Abstract:
OBJECTIVE:To determine whether parapapillary choroidal microvasculature (PPCMv) density as measured by optical coherence tomography angiography differs between pseudoexfoliation syndrome (PXS) and pseudoexfoliation glaucoma (PXG). DESIGN:Cross-sectional study. METHODS:One hundred ninety-two eyes of 120 subjects from 2 academic referral institutions were enrolled. Automated PPCMv density was calculated using custom Matlab software in inner and outer annuli around the optic nerve region in addition to peripapillary superficial vasculature. Linear modeling was used to compare vessel densities among groups. RESULTS:Data from 64 eyes with PXS, 84 eyes with PXG, and 44 eyes healthy control subjects were analyzed. The differences of visual field mean deviation and peripapillary retinal nerve fiber layer thickness among study groups were statistically significant with lower values in PXG eyes compared with the PXS and control groups. Peripapillary superficial retinal vessel densities were significantly reduced in patients with PXG compared with patients with PXS and normal control subjects (all P < .001) without a difference between PXS and control eyes. Customized outer annular PPCMv density in the PXG group with a value of 11.1% (SD 5.1%) was lower than that in PXS with a value of 13.2% (SD 5.3%; P = .001). Similarly, PXS values were lower than those of control eyes with a value of 18.6% (SD 5.1%; P < .001). CONCLUSION:A progressive decrease in outer PPCMv from the control group to those with PXS without glaucoma to those with PXS and glaucoma (PXG) showed deep peripapillary vasculopathy in pseudoexfoliation syndrome. Choroidal vessel density may be affected early in the course of pseudoexfoliation before glaucoma develops.
journal_name
Am J Ophthalmoljournal_title
American journal of ophthalmologyauthors
Aghsaei Fard M,Safizadeh M,Shabani A,Kafieh R,Hojati S,Afzali M,Suwan Y,Ritch R,Moghimi Sdoi
10.1016/j.ajo.2020.12.002subject
Has Abstractpub_date
2020-12-10 00:00:00eissn
0002-9394issn
1879-1891pii
S0002-9394(20)30659-0pub_type
杂志文章abstract:PURPOSE:To describe the ultrasound biomicroscopic features of eyes with aniridia. DESIGN:Observational case series. METHODS:Nineteen eyes of 10 patients with aniridia (six males and four females) ranging in age from 3 months to 53 years (21.0 +/- 16.4, mean +/- SD), and 50 normal subjects (30 men and 20 women) rangin...
journal_title:American journal of ophthalmology
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