A rat model for acute rise in intraocular pressure: immune modulation as a therapeutic strategy.


PURPOSE:To establish a rat model of acute increase in intraocular pressure (IOP) and to investigate the therapeutic window for protection against death of retinal ganglion cells (RGCs) by vaccination with glatiramer acetate (Cop-1) or by treatment with brimonidine or MK-801. DESIGN:Animal study, laboratory investigation. METHODS:IOP was transiently increased in anesthetized Lewis rats by infusing normal saline (0.9%) into the anterior chamber of the eye for one hour. RGC survival was assessed one week and two weeks later by counting the RGCs retrogradely labeled with rhodamine dextran. MAIN OUTCOME MEASURES:RGC survival. RESULTS:IOP rose to 100 cm H(2)O (76 mm Hg) and returned to baseline after 24 hours. The RGC count decreased by 23% a week after the insult and by a further 7% after the second week. Vaccination with Cop-1 on the day of the insult prevented 50% of the IOP-induced RGC loss. Similar neuroprotection was achieved by daily intraperitoneal injections of brimonidine, but not with MK-801. CONCLUSIONS:A transient increase in IOP to 100 cm H(2)O causes death of RGCs in rats. A single immunization with Cop-1 or daily injections of brimonidine protected up to 50% of potentially doomed RGCs from IOP-induced death, suggesting that not all of the cell death in the untreated model results from the IOP insult directly, but that some of it is caused by insult-induced environmental cytotoxicity, which is unrelated to glutamate toxicity or at least to NMDA receptors. These findings can be applied immediately as a basis for acute glaucoma therapy.


Am J Ophthalmol


Ben Simon GJ,Bakalash S,Aloni E,Rosner M




Has Abstract


2006-06-01 00:00:00














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    journal_title:American journal of ophthalmology

    pub_type: 杂志文章


    authors: Nagpal KC,Patrianakos D,Asdourian GK,Goldberg MF,Rabb M,Jampol L

    更新日期:1975-11-01 00:00:00

  • Positional changes in the vasculature of the optic disk in glaucoma.

    abstract::We analyzed 34 sets of optic disk photographs from 19 patients with glaucoma who had been followed up for ten years to evaluate changes in the position of the vasculature of the optic disks over time. Each photograph was analyzed by an image analyzer's edge-defining program for optic disk analysis and by three experie...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章


    authors: Varma R,Spaeth GL,Hanau C,Steinmann WC,Feldman RM

    更新日期:1987-11-15 00:00:00

  • The cerebro-oculo-facio-skeletal syndrome.

    abstract::A 3 1/2-month-old boy with the cerebro-oculo-facio-skeletal syndrome had low birth weight, microcephaly, microphthalmia, cataracts, blepharophimosis, high nasal bridge, micrognathia, kyphosis, rocker-bottom feet, and a longitudinal foot groove. The product of a consanguineous parentage, he showed marked developmental ...

    journal_title:American journal of ophthalmology

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    authors: Grizzard WS,O'Donnell JJ,Carey JC

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    更新日期:2020-05-01 00:00:00

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    authors: Do JL,Xu BY,Wong B,Camp A,Ngai P,Long C,Proudfoot J,Moghimi S,Yan D,Welsbie DS,Weinreb RN

    更新日期:2020-12-01 00:00:00

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    authors: Townsend-Pico WA,Meyers SM,Lewis H

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    journal_title:American journal of ophthalmology

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    authors: Williams JM Sr,de Juan E Jr,Machemer R

    更新日期:1988-05-15 00:00:00

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    journal_title:American journal of ophthalmology

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    authors: Carlson DW,Alward WL,Folberg R

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    authors: Sorkin JA,Shoffner JM,Grossniklaus HE,Drack AV,Lambert SR

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    journal_title:American journal of ophthalmology

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    authors: Bellows AR,Grant WM

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    更新日期:2018-02-01 00:00:00

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    authors: Jang SY,Ohn YH,Kim SW

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    journal_title:American journal of ophthalmology

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    authors: Gil-Carrasco F,Granados J,Barojas-Weber E,Gilbert-Lucido ME,Vargas-Alarcón G

    更新日期:1994-12-15 00:00:00

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    更新日期:2017-07-01 00:00:00

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    journal_title:American journal of ophthalmology

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    authors: Valenton MJ,Tan RV

    更新日期:1975-10-01 00:00:00

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    authors: Morse PH,Leveille AS,Antel JP,Burch JV

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    journal_title:American journal of ophthalmology

    pub_type: 杂志文章


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    journal_title:American journal of ophthalmology

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    journal_title:American journal of ophthalmology

    pub_type: 杂志文章


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  • Separate and combined effects of timolol maleate and acetazolamide in open-angle glaucoma.

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    journal_title:American journal of ophthalmology

    pub_type: 杂志文章


    authors: Berson FG,Epstein DL

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  • Vernal conjunctivitis and contact lens-associated giant papillary conjunctivitis compared and contrasted.

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    journal_title:American journal of ophthalmology

    pub_type: 杂志文章


    authors: Allansmith MR,Baird RS,Greiner JV

    更新日期:1979-04-01 00:00:00

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    journal_title:American journal of ophthalmology

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    authors: Zografos L,Egger E,Bercher L,Chamot L,Munkel G

    更新日期:1998-08-01 00:00:00