Abstract:
PURPOSE:To investigate the effect of cataract surgery on the concentration of moxifloxacin in aqueous and vitreous humor after topical application. DESIGN:Prospective laboratory intervention using a rabbit model. METHODS:Following topical administration of 0.5% moxifloxacin, 60 minutes before surgery and immediately post cataract surgery, aqueous and vitreous humor were sampled at 30, 60, and 120 minutes postsurgery. Moxifloxacin concentrations were determined by high-pressure liquid chromatography (HPLC). Mean tissue concentrations obtained in surgical eyes were compared with concentrations obtained in nonsurgical eyes. The potential effectiveness of moxifloxacin in providing prophylaxis against intracameral bacterial inoculation was investigated by comparing antibiotic concentrations to minimum inhibitory concentration (median MIC90) values for Staphylococcus aureus and Staphylococcus epidermidis. RESULTS:In surgical eyes, mean moxifloxacin concentrations in aqueous were 13.9, 16.2, and 12.2 microg/ml versus 25.3, 32.6, and 15.7 microg/ml in nonoperated eyes at 30, 60, and 120 minutes, respectively. No statistically significant differences were found between surgical and nonsurgical eyes. In surgical eyes, mean moxifloxacin concentrations in vitreous were 66.8, 66.6, and 400.2 ng/ml versus 43.1, 199.8, and 54.4 ng/ml in nonoperated eyes at 30, 60, and 120 minutes, respectively. These differences were not statistically significant. CONCLUSIONS:There were no statistically significant differences in the penetration of topical moxifloxacin in eyes undergoing cataract surgery compared with unoperated eyes. A multiple-drop schedule of moxifloxacin produced aqueous concentrations that were well above the MICs of even resistant strains of the most common organisms implicated in postcataract surgery endophthalmitis.
journal_name
Am J Ophthalmoljournal_title
American journal of ophthalmologyauthors
Mather R,Stewart JM,Prabriputaloong T,Wong J,McLeod SDdoi
10.1016/j.ajo.2004.05.011subject
Has Abstractpub_date
2004-10-01 00:00:00pages
554-9issue
4eissn
0002-9394issn
1879-1891pii
S0002-9394(04)00530-6journal_volume
138pub_type
杂志文章abstract:PURPOSE:To compare the effects of extracapsular cataract extraction with posterior chamber intraocular lens (ECCE/PC-IOL) vs intracapsular cataract extraction with aphakic glasses (ICCE-AG) on everyday visual functioning and quality of life. METHODS:In a nonmasked randomized controlled clinical trial, 3,400 bilateral ...
journal_title:American journal of ophthalmology
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更新日期:2013-12-01 00:00:00
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journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(99)80185-8
更新日期:1998-04-01 00:00:00
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journal_title:American journal of ophthalmology
pub_type: 杂志文章
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更新日期:2004-08-01 00:00:00
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更新日期:2003-10-01 00:00:00
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journal_title:American journal of ophthalmology
pub_type: 杂志文章,随机对照试验
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更新日期:2017-05-01 00:00:00
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journal_title:American journal of ophthalmology
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更新日期:1988-03-15 00:00:00
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journal_title:American journal of ophthalmology
pub_type: 杂志文章
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更新日期:2017-11-01 00:00:00
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journal_title:American journal of ophthalmology
pub_type: 杂志文章
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更新日期:1998-02-01 00:00:00
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journal_title:American journal of ophthalmology
pub_type: 临床试验,杂志文章
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更新日期:2008-10-01 00:00:00
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journal_title:American journal of ophthalmology
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