Abstract：
PURPOSE:To evaluate the efficacy of reduced-fluence photodynamic therapy (PDT) for treating symptomatic subfoveal serous pigment epithelial detachments (PEDs) with hyperfluorescence on late-phase indocyanine green angiography (ICGA) without choroidal neovascularization (CNV). DESIGN:Retrospective, interventional case series. METHODS:Fifteen eyes of 15 patients (mean age, 55.3 years) with a serous PED were included. Baseline ICGA showed hyperpermeable choroidal vessels but no CNV in any eyes. Reduced-fluence PDT was applied and included treatment of hyperfluorescent areas on late-phase ICGA. We evaluated changes in the PEDs and hyperfluorescence on late-phase ICGA at baseline and 3 months after PDT. We compared the subfoveal choroidal thickness and best-corrected visual acuity (BCVA). RESULTS:The baseline ICGA showed mild to intense hyperfluorescence at the PED with hyperpermeable choroidal vessels. One month after reduced-fluence PDT, the PED resolved in 14 eyes (93%) and decreased in height in 1 eye. The PED flattening continued for more than 3 months. The baseline hyperfluorescence on ICGA decreased at month 3 except for 1 eye. The subfoveal choroidal thickness decreased significantly (P < .0001) from 297 to 238 μm; the BCVA significantly (P = .019) improved from 0.08 to -0.01 between baseline and month 3. The month-3 BCVA was significantly associated with the baseline BCVA and the duration and size of the PED. No PEDs recurred or complications developed, such as secondary CNV or retinal pigment epithelial tears. CONCLUSION:Serous PEDs accompanying hyperfluorescence on ICGA are considered a variant of central serous chorioretinopathy. Reduced-fluence PDT is beneficial for resolving PEDs.
journal_name
Am J Ophthalmoljournal_title
American journal of ophthalmologyauthors
Goto S,Gomi F,Ueno C,Nishida Kdoi
10.1016/j.ajo.2012.05.001subject
Has Abstractpub_date
2012-11-01 00:00:00pages
865-871.e1issue
5eissn
0002-9394issn
1879-1891pii
S0002-9394(12)00348-0journal_volume
154pub_type
杂志文章abstract：PURPOSE:To report a case of chronic recurrent varicella virus epithelial keratitis in a child. DESIGN:Case report. METHODS:Clinical examination and polymerase chain reaction analysis of corneal epithelium. RESULTS:A 10-year-old healthy child developed chronic recurrent varicella virus keratitis with pseudodendrites ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
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更新日期：2005-06-01 00:00:00
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journal_title：American journal of ophthalmology
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journal_title：American journal of ophthalmology
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更新日期：2010-05-01 00:00:00
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journal_title：American journal of ophthalmology
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journal_title：American journal of ophthalmology
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journal_title：American journal of ophthalmology
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journal_title：American journal of ophthalmology
pub_type： 杂志文章,多中心研究,随机对照试验
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更新日期：2008-03-01 00:00:00
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pub_type： 杂志文章
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journal_title：American journal of ophthalmology
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journal_title：American journal of ophthalmology
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journal_title：American journal of ophthalmology
pub_type： 杂志文章
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更新日期：2003-12-01 00:00:00
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journal_title：American journal of ophthalmology
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更新日期：1999-01-01 00:00:00
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journal_title：American journal of ophthalmology
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更新日期：1983-01-01 00:00:00
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journal_title：American journal of ophthalmology
pub_type： 杂志文章,评审
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更新日期：2014-02-01 00:00:00
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journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(79)90569-5
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更新日期：1990-04-15 00:00:00
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journal_title：American journal of ophthalmology
pub_type： 杂志文章
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更新日期：2019-03-01 00:00:00
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journal_title：American journal of ophthalmology
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更新日期：2003-02-01 00:00:00
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journal_title：American journal of ophthalmology
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更新日期：2005-07-01 00:00:00
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journal_title：American journal of ophthalmology
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更新日期：1980-09-01 00:00:00
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journal_title：American journal of ophthalmology
pub_type： 杂志文章
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更新日期：2017-06-01 00:00:00
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journal_title：American journal of ophthalmology
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更新日期：2013-11-01 00:00:00
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journal_title：American journal of ophthalmology
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更新日期：1994-01-15 00:00:00
