Abstract:
PURPOSE:We sought to understand better the efficacy and risks of local therapies (direct placement of drug into the eye) for the treatment of cytomegalovirus retinopathy. This understanding can be used to design rational treatment regimens, to formulate indications for use of local therapy, and to establish criteria for assessment of future results in this area. METHODS:We collected information about local therapies through a review of published literature. RESULTS:Intraocular injection of ganciclovir and foscarnet and implantation of intraocular devices that slowly release ganciclovir are able to decrease the activity of cytomegalovirus retinopathy lesions and prevent their enlargement for variable periods of time. The time to disease progression (lesion enlargement) may be longer with intraocular devices than with current treatments using intravenously administered antiviral drugs. Local therapies have many advantages (for example, convenience, reduced cost, and lack of systemic toxicity), but there are potential disadvantages, including endophthalmitis, increased rates of retinal detachment, and development of nonocular cytomegalovirus disease and cytomegalovirus retinopathy in fellow, uninvolved eyes. CONCLUSIONS:Local therapies are effective for the treatment of cytomegalovirus retinopathy, but their relative risks and benefits, when compared with those of intravenous drug therapy, have yet to be fully evaluated. We anticipate that local therapy will be an important treatment modality for selected patients with cytomegalovirus retinopathy. Indications include the use of local therapy as an alternative therapy for patients who are unable to receive systemic therapy (intolerance to intravenous or oral medication, or lack of intravenous access) and as supplementation in patients whose retinal disease is incompletely controlled by maximum tolerated systemic medications. The use of local therapy as sole initial treatment in lieu of systemic therapy remains controversial. Its most useful role may be in conjunction with oral forms of antiviral drugs now in development.
journal_name
Am J Ophthalmoljournal_title
American journal of ophthalmologyauthors
Engstrom RE Jr,Holland GNdoi
10.1016/s0002-9394(14)72168-3subject
Has Abstractpub_date
1995-09-01 00:00:00pages
376-85issue
3eissn
0002-9394issn
1879-1891pii
S0002-9394(14)72168-3journal_volume
120pub_type
杂志文章,评审abstract:PURPOSE:To determine the trends and disparities in inpatient costs for eye trauma in the United States from 2001 through 2014. DESIGN:Retrospective population-based cross-sectional study. METHODS:National Inpatient Sample, a representative sample of U.S. hospital discharges, was used to determine costs of eye trauma ...
journal_title:American journal of ophthalmology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.ajo.2019.05.021
更新日期:2019-11-01 00:00:00
abstract:PURPOSE:To assess the clinical outcomes of conventional and wavefront-guided myopic laser in situ keratomileusis (LASIK) retreatment. DESIGN:Retrospective, nonrandomized case series. METHODS:The study comprised a cohort of 97 eyes having LASIK retreatment for residual myopia after primary LASIK. The eyes were divided...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2005.11.011
更新日期:2006-04-01 00:00:00
abstract::Deposits resembling foreign-body giant cells, which can be seen on specular reflex slit-lamp examination, were studied in vivo with a wide-field specular microscope using a low-power dipping cone lens in three cases of posterior chamber lens implantation. The deposits seen as iris pigment on routine examination showed...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/0002-9394(85)90360-5
更新日期:1985-03-15 00:00:00
abstract:PURPOSE:To report an inter-eye difference of the ocular pulse amplitude (OPA) in a case of innominate steal syndrome, as measured by recording applanation tonometry. METHODS:OPA was measured in a 49-year-old male before and after percutaneous transluminal angioplasty of the innominate artery. RESULTS:Before dilation ...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(01)01249-1
更新日期:2002-01-01 00:00:00
abstract::Fine-needle aspiration was used as a primary orbital diagnostic technique in 156 patients. A 20-mm syringe, a 22-gauge, 3.75-cm needle, and a plastic pistol grip were used. Local anesthetic was not necessary. When the needle is in the lesion, small to-and-fro movements with a minimum of angulation are helpful. The asp...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(14)77955-3
更新日期:1985-05-15 00:00:00
abstract:PURPOSE:To evaluate the efficacy of spectral-domain optical coherence tomography (SD OCT) compared to indocyanine green angiography (ICGA) in detecting idiopathic polypoidal choroidal vasculopathy (PCV) and in differentiating between PCV and occult choroidal neovascularization (CNV). DESIGN:Retrospective observational...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2014.08.025
更新日期:2014-12-01 00:00:00
abstract::We made 344 stereoacuity determinations (Titmus Stereotest) on 321 children, ages 1 1/2 to 13 years, who had normal binocular single vision tested by other factors. The data showed a gradual improvement in stereoacuity scores with increasing age--up to age 9--when a normal stereoacuity of 40 seconds of arc was consist...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/0002-9394(75)90679-0
更新日期:1975-06-01 00:00:00
abstract:PURPOSE:To evaluate changes in anterior chamber depth (ACD) and angle width after neodymium-yttrium-aluminum-garnet (Nd:YAG) laser capsulotomy. DESIGN:Prospective interventional case series. METHODS:In a single institution, 43 eyes of 43 consecutive pseudophakic patients with symptomatic posterior capsule opacificati...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2014.08.008
更新日期:2014-11-01 00:00:00
abstract::Fifty-five patients with primary open-angle glaucoma and early glaucomatous damage who had medical therapy and laser trabeculoplasty were followed up for four to 11 years or until progressive glaucomatous damage was documented. Factors associated with the stability or progression of glaucoma were evaluated. Eyes with ...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(14)76896-5
更新日期:1991-01-15 00:00:00
abstract:PURPOSE:To describe the long-term surgical course of patients with open globe injury. DESIGN:Retrospective case series. METHODS:Patients with open globe injuries (848 in total) treated surgically at the Massachusetts Eye and Ear Infirmary between 2000 and 2009 were retrospectively reviewed. Data from presentation, in...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2011.10.013
更新日期:2012-05-01 00:00:00
abstract:PURPOSE:Photorefractive keratectomy has the potential to cause transient corneal haze. The purpose of this study was to evaluate the relationship between transient corneal haze as measured by an objective means and high and low contrast visual performance. METHODS:In a prospective study, 44 eyes of 28 patients were ex...
journal_title:American journal of ophthalmology
pub_type: 临床试验,杂志文章
doi:10.1016/s0002-9394(01)01003-0
更新日期:2001-08-01 00:00:00
abstract:PURPOSE:To report the successful use of topical cysteamine formulated from the oral preparation in the treatment of severe photophobia from corneal crystal deposition in cystinosis. DESIGN:Interventional case report. METHODS:Retrospective chart review. RESULTS:An 8-year-old boy with nephropathic cystinosis was exper...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2004.05.005
更新日期:2004-10-01 00:00:00
abstract::The transmission characteristics of a new filter combination for fluorescein angiography were selected on the basis of in vivo measurements of the excitation and emission spectra of fluorescein dye during its transit in the fundus. This combination of filters was characterized by separation of 530 nm between the spect...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/0002-9394(76)90542-0
更新日期:1976-10-01 00:00:00
abstract:PURPOSE:To examine the relationships of retinal vascular caliber with optic disc, macular, and retinal nerve fiber layer (RNFL) characteristics as measured with optical coherence tomography (OCT). DESIGN:Observational cross-sectional study. METHODS:This study included a subset of healthy children enrolled in the Sing...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2009.04.006
更新日期:2009-09-01 00:00:00
abstract:PURPOSE:To describe clinical outcomes of complications afflicting the autologous oral mucous membrane graft after modified osteo-odonto keratoprosthesis surgery in chronic Stevens-Johnson syndrome (SJS). DESIGN:Prospective case series. METHODS:This study included 30 eyes of 30 patients with SJS-induced dry keratinize...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2013.06.012
更新日期:2013-11-01 00:00:00
abstract:PURPOSE:To evaluate changes in contrast sensitivity after surgery for macula-on rhegmatogenous retinal detachment (RRD). DESIGN:Prospective, interventional, consecutive, case-control study. METHODS:This study included 84 eyes of 84 patients with unilateral macula-on RRD undergoing primary scleral buckling or vitrecto...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2013.05.017
更新日期:2013-10-01 00:00:00
abstract:PURPOSE:We previously demonstrated that selective suture removal reduces keratoplasty astigmatism; however, a myopic shift was induced with the increasing number of interrupted sutures removed. This study is an attempt to determine the effects of a modified surgical technique on postkeratoplasty myopia, astigmatism, an...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(02)02287-0
更新日期:2003-06-01 00:00:00
abstract:PURPOSE:To report the association of antiretinal antibodies in patients with bilateral cystoid macular edema and retinitis pigmentosa. METHODS:In a prospective study, 30 consecutive patients with bilateral cystoid macular edema and retinitis pigmentosa were tested for antiretinal antibodies. As control subjects, 30 co...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(98)00446-2
更新日期:1999-05-01 00:00:00
abstract:PURPOSE:To delineate the clinical features, course, complications, and associated systemic diseases in patients with HLA-B27-associated uveitis. METHODS:We reviewed the records of 148 patients with HLA-B27-associated uveitis from two large uveitis practices. RESULTS:There were 127 (86%) white and 21 (14%) nonwhite pa...
journal_title:American journal of ophthalmology
pub_type: 杂志文章,评审
doi:10.1016/s0002-9394(14)70533-1
更新日期:1996-01-01 00:00:00
abstract:PURPOSE:To describe and quantify the appearance of the optic disk in patients with advanced age-related macular degeneration (ARMD). DESIGN:Retrospective comparative study. METHODS:A total of 316 charts were reviewed. From these, 45 subjects with advanced ARMD (defined as geographic atrophy or disciform scar) in at l...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2004.02.021
更新日期:2004-07-01 00:00:00
abstract::A 57-year-old man had a clinically suspected malignant melanoma in his left eye. On microscopic study, the enucleated eye harbored an unusual choroidal tumor that had extended extraocularly. This tumor had been variously interpreted microscopically as an angiosarcoma, an atpical angioma, a glioma, or a neurilemoma. El...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/0002-9394(76)90419-0
更新日期:1976-08-01 00:00:00
abstract:PURPOSE:To evaluate the repeatability of an extensive number of relevant indices with the Pentacam HR in keratoconus of varying severity and normal eyes. DESIGN:Reliability analysis. METHODS:This study was performed at Antwerp University Hospital, Belgium, and enrolled 20 healthy volunteers (20 eyes) and 69 patients ...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2020.06.013
更新日期:2020-11-01 00:00:00
abstract:PURPOSE:To describe the ultrasound biomicroscopic features of eyes with aniridia. DESIGN:Observational case series. METHODS:Nineteen eyes of 10 patients with aniridia (six males and four females) ranging in age from 3 months to 53 years (21.0 +/- 16.4, mean +/- SD), and 50 normal subjects (30 men and 20 women) rangin...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2003.12.014
更新日期:2004-05-01 00:00:00
abstract:PURPOSE:To study the tomographic and pathomorphologic features of dome-shaped maculas with swept-source optical coherence tomography (OCT). DESIGN:Prospective, cross-sectional study. METHODS:The macular area of 51 highly myopic eyes (35 patients) with dome-shaped maculas was studied with swept-source OCT at 1050 nm. ...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2012.08.007
更新日期:2013-02-01 00:00:00
abstract:PURPOSE:To present a large series of choroidal hemangiomas treated with proton beam irradiation and to describe the treatment outcomes. METHODS:We treated 54 eyes of 53 patients with choroidal hemangioma. The lesions consisted of 48 circumscribed hemangiomas and six diffuse hemangiomas in patients with Sturge-Weber sy...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(98)00150-0
更新日期:1998-08-01 00:00:00
abstract::A 3 1/2-month-old boy with the cerebro-oculo-facio-skeletal syndrome had low birth weight, microcephaly, microphthalmia, cataracts, blepharophimosis, high nasal bridge, micrognathia, kyphosis, rocker-bottom feet, and a longitudinal foot groove. The product of a consanguineous parentage, he showed marked developmental ...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/0002-9394(80)90127-0
更新日期:1980-02-01 00:00:00
abstract:PURPOSE:To report the association of Marcus Gunn jaw-winking phenomenon and pseudo inferior oblique overaction. METHODS:Case report. RESULTS:A 21-year-old woman presented with right eyelid elevation on the chewing movement since infancy. Examination showed that both Marcus Gunn jaw-winking phenomenon and pseudo infer...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(00)00705-4
更新日期:2001-01-01 00:00:00
abstract:PURPOSE:To examine acquired pit of the optic nerve as a risk factor for progression of glaucoma. METHODS:In a retrospective longitudinal study, 25 open-angle glaucoma patients with acquired pit of the optic nerve were compared with a group of 24 open-angle glaucoma patients without acquired pit of the optic nerve. The...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(99)80185-8
更新日期:1998-04-01 00:00:00
abstract:PURPOSE:To correlate fractal dimension (FD) of the retinal vasculature with the extent of retinal nonperfusion area in diabetic retinopathy (DR) on ultrawide-field fluorescein angiography (FA). DESIGN:Cross-sectional study. METHODS:Baseline Optos 200Tx ultrawide-field FA images of 80 eyes with DR from the DAVE (NCT01...
journal_title:American journal of ophthalmology
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.ajo.2019.08.015
更新日期:2020-01-01 00:00:00
abstract:PURPOSE:We describe a case demonstrating a submacular deposition of triamcinolone acetonide (TA) after a TA-assisted vitrectomy for retinal detachment. DESIGN:Interventional case report. METHODS:A 48-year-old Japanese man with rhegmatogenous retinal detachment in his left eye underwent a TA-assisted vitrectomy, endol...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(02)01917-7
更新日期:2003-02-01 00:00:00