Abstract：
:We evaluated the effect of a collagen shield on epithelial healing in keratectomy wounds in rabbit eyes. Superficial keratectomies 6 mm in diameter were created in 12 eyes of six rabbits. Six eyes received collagen shields every eight hours; six eyes received no treatment (control group). Epithelial healing was significantly faster (P less than .01) in corneas treated with collagen shields (47.8 +/- 1.1 microns/hr) compared to untreated control corneas (40.8 +/- 1.6 microns/hr). Regression analysis gave a projected time for closure of treated corneas of 73.96 hours, compared to 83.41 hours for untreated corneas. Scanning electron microscopy of collagen shields after eight hours of wear showed a large number of polymorphonuclear leukocytes entrapped in the collagen matrix. Light microscopy of healed corneas showed that the appearance of the regenerated epithelium in treated and untreated corneas was similar. These results demonstrate that collagen shields speed reepithelialization of keratectomy wounds in the rabbit cornea.
journal_name
Am J Ophthalmoljournal_title
American journal of ophthalmologyauthors
Frantz JM,Dupuy BM,Kaufman HE,Beuerman RWdoi
10.1016/0002-9394(89)90428-5subject
Has Abstractpub_date
1989-11-15 00:00:00pages
524-8issue
5eissn
0002-9394issn
1879-1891pii
0002-9394(89)90428-5journal_volume
108pub_type
杂志文章abstract：PURPOSE:To evaluate the efficacy of reduced-fluence photodynamic therapy (PDT) for treating symptomatic subfoveal serous pigment epithelial detachments (PEDs) with hyperfluorescence on late-phase indocyanine green angiography (ICGA) without choroidal neovascularization (CNV). DESIGN:Retrospective, interventional case ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2012.05.001
更新日期：2012-11-01 00:00:00
abstract：:Lenses removed in 408 cataract operations were cultured for bacteria. Most (78%) lenses were sterile. Of the positive cultures, 48% were positive for Staphylococcus epidermidis and 15.4% for S. aureus. These findings reflect the flora of the normal preoperative conjunctiva, and the organisms most commonly implicated i...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)76805-9
更新日期：1978-08-01 00:00:00
abstract：:In three cases infarction in the inferotemporal prelaminar portion of the optic disk resulted in shallow cupping and arcuate visual field defects. Such changes occurred acutely, were not progressive, and required no treatment. ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)77720-7
更新日期：1978-03-01 00:00:00
abstract：PURPOSE:We compared the efficacy of different contact lens disinfection systems to eliminate adenovirus. METHODS:Laboratory study evaluating the elimination of adenoviral ocular isolates by contact lens disinfection systems. Hard (gas permeable) and soft contact lenses were contaminated with adenovirus serotypes 8 and...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(01)01128-x
更新日期：2001-11-01 00:00:00
abstract：:We determined antigens of the major histocompatibility complex classes I, II, and III in 25 families of Mexican mestizo glaucomatous patients. Patients and family members were examined, and the predisposition of first-degree relatives to a corticosteroid-provocative test was determined. The results showed a high frequ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)72553-x
更新日期：1994-12-15 00:00:00
abstract：PURPOSE:To describe rifabutin-associated uveitis with opacities in the inferior and posterior vitreous in three patients with acquired immunodeficiency syndrome. METHOD:Case reports of the three patients are presented. RESULTS:The patients, who were being treated with rifabutin and fluconazole, developed anterior and...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)72124-5
更新日期：1996-10-01 00:00:00
abstract：PURPOSE:To provide an overview of angiogenesis and vascular endothelial growth factor (VEGF) and discusses the development approach, safety, and efficacy results of current and emerging anti-VEGF therapies for ocular diseases. DESIGN:Analysis of literature and current clinical trials of antiangiogenic agents for age-r...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2006.05.061
更新日期：2006-10-01 00:00:00
abstract：PURPOSE:To report a young girl with spontaneous separation of an idiopathic epiretinal membrane and notable visual recovery. METHOD:Case report. RESULT:A 12-year-old girl had spontaneous improvement in visual acuity of the left eye from 20/100 to 20/40 attributable to spontaneous peeling of an idiopathic epiretinal m...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(99)00021-5
更新日期：1999-06-01 00:00:00
abstract：:Two patients had ocular myasthenia gravis coexistent with Hashimoto's thyroiditis. A 37-year-old woman presented with diplopia and displayed a head tremor and thyroid enlargement. Thyroid function tests showed an elevated thyroid stimulating hormone (TSH). A quantitative Tensilon test yeilded a "perverse" response and...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(75)90691-1
更新日期：1975-06-01 00:00:00
abstract：:We analyzed the vitreous findings in 62 patients (62 eyes) with major branch retinal vein occlusion to determine whether vitreous examination was useful in predicting the development of retinal or disk neovascularization, or both. In 18 eyes with no or partial posterior vitreous detachment and large areas of capillary...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(88)90115-8
更新日期：1988-01-15 00:00:00
abstract：:We used specular microscopy to investigate corneal endothelial changes after excimer laser photorefractive keratectomy. Twenty patients (26 eyes) underwent photorefractive keratectomy for the correction of myopia. The central cornea endothelium of each eye was observed preoperatively and one month postoperatively. Six...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)73467-1
更新日期：1993-12-15 00:00:00
abstract：PURPOSE:To evaluate whether the full-field flicker test, a psychophysical test employing full-field flickering stimuli to measure temporal contrast sensitivity, can detect glaucomatous optic nerve damage in patients with increased intraocular pressure and glaucomatous optic disk abnormalities but normal visual fields. ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)70126-6
更新日期：1997-03-01 00:00:00
abstract：PURPOSE:To report bilateral optic disk edema and blindness as the unusual initial presentation of acute lymphocytic leukemia (ALL) in an adult. METHODS:A 19-year-old man presented with a history of headaches, back pain, and 10 days of worsening vision that progressed to blindness. Ocular examination revealed light per...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(02)01465-4
更新日期：2002-07-01 00:00:00
abstract：:We investigated the influence of a racial match or mismatch between the corneal donor and recipient on the risk of endothelial rejection and subsequent graft failure in 998 corneal transplant recipients. Actuarial survival analysis showed no significant difference in the cumulative risk of endothelial rejection betwee...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(88)90058-x
更新日期：1988-06-15 00:00:00
abstract：PURPOSE:To study the effect of higher-order aberrations (HOAs) on visual function in keratoconus with a rigid gas permeable (RGP) contact lens (CLs). DESIGN:Retrospective nonrandomized study. METHODS:Thirteen eyes of 10 subjects with keratoconus who wore a RGP CLs (KC-RGP group), 15 eyes of nine normal subjects (norm...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2007.08.004
更新日期：2007-12-01 00:00:00
abstract：PURPOSE:To determine whether glaucoma patients exhibit an abnormal melatonin concentration in aqueous humor. DESIGN:Case-controlled study, laboratory investigation. METHODS:Aqueous humor and plasma samples of 28 patients with primary open-angle glaucoma and 31 nonglaucoma control patients were collected during surger...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2006.03.040
更新日期：2006-08-01 00:00:00
abstract：PURPOSE:To evaluate posterior subtenon injection of triamcinolone acetonide for refractory diabetic macular edema (DME). DESIGN:Retrospective, interventional, case series. METHODS: SETTING:Clinical practice. PATIENT POPULATION:Patients with persistent clinically significant DME involving the center of the fovea 3 o...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2004.09.038
更新日期：2005-02-01 00:00:00
abstract：PURPOSE:To determine the frequency of retinal thickening (RT) in eyes with iridocyclitis and to examine the correlations among anterior chamber (AC) inflammation, RT, and visual acuity. DESIGN:Retrospective, observational case series. METHODS:Records were reviewed of patients seen at the Duke University Eye Center Uv...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2009.03.034
更新日期：2009-09-01 00:00:00
abstract：:We analyzed 34 sets of optic disk photographs from 19 patients with glaucoma who had been followed up for ten years to evaluate changes in the position of the vasculature of the optic disks over time. Each photograph was analyzed by an image analyzer's edge-defining program for optic disk analysis and by three experie...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)74101-7
更新日期：1987-11-15 00:00:00
abstract：:A controlled chemotherapy trial of trachoma was carried out in a Tunisian oasis among schoolchildren with active disease. We compared 1% tetracycline ointment (79 patients) or 1% rifampicin ointment (76 patients) with 5% boric acid ointment (79 patients). Medications were administered twice daily, six days a week, for...
journal_title：American journal of ophthalmology
pub_type： 临床试验,杂志文章
doi：10.1016/0002-9394(75)90740-0
更新日期：1975-05-01 00:00:00
abstract：PURPOSE:To investigate the effect of cataract surgery on the concentration of moxifloxacin in aqueous and vitreous humor after topical application. DESIGN:Prospective laboratory intervention using a rabbit model. METHODS:Following topical administration of 0.5% moxifloxacin, 60 minutes before surgery and immediately ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2004.05.011
更新日期：2004-10-01 00:00:00
abstract：PURPOSE:To determine the prevalence of artifacts on segmented spectral-domain optical coherence tomography (SDOCT) images and assess their impact on the interpretation of glaucomatous progression in the retinal nerve fiber layer (RNFL) profile and macular thickness map. DESIGN:Retrospective reliability analysis. METH...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2020.08.018
更新日期：2021-01-01 00:00:00
abstract：:Lamellar keratoplasty was done in 18 eyes with keratoconus in an attempt to obtain a more satisfactory postoperative refractive error than that after penetrating keratoplasty. The refractive error after lamellar keratoplasty was better than that after 7.5-mm penetrating keratoplasties, but the vision was not as good. ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(77)90563-3
更新日期：1977-04-01 00:00:00
abstract：:We conducted a study of 35 patients with exudative diabetic retinopathy who chose to have laser photocoagulation and 35 similar controls who did not. The mean follow-up period was 17 months. A trend toward stabilizing and improving visual acuity was noted in the treated group, but the difference between groups was not...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(79)90746-3
更新日期：1979-07-01 00:00:00
abstract：PURPOSE:To present the first detailed assessment of the clinical features of CL-induced subconjunctival hemorrhage and associated risk factors. DESIGN:Cross-sectional and case-control study of age-matched randomized groups. METHODS:A total of 45 CL wearers with subconjunctival hemorrhage aged 18 to 45 years (CL-Hemor...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2010.05.028
更新日期：2010-11-01 00:00:00
abstract：:Normal volunteers used 1, 2, and 4% pilocarpine eyedrops, three times daily, or ocular therapeutic systems placed in the conjunctival cul-de-sac to control intraocular pressure. The systems continuously release 20 and 40 mug/hour of pilocarpine for one week. Although the amount of drug delivered to the eye from the o...
journal_title：American journal of ophthalmology
pub_type： 临床试验,杂志文章
doi：10.1016/0002-9394(75)90404-3
更新日期：1975-10-01 00:00:00
abstract：PURPOSE:Progressive change in optic disk appearance has been suggested as the best available reference standard for glaucoma diagnosis. We evaluated the accuracy of scanning laser polarimetry (SLP) with variable corneal compensation to discriminate patients with documented progressive optic disk change from healthy sub...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2005.01.003
更新日期：2005-06-01 00:00:00
abstract：:Although surgical excision, with or without adjunctive cryotherapy, is an accepted method of managing conjunctival squamous cell carcinoma, histologically verified tumor-free surgical margins cannot be assured by excision alone. We used a tissue conservation method, an adaptation of the Mohs' micrographic technique fo...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)73021-1
更新日期：1994-01-15 00:00:00
abstract：PURPOSE:To determine whether ocular phenotypic features of keratoconjunctivitis sicca (KCS) and/or participant-reported symptoms of dry eye disease are associated with depression in women participants enrolled in the Sjögren's International Collaborative Clinical Alliance (SICCA). DESIGN:Cross-sectional study. METHOD...
journal_title：American journal of ophthalmology
pub_type： 杂志文章,多中心研究
doi：10.1016/j.ajo.2018.04.004
更新日期：2018-07-01 00:00:00
abstract：PURPOSE:Longstanding corneal edema can lead to anterior stromal scarring that may limit visual acuity following Descemet stripping endothelial keratoplasty (DSEK). The ideal time to perform DSEK to prevent permanent changes is unclear. Our aim is to determine whether earlier DSEK is associated with improved visual outc...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2016.09.006
更新日期：2016-12-01 00:00:00
