Limbal stem cell deficiency following topical mitomycin C treatment of conjunctival-corneal intraepithelial neoplasia.


PURPOSE:To report a case of conjunctival-corneal intraepithelial neoplasia (CCIN) in an elderly African American patient treated with topical mitomycin C and the subsequent complication of limbal stem cell deficiency. DESIGN:Interventional case report. METHODS:A 92-year-old African American woman was diagnosed with CCIN in the right eye. Following incisional biopsy, the patient received five 1-week courses of 0.04% mitomycin C and was followed over a period of 10 months. RESULTS:The CCIN regressed completely following mitomycin C therapy. Three months later, the patient developed recurrent nonhealing epithelial defects in the right cornea. CONCLUSIONS:Conjunctival-corneal intraepithelial neoplasia may occur in the African American population. Although MMC is effective in eradicating CCIN, a limbal stem cell deficiency may complicate the treatment.


Am J Ophthalmol


Dudney BW,Malecha MA




Has Abstract


2004-05-01 00:00:00














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    journal_title:American journal of ophthalmology

    pub_type: 杂志文章


    authors: Li L,Bian A,Zhou Q,Mao J

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    journal_title:American journal of ophthalmology

    pub_type: 杂志文章


    authors: Freund KB,Gattoussi S,Leong BCS

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    pub_type: 杂志文章


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