and headache, and eye pain also occurred. Correct diagnosis is possible ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(86)90600-8
更新日期：1986-02-15 00:00:00
abstract：PURPOSE:To describe optical coherence tomographic (OCT) angiography findings in chronic central serous chorioretinopathy (CSC), and to characterize their OCT B-scans by means of the split-spectrum amplitude-decorrelation angiography algorithm. DESIGN:Evaluation of an imaging technique in a cohort of patients. METHODS...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2015.06.016
更新日期：2015-09-01 00:00:00
abstract：:A clinical study of eyes with rhegmatogenous retinal detachment compared the reattachment rate in two groups of eyes: in the control group, cryopexy was applied over the retinal breaks during surgery; in the test group, cryopexy was not applied. There was a similar rate of retinal reattachment in the two groups in the...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(81)90235-x
更新日期：1981-04-01 00:00:00
abstract：PURPOSE:To determine the morphologic changes in human corneas over time following radiofrequency-based conductive keratoplasty (CK) treatment. DESIGN:Prospective, observational case series. METHODS:In a single-center study six human corneas of six patients with localized peripheral keratoconus underwent CK treatment ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2005.06.027
更新日期：2005-12-01 00:00:00
abstract：PURPOSE:To report glaucoma outcomes after Boston type 1 keratoprosthesis (KPro) surgery, in particular, glaucoma prevalence, progression, and treatment. DESIGN:Consecutive, retrospective, interventional case series. METHODS:setting: Tertiary care institution. study population: Thirty-eight eyes in 38 patients. interv...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2011.07.022
更新日期：2012-02-01 00:00:00
abstract：:Presumed accidental corneal exposure to Hibiclens (chlorhexidine 4% and detergent) in two patients resulted in severe and permanent corneal opacification. We investigated the corneal toxicity of Hibiclens by gross, biomicroscopic, and histopathologic studies of rabbit eyes exposed to Hibiclens for varying time interva...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(87)90292-3
更新日期：1987-07-15 00:00:00
abstract：PURPOSE:To provide current estimates of the prevalence of diagnosed dry eye disease (DED) and associated demographics among US adults aged ≥18 years. DESIGN:Cross-sectional, population-based survey. METHODS:Data were analyzed from 75 000 participants in the 2013 National Health and Wellness Survey to estimate prevale...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2017.06.033
更新日期：2017-10-01 00:00:00
