Abstract：
:Bleomycin was administered to 126 normal or human-tumor-bearing baby rats we observed for the development of cataracts. Eighty-four percent of the rats receiving this drug before the age of 10 days developed lens opacities. Bleomycin given to 10-day-old rats or older did not induce cataract formation. The cataracts initially occurred in the nuclear area and later involved most of the lens whether or not bleomycin was later discontinued. The presence of the tunica vasculosa lentis in rats younger than 10 days old may explain why cataracts developed only in these young animals.
journal_name
Am J Ophthalmoljournal_title
American journal of ophthalmologyauthors
Edwards GA,Bernardino VB Jr,Babcock VI,Southam CMdoi
10.1016/0002-9394(75)90223-8subject
Has Abstractpub_date
1975-09-01 00:00:00pages
538-42issue
3 Pt 2eissn
0002-9394issn
1879-1891pii
0002-9394(75)90223-8journal_volume
80pub_type
杂志文章abstract：PURPOSE:To investigate the effect of refractive astigmatism on all-distance visual acuity (VA) in eyes implanted with a diffractive trifocal or bifocal intraocular lens (IOL). DESIGN:Cross-sectional study. METHODS:Fifty eyes with trifocal IOLs (PanOptix; Alcon) and 50 eyes with bifocal IOLs (ReSTOR +3D) were enrolled...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2020.07.051
更新日期：2021-01-01 00:00:00
abstract：:We examined more than 300 children as outpatients with orally administered chloral hydrate sedation during the past three years; 175 of them have been examined in the last year. Without chloral hydrate sedation, examination under anesthesia would have been necessary or the results would have been less than satisfactor...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(80)90066-5
更新日期：1980-04-01 00:00:00
abstract：PURPOSE:To evaluate the possible toxicity of indocyanine green (ICG) dye in macular hole surgery by comparing functional results after successful surgeries performed with and without staining. DESIGN:Prospective observational case series. METHODS:In a study conducted at our department, 30 eyes of 29 patients with idi...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2006.05.054
更新日期：2006-11-01 00:00:00
abstract：:Visual field testing of 166 phakic eyes with optic nerve damage from open-angle glaucoma before and after one year of treatment showed that the visual fields of myopic eyes improved more often than those of nonmyopic eyes (12% vs 6%) and worsened less often (6% vs 18%). These results suggested that myopia, which adver...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)77378-7
更新日期：1982-05-01 00:00:00
abstract：PURPOSE:To describe a case series of neovascular glaucoma (NVG) caused by central retinal vein occlusion (CRVO) that was treated with intravitreal bevacizumab (IVB; Avastin). DESIGN:Retrospective interventional case series. METHODS:Six consecutive patients with NVG and a refractory, symptomatic elevation of intraocul...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2006.06.066
更新日期：2006-12-01 00:00:00
abstract：PURPOSE:To report a child with the mitochondrial cytopathy of Pearson syndrome and zonular cataract. METHOD:Case report. We describe a 6-year-old boy with Pearson syndrome. RESULTS:At age 3 years, the boy developed secondary strabismus caused by bilateral zonular cataract. Subsequently, he underwent successful bilate...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(99)80105-6
更新日期：1998-02-01 00:00:00
abstract：:A review of lens implant surgery using different implant styles and both methods of cataract extraction revealed that there is little difference in the final visual acuity regardless of which implant or cataract technique is used. There appears to be a higher rate of cystoid macular edema with the intracapsular techni...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(79)90558-0
更新日期：1979-11-01 00:00:00
abstract：:Fifty-five patients with primary open-angle glaucoma and early glaucomatous damage who had medical therapy and laser trabeculoplasty were followed up for four to 11 years or until progressive glaucomatous damage was documented. Factors associated with the stability or progression of glaucoma were evaluated. Eyes with ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)76896-5
更新日期：1991-01-15 00:00:00
abstract：PURPOSE:To evaluate the efficacy and safety of transpupillary thermotherapy (TTT) for subfoveal neovascularization (SRNVM) in patients with group 2A Idiopathic Juxtafoveolar Telangiectasis (IJFT). DESIGN:Nonrandomized interventional case series. METHODS:We performed TTT for subfoveal SRNVM in 14 eyes of 13 patients w...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2004.01.047
更新日期：2004-07-01 00:00:00
abstract：:Rabbit eyes in which vitrectomy was performed underwent three hours of hypothermic perfusion with either 22 C or 2 C lactated Ringer's solution. Clinical, electroretinographic, fluorescein angiographic, histologic, and ultrastructural examinations were performed. No changes were noted in eyes cooled with 22 C fluid. R...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)74615-x
更新日期：1990-04-15 00:00:00
abstract：:In the elderly patient with a massive vitreous hemorrhage in one eye and senile macular choroidal degenerative changes in the fellow eye, a hemorrhagic disciform detachment causing this massive vitreous hemorrhage must be considered in the differential diagnosis. Ultrasonography selectively combined with radioactive p...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)75023-8
更新日期：1980-10-01 00:00:00
abstract：PURPOSE:To report rapidly progressive rhino-orbitocerebral mucormycosis in a 47-year-old woman with both diabetes mellitus and the acquired immunodeficiency syndrome (AIDS). METHOD:Case report including postmortem examination of the eyes, orbit, and brain of a patient with rhino-orbitocerebral mucormycosis, diabetes m...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)70392-7
更新日期：1996-12-01 00:00:00
abstract：PURPOSE:To report the incidence and outcomes of intraoperative Descemet membrane (DM) perforations during deep anterior lamellar keratoplasty (DALK). DESIGN:Retrospective, consecutive, interventional case series. METHODS:A retrospective audit of all DALK cases performed from 2004 to 2015 in a tertiary center, with an...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2018.10.026
更新日期：2019-03-01 00:00:00
abstract：PURPOSE:To explore the association between the consumption of fruits and vegetables and the presence of glaucoma. DESIGN:Cross-sectional cohort study. METHODS:In a sample of 1,155 women located in multiple centers in the United States, glaucoma specialists diagnosed glaucoma in at least one eye by assessing optic ner...
journal_title：American journal of ophthalmology
pub_type： 杂志文章,多中心研究
doi：10.1016/j.ajo.2008.01.022
更新日期：2008-06-01 00:00:00
abstract：PURPOSE:To evaluate the involvement of the anterior ocular segment in Harada disease. METHODS:In a prospective study, ultrasound biomicroscopy was performed in 18 consecutive eyes of nine patients with Harada disease in its acute phase before and after onset of systemic corticosteroid therapy. Examination was repeated...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(98)00033-6
更新日期：1998-05-01 00:00:00
abstract：PURPOSE:To compare the prediction accuracy of new intraocular lens (IOL) calculation formulas (Barrett Universal II [BUII], Emmetropia Verifying Optical [EVO], Kane and Ladas Super formula) and traditional formulas (Haigis, Hoffer Q, Holladay 1, and SRK/T) with Wang-Koch (WK) axial length (AL) adjustment in vitrectomiz...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2020.04.035
更新日期：2020-09-01 00:00:00
abstract：:Lenses removed in 408 cataract operations were cultured for bacteria. Most (78%) lenses were sterile. Of the positive cultures, 48% were positive for Staphylococcus epidermidis and 15.4% for S. aureus. These findings reflect the flora of the normal preoperative conjunctiva, and the organisms most commonly implicated i...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)76805-9
更新日期：1978-08-01 00:00:00
abstract：PURPOSE:To evaluate the effects of the Boston Ocular Surface Prosthesis (Boston Foundation for Sight, Needham, Massachusetts, USA) on visual acuity (VA) and visual functioning in patients with severe corneal ectasia, irregular astigmatism, or ocular surface disease. DESIGN:Prospective, interventional case series. MET...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2009.07.037
更新日期：2010-01-01 00:00:00
abstract：PURPOSE:To determine the feasibility of using a modified femtosecond laser to perform penetrating corneal resections. DESIGN:Controlled laboratory study. METHODS:Fourteen corneoscleral rims were mounted on an artificial anterior chamber. Eight underwent traditional penetrating keratoplasty (PKP) and six underwent "to...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2006.11.043
更新日期：2007-04-01 00:00:00
abstract：PURPOSE:To determine the incidence of Graves' ophthalmopathy. METHODS:A population-based cohort of all Olmsted County, Minnesota, residents who had ophthalmopathy associated with autoimmune thyroid disease between Jan. 1, 1976, and Dec. 31, 1990, was identified through the medical diagnostic index of the Mayo Clinic a...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)72666-2
更新日期：1995-10-01 00:00:00
abstract：:A 7-year-old boy with acute lymphocytic leukemia developed iris infiltration, blood-streaked hypopyon, and high intraocular pressure. A diagnostic anterior chamber paracentesis was performed, which provided a cytologic diagnosis. The aspirate was studied by both the millipore filter technique with Papanicolaou stain a...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(80)90112-9
更新日期：1980-02-01 00:00:00
abstract：PURPOSE:To investigate the value of whole-body positron emission tomography/computed tomography (PET/CT) as a screening tool for patients with uveal metastasis. DESIGN:Retrospective observational case series. METHODS:setting: Clinical practice. study population: Eighteen patients with uveal metastatic tumors were eva...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2011.09.028
更新日期：2012-04-01 00:00:00
abstract：PURPOSE:To report the clinical outcome in 48 eyes of 48 children who received a Baerveldt glaucoma implant (BGI) for the management of pediatric glaucoma. DESIGN:Retrospective, noncomparative case series. METHODS:The medical records of all patients with pediatric glaucoma who underwent a BGI at two tertiary care refe...
journal_title：American journal of ophthalmology
pub_type： 杂志文章,多中心研究
doi：10.1016/j.ajo.2004.12.028
更新日期：2005-05-01 00:00:00
abstract：PURPOSE:To report dry eye patients' functional visual acuity, which was measured after sustained eye opening for 10-20 seconds, as a simulation of visual function of daily acts of gazing, which is defined as looking at an object with involuntary blink suppression. METHODS:Interventional clinical nonrandomized comparat...
journal_title：American journal of ophthalmology
pub_type： 临床试验,杂志文章
doi：10.1016/s0002-9394(01)01365-4
更新日期：2002-02-01 00:00:00
abstract：PURPOSE:To report two cases of diffuse unilateral subacute neuroretinitis (DUSN) with unusual findings. DESIGN:Observational and interventional case series. METHODS:Two patients with DUSN were found to have the unusual findings of a large live worm in one eye and macular cyst in the other. Both patients underwent fun...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2006.06.005
更新日期：2006-11-01 00:00:00
abstract：:We examined three affected members of a Chinese-American family with Bietti's crystalline retinopathy. The clinical characteristics of a 24-year-old proband are contrasted to the clinical findings of her grandmother, for whom we have 26 years of follow-up data. Lymphocytes and fibroblasts from a skin biopsy of the gra...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)76572-9
更新日期：1994-11-15 00:00:00
abstract：PURPOSE:To describe the clinical features and complications of diabetic retinopathy, visual acuity, and number of repeat treatments after panretinal photocoagulation for proliferative diabetic retinopathy in a tertiary care center. METHODS:A cohort study was conducted with data collection from medical records of patie...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(99)00322-0
更新日期：2000-02-01 00:00:00
abstract：:We treated 84 patients with a partially refractive accommodative esotropia with bifocals. Twelve patients were able to fuse without bifocals at the end of therapy; in 19, the bifocal power could be reduced and further improvement can be expected in the future. Thirty-nine remained dependent on bifocals; and in 14, fus...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)78113-9
更新日期：1978-06-01 00:00:00
abstract：PURPOSE:To report the cotransmission of retinitis punctata albescens (RPA) and congenital sensorineural deafness. METHODS:Case reports of two siblings with nyctalopia and profound bilateral sensorineural deafness. RESULTS:The affected siblings, an 11-year-old female and a 7-year-old male, presented with decreased vis...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(99)00060-4
更新日期：1999-08-01 00:00:00
abstract：PURPOSE:To investigate the presence of the fibronectin isoform containing the extradomain B (B-FN), a marker-protein of angiogenesis, in surgically excised human choroidal neovascular membranes (CNVM) to evaluate whether B-FN could be used as a therapeutic target for specific antibody-photosensitizer immunoconjugates. ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(02)01839-1
更新日期：2003-01-01 00:00:00
