Immune deposits in iris biopsy specimens from patients with Fuchs' heterochromic iridocyclitis.

Abstract:

:To investigate whether Fuchs' heterochromic iridocyclitis may be an immune complex vasculitis, we used an immunofluorescence technique to detect immunoglobulins and complement in iris biopsy specimens from nine patients with Fuchs' heterochromic iridocyclitis, 12 patients with other types of uveitis, and nine patients with glaucoma but without uveitis. No specific immune deposits were observed in the irises of the patients with Fuchs' heterochromic iridocyclitis. Immunoglobulin G, IgA, IgM, and complement were detected in patients with Fuchs' heterochromic iridocyclitis and patients with uveitis, and these results differed significantly (P less than .05) from the group without uveitis. The immune deposits were found only in the iris vessel walls. No light-microscopic evidence of an inflammatory vascular process could be detected. Further studies are necessary to investigate whether the immune reactants originate from the circulation or result from local formation.

journal_name

Am J Ophthalmol

authors

La Hey E,Mooy CM,Baarsma GS,de Vries J,de Jong PT,Kijlstra A

doi

10.1016/s0002-9394(14)75757-5

subject

Has Abstract

pub_date

1992-01-15 00:00:00

pages

75-80

issue

1

eissn

0002-9394

issn

1879-1891

pii

S0002-9394(14)75757-5

journal_volume

113

pub_type

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