Abstract:
PURPOSE:Macular imaging with optical coherence tomography (OCT) measures the most critical retinal ganglion cells (RGCs) in the human eye. The goal of this perspective is to review the challenges to detection of glaucoma progression with macular OCT imaging and propose ways to enhance its performance. DESIGN:Perspective with review of relevant literature. METHODS:Review of challenges and issues related to detection of change on macular OCT images in glaucoma eyes. The primary outcome measures were confounding factors affecting the detection of change on macular OCT images. RESULTS:The main challenges to detection of structural progression in the macula consist of the magnitude of and the variable amount of test-retest variability among patients, the confounding effect of aging, lack of a reliable and easy-to-measure functional outcome or external standard, the confounding effects of concurrent macular conditions including myopia, and the measurement floor of macular structural outcomes. Potential solutions to these challenges include controlling head tilt or torsion during imaging, estimating within-eye variability for individual patients, improved data visualization, the use of artificial intelligence methods, and the implementation of statistical approaches suitable for multidimensional longitudinal data. CONCLUSIONS:Macular OCT imaging is a crucial structural imaging modality for assessing central RGCs. Addressing the current shortcomings in acquisition and analysis of macular volume scans can enhance its utility for measuring the health of central RGCs and therefore assist clinicians with timely institution of appropriate treatment.
journal_name
Am J Ophthalmoljournal_title
American journal of ophthalmologyauthors
Nouri-Mahdavi K,Weiss REdoi
10.1016/j.ajo.2020.09.026subject
Has Abstractpub_date
2020-09-18 00:00:00pages
277-284eissn
0002-9394issn
1879-1891pii
S0002-9394(20)30520-1journal_volume
222pub_type
杂志文章abstract:PURPOSE:To compare the efficacy and visual results of phacoemulsification vs manual sutureless small-incision extracapsular cataract surgery (SICS) for the treatment of cataracts in Nepal. DESIGN:Prospective, randomized comparison of 108 consecutive patients with visually significant cataracts. METHODS:settings: Outr...
journal_title:American journal of ophthalmology
pub_type: 杂志文章,随机对照试验
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更新日期:2007-01-01 00:00:00
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journal_title:American journal of ophthalmology
pub_type: 杂志文章
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更新日期:2004-10-01 00:00:00
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journal_title:American journal of ophthalmology
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journal_title:American journal of ophthalmology
pub_type: 杂志文章,评审
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journal_title:American journal of ophthalmology
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journal_title:American journal of ophthalmology
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journal_title:American journal of ophthalmology
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更新日期:2005-01-01 00:00:00
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journal_title:American journal of ophthalmology
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1998-03-01 00:00:00
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journal_title:American journal of ophthalmology
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doi:
更新日期:1976-04-01 00:00:00
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更新日期:2007-04-01 00:00:00
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更新日期:2014-07-01 00:00:00
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journal_title:American journal of ophthalmology
pub_type: 杂志文章
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更新日期:2010-06-01 00:00:00
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journal_title:American journal of ophthalmology
pub_type: 杂志文章
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更新日期:2010-09-01 00:00:00
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journal_title:American journal of ophthalmology
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journal_title:American journal of ophthalmology
pub_type: 杂志文章
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