Intraocular levels of methotrexate after intravenous administration.

Abstract:

PURPOSE:To determine if adequate intraocular levels of methotrexate are achieved after intravenous administration. METHODS:After intravenous administration, methotrexate levels were determined in the serum, the anterior chamber, and the cerebrospinal fluids of a patient with recurrent ocular lymphoma. A fluorescence polarization immunoassay was used to make the determinations. RESULTS:At seven hours into a 24-hour intravenous infusion, methotrexate was at cytotoxic level in all samples. At 74 hours, cytotoxic levels were present only in the aqueous humor. CONCLUSION:Sustained cytotoxic ocular methotrexate levels are achievable after systemic administration.

journal_name

Am J Ophthalmol

authors

de Smet MD,Stark-Vancs V,Kohler DR,Smith J,Wittes R,Nussenblatt RB

doi

10.1016/s0002-9394(14)70444-1

subject

Has Abstract

pub_date

1996-04-01 00:00:00

pages

442-4

issue

4

eissn

0002-9394

issn

1879-1891

pii

S0002-9394(14)70444-1

journal_volume

121

pub_type

杂志文章
  • Linezolid-induced optic neuropathy.

    abstract:PURPOSE:To report a case of optic neuropathy associated with prolonged use of a new antibiotic, linezolid. DESIGN:Interventional case report. METHODS:Optic and peripheral neuropathy occurred in a 27-year-old woman who was undergoing prolonged linezolid therapy for osteomyelitis. The use of corticosteroid exacerbated ...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1016/j.ajo.2004.11.047

    authors: Saijo T,Hayashi K,Yamada H,Wakakura M

    更新日期:2005-06-01 00:00:00

  • Ocular toxoplasmosis in human immunodeficiency virus-infected patients.

    abstract::The files of 45 human immunodeficiency virus-infected patients with ocular toxoplasmosis were reviewed, with a median follow-up of eight months. The condition was unilateral in 37 of the 45 patients (82%) and was bilateral in eight (18%). Inflammation of the anterior chamber and the vitreous was present in 32 of 53 ey...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1016/s0002-9394(14)73975-3

    authors: Cochereau-Massin I,LeHoang P,Lautier-Frau M,Zerdoun E,Zazoun L,Robinet M,Marcel P,Girard B,Katlama C,Leport C

    更新日期:1992-08-15 00:00:00

  • Design of the low vision quality-of-life questionnaire (LVQOL) and measuring the outcome of low-vision rehabilitation.

    abstract:PURPOSE:To design and validate a vision-specific quality-of-life assessment tool to be used in a clinical setting to evaluate low-vision rehabilitation strategy and management. METHODS:Previous vision-related questionnaires were assessed by low-vision rehabilitation professionals and patients for relevance and coverag...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1016/s0002-9394(00)00610-3

    authors: Wolffsohn JS,Cochrane AL

    更新日期:2000-12-01 00:00:00

  • Nodular adenomatosis of iris pigment epithelium.

    abstract::A 62-year-old man manifested multiple nodular growths in his left iris and unilateral glaucoma. Detailed clinical and pathologic studies showed that these lesions were adenomas derived from the spurs of Fuchs, Michel, and Grunert in the iris pigment epithelium. We suggest terming this newly described entity nodular ad...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1016/s0002-9394(14)74989-x

    authors: Tso MO,Goldberg MF,Sugar J

    更新日期:1985-07-15 00:00:00

  • Clinical features of idiopathic preretinal macular fibrosis. Schoenberg Lecture.

    abstract::Of 150 consecutive cases of preretinal macular fibrosis that occurred predominantly in older subjects, 118 cases involved only one eye while 32 occurred binocularly. The ratio of women to men was 3:2. Visual acuity was usually 20/50 or better, and only four of 178 eyes had acuity below 20/200. The vast majority of les...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1016/0002-9394(75)90605-4

    authors: Wise GN

    更新日期:1975-03-01 00:00:00

  • Serum obstruction of aqueous outflow in enucleated eyes.

    abstract::We perfused enucleated human eyes via the anterior chamber by the constant pressure technique. Infusion of human serum into the anterior chamber of enucleated human eyes for 30 minutes at 23 mm Hg pressure induced a 42% decrease in facility of outflow, which was not relieved by irrigation of the anterior chamber with ...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1016/0002-9394(78)90023-5

    authors: Epstein DL,Hashimoto JM,Grant WM

    更新日期:1978-07-01 00:00:00

  • A makeshift retinoscopy rack.

    abstract::A simple makeshift retinoscopy rack consists of various trial lenses placed into the slots of a nonfrosted, 35-mm slide viewing sheet. It is useful in determining the patient's refractive error at the bedside and in the operating room. ...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1016/0002-9394(80)90242-1

    authors: Wing GL

    更新日期:1980-01-01 00:00:00

  • Optic disk size correlated with refractive error.

    abstract:PURPOSE:To evaluate for which range of refractive error the optic disk size depends on, or is independent of, the refractive error. DESIGN:Clinical observational study. METHODS:The study included 1999 eyes of 1011 subjects with a mean refractive error of -0.97 +/- 2.72 diopters (range, -24.25 to +9.4 diopters). Optic...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1016/j.ajo.2004.07.047

    authors: Jonas JB

    更新日期:2005-02-01 00:00:00

  • Optical coherence tomography findings of acute traumatic maculopathy following motor vehicle accident.

    abstract:PURPOSE:To describe two cases of acute traumatic maculopathy using optical coherence tomography (OCT) following high-speed motor vehicle accidents. DESIGN:Case reports. METHODS:Patients were examined soon after the accident using Snellen visual acuity (VA), dilated fundus examination, and OCT. Re-examination was cond...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1016/j.ajo.2006.09.024

    authors: Pham TQ,Chua B,Gorbatov M,Mitchell P

    更新日期:2007-02-01 00:00:00

  • Lens capsule and epithelium in age-related cataract.

    abstract::On the basis of preoperative assessment of patient characteristics, intraoperative obtainment of a lens-capsule and epithelium specimen, histopathologic investigation of lens capsule and epithelium, and biochemical analysis of glutathione reductase in lens epithelium, age-related cataract was studied in 50 adult patie...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1016/s0002-9394(14)76729-7

    authors: Straatsma BR,Lightfoot DO,Barke RM,Horwitz J

    更新日期:1991-09-15 00:00:00

  • Metastatic adenocarcinoma to the retina in a patient with Muir-Torre syndrome.

    abstract:PURPOSE/METHODS:A 74-year-old woman had multiple tumors including a retinal mass. Her medical history included cutaneous sebaceous adenomas, adenocarcinoma of the breast, and colonic adenocarcinoma. Her involved eye became painful and was enucleated. RESULTS/CONCLUSIONS:Examination of the enucleated eye disclosed meta...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1016/s0002-9394(14)72616-9

    authors: Spraul CW,Lang GE,Grossniklaus HE,Lang GK

    更新日期:1995-08-01 00:00:00

  • Histologic study of eyes with transsclerally sutured posterior chamber intraocular lenses.

    abstract::We studied the postmortem histologic characteristics of two eyes that had undergone penetrating keratoplasty and transscleral suturing of a posterior chamber intraocular lens for bullous keratopathy. The eyes were studied three days postoperatively in a 79-year-old man with pseudophakia and six months postoperatively ...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1016/s0002-9394(14)76337-8

    authors: Lubniewski AJ,Holland EJ,Van Meter WS,Gussler D,Parelman J,Smith ME

    更新日期:1990-09-15 00:00:00

  • Long-term follow-up after macular hole surgery with internal limiting membrane peeling.

    abstract:PURPOSE:To report long-term anatomical and functional results after pars plana vitrectomy with peeling of the internal limiting membrane (ILM) for idiopathic macular hole. DESIGN:Prospective, nonrandomized, consecutive series. METHODS:Ninety-nine patients with a follow-up of at least 12 months were included. The surg...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1016/s0002-9394(02)01751-8

    authors: Haritoglou C,Gass CA,Schaumberger M,Gandorfer A,Ulbig MW,Kampik A

    更新日期:2002-11-01 00:00:00

  • Reversible night blindness associated with intestinal bypass surgery.

    abstract::A 33-year-old man had a sudden onset of night blindness 3 1/2 years after intestinal bypass surgery for morbid obesity. Ocular examination disclosed a probable Bitot's spot and electrophysiologic testing showed markedly impaired dark adaptation and subnormal electroretinography. After therapy with orally administered ...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1016/0002-9394(80)90164-6

    authors: Brown GC,Felton SM,Benson WE

    更新日期:1980-06-01 00:00:00

  • Stereoacuity development in children with normal binocular single vision.

    abstract::We made 344 stereoacuity determinations (Titmus Stereotest) on 321 children, ages 1 1/2 to 13 years, who had normal binocular single vision tested by other factors. The data showed a gradual improvement in stereoacuity scores with increasing age--up to age 9--when a normal stereoacuity of 40 seconds of arc was consist...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1016/0002-9394(75)90679-0

    authors: Romano PE,Romano JA,Puklin JE

    更新日期:1975-06-01 00:00:00

  • Reduction of retinal sensitivity in eyes with reticular pseudodrusen.

    abstract:PURPOSE:To evaluate the effect of macular reticular pseudodrusen on retinal function using multiple imaging methods. DESIGN:Prospective cross-sectional study. METHODS:Thirteen eyes with reticular pseudodrusen, but without any other macular abnormality or glaucoma, and 20 normal eyes were evaluated. All subjects under...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1016/j.ajo.2013.06.036

    authors: Ooto S,Ellabban AA,Ueda-Arakawa N,Oishi A,Tamura H,Yamashiro K,Tsujikawa A,Yoshimura N

    更新日期:2013-12-01 00:00:00

  • Expression of a mucin-like glycoprotein produced by ocular surface epithelium in normal and keratinized cells.

    abstract:PURPOSE:We previously characterized a monoclonal antibody (H185) to a mucin-like glycoprotein produced by human ocular surface epithelium. In the current study, we used H185 to investigate the pattern of the mucin-like glycoprotein in normal and keratinized apical cells of the ocular surface epithelium. METHODS:We com...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1016/s0002-9394(14)71691-5

    authors: Watanabe H,Maeda N,Kiritoshi A,Hamano T,Shimomura Y,Tano Y

    更新日期:1997-12-01 00:00:00

  • Intravitreal triamcinolone acetonide in the management of exogenous bacterial endophthalmitis.

    abstract:PURPOSE:To determine the effectiveness of intravitreal triamcinolone acetonide in the management of bacterial endophthalmitis. DESIGN:Interventional case series. METHODS:This pilot case series included five patients (three patients after trauma and two patients after cataract surgery) with culture proven bacterial en...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1016/j.ajo.2005.11.043

    authors: Pathengay A,Shah GY,Das T,Sharma S

    更新日期:2006-05-01 00:00:00

  • Brief hospital admissions for pediatric strabismus surgery.

    abstract::We performed strabismus surgery on 170 children on an outpatient basis. Endotracheal intubation was utilized in all cases as the means of delivery of the anesthetic agent. Atropine used alone as a preoperative medication reduced the incidence of postoperative vomiting. Parental acceptance of this method of surgery was...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1016/0002-9394(75)90221-4

    authors: Weinstock SM,Flynn JT

    更新日期:1975-09-01 00:00:00

  • The Genetic Influence on Corticosteroid-Induced Ocular Hypertension: A Field Positioned for Discovery.

    abstract:PURPOSE:To provide evidence that corticosteroid-induced ocular hypertension has a genetic component. DESIGN:Evidence-based perspective. METHODS:We conducted a comprehensive literature search for studies exploring genetic influences on intraocular pressure responses to corticosteroid treatment. RESULTS:Studies demons...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章,评审

    doi:10.1016/j.ajo.2019.02.001

    authors: Chan W,Wiggs JL,Sobrin L

    更新日期:2019-06-01 00:00:00

  • Gonioscopic differences between primary open-angle glaucoma and normal subjects over 40 years of age.

    abstract::Gonioscopy was performed on 110 patients with primary open-angle glaucoma over 40 years of age and an equal number of normal sugjects, matched by race and age. The frequency distribution of various angle features differed in the two groups: in the glaucoma group, there were more iris processes at all levels of inserti...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1016/0002-9394(75)90869-7

    authors: Kimura R,Levene RZ

    更新日期:1975-07-01 00:00:00

  • Ocular flora and their antibiotic resistance patterns in the midwest: a prospective study of patients undergoing cataract surgery.

    abstract:PURPOSE:To determine the spectrum of conjunctival flora and the antibiotic susceptibility profiles of patients undergoing cataract surgery at a Midwestern university. DESIGN:Prospective in vitro laboratory investigation of a patient cohort. METHODS:Conjunctival cultures were obtained from patients undergoing cataract...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1016/j.ajo.2012.06.024

    authors: Hsu HY,Lind JT,Tseng L,Miller D

    更新日期:2013-01-01 00:00:00

  • Stromal keratitis complicating anterior membrane dystrophy.

    abstract::Recurrent erosion of the cornea has been well documented in patients with nontraumatic anterior membrane dystrophies of various types. We examined five patients who, in addition to an erosion, developed stromal keratitis. Three of these patients were subjected to a complete microbiologic workup, but the lesions were a...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1016/s0002-9394(14)75006-8

    authors: Shoch DE,Stock EL,Schwartz AE

    更新日期:1985-07-15 00:00:00

  • Threshold for retinal damage associated with the use of high-power neodymium-YAG lasers in the vitreous.

    abstract::Ultrashort, Q-switched or mode-locked, neodymium-YAG laser pulses focused within 2 mm of the retina caused reproducible retinal damage in four eyes of two monkeys and in four eyes of three rabbits. The distance of the laser focus from the retina for clinically observed threshold retinal damage was characterized for pu...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1016/s0002-9394(14)77782-7

    authors: Bonner RF,Meyers SM,Gaasterland DE

    更新日期:1983-08-01 00:00:00

  • Autosomal recessive pericentral pigmentary retinopathy.

    abstract::A brother and sister, born to consanguineous parents, had pigmentary retinopathy in a pericentral distribution. The retinopathy was noted in infancy when the siblings were examined for strabismus. The optic disks, maculae, and retinal vessels were normal. There was mild reduction in amplitude of both scotopic and phot...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1016/0002-9394(88)90584-3

    authors: Traboulsi EI,O'Neill JF,Maumenee IH

    更新日期:1988-11-15 00:00:00

  • Determination and Validation of Thresholds of Anterior Chamber Parameters by Dedicated Anterior Segment Optical Coherence Tomography.

    abstract:PURPOSE:To determine and validate thresholds of anterior chamber angle (ACA) parameters in discriminating open- vs narrow-angle eyes using images from dedicated anterior segment optical coherence tomography (DASOCT). DESIGN:Reliability analysis. METHODS:Eyes imaged by DASOCT and examined with gonioscopy were reviewed...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1016/j.ajo.2016.06.032

    authors: Melese EK,Chan JD,Blieden LS,Chuang AZ,Baker LA,Bell NP,Feldman RM

    更新日期:2016-09-01 00:00:00

  • Orbital ganglioglioma arising from ectopic neural tissue.

    abstract:PURPOSE:To report a case of neonatal orbital ganglioglioma originating from ectopic neural tissue. METHOD:Case report. RESULTS:An African-American male presented at birth with proptosis and expansion of the left orbit. A discrete soft-tissue mass was located inferolateral to the globe, which proved to be a gangliogli...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1016/s0002-9394(99)00288-3

    authors: Harmon HL,Gossman MD,Buchino JJ,Eberly SM,Roberts DM,Fishman PH

    更新日期:2000-01-01 00:00:00

  • Aggressive nevus of the iris with secondary glaucoma in a child.

    abstract:PURPOSE/METHODS:We studied a case of an aggressive iris nevus that caused secondary glaucoma in a child. RESULTS/CONCLUSION:Unlike most iris tumors, this tumor grew from the superior aspect of the iris. The nevus was also unusual because it invaded the trabecular meshwork and caused secondary glaucoma. ...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1016/s0002-9394(14)71184-5

    authors: Carlson DW,Alward WL,Folberg R

    更新日期:1995-03-01 00:00:00

  • Short-term intraocular pressure trends after intravitreal triamcinolone injection.

    abstract:PURPOSE:To report the trends in intraocular pressures (IOP) within the first week after intravitreal injection of triamcinolone acetonide (Kenalog) for the treatment of retinal disease. DESIGN:Retrospective chart review. METHODS:Review of 43 consecutive patients and 50 intravitreal injections of 4 mg triamcinolone ac...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1016/j.ajo.2006.08.033

    authors: Lee EW,Hariprasad SM,Mieler WF,Newman TL,Apte RS

    更新日期:2007-02-01 00:00:00

  • Syphilitic neuroretinitis.

    abstract::Four patients (three men, 32, 43, and 53 years old, and one 37-year-old woman) with syphilitic neuroretinitis had cerebrospinal fluid evidence of neurosyphilis. Therapy failed in one patient given penicillin G benzathine intramuscularly and it may have failed in a second patient. Another treatment failure occurred in ...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1016/0002-9394(83)90268-4

    authors: Folk JC,Weingeist TA,Corbett JJ,Lobes LA,Watzke RC

    更新日期:1983-04-01 00:00:00