Ocular myasthenia gravis and Hashimoto's thyroiditis.

Abstract:

:Two patients had ocular myasthenia gravis coexistent with Hashimoto's thyroiditis. A 37-year-old woman presented with diplopia and displayed a head tremor and thyroid enlargement. Thyroid function tests showed an elevated thyroid stimulating hormone (TSH). A quantitative Tensilon test yeilded a "perverse" response and a needle biopsy indicated Hashimoto's disease. A 26-year-old woman presented with diplopia and subsequently developed blepharoptosis and thyroid enlargement. Examination revealed Cogan's eyelid twitch sign, a paradoxical quantitative Tensilon test, and laboratory studies revealed normal thyroid function tests. Treatment was directed at each disease entity separately. Ocular myasthenia gravis was managed with an anticholinesterase agent in combination with oral corticosteroids that provided additional control. Suppressive therapy with desiccated thyroid hormone reduced the size of the thyroid gland, diminished the signs and symptoms of hypothyroidism, and lowered the levels of TSH, possibly decreasing the risk of thyroid carcinoma. Both patients showed gratifying responses to therapy.

journal_name

Am J Ophthalmol

authors

Osher RH,Smith JL

doi

10.1016/0002-9394(75)90691-1

subject

Has Abstract

pub_date

1975-06-01 00:00:00

pages

1038-43

issue

6

eissn

0002-9394

issn

1879-1891

pii

0002-9394(75)90691-1

journal_volume

79

pub_type

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