Abstract：
PURPOSE:To determine the etiologies and management of calcific band keratopathy (CBK), and assess the results and long-term follow-up after ethylenediamine-tetraacetic acid (EDTA) chelation. DESIGN:Retrospective interventional case series. METHODS:Two hundred thirty patients with clinically significant CBK were included from January 1996 to July 2002. Among these, 54 patients (65 eyes) underwent EDTA chelation. Outcome measures included symptomatic relief, visual improvement, and recurrences. The improvement or worsening of the number of lines of Snellen best-corrected visual acuity was determined at 1 month and at last follow-up visit. RESULTS:The most common causes of CBK were chronic corneal edema in 80 eyes (28%) and idiopathic in 74 eyes (25.9%). The mean follow-up time after EDTA chelation was 36.6 months (range, 1 month to 29.6 years). Forty-four of 45 patients (98%) reported partial or complete symptomatic relief. Seventeen eyes (33.3%) improved 2 or more lines at 1 month and 18 eyes (35.2%) at last follow-up visit (P =.0001). In patients with an initial visual acuity between 20/50 and 20/400, 15 eyes (47%) improved 2 or more lines at 1 month and 16 eyes (50%) at last follow-up visit. Ten of 56 eyes (17.8%) had a recurrence at a mean time of 17.7 years (range, 1 month to 26 years). The highest number of recurrences was in three of five eyes with uveitis (60%; P =.03). CONCLUSION:Chelation with EDTA is an effective treatment of CBK. Visual acuity improves most in eyes with acuity between 20/50 and 20/400. This treatment can be used as the initial surgical intervention after conservative measures fail.
journal_name
Am J Ophthalmoljournal_title
American journal of ophthalmologyauthors
Najjar DM,Cohen EJ,Rapuano CJ,Laibson PRdoi
10.1016/j.ajo.2004.01.036subject
Has Abstractpub_date
2004-06-01 00:00:00pages
1056-64issue
6eissn
0002-9394issn
1879-1891pii
S0002939404000376journal_volume
137pub_type
杂志文章abstract：PURPOSE:To assess photoreceptor integrity in patients with retinitis pigmentosa (RP) and related diseases using ultra-high resolution optical coherence tomography (UHR-OCT) and to correlate foveal photoreceptor loss with visual acuity. DESIGN:Observational case series. METHODS:Nine eyes of nine patients with RP and r...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2006.07.024
更新日期：2006-12-01 00:00:00
abstract：:The transmission characteristics of a new filter combination for fluorescein angiography were selected on the basis of in vivo measurements of the excitation and emission spectra of fluorescein dye during its transit in the fundus. This combination of filters was characterized by separation of 530 nm between the spect...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(76)90542-0
更新日期：1976-10-01 00:00:00
abstract：:Of a series of 57 formerly amblyopic patients who attained equal visual acuities (20/20 or better in each eye), only 29 were able to alternate after treatment. The oldest patient was 5 years old. The pattern visual-evoked response of the previously amblyopic eye in nonalternators showed a reduced amplitude as compared...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)75868-4
更新日期：1985-01-15 00:00:00
abstract：PURPOSE:Macular imaging with optical coherence tomography (OCT) measures the most critical retinal ganglion cells (RGCs) in the human eye. The goal of this perspective is to review the challenges to detection of glaucoma progression with macular OCT imaging and propose ways to enhance its performance. DESIGN:Perspecti...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2020.09.026
更新日期：2020-09-18 00:00:00
abstract：PURPOSE:To correlate the histologic and clinical classification of type 1 (subretinal pigment epithelium) and type 2 (subsensory retina) choroidal neovascularization. METHODS:Ten eyes of 10 patients with surgically excised choroidal neovascularization that were routinely processed and could be histologically classifie...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(98)00145-7
更新日期：1998-07-01 00:00:00
abstract：:Visual field testing of 166 phakic eyes with optic nerve damage from open-angle glaucoma before and after one year of treatment showed that the visual fields of myopic eyes improved more often than those of nonmyopic eyes (12% vs 6%) and worsened less often (6% vs 18%). These results suggested that myopia, which adver...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)77378-7
更新日期：1982-05-01 00:00:00
abstract：PURPOSE:To determine the types and incidence of caruncular lesions and to investigate the correlation between clinical and histologic diagnosis. DESIGN:Retrospective, observational case series. METHODS:Records of patients with a lesion of the caruncle that was excised and submitted to our ocular pathology department ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2006.04.035
更新日期：2006-09-01 00:00:00
abstract：PURPOSE:To describe the presentation and subsequent management of a case of severe gonococcal keratitis in a young man. DESIGN:Case report. METHODS:A young man presented with severe gonococcal keratitis. Topical and systemic antibiotics were given with no improvement, and progressive corneal melting was noted. Deep l...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2004.04.014
更新日期：2004-09-01 00:00:00
abstract：:To evaluate the ability of the Friedmann visual field analyzer to determine visual threshold and the depth of visual field defects, we correlated the visual threshold determined kinetically (Goldmann perimeter) with the static threshold (Friedmann analyzer) in various parts of the central field. We found the following...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(83)90390-2
更新日期：1983-05-01 00:00:00
abstract：PURPOSE:To evaluate changes in anterior chamber depth (ACD) and angle width after neodymium-yttrium-aluminum-garnet (Nd:YAG) laser capsulotomy. DESIGN:Prospective interventional case series. METHODS:In a single institution, 43 eyes of 43 consecutive pseudophakic patients with symptomatic posterior capsule opacificati...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2014.08.008
更新日期：2014-11-01 00:00:00
abstract：PURPOSE:To establish a rat model of acute increase in intraocular pressure (IOP) and to investigate the therapeutic window for protection against death of retinal ganglion cells (RGCs) by vaccination with glatiramer acetate (Cop-1) or by treatment with brimonidine or MK-801. DESIGN:Animal study, laboratory investigati...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2006.01.073
更新日期：2006-06-01 00:00:00
abstract：PURPOSE:To report ocular findings in the mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS syndrome) in a family with the A to G 3243 mitochondrial (mt) DNA point mutation. METHODS:Case reports. Ocular findings are described from four family members with the MELAS associated A to G 3243...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(99)00057-4
更新日期：1999-07-01 00:00:00
abstract：:We examined two patients who had sudden decrease in vision after intranasal cocaine or methamphetamine abuse. A 38-year-old woman with a history of systemic arterial hypertension developed a central retinal artery occlusion four hours after intranasal use of cocaine. A 26-year-old woman had blurred vision and intraret...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)73979-0
更新日期：1992-08-15 00:00:00
abstract：PURPOSE:To determine whether hypothermia of 8 degrees C can protect cultured human retinal pigment epithelial (ARPE-19) cells and rat retinal ganglion cells (RGC-5) against trypan blue (TB) toxicity. DESIGN:Laboratory investigation. METHODS:ARPE-19 cells and RGC-5 were exposed to balanced salt solution as controls, a...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2005.10.054
更新日期：2006-04-01 00:00:00
abstract：:We measured skin reactions serum antibody, and lymphocyte stimulation to Histoplasma antigens in a series of patients with presumed ocular histoplasmosis syndrome and in controls. The most sensitive test, lymphocyte stimulation to H. capsulatum sonicate, also correlated with severity of the disease. Lymphocyte stimula...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(79)90069-2
更新日期：1979-03-01 00:00:00
abstract：:Fifty-five patients with primary open-angle glaucoma and early glaucomatous damage who had medical therapy and laser trabeculoplasty were followed up for four to 11 years or until progressive glaucomatous damage was documented. Factors associated with the stability or progression of glaucoma were evaluated. Eyes with ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)76896-5
更新日期：1991-01-15 00:00:00
abstract：PURPOSE:To identify baseline structural parameters that predict the progression of visual field (VF) loss in patients with open-angle glaucoma. DESIGN:Multicenter cohort study. METHODS:Participants from the Advanced Imaging for Glaucoma (AIG) study were enrolled and followed up. VF progression is defined as either a ...
journal_title：American journal of ophthalmology
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1016/j.ajo.2016.09.015
更新日期：2016-12-01 00:00:00
abstract：PURPOSE:To investigate the efficacy of ciliary body endophotocoagulation during pars plana vitrectomy in eyes of pediatric patients with medically uncontrolled glaucoma. METHOD:We compared preoperative and postoperative intraocular pressure and visual acuity in five eyes of five patients aged between 10 months and 14....
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(98)00184-6
更新日期：1998-11-01 00:00:00
abstract：PURPOSE:To report a case of unilateral blindness after ipsilateral prophylactic transcranial optic canal decompression for fibrous dysplasia. METHODS:Case report. A 37-year-old woman with fibrous dysplasia underwent a prophylactic left optic canal decompression. Preoperatively, the left eye had a visual acuity of 20/2...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(98)00118-4
更新日期：1998-09-01 00:00:00
abstract：PURPOSE/METHODS:Central retinal artery occlusion occurs infrequently in children. We treated a child with central retinal artery occlusion before a systemic disease was discovered. RESULTS/CONCLUSION:Vision improved after paracentesis and anticoagulation. Systemic T-cell lymphoma was subsequently diagnosed. In contras...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)73772-9
更新日期：1995-07-01 00:00:00
abstract：:We studied cell-mediated immunity to staphylococcal antigens in 116 patients with chronic blepharitis and eight normal subjects. Antibodies in tears and blood were measured. Enhanced cell-mediated immunity to Staphylococcus aureus was demonstrated in 46 of 116 patients (40%) in the absence of antibodies to teichoic ac...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)72383-9
更新日期：1991-04-15 00:00:00
abstract：:A 59-year-old woman with no evidence of glaucoma developed secondary open-angle glaucoma after an intracapsular cataract extraction complicated by vitreous and iris incarceration. Histopathologic and scanning and electron microscopic studies of the enucleated eye 22 years later revealed extensive proliferation of iris...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(79)90520-8
更新日期：1979-09-01 00:00:00
abstract：PURPOSE:A report of two Japanese brothers with gelatinous drop-like corneal dystrophy, one with and one without the typical gelatinous drop-like region. DESIGN:Interventional case report and observational case report. METHODS:After penetrating keratoplasty, the corneal button, right eye, of the elder brother, 39 year...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(02)01407-1
更新日期：2002-06-01 00:00:00
abstract：:Digital fundus angiography has advantages over conventional photography. However, digital angiography as it is normally performed, provides no stereoscopic information. Because stereoscopic data can be crucial in the evaluation of conditions such as age-related macular degeneration, we developed methods to record ster...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)71409-6
更新日期：1993-10-15 00:00:00
abstract：PURPOSE:To report the clinical outcomes of penetrating keratoplasty (PK) after autologous cultivated limbal epithelial transplantation in eyes with limbal stem cell deficiency (LSCD) after ocular surface burns. DESIGN:Retrospective case series. METHODS:This study included 47 patients with unilateral LSCD treated by a...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2011.05.019
更新日期：2011-12-01 00:00:00
abstract：:Forty-three patients who initially presented with Krikenberg's spindles but with no glaucomatous field defects were observed for an average of 5.8 years in an attempt to evaluate the prognostic implication of spindle presence. Twenty-two of the patients had been followed for a minimum of five years. Analysis of the st...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(75)90075-6
更新日期：1975-02-01 00:00:00
abstract：:In a postmortem study of 57 diabetic patients, 19 of 23 patients with blood glucose levels greater than 200 mg/100 ml in the 72-hour period before death showed the characteristic histologic findings of "lacy" vacuolation of the iris pigment epithelium as well as vacuolation of the renal tubules (Armanni-Ebstein nephro...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(75)90749-7
更新日期：1975-05-01 00:00:00
abstract：:The extent of visual function loss from nuclear cataractous change can be estimated by observing the extinction of blue light compared to white light as a function of sagittal lens depth in standard slit lamps. Apparent extinction (loss of transmissivity) of 50% or more of the depth of the lens in blue light of maxima...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(81)90057-x
更新日期：1981-05-01 00:00:00
abstract：PURPOSE:To assess whether successful surgical intervention for intermittent exotropia, or the timing of intervention, has any effect on the development of mental illness. DESIGN:Retrospective, observational case series. METHODS:All patients (<19 years of age) diagnosed with intermittent exotropia in Olmsted County, M...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2014.06.008
更新日期：2014-10-01 00:00:00
abstract：PURPOSE:To compare the visual outcome after foveal translocation by scleral shortening and that after 360 degrees retinotomy with extraocular muscle surgery in a patient with bilateral myopic neovascular maculopathy. METHODS:Case report. RESULTS:A 52-year-old woman with bilateral myopic neovascular maculopathy underw...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(00)00582-1
更新日期：2000-10-01 00:00:00
