Abstract:
PURPOSE:To describe the clinical features and management of ocular surface squamous neoplasia (OSSN) after corneal graft. DESIGN:Retrospective case series of 4 patients. METHODS:Four eyes of 4 patients treated for OSSN after corneal graft in an institutional setting were included. All 4 patients were treated with topical chemotherapy and additionally 1 patient each was treated with excisional biopsy and photodynamic therapy. The main outcome measure was the recurrence of OSSN and the clarity of corneal graft after treatment. RESULTS:The mean time interval between corneal graft and diagnosis of OSSN was 36 months (range, 2 to 73 months). All 4 eyes were on chronic treatment with topical steroids for a minimum duration of 2 months and 2 eyes had previous herpes keratitis. Misdiagnosis of graft rejection was found in 2 cases. The mean tumor basal diameter was 18 mm (range, 14- to 25-mm) and the tumor involved a mean of 76% of the corneal surface (range, 15% to 90%). Management was successful in all cases using topical mitomycin C (n = 1), topical interferon alpha2b (n = 4), and photodynamic therapy (n = 1). At mean follow-up of 20 months, tumor control was achieved in all cases and all 4 eyes showed chronic graft opacification with vascularization but no intraocular tumor. CONCLUSION:Corneal OSSN should be considered in patients using chronic topical steroids for corneal graft. Nonsurgical management with topical chemotherapy or photodynamic therapy can achieve tumor control.
journal_name
Am J Ophthalmoljournal_title
American journal of ophthalmologyauthors
Ramasubramanian A,Shields CL,Sinha N,Shields JAdoi
10.1016/j.ajo.2009.07.026subject
Has Abstractpub_date
2010-01-01 00:00:00pages
62-5issue
1eissn
0002-9394issn
1879-1891pii
S0002-9394(09)00538-8journal_volume
149pub_type
杂志文章abstract:PURPOSE:To describe a modified laser technique for identification of bullous retinoschisis. DESIGN:Retrospective interventional case series collected over 10 years. METHODS:Forty-one eyes with presumed bullous retinoschisis and breaks in the inner layers underwent a low-energy argon green laser application at the sam...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(03)00485-9
更新日期:2003-11-01 00:00:00
abstract:PURPOSE:To determine the ability to detect normal vitreous structure, evolving posterior vitreous detachment (PVD), and related vitreoretinal changes with combined spectral-domain optical coherence tomography (SD-OCT) and scanning laser ophthalmoscopy (SLO). DESIGN:Observational cross-sectional study. METHODS:Simulta...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2009.11.016
更新日期:2010-04-01 00:00:00
abstract::A 2-week-old premature child with congenital glaucoma secondary to anterior cleavage syndrome was treated with timolol maleate and cyclocryotherapy. The patient had apneic spells of up to 30 seconds that stopped soon after timolol maleate therapy was discontinued. No apnea was seen before timolol maleate administratio...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/0002-9394(79)90766-9
更新日期:1979-07-01 00:00:00
abstract:PURPOSE:To review the contributions to ophthalmic genetics through the American Journal of Ophthalmology (AJO). DESIGN:Perspective. METHODS:A literature search to retrieve original articles, letters, editorials, and published lectures from 1966 to 2017, providing a 50-year review. Titles were excluded that gave no re...
journal_title:American journal of ophthalmology
pub_type: 杂志文章,评审
doi:10.1016/j.ajo.2018.03.004
更新日期:2018-06-01 00:00:00
abstract::New criteria for diagnosing congenital stationary night blindness include loss of the oscillatory potentials in the photopic and bright-flash dark-adapted electroretinogram, and atrophy or dysplastic changes, or both, in the optic nerve head. Ten patients (seven male and three female, ranging in age from 6 to 19 years...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(14)77917-6
更新日期:1983-10-01 00:00:00
abstract::Eight patients with severe traumatic hyphemas underwent clot evacuation with vitrectomy instrumentation. The patients were followed up for periods of one to four years. No significant intraoperative complications were noted, but one eye developed a postoperative flat anterior chamber and another developed multiple sta...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/0002-9394(79)90574-9
更新日期:1979-11-01 00:00:00
abstract::One hundred consecutive eyes underwent vitrectomy with the disposable vitrophage via a pars plana approach. Eyes were divided into two main categories based on opacity location-in the anterior or posterior segment. Patients with posterior segment opacities had diabetic retinopathy, nondiabetic vitreous hemorrhages, re...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/0002-9394(76)90239-7
更新日期:1976-03-01 00:00:00
abstract:PURPOSE:To describe rifabutin-associated uveitis with opacities in the inferior and posterior vitreous in three patients with acquired immunodeficiency syndrome. METHOD:Case reports of the three patients are presented. RESULTS:The patients, who were being treated with rifabutin and fluconazole, developed anterior and...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(14)72124-5
更新日期:1996-10-01 00:00:00
abstract::I devised a new technique using a thermal wedge resection at the time of keratoplasty to reduce excessive amounts of corneal astigmatism. Surface cautery was used to draw this thermal wedge of corneal tissue into the area to be trephined, and removed at surgery from the patient's cornea. The final result was the same ...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(14)74844-5
更新日期:1980-08-01 00:00:00
abstract:PURPOSE:To report a case series of contact lens-related corneal ulcers in compliant patients with no apparent predisposing factors. DESIGN:Retrospective case series. METHODS:Charts of 70 patients with contact lens-related corneal ulcers from July 1999 to June 2002 were reviewed. Lens care hygiene and method of disinf...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(03)00722-0
更新日期:2004-01-01 00:00:00
abstract::Although surgical excision, with or without adjunctive cryotherapy, is an accepted method of managing conjunctival squamous cell carcinoma, histologically verified tumor-free surgical margins cannot be assured by excision alone. We used a tissue conservation method, an adaptation of the Mohs' micrographic technique fo...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(14)73021-1
更新日期:1994-01-15 00:00:00
abstract::We used specular microscopy to investigate corneal endothelial changes after excimer laser photorefractive keratectomy. Twenty patients (26 eyes) underwent photorefractive keratectomy for the correction of myopia. The central cornea endothelium of each eye was observed preoperatively and one month postoperatively. Six...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(14)73467-1
更新日期:1993-12-15 00:00:00
abstract:PURPOSE:This study sought to compare the postoperative visual outcomes of toric implantable collamer lens (T-ICL) with toric Artiflex (T-Artiflex) lenses. DESIGN:Alternating treatment, contralateral eye matched clinical study. METHODS:This study compared 82 eyes of 41 patients with T-ICL lenses in one eye and toric A...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2020.06.021
更新日期:2020-11-01 00:00:00
abstract::Corneas for penetrating keratoplasty that have been excised from the globe for storage ordinarily require punching of the donor tissue from the posterior surface. They may be trephined from the anterior surface when they are mounted on an instrument that forms a seal around the scleral rim of the excised cornea, allow...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/0002-9394(76)90021-0
更新日期:1976-11-01 00:00:00
abstract::We used wide-field color specular microscopy of the human corneal surface to study the morphologic changes that occur under extended-wear contact lenses. There was a shift in the frequency distribution of surface cells by size to larger cells, suggesting a prolonged residence time on the ocular surface. Other abnormal...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/0002-9394(86)90818-4
更新日期:1986-03-15 00:00:00
abstract:PURPOSE:To report an unusual case of orbital floor implant migration across the ethmoidal sinuses and nasal septum. METHOD:Case report. A 61-year-old woman with a history of right orbital floor fracture repair 25 years earlier is described. RESULTS:The patient presented with sinus congestion and difficulty breathing ...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(98)00239-6
更新日期:1998-12-01 00:00:00
abstract::In five cases choroidal malignant melanoma spontaneously converted from epitheloid to spindle cell and vice versa. The cultured epitheloid cells divided more frequently and grew faster than the spindle cells. Cells from one tumor were cloned and developed into a cell line. ...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/0002-9394(75)90528-0
更新日期:1975-09-01 00:00:00
abstract:PURPOSE:To evaluate the long-term outcomes of laser in situ keratomileusis (LASIK) for high myopia. DESIGN:A long-term (10 years) follow-up retrospective interventional case series study. METHODS:The study included 196 myopic eyes of 118 patients with a mean preoperative spherical equivalent of -13.95 +/- 2.79 diopte...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2007.08.035
更新日期:2008-01-01 00:00:00
abstract::Visual field testing of 166 phakic eyes with optic nerve damage from open-angle glaucoma before and after one year of treatment showed that the visual fields of myopic eyes improved more often than those of nonmyopic eyes (12% vs 6%) and worsened less often (6% vs 18%). These results suggested that myopia, which adver...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(14)77378-7
更新日期:1982-05-01 00:00:00
abstract::A study of ten patients (six girls and four boys ranging in age from 17 months to 9 1/2 years) with congenital third nerve palsies showed that not all cases are benign without other signs of focal neurologic damage. Six of the ten children showed some degree of pupillary involvement, five had signs of oculomotor synki...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/0002-9394(84)90629-9
更新日期:1984-03-01 00:00:00
abstract:PURPOSE:To report a patient with uveal effusion and intermittent angle-closure glaucoma associated with primary pulmonary hypertension. METHODS:Observational case report. RESULTS:A 78-year-old woman with primary pulmonary hypertension noticed pain and decreased vision in her right eye. Ocular examination disclosed ex...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(02)02090-1
更新日期:2003-05-01 00:00:00
abstract:PURPOSE:To explore the association between the consumption of fruits and vegetables and the presence of glaucoma. DESIGN:Cross-sectional cohort study. METHODS:In a sample of 1,155 women located in multiple centers in the United States, glaucoma specialists diagnosed glaucoma in at least one eye by assessing optic ner...
journal_title:American journal of ophthalmology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.ajo.2008.01.022
更新日期:2008-06-01 00:00:00
abstract:PURPOSE:To evaluate the contribution of maximal removal of the deep lateral wall of the orbit to exophthalmos reduction in Graves' orbitopathy and its influence on the onset of consecutive diplopia. DESIGN:Case-control study. METHODS:The medical records of two cohorts of patients affected by Graves' orbitopathy with ...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2005.04.023
更新日期:2005-10-01 00:00:00
abstract::Seven patients who had the complete form of mandibulofacial dysostosis were examined to determine the prevalence of nasolacrimal abnormalities. Bilateral inferior punctal atresia (and, by implication, accompanying inferior canalicular atresia) was identified in all seven patients; a 95% confidence interval for the tru...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(14)70688-9
更新日期:1990-05-15 00:00:00
abstract:PURPOSE:To determine the incidence of developing an idiopathic full-thickness macular hole in fellow eyes that have vitreofoveal attachments and perifoveal vitreous detachment in patients with unilateral idiopathic macular hole. DESIGN:Retrospective cross-sectional observational study. METHODS:The fellow eyes of 201 ...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2005.03.070
更新日期:2005-09-01 00:00:00
abstract:PURPOSE:To determine the type of herpes simplex virus in acute retinal necrosis syndrome associated with herpes simplex virus. METHODS:Herpes simplex virus type 1, herpes simplex virus type 2, varicella-zoster virus, Epstein-Barr virus, and cytomegalovirus were examined by polymerase chain reaction in intraocular spec...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(99)00391-8
更新日期:2000-03-01 00:00:00
abstract:UNLABELLED:To examine prospectively the efficacy and safety of photorefractive keratectomy and photoastigmatic refractive keratectomy. METHODS:We treated 645 eyes (440 patients) with a VisX Twenty/Twenty excimer laser and followed them up for 12 months. RESULTS:The percentage of eyes with myopia between -5.01 and -10...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(14)70433-7
更新日期:1996-04-01 00:00:00
abstract:PURPOSE:To look for associations of preoperative A-scan ultrasound ocular dimensions with complications during phacoemulsification in eyes with pseudoexfoliation. METHODS:A total of 174 eyes with pseudoexfoliation of 135 patients undergoing planned cataract surgery were included in a prognostic study based on the revi...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(99)00365-7
更新日期:2000-03-01 00:00:00
abstract:PURPOSE:To analyze the comparative safety and efficacy of two techniques of corneal neurotization (CN) (direct corneal neurotization [DCN] vs indirect corneal neurotization [ICN]) for the treatment of neurotrophic keratopathy (NK). DESIGN:Multicenter interventional prospective comparative case series. METHODS:This st...
journal_title:American journal of ophthalmology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.ajo.2020.07.003
更新日期:2020-12-01 00:00:00
abstract:PURPOSE:To compare visual outcomes among eyes that underwent pars plana vitrectomy (PPV) in combination with either anterior chamber intraocular lens implantation (ACIOL) or scleral suturing of posterior chamber lens (PCIOL). DESIGN:Retrospective comparative case series. METHODS:All eyes presented with aphakia or lux...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2016.05.006
更新日期:2016-08-01 00:00:00