Baseline Fourier-Domain Optical Coherence Tomography Structural Risk Factors for Visual Field Progression in the Advanced Imaging for Glaucoma Study.


PURPOSE:To identify baseline structural parameters that predict the progression of visual field (VF) loss in patients with open-angle glaucoma. DESIGN:Multicenter cohort study. METHODS:Participants from the Advanced Imaging for Glaucoma (AIG) study were enrolled and followed up. VF progression is defined as either a confirmed progression event on Humphrey Progression Analysis or a significant (P < .05) negative slope for VF index (VFI). Fourier-domain optical coherence tomography (FDOCT) was used to measure optic disc, peripapillary retinal nerve fiber layer (NFL), and macular ganglion cell complex (GCC) thickness parameters. RESULTS:A total of 277 eyes of 188 participants were followed up for 3.7 ± 2.1 years. VF progression was observed in 83 eyes (30%). Several baseline NFL and GCC parameters, but not disc parameters, were found to be significant predictors of progression on univariate Cox regression analysis. The most accurate single predictors were the GCC focal loss volume (FLV), followed closely by NFL-FLV. An abnormal GCC-FLV at baseline increased risk of progression by a hazard ratio of 3.1. Multivariate Cox analysis showed that combining age and central corneal thickness with GCC-FLV in a composite index called "Glaucoma Composite Progression Index" (GCPI) further improved the accuracy of progression prediction. GCC-FLV and GCPI were both found to be significantly correlated with the annual rate of change in VFI. CONCLUSION:Focal GCC and NFL loss as measured by FDOCT are the strongest predictors for VF progression among the measurements considered. Older age and thinner central corneal thickness can enhance the predictive power using the composite risk model.


Am J Ophthalmol


Zhang X,Dastiridou A,Francis BA,Tan O,Varma R,Greenfield DS,Schuman JS,Sehi M,Chopra V,Huang D,Advanced Imaging for Glaucoma Study Group.




Has Abstract


2016-12-01 00:00:00












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    pub_type: 杂志文章


    authors: Vidaurri-Leal J,de Bustros S,Michels RG

    更新日期:1984-10-15 00:00:00

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    abstract:PURPOSE:To describe ocular motility in patients having genetically characterized dominant cerebellar ataxia. DESIGN:Observational case series. METHOD:Nine ataxic adults having the following molecular genetic diagnoses underwent ophthalmic examination and ocular motility recordings: four with spinocerebellar ataxia ty...

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    pub_type: 杂志文章


    authors: Durig JS,Jen JC,Demer JL

    更新日期:2002-05-01 00:00:00

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    abstract:PURPOSE:To investigate the effect of timolol-dorzolamide and timolol-pilocarpine fixed combinations on retrobulbar vessel blood flow. DESIGN:Prospective, randomized, masked, crossover clinical trial. METHODS:Sixteen patients with primary open angle glaucoma, treated with timolol 0.5%, received timolol 0.5%-dorzolamid...

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    authors: Uva MG,Longo A,Reibaldi M,Reibaldi A

    更新日期:2006-06-01 00:00:00

  • Effects of beta-aminopropionitrile after posterior penetrating injury in the rabbit.

    abstract::Beta-aminopropionitrile, an inhibitor of collagen cross-linking, effectively limited the degree of posttraumatic vitreous proliferation in rabbits three weeks after double perforating injury. Light microscopic examination of the sites of perforating injury after five weeks showed minimal intravitreal fibrous prolifera...

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    pub_type: 杂志文章


    authors: Moorhead LC

    更新日期:1983-01-01 00:00:00

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    abstract::We studied cell-mediated immunity to staphylococcal antigens in 116 patients with chronic blepharitis and eight normal subjects. Antibodies in tears and blood were measured. Enhanced cell-mediated immunity to Staphylococcus aureus was demonstrated in 46 of 116 patients (40%) in the absence of antibodies to teichoic ac...

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    pub_type: 杂志文章


    authors: Ficker L,Ramakrishnan M,Seal D,Wright P

    更新日期:1991-04-15 00:00:00

  • Correlation between clinical suspicion and polymerase chain reaction verification of infectious vitritis.

    abstract:PURPOSE:To compare polymerase chain reaction (PCR) results to presumptive clinical diagnosis in patients with vitritis. DESIGN:Retrospective review of PCR laboratory records from vitreous samples. METHODS:Fifty consecutive laboratory records of vitreous samples sent for PCR testing were reviewed. Three reviewers with...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章


    authors: Acharya N,Lietman T,Cevallos V,Whitcher JP,Saidel M,Stone D,Duncan J,Margolis TP

    更新日期:2006-03-01 00:00:00

  • Photic retinopathy from the operating room microscope.

    abstract::Photic retinopathy was produced in two patients after a 60-minute exposure to light from an operating room microscope (Zeiss OpMi 6). The first patient had a blind eye with clear (phakic) media and a normal-appearing retina. A 60-minute exposure produced an oval gray lesion in the posterior pole at the level of the pi...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章


    authors: Robertson DM,Feldman RB

    更新日期:1986-05-15 00:00:00

  • Incidence and Risk Factors of Elevated Intraocular Pressure Following Deep Anterior Lamellar Keratoplasty.

    abstract:PURPOSE:To report the incidence and risk factors of elevated IOP following deep anterior lamellar keratoplasty (DALK). DESIGN:A retrospective case series. METHODS:A retrospective study investigating the 5-year incidence of raised IOP following DALK cases performed from 2004 to 2008 in a tertiary center. Patients with...

    journal_title:American journal of ophthalmology

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    authors: Huang OS,Mehta JS,Htoon HM,Tan DT,Wong TT

    更新日期:2016-10-01 00:00:00

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    abstract:PURPOSE:To report hypertrichosis and increased pigmentation of vellus hairs of the malar region associated with topical bimatoprost usage. DESIGN:Interventional case report METHODS:In a female Hispanic patient with open-angle glaucoma, hypertrichosis, and increased pigmentation of the vellus hairs of the malar region...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章


    authors: Hart J,Shafranov G

    更新日期:2004-04-01 00:00:00

  • Prevalence of ciliochoroidal effusion after prophylactic laser iridotomy.

    abstract:PURPOSE:To study the prevalence of ciliochoroidal effusion (CE) after prophylactic laser iridotomy (LI). METHODS:An ultrasound biomicroscope (UBM) examination was performed before, 2, and 24 hours after LI to investigate the changes in supraciliary-choroidal space after LI in circumference of 38 eyes in 23 chronic pri...

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    authors: Sakai H,Ishikawa H,Shinzato M,Nakamura Y,Sakai M,Sawaguchi S

    更新日期:2003-09-01 00:00:00

  • Leukemic iris infiltration.

    abstract::A 7-year-old boy with acute lymphocytic leukemia developed iris infiltration, blood-streaked hypopyon, and high intraocular pressure. A diagnostic anterior chamber paracentesis was performed, which provided a cytologic diagnosis. The aspirate was studied by both the millipore filter technique with Papanicolaou stain a...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章


    authors: Zakka KA,Yee RD,Shorr N,Smith GS,Pettit TH,Foos RY

    更新日期:1980-02-01 00:00:00

  • Vitrectomy for retinal detachment associated with acute retinal necrosis.

    abstract::Six patients with retinal detachment associated with the acute retinal necrosis syndrome were treated by the combination of vitrectomy, gas injection, and laser photocoagulation. The retinas were successfully reattached in each patient with one operation. Five of the patients achieved a visual acuity of 20/200 or bett...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章


    authors: Blumenkranz M,Clarkson J,Culbertson WW,Flynn HW,Lewis ML,Young GA

    更新日期:1988-10-15 00:00:00

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    abstract:PURPOSE:To determine the clinical differences between three-piece (3P) and single-piece (SP) truncated hydrophobic acrylic intraocular lenses (IOL). DESIGN:Retrospective cohort clinical study. METHODS:The setting was an academic clinical practice. The patient population consisted of subjects without confounding comor...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章


    authors: Wallin TR,Hinckley M,Nilson C,Olson RJ

    更新日期:2003-10-01 00:00:00

  • Serous detachment of the ciliary body in Harada disease.

    abstract:PURPOSE:To evaluate the involvement of the anterior ocular segment in Harada disease. METHODS:In a prospective study, ultrasound biomicroscopy was performed in 18 consecutive eyes of nine patients with Harada disease in its acute phase before and after onset of systemic corticosteroid therapy. Examination was repeated...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章


    authors: Maruyama Y,Kimura Y,Kishi S,Shimizu K

    更新日期:1998-05-01 00:00:00

  • Intraoperative crystallization on the intraocular lens surface.

    abstract:PURPOSE:To report a physician survey, laboratory studies, and clinical observations of intraoperative crystallization on the surface of the intraocular lens (IOL). METHOD:We sent a survey to all ophthalmologists in the states of Wyoming, Idaho, Montana, Utah, and Colorado asking whether crystallization on the IOL surf...

    journal_title:American journal of ophthalmology

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    authors: Olson RJ,Caldwell KD,Crandall AS,Jensen MK,Huang SC

    更新日期:1998-08-01 00:00:00

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    abstract:PURPOSE:To describe the clinical features and complications of diabetic retinopathy, visual acuity, and number of repeat treatments after panretinal photocoagulation for proliferative diabetic retinopathy in a tertiary care center. METHODS:A cohort study was conducted with data collection from medical records of patie...

    journal_title:American journal of ophthalmology

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    authors: Kaiser RS,Maguire MG,Grunwald JE,Lieb D,Jani B,Brucker AJ,Maguire AM,Ho AC,Fine SL

    更新日期:2000-02-01 00:00:00

  • Spontaneous resolution of foveal detachments and macular breaks.

    abstract:PURPOSE:To evaluate the mechanism of spontaneous resolution of foveal detachments and idiopathic macular breaks. METHODS:We reviewed the records of 139 consecutive eyes (94 patients) with either a foveal detachment or a macular break in patients who were examined between 1989 and 1992. There were 26 men and 68 women (...

    journal_title:American journal of ophthalmology

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    authors: Kakehashi A,Schepens CL,Akiba J,Hikichi T,Trempe CL

    更新日期:1995-12-01 00:00:00

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    abstract:PURPOSE:To evaluate the microbiology of pediatric orbital cellulitis associated with sinusitis. DESIGN:Retrospective review of medical records of pediatric patients treated for orbital cellulitis. METHODS:All pediatric patients treated for orbital cellulitis associated with sinusitis at Texas Children's Hospital betw...

    journal_title:American journal of ophthalmology

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    authors: McKinley SH,Yen MT,Miller AM,Yen KG

    更新日期:2007-10-01 00:00:00

  • Complications of hydrogel explants used in scleral buckling surgery.

    abstract:PURPOSE:To report a group of patients with symptoms of pain, strabismus, sensation of orbital fullness, and presence of a subconjunctival mass many years after successful scleral buckling surgery using hydrogel explants. DESIGN:We present an interventional consecutive case series of patients who underwent scleral buck...

    journal_title:American journal of ophthalmology

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    authors: Kearney JJ,Lahey JM,Borirakchanyavat S,Schwartz DM,Wilson D,Tanaka SC,Robins D

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  • Serious corneal complications of glaucoma filtering surgery with postoperative 5-fluorouracil.

    abstract::We studied four patients who, having received postoperative 5-fluorouracil after glaucoma filtering operations, developed serious corneal complications. All four patients had preexisting corneal abnormalities including keratoconjunctivitis sicca, exposure keratopathy, and bullous keratopathy. All of the patients devel...

    journal_title:American journal of ophthalmology

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    authors: Knapp A,Heuer DK,Stern GA,Driebe WT Jr

    更新日期:1987-02-15 00:00:00

  • Peripheral Changes Associated With Delayed Dark Adaptation in Age-related Macular Degeneration.

    abstract:PURPOSE:To study the association between peripheral changes in age-related macular degeneration (AMD) and dark adaptation (DA). DESIGN:Prospective, cross-sectional study. METHODS:We recruited patients with AMD and a control group (>50 years) without any vitreoretinal disease. Ultra-widefield (UWF) pseudocolor and fun...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章


    authors: Laíns I,Park DH,Mukai R,Silverman R,Oellers P,Mach S,Kim IK,Vavvas DG,Miller JW,Miller JB,Husain D

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  • The removal of the deep lateral wall in orbital decompression: its contribution to exophthalmos reduction and influence on consecutive diplopia.

    abstract:PURPOSE:To evaluate the contribution of maximal removal of the deep lateral wall of the orbit to exophthalmos reduction in Graves' orbitopathy and its influence on the onset of consecutive diplopia. DESIGN:Case-control study. METHODS:The medical records of two cohorts of patients affected by Graves' orbitopathy with ...

    journal_title:American journal of ophthalmology

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    authors: Baldeschi L,MacAndie K,Hintschich C,Wakelkamp IM,Prummel MF,Wiersinga WM

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  • Recurrent anterior uveitis associated with streptococcal pharyngitis in a patient with a history of poststreptococcal syndrome.

    abstract:PURPOSE:To provide additional evidence that anterior uveitis can be a manifestation of poststreptococcal syndrome. METHOD:A case report providing follow-up information on a previously described patient. RESULTS:An adolescent girl in whom anterior uveitis was the only manifestation of poststreptococcal syndrome subseq...

    journal_title:American journal of ophthalmology

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    authors: Holland GN

    更新日期:1999-03-01 00:00:00

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    abstract::We conducted a retrospective study of 25 patients with acute-onset comitant esotropia to evaluate whether the timing of the start of treatment is a critical factor in the development of normal stereopsis. The mean age at onset was 12 years 4 months, and mean age at the start of treatment was 17 years 9 months. Bifixat...

    journal_title:American journal of ophthalmology

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    authors: Ohtsuki H,Hasebe S,Kobashi R,Okano M,Furuse T

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    authors: Chauhan BC,Drance SM,Douglas GR

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    authors: Cohen KL,Peiffer RL,Lipper S

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