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Immunohistologic findings and results of treatment with cyclosporine in ligneous conjunctivitis.

Abstract：

:Using immunohistochemical techniques, we studied ligneous conjunctival lesions from two patients. A significant immune reaction was detected that was characterized by activated T lymphocytes and focal accumulation of plasma cells and B lymphocytes. Immunofluorescent studies demonstrated that IgG was a prominent component of the amorphous hyaline material seen in these lesions. After previous treatment methods had failed, both patients were treated with excisional biopsy and topical cyclosporine. Patient 1 had a dramatic response, with complete resolution of the lesions. Patient 2 had a significant improvement resulting in small, slow-growing recurrences instead of the rapid and extensive recurrences that occurred before treatment with cyclosporine.

journal_name

Am J Ophthalmol

journal_title

American journal of ophthalmology

authors

Holland EJ,Chan CC,Kuwabara T,Palestine AG,Rowsey JJ,Nussenblatt RB

doi

10.1016/0002-9394(89)90216-x

subject

Has Abstract

pub_date

1989-02-15 00:00:00

pages

160-6

issue

2

eissn

0002-9394

issn

1879-1891

pii

0002-9394(89)90216-X

journal_volume

107

pub_type

杂志文章

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