Abstract:
PURPOSE:beta-Adrenergic blocking drugs lower intraocular pressure. The question of whether these drugs also alter, either directly or indirectly, orbital hemodynamics is potentially of great importance for patients with normal-tension glaucoma who may have some degree of reversible vasospasm. METHODS:We compared the effect of selective (betaxolol) and nonselective (timolol) beta-adrenergic blocking drugs on flow velocities (as determined by color Doppler imaging) in orbital vessels in 13 patients with normal-tension glaucoma (mean age, 62 +/- 3 years; mean intraocular pressure, 15 +/- 2 mm Hg). A one-month drug treatment double-masked crossover design, with a three-week washout before each drug, was used. RESULTS:Neither drug changed peak systolic velocity in any of the four vessels studied (ophthalmic, nasal and temporal posterior ciliary, and central retinal arteries). Additionally, timolol did not alter end-diastolic velocity or resistance index (defined as [peak systolic velocity minus end-diastolic velocity] divided by peak systolic velocity) in any of the vessels measured. In contrast, betaxolol tended to increase end-diastolic velocity and to decrease resistance index: the four-vessel average end-diastolic velocity increased 30% (P = .08), and the four-vessel average resistance index decreased significantly (P = .04). These reductions in resistance index occurred despite that betaxolol, in contrast to timolol, did not significantly decrease intraocular pressure. CONCLUSIONS:These results suggest that, in patients with normal-tension glaucoma, selective beta-adrenergic blockade (betaxolol) may have ocular vasorelaxant effects independent of any influence on intraocular pressure, whereas nonselective blockade (timolol) lowers intraocular pressure without apparently altering orbital hemodynamics.
journal_name
Am J Ophthalmoljournal_title
American journal of ophthalmologyauthors
Harris A,Spaeth GL,Sergott RC,Katz LJ,Cantor LB,Martin BJdoi
10.1016/s0002-9394(14)72604-2subject
Has Abstractpub_date
1995-08-01 00:00:00pages
168-75issue
2eissn
0002-9394issn
1879-1891pii
S0002-9394(14)72604-2journal_volume
120pub_type
临床试验,杂志文章,随机对照试验abstract::Rabbit eyes in which vitrectomy was performed underwent three hours of hypothermic perfusion with either 22 C or 2 C lactated Ringer's solution. Clinical, electroretinographic, fluorescein angiographic, histologic, and ultrastructural examinations were performed. No changes were noted in eyes cooled with 22 C fluid. R...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(14)74615-x
更新日期:1990-04-15 00:00:00
abstract:PURPOSE:To evaluate the efficacy of hyperdry amniotic membrane (AM) patching attached using a tissue adhesive for corneal perforations and glaucoma filtering bleb leaks. DESIGN:Prospective, noncomparative, interventional case series. METHODS:Five eyes of 5 patients (glaucoma bleb leaks, 2 eyes; corneal perforations, ...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2009.03.030
更新日期:2009-09-01 00:00:00
abstract:PURPOSE:To determine the safety and efficacy of verteporfin photodynamic therapy (PDT) for the treatment of persistent choroidal neovascularization (CNV) previously treated with external beam radiotherapy (EBRT). DESIGN:Retrospective case series. METHODS:Verteporfin PDT was performed on 14 eyes of 13 patients with sy...
journal_title:American journal of ophthalmology
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doi:10.1016/j.ajo.2004.09.019
更新日期:2005-03-01 00:00:00
abstract::Communication between the retinal and the choroidal circulation occurred in one case of proliferative diabetic retinopathy and one case of Leber's disease (multiple miliary aneurysms) after argon laser photocoagulation treatment to eliminate abnormal retinal vasculature. In both instances rapid-sequence fluorescein an...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
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更新日期:1976-08-01 00:00:00
abstract:PURPOSE:To report a case of progressive axial myopia associated with traumatic glaucoma in a juvenile patient with no systemic disease. DESIGN:Interventional case report. METHODS:In a 15-year-old male, serial ocular examinations, including manifest refraction, tonometry, and axial eye length measurement, were perform...
journal_title:American journal of ophthalmology
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doi:10.1016/s0002-9394(02)01330-2
更新日期:2002-05-01 00:00:00
abstract:PURPOSE:To describe microscopic changes in the structure of human sclera immediately after enucleation (negative control group) and to compare them after being stored for three months in four different media: pure glycerin, absolute alcohol, benzalkonium chloride diluted in absolute alcohol (1:5000), and benzalkonium c...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2008.05.015
更新日期:2008-09-01 00:00:00
abstract::Unilateral secondary acute closed-angle glaucoma was associated with a ciliochoroidal detachment in two patients. One patient, aged 17 years, had an orbital arteriovenous fistula. The other patient, aged 73 years, had a dural arteriovenous fistula that originated from branches of the right internal maxillary artery. I...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
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更新日期:1989-02-15 00:00:00
abstract:PURPOSE:To describe a Japanese patient with incomplete congenital stationary night blindness (iCSNB) with atypical retinal atrophy and kinetic visual field defects. METHODS:An ophthalmologic examination was performed, and the CACNA1F gene was analyzed by direct genomic sequencing. RESULTS:The patient had a hemizygous...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(02)01541-6
更新日期:2002-09-01 00:00:00
abstract::In three cases infarction in the inferotemporal prelaminar portion of the optic disk resulted in shallow cupping and arcuate visual field defects. Such changes occurred acutely, were not progressive, and required no treatment. ...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
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更新日期:1978-03-01 00:00:00
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journal_title:American journal of ophthalmology
pub_type: 杂志文章,随机对照试验
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更新日期:2016-09-01 00:00:00
abstract::Bilateral homonymous hemianopia occurred in 15 patients seen during a four-year period. Persons with this visual deficit had similarly shaped visual field defects on corresponding sides of the vertical midline for each eye, equal visual acuity which is generally normal, and normal pupil and fundus examinations. The mo...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/0002-9394(78)90303-3
更新日期:1978-10-01 00:00:00
abstract::A 53-year-old woman had a spontaneous nontraumatic rupture of the globe secondary to severely increased orbital pressure from an orbital cellulitis. To our knowledge this is the first such case reported. ...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/0002-9394(79)90477-x
更新日期:1979-08-01 00:00:00
abstract:PURPOSE:To determine the frequency of retinal thickening (RT) in eyes with iridocyclitis and to examine the correlations among anterior chamber (AC) inflammation, RT, and visual acuity. DESIGN:Retrospective, observational case series. METHODS:Records were reviewed of patients seen at the Duke University Eye Center Uv...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2009.03.034
更新日期:2009-09-01 00:00:00
abstract::A 32-year-old obese woman with hypertension and a three-year history of pseudotumor cerebri developed bilateral juxtapapillary subretinal neovascular membranes. To our knowledge, this is the first reported case of bilateral subretinal neovascular membranes complicating the course of this disease. The subretinal neovas...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
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journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2012.07.005
更新日期:2013-01-01 00:00:00
abstract:PURPOSE:To report a patient with unilateral vision loss and neovascular glaucoma after attempted superior ophthalmic vein embolization in the treatment of a carotid-cavernous sinus fistula. METHODS:A 69-year-old man with a history of a left dural carotid-cavernous sinus fistula underwent attempted treatment with super...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(14)71711-8
更新日期:1997-12-01 00:00:00
abstract:PURPOSE:To report the association of antiretinal antibodies in patients with bilateral cystoid macular edema and retinitis pigmentosa. METHODS:In a prospective study, 30 consecutive patients with bilateral cystoid macular edema and retinitis pigmentosa were tested for antiretinal antibodies. As control subjects, 30 co...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(98)00446-2
更新日期:1999-05-01 00:00:00
abstract::We examined the ability of hypothermic infusion fluid to reduce the risk of light damage to the retina from the intraocular fiberoptic probe during vitreous surgery. Following vitrectomy, we exposed the retina of rabbits to light from an intraocular fiberoptic probe during infusion of fluid at body temperature (39 C) ...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
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journal_title:American journal of ophthalmology
pub_type: 杂志文章
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abstract:PURPOSE:To report bilateral optic disk edema and blindness as the unusual initial presentation of acute lymphocytic leukemia (ALL) in an adult. METHODS:A 19-year-old man presented with a history of headaches, back pain, and 10 days of worsening vision that progressed to blindness. Ocular examination revealed light per...
journal_title:American journal of ophthalmology
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更新日期:2002-07-01 00:00:00
abstract::I have modified a Maumenee-Park eyelid speculum to permit eyelid retraction in the direct plane of action of the lids and to avoid pressure on the globe from the speculum weight. A ball-joint at the end of the blade allows the blade to adjust with the eyelid. Increased angulation of the sidearm places the blade perpen...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
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更新日期:1982-01-01 00:00:00
abstract::Minute multiple dust particles enclosed in long stick mucous filaments may remain hidden in the recesses of the upper fornix for considerable periods of time. They produce the subjective sensations of grittiness or smarting. After repeated maneuvers of eversion of the upper eyelid and blinking, the nasal end of the m...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
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更新日期:1977-02-01 00:00:00
abstract::We studied the bilateral intraocular pressure lowering effect of long-term unilateral timolol maleate 0.5% in 30 patients in whom early primary open-angle glaucoma had recently been diagnosed. A significant intraocular pressure reduction was found in the untreated fellow eyes (21.9 mm Hg from 26.4 mm Hg at baseline) (...
journal_title:American journal of ophthalmology
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更新日期:1987-12-15 00:00:00
abstract::Conjunctivodacryocystorhinostomy with a Jones tube is an accepted procedure for the treatment of epiphora resulting from obstructed canaliculi. Because of our clinical impression that a high rate of functional success after surgery is associated with a lower rate of patient satisfaction, we analyzed the results and pa...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
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更新日期:1994-05-15 00:00:00
abstract:PURPOSE:To compare silicone-hydrogel, poly(2-hydroxyethyl methacrylate) (pHEMA), and phosphorylcholine-coated (PC-C) contact lenses in terms of their susceptibility to biofilm formation by Staphylococcus epidermidis and Pseudomonas aeruginosa. DESIGN:Laboratory investigation. METHODS:Biofilm formation on colonized te...
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pub_type: 杂志文章
doi:10.1016/j.ajo.2008.07.032
更新日期:2009-01-01 00:00:00
abstract:PURPOSE:To evaluate the relationships among age-related macular degeneration (AMD), mortality, and biomarkers of systemic inflammation in patients with acquired immunodeficiency syndrome (AIDS). DESIGN:Case-control study. METHODS:In participants with intermediate-stage AMD at enrollment in the Longitudinal Study of t...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
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更新日期:2019-03-01 00:00:00
abstract::We believe axoplasmic transport alteration is the anatomic substrate for formation of drusen of the optic disk. In familial cases the cause of axoplasmic transport alteration may be related to the presence of a genetically determined, small, crowded optic nerve head. We believe these congenitally elevated nerve heads ...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
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更新日期:1978-01-01 00:00:00
abstract:PURPOSE:To evaluate the natural history and ophthalmologic morbidity of Mycoplasma pneumoniae-induced rash and mucositis (MIRM) and propose a treatment algorithm. DESIGN:Retrospective, interventional case series. METHODS:Retrospective chart review of all MIRM patients examined by the department of ophthalmology at a ...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
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更新日期:2020-11-01 00:00:00
abstract:PURPOSE:To evaluate the potential of Histoplasma capsulatum to cause optic neuritis in the setting of the acquired immunodeficiency syndrome (AIDS). METHODS:We examined a 35-year-old man with a history of AIDS and disseminated histoplasmosis who developed a unilateral progressive optic neuritis of enigmatic origin. An...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(14)70285-5
更新日期:1996-03-01 00:00:00
abstract:PURPOSE:To quantify, compare, and assess differences between retinal and choroidal hemodynamics in normal control subjects and patients with ocular hypertension, primary open-angle glaucoma, and normal-pressure glaucoma. METHODS:Video fluorescein angiograms were made in 20 normal subjects, 11 patients with ocular hype...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(14)71077-3
更新日期:1997-05-01 00:00:00