当前位置： SCI文献检索 > AMERICAN JOURNAL OF OPHTHALMOLOGY期刊下所有文献 > SCORE2 Report 13: Intraretinal Hemorrhage Changes in Eyes With Central or Hemiretinal Vein Occlusion Managed With Aflibercept, Bevacizumab or Observation. Secondary Analysis of the SCORE and SCORE2 Clinical Trials.

SCORE2 Report 13: Intraretinal Hemorrhage Changes in Eyes With Central or Hemiretinal Vein Occlusion Managed With Aflibercept, Bevacizumab or Observation. Secondary Analysis of the SCORE and SCORE2 Clinical Trials.

Abstract：

PURPOSE:To investigate the relationship between intraretinal macular hemorrhage and visual acuity outcomes in eyes with central retinal vein occlusion or hemiretinal vein occlusion managed with aflibercept, bevacizumab, or observation. DESIGN:Retrospective analysis of data from 2 randomized clinical trials. METHODS:A total of 362 participants were randomized in the Study of Comparative Treatments for Retinal Vein Occlusion 2, and 88 participants randomized to observation in the Standard Care vs Corticosteroid in Retinal Vein Occlusion Study. Participants received monthly intravitreal aflibercept or bevacizumab through month 6 or observation through month 8. The main outcome was visual acuity letter score (VALS). RESULTS:Reduced area of hemorrhage by month 6 was observed in 70.7% (116 of 164) of aflibercept-treated eyes, 63.8% (104 of 163) of bevacizumab-treated eyes, and 42.2% (27 of 64) of observation eyes by month 8 (P < .01). Relative to eyes with hemorrhage during follow-up, aflibercept-treated eyes without hemorrhage at month 6 had a mean VALS improvement of 8.0 (99% confidence interval [CI]: 1.9, 14.2); bevacizumab-treated eyes without hemorrhage at month 6 had a mean VALS improvement of 3.2 (99% CI: -4.6, 11.0); and observation eyes without hemorrhage at month 8 had a mean VALS improvement of 13.5 (99% CI: 0.4, 26.5). At month 6, the presence of hemorrhage and the change in central subfield thickness (CST) were significantly associated with the change in VALS; however, CST was a more important predictor. CONCLUSION:Improvement in hemorrhage during follow-up was associated with visual acuity improvements and predicted visual acuity changes beyond what was explained by CST. These findings suggest that intraretinal macular hemorrhage is an important indicator of disease severity in retinal vein occlusion.

journal_name

Am J Ophthalmol

journal_title

American journal of ophthalmology

authors

Hendrick A,VanVeldhuisen PC,Scott IU,King J,Blodi BA,Ip MS,Khurana RN,Oden NL,SCORE2 Investigator Group.

doi

10.1016/j.ajo.2020.08.030

subject

Has Abstract

pub_date

2020-08-20 00:00:00

pages

185-193

eissn

0002-9394

issn

1879-1891

pii

S0002-9394(20)30459-1

journal_volume

222

pub_type

杂志文章

相关文献

AMERICAN JOURNAL OF OPHTHALMOLOGY文献大全
  • Use of Donors Predisposed by Corneal Collagen Cross-linking in Penetrating Keratoplasty for Treating Patients With Keratoconus.

    abstract：PURPOSE:To investigate whether use of donors predisposed by corneal collagen cross-linking (CXL) reduced myopic refractive errors for keratoconic eyes after penetrating keratoplasty (PK). DESIGN:Randomized controlled trial. METHODS:One hundred sixteen eyes of 116 patients with keratoconus from Zhongshan Ophthalmic Ce...

    journal_title：American journal of ophthalmology

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.ajo.2017.10.003

    authors： Huang T,Ye R,Ouyang C,Hou C,Hu Y,Wu Q

    更新日期：2017-12-01 00:00:00

  • Comparative toxicity of mitomycin C and 5-fluorouracil in vitro.

    abstract：:The adjunctive use of antimetabolites has revolutionized surgical procedures to correct glaucoma in the past decade. Although much is known about the in vitro and in vivo actions of 5-fluorouracil and mitomycin C, their use in the eye has raised new questions about cellular toxicity. For example, filtering blebs after...

    journal_title：American journal of ophthalmology

    pub_type： 杂志文章

    doi：10.1016/s0002-9394(14)72957-5

    authors： Smith S,D'Amore PA,Dreyer EB

    更新日期：1994-09-15 00:00:00

  • The blood-aqueous barrier in five species.

    abstract：:The in vivo sites of the blood-aqueous barrier were determined in five animal species, using acriflavine neutral (224 mol. wt.), ultrafreezing and drying, fluorescence microscopy, and fluorometry. Not toxic, acriflavine had specific in vivo affinity for nuclear DNA and RNA, produced intense fluorescence, and did not p...

    journal_title：American journal of ophthalmology

    pub_type： 杂志文章

    doi：10.1016/0002-9394(75)90405-5

    authors： Rodriguez-Peralta L

    更新日期：1975-10-01 00:00:00

  • Anterior segment indocyanine green angiography in pterygium surgery with conjunctival autograft transplantation.

    abstract：PURPOSE:To assess indocyanine green angiography (ICGA) as a method for monitoring autograft perfusion after pterygium excision with limbal-conjunctival autograft transplantation (LCAT) and to compare ICGA with anterior segment fluorescein angiography (ASFA). DESIGN:Nonrandomized prospective interventional case series....

    journal_title：American journal of ophthalmology

    pub_type： 杂志文章

    doi：10.1016/s0002-9394(02)01834-2

    authors： Tayanc E,Akova Y,Yilmaz G,Aydin P

    更新日期：2003-01-01 00:00:00

  • Safety results of two phase III trials of an intravitreous injection of highly purified ovine hyaluronidase (Vitrase) for the management of vitreous hemorrhage.

    abstract：PURPOSE:To evaluate the safety of intravitreous ovine hyaluronidase for the management of vitreous hemorrhage. DESIGN:Two prospective, randomized, placebo-controlled, double-masked studies. Pooled efficacy data are presented in a companion article in this issue of The Journal. METHODS:Subjects with vitreous hemorrhag...

    journal_title：American journal of ophthalmology

    pub_type： 临床试验,杂志文章,多中心研究,随机对照试验

    doi：10.1016/j.ajo.2005.06.022

    authors： Kuppermann BD,Thomas EL,de Smet MD,Grillone LR,Vitrase for Vitreous Hemorrhage Study Groups.

    更新日期：2005-10-01 00:00:00

  • A magnetic resonance imaging study of the upshoot-downshoot phenomenon of Duane's retraction syndrome.

    abstract：:Patients with Duane's retraction syndrome may have an associated upshoot or downshoot of the involved eye in adduction. This vertical movement has been attributed to the lateral rectus muscle slipping over or under the globe and acting as an elevator or depressor, respectively ("bridle-effect"). We used magnetic reson...

    journal_title：American journal of ophthalmology

    pub_type： 杂志文章

    doi：10.1016/s0002-9394(14)73696-7

    authors： Bloom JN,Graviss ER,Mardelli PG

    更新日期：1991-05-15 00:00:00

  • Long-term increase in subfoveal choroidal thickness after surgery for senile cataracts.

    abstract：PURPOSE:To evaluate the impact of cataract surgery on subfoveal choroidal thickness and central retinal thickness in the elderly. DESIGN:Prospective observational case series. METHODS:This cohort study included 29 eyes of 29 patients with senile cataract, but no previous ocular surgery or other ocular abnormality. Al...

    journal_title：American journal of ophthalmology

    pub_type： 杂志文章

    doi：10.1016/j.ajo.2014.05.016

    authors： Noda Y,Ogawa A,Toyama T,Ueta T

    更新日期：2014-09-01 00:00:00

  • The Diagnostic Utility of Multifocal Electroretinography in Detecting Chloroquine and Hydroxychloroquine Retinal Toxicity.

    abstract：PURPOSE:To evaluate multifocal electroretinography (mfERG) as a screening test for detecting hydroxychloroquine and chloroquine toxicity. DESIGN:Diagnostic accuracy study. METHODS:Patients referred to the University of Ottawa for hydroxychloroquine or chloroquine retinopathy screening during 2011-2014 underwent 10-2 ...

    journal_title：American journal of ophthalmology

    pub_type： 杂志文章

    doi：10.1016/j.ajo.2019.04.025

    authors： Tsang AC,Ahmadi S,Hamilton J,Gao J,Virgili G,Coupland SG,Gottlieb CC

    更新日期：2019-10-01 00:00:00

  • Change in cell type of human choroidal malignant melanoma in tissue culture.

    abstract：:In five cases choroidal malignant melanoma spontaneously converted from epitheloid to spindle cell and vice versa. The cultured epitheloid cells divided more frequently and grew faster than the spindle cells. Cells from one tumor were cloned and developed into a cell line. ...

    journal_title：American journal of ophthalmology

    pub_type： 杂志文章

    doi：10.1016/0002-9394(75)90528-0

    authors： Irvine AR,Mannagh J,Arya DV

    更新日期：1975-09-01 00:00:00

  • The effect of long-term medical therapy on the outcome of filtration surgery.

    abstract：:Long-term medical therapy and laser trabeculoplasty have been implicated as risk factors in the outcome of glaucoma filtration surgery. A retrospective analysis was performed of patients undergoing primary trabeculectomy during three key periods: before use of beta-blockers and laser trabeculoplasty (1975 and 1976), a...

    journal_title：American journal of ophthalmology

    pub_type： 杂志文章

    doi：10.1016/s0002-9394(14)73068-5

    authors： Johnson DH,Yoshikawa K,Brubaker RF,Hodge DO

    更新日期：1994-02-15 00:00:00

  • The relationship of optic disk cupping to retinal vein occlusion: the Beaver Dam Eye Study.

    abstract：PURPOSE:To examine the association between optic disk cupping and retinal vein occlusion (RVO). DESIGN:Prospective epidemiologic study. METHODS:setting: Population-based prospective study in Beaver Dam, Wisconsin. study population: Adults aged 43 to 86 years at baseline (n = 4926). observation procedures: Optic disk ...

    journal_title：American journal of ophthalmology

    pub_type： 杂志文章

    doi：10.1016/j.ajo.2005.12.015

    authors： Klein BE,Meuer SM,Knudtson MD,Klein R

    更新日期：2006-05-01 00:00:00

  • Retinal detachment in myopic eyes after intracapsular and extracapsular cataract extraction.

    abstract：:We analyzed two consecutive series of cataract extractions in patients with moderate to severe myopia for the incidence of postoperative retinal detachment. One series consisted of 122 intracapsular cataract extractions without surgical loss of vitreous and the other series consisted of 151 extracapsular (phacoemulsif...

    journal_title：American journal of ophthalmology

    pub_type： 杂志文章

    doi：10.1016/0002-9394(84)90445-8

    authors： Jaffe NS,Clayman HM,Jaffe MS

    更新日期：1984-01-01 00:00:00

  • Involutional diabetic retinopathy.

    abstract：:The end-stage or involutional phase of proliferative diabetic retinopathy may result in stabilization of vision for long periods of time. However, the clinical resemblance to the progressive tapetoretinal degenerations suggests that marked functional impairment of the retina is present in such eyes. We studied 19 eyes...

    journal_title：American journal of ophthalmology

    pub_type： 杂志文章

    doi：10.1016/0002-9394(77)90509-8

    authors： Ramsay WJ,Ramsay RC,Purple RL,Knobloch WH

    更新日期：1977-12-01 00:00:00

  • Once-Daily Netarsudil Versus Twice-Daily Timolol in Patients With Elevated Intraocular Pressure: The Randomized Phase 3 ROCKET-4 Study.

    abstract：PURPOSE:To compare the intraocular pressure (IOP)-lowering efficacy and safety of netarsudil once daily (QD) and timolol twice daily (BID). DESIGN:Double-masked, randomized, phase 3, noninferiority study. METHODS:Patients with open-angle glaucoma or ocular hypertension (unmedicated baseline IOP >20 to <30 mm Hg at 8:...

    journal_title：American journal of ophthalmology

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1016/j.ajo.2019.03.002

    authors： Khouri AS,Serle JB,Bacharach J,Usner DW,Lewis RA,Braswell P,Kopczynski CC,Heah T,Rocket-4 Study Group.

    更新日期：2019-08-01 00:00:00

  • Infliximab to treat chronic noninfectious uveitis in children: retrospective case series with long-term follow-up.

    abstract：PURPOSE:To assess a response to infliximab therapy in childhood uveitis. DESIGN:Retrospective case series. METHODS:We reviewed the course of 16 children with noninfectious uveitis treated with infliximab at an academic medical center. Outcome measures included incidence of uveitis recurrences, proportion of patients ...

    journal_title：American journal of ophthalmology

    pub_type： 杂志文章

    doi：10.1016/j.ajo.2007.08.018

    authors： Ardoin SP,Kredich D,Rabinovich E,Schanberg LE,Jaffe GJ

    更新日期：2007-12-01 00:00:00

  • The histologic basis of optic disk pallor in experimental optic atrophy.

    abstract：:We studied the clinical and microscopic appearances of the optic nerve head in squirrel monkeys with optic nerve degeneration produced by optic nerve transection at the orbital apex. The ophthalmoscopic development of optic disk pallor coincided with the loss of nerve fiber bundles and the rearrangement of the remaini...

    journal_title：American journal of ophthalmology

    pub_type： 杂志文章

    doi：10.1016/0002-9394(77)90138-6

    authors： Quigley HA,Anderson DR

    更新日期：1977-05-01 00:00:00

  • The treatment of congenital dacryocystocele.

    abstract：PURPOSE:To determine the proper management of congenital dacryocystocele. DESIGN:Retrospective interventional case series. METHODS: SETTINGS:Clinical practice. STUDY POPULATION:Twenty-seven consecutive patients with 29 congenital dacryocystoceles who presented from 1987 through 2006. MAIN OUTCOME MEASURES:The char...

    journal_title：American journal of ophthalmology

    pub_type： 杂志文章

    doi：10.1016/j.ajo.2006.05.043

    authors： Becker BB

    更新日期：2006-11-01 00:00:00

  • A study of interactions between pharmaceutical representatives and ophthalmology trainees.

    abstract：PURPOSE:To evaluate the behavior and attitudes among ophthalmology trainees toward pharmaceutical promotions. DESIGN:Questionnaire survey. METHODS:A questionnaire on behavior and attitudes toward interactions with pharmaceutical representatives was distributed to 110 ophthalmology residency programs in the United Sta...

    journal_title：American journal of ophthalmology

    pub_type： 杂志文章

    doi：10.1016/j.ajo.2009.05.011

    authors： Wang Y,Adelman RA

    更新日期：2009-10-01 00:00:00

  • Indocyanine green selectively stains the internal limiting membrane.

    abstract：PURPOSE:To demonstrate whether indocyanine green stains the inner limiting membrane of the retina or residual vitreous cortex. METHODS:We report on the intraoperative staining patterns of the vitreomacular interface in 10 eyes of 10 consecutive patients who underwent vitrectomy with indocyanine green staining for macu...

    journal_title：American journal of ophthalmology

    pub_type： 杂志文章

    doi：10.1016/s0002-9394(00)00924-7

    authors： Gandorfer A,Messmer EM,Ulbig MW,Kampik A

    更新日期：2001-03-01 00:00:00

  • Modification of the classification of the eye changes of Graves' disease.

    abstract：:The original (1969) classification of the Eye Changes of Graves' Disease has been retained except for Classes 1 and 3. Class 1 has been limited so that proptosis of 23 mm or greater is placed in Class 3, even if the patient is asymptomatic. Grading of Classes 1 and 2 has been left to the individual physician or clinic...

    journal_title：American journal of ophthalmology

    pub_type： 杂志文章

    doi：10.1016/0002-9394(77)90140-4

    authors： Werner SC

    更新日期：1977-05-01 00:00:00

  • Bartonella henselae infection associated with neuroretinitis, central retinal artery and vein occlusion, neovascular glaucoma, and severe vision loss.

    abstract：PURPOSE:To report a case of Bartonella henselae infection. DESIGN:Observational case report. METHODS:Review of the clinical, laboratory, photographic, and angiographic records of a patient with cat scratch disease associated with central retinal artery and vein occlusion, neovascular glaucoma, and severe vision loss....

    journal_title：American journal of ophthalmology

    pub_type： 杂志文章

    doi：10.1016/s0002-9394(03)00784-0

    authors： Gray AV,Michels KS,Lauer AK,Samples JR

    更新日期：2004-01-01 00:00:00

  • Acute transient myopia induced by indapamide.

    abstract：PURPOSE:To report on a case of acute transient myopia associated with ciliochoroidal detachment induced by indapamide. METHOD:Case report. Clinical examination, ultrasonography, and fluorescein angiography were performed during the acute phase of disease and convalescence. RESULTS:After indapamide was discontinued, a...

    journal_title：American journal of ophthalmology

    pub_type： 杂志文章

    doi：10.1016/s0002-9394(99)00402-x

    authors： Blain P,Paques M,Massin P,Erginay A,Santiago P,Gaudric A

    更新日期：2000-04-01 00:00:00

  • Delayed patchy choroidal filling in the Comparison of Age-Related Macular Degeneration Treatments Trials (CATT).

    abstract：PURPOSE:To determine the relationship between delayed patchy choroidal filling and morphologic and functional outcomes among eyes treated with ranibizumab or bevacizumab. DESIGN:Cohort study. METHODS:Comparison of Age-related Macular Degeneration Treatment Trials participants were assigned randomly to ranibizumab or ...

    journal_title：American journal of ophthalmology

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1016/j.ajo.2014.06.004

    authors： Gewaily DY,Grunwald JE,Pistilli M,Ying GS,Maguire MG,Daniel E,Ostroff CP,Fine SL,CATT Research Group.

    更新日期：2014-09-01 00:00:00

  • Mucosal complications of modified osteo-odonto keratoprosthesis in chronic Stevens-Johnson syndrome.

    abstract：PURPOSE:To describe clinical outcomes of complications afflicting the autologous oral mucous membrane graft after modified osteo-odonto keratoprosthesis surgery in chronic Stevens-Johnson syndrome (SJS). DESIGN:Prospective case series. METHODS:This study included 30 eyes of 30 patients with SJS-induced dry keratinize...

    journal_title：American journal of ophthalmology

    pub_type： 杂志文章

    doi：10.1016/j.ajo.2013.06.012

    authors： Basu S,Pillai VS,Sangwan VS

    更新日期：2013-11-01 00:00:00

  • Aqueous humor levels of vascular endothelial growth factor and pigment epithelium-derived factor in polypoidal choroidal vasculopathy and choroidal neovascularization.

    abstract：PURPOSE:To determine the aqueous levels of vascular endothelial growth factor (VEGF) and pigment epithelium-derived factor (PEDF) in patients with active polypoidal choroidal vasculopathy (PCV) and choroidal neovascularization (CNV) secondary to age-related macular degeneration (AMD) and pathologic myopia. DESIGN:Pros...

    journal_title：American journal of ophthalmology

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.ajo.2005.10.012

    authors： Tong JP,Chan WM,Liu DT,Lai TY,Choy KW,Pang CP,Lam DS

    更新日期：2006-03-01 00:00:00

  • Uveitis precipitated by nonpenetrating ocular trauma.

    abstract：:Although penetrating trauma is a well-recognized cause of uveitis, the role of nonpenetrating trauma in initiating uveitis is not defined. We analyzed the records of 496 patients seen at the uveitis clinic at our institution. Twenty-four of these 496 patients (4.8%) suspected that the cause of their intraocular inflam...

    journal_title：American journal of ophthalmology

    pub_type： 杂志文章

    doi：10.1016/s0002-9394(14)76245-2

    authors： Rosenbaum JT,Tammaro J,Robertson JE Jr

    更新日期：1991-10-15 00:00:00

  • Familial dysplasminogenemia with central retinal vein and cilioretinal artery occlusion.

    abstract：PURPOSE:To report a 49-year-old woman with unilateral central retinal vein occlusion and ipsilateral cilioretinal artery occlusion who showed familial dysplasminogenemia associated with elevated lipoprotein(a). METHOD:Case report. RESULTS:Extensive hemostatic and coagulation studies for causes of thrombosis, as well ...

    journal_title：American journal of ophthalmology

    pub_type： 杂志文章

    doi：10.1016/s0002-9394(98)00163-9

    authors： Iijima H,Gohdo T,Tsukahara S

    更新日期：1998-08-01 00:00:00

  • The Enigmatic Cornea and Intraocular Lens Calculations: The LXXIII Edward Jackson Memorial Lecture.

    abstract：PURPOSE:To review the progress and challenges in obtaining accurate corneal power measurements for intraocular lens (IOL) calculations. DESIGN:Personal perspective, review of literature, case presentations, and personal data. METHODS:Through literature review findings, case presentations, and data from the author's c...

    journal_title：American journal of ophthalmology

    pub_type：

    doi：10.1016/j.ajo.2016.08.020

    authors： Koch DD

    更新日期：2016-11-01 00:00:00

  • Prolonged complementary chromatopsia in users of video display terminals.

    abstract：:Induced prolonged complementary chromatopsia in four subjects (two men, 26 and 34 years old, and two women, 34 and 45 years old) was documented by abnormal responses to pseudoisochromatic color plates 30 minutes after cessation of monochrome video display terminal use. This phenomenon was unrelated to preexisting colo...

    journal_title：American journal of ophthalmology

    pub_type： 杂志文章

    doi：10.1016/0002-9394(84)90694-9

    authors： Khan JA,Fitz J,Psaltis P,Ide CH

    更新日期：1984-12-15 00:00:00

  • Peribulbar anesthesia for strabismus surgery.

    abstract：:We prospectively studied 76 patients to analyze the effectiveness of peribulbar anesthesia during strabismus surgery. The patients, ranging in age from 14 to 77 years, were given anesthesia with standard preoperative medication and a peribulbar injection of a mixture of 2% mepivacaine hydrochloride and hyaluronidase. ...

    journal_title：American journal of ophthalmology

    pub_type： 杂志文章

    doi：10.1016/s0002-9394(14)72440-7

    authors： Sanders RJ,Nelson LB,Deutsch JA

    更新日期：1990-06-15 00:00:00