Abstract：
PURPOSE:We hypothesized that major American dietary patterns are associated with risk for age-related macular degeneration (AMD). DESIGN:Cross-sectional study. METHODS:We classified 8103 eyes in 4088 eligible participants in the baseline Age-Related Eye Disease Study (AREDS). They were classified into control (n = 2739), early AMD (n = 4599), and advanced AMD (n = 765) by the AREDS AMD Classification System. Food consumption data were collected by using a 90-item food frequency questionnaire. RESULTS:Two major dietary patterns were identified by factor (principal component) analysis based on 37 food groups and named Oriental and Western patterns. The Oriental pattern was characterized by higher intake of vegetables, legumes, fruit, whole grains, tomatoes, and seafood. The Western pattern was characterized by higher intake of red meat, processed meat, high-fat dairy products, French fries, refined grains, and eggs. We ranked our participants according to how closely their diets line up with the 2 patterns by calculating the 2 factor scores for each participant. For early AMD, multivariate-adjusted odds ratio (OR) from generalized estimating equation logistic analysis comparing the highest to lowest quintile of the Oriental pattern score was ORE5O = 0.74 (95% confidence interval (CI): 0.59-0.91; Ptrend =0.01), and the OR comparing the highest to lowest quintile of the Western pattern score was ORE5W = 1.56 (1.18-2.06; Ptrend = 0.01). For advanced AMD, the ORA5O was 0.38 (0.27-0.54; Ptrend < 0.0001), and the ORA5W was 3.70 (2.31-5.92; Ptrend < 0.0001). CONCLUSIONS:Our data indicate that overall diet is significantly associated with the odds of AMD and that dietary management as an AMD prevention strategy warrants further study.
journal_name
Am J Ophthalmoljournal_title
American journal of ophthalmologyauthors
Chiu CJ,Chang ML,Zhang FF,Li T,Gensler G,Schleicher M,Taylor Adoi
10.1016/j.ajo.2014.04.016subject
Has Abstractpub_date
2014-07-01 00:00:00pages
118-127.e1issue
1eissn
0002-9394issn
1879-1891pii
S0002-9394(14)00219-0journal_volume
158pub_type
杂志文章abstract：PURPOSE:To summarize observational studies that focus on the use of glaucoma medications and to identify gaps in knowledge to guide future investigation. DESIGN:Literature study. METHODS:We searched the electronic databases MEDLINE, EMBASE, and PubMed for English language articles published through December 2009 usin...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2010.05.005
更新日期：2010-10-01 00:00:00
abstract：PURPOSE:To evaluate the safety and potential efficacy of gevokizumab, an anti-interleukin 1β (IL-1β) monoclonal antibody, in the treatment of active, noninfectious, non-necrotizing anterior scleritis. DESIGN:Phase 1/2, open label, nonrandomized, prospective, single-arm pilot trial. METHODS:Eight patients with active,...
journal_title：American journal of ophthalmology
pub_type： 临床试验,杂志文章
doi：10.1016/j.ajo.2016.09.017
更新日期：2016-12-01 00:00:00
abstract：PURPOSE:To report an HIV-negative lymphoma patient who developed progressive outer retinal necrosis syndrome and who had a good visual outcome after treatment with two-drug antiviral therapy and intravenous immunoglobulin. METHODS:Case report. RESULTS:A 43-year-old man with small lymphocytic lymphoma was diagnosed wi...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(00)00951-x
更新日期：2001-07-01 00:00:00
abstract：PURPOSE:To investigate the complication profile and the long-term functional outcome of combined pars plana vitrectomy and scleral-fixated sutured posterior chamber lens (PC IOL) implantation. DESIGN:Retrospective, consecutive, interventional case series. METHODS:The records of 63 patients (mean age, 67.5 years) were...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2007.05.014
更新日期：2007-09-01 00:00:00
abstract：PURPOSE:To determine the incidence and possible causes of a late recurrence of a retinal detachment (RD) in eyes with stages 4B and 5 retinopathy of prematurity (ROP), in which the retina was once reattached by lensectomy and vitrectomy. DESIGN:Retrospective, comparative case series. METHODS:The medical records of 12...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2008.10.006
更新日期：2009-04-01 00:00:00
abstract：PURPOSE:To report the clinicopathologic findings in patient with optic nerve sheath hemangiopericytoma. DESIGN:Clinicopathologic report. METHODS:The clinical, histologic, and immunohistochemical findings of a patient with optic nerve sheath hemangiopericytoma were reviewed. RESULTS:An excisional biopsy of an optic n...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2006.11.046
更新日期：2007-05-01 00:00:00
abstract：PURPOSE:To investigate whether abnormal glucose metabolism and duration of diabetes mellitus (DM) affected the corneal and lens clarity in children with well-controlled type 1 DM and to compare the results obtained with those in healthy children. DESIGN:Cross-sectional prospective study. METHODS:This multicenter stud...
journal_title：American journal of ophthalmology
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.ajo.2017.05.010
更新日期：2017-07-01 00:00:00
abstract：PURPOSE:To report intraocular oxygen tension in eyes of diabetic and nondiabetic patients. DESIGN:A prospective, interventional consecutive case series. METHODS:Oxygen was measured with an optical oxygen sensor in patients who were undergoing vitrectomy. Before turning on the infusion fluid, intraocular oxygen tensio...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2006.01.016
更新日期：2006-06-01 00:00:00
abstract：PURPOSE:In juvenile X-linked retinoschisis (XLRS), fluorescein angiography is usually unremarkable and contributes poorly to the diagnosis. However, indocyanine green (ICG) angiography features in eyes that are affected with XLRS were not yet described. DESIGN:Retrospective observational case series. METHODS:A comple...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2005.03.051
更新日期：2005-09-01 00:00:00
abstract：:There is no single method of perimetric examination which is applicable to all types of visual field defects. Perimetry is a subjective psychophysical sensory examination. It is not an exact science unless one includes the objective measurement of visual evoked response in the optic cortex. Until such a method becomes...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(75)90527-9
更新日期：1975-09-01 00:00:00
abstract：PURPOSE:To determine the relationship between delayed patchy choroidal filling and morphologic and functional outcomes among eyes treated with ranibizumab or bevacizumab. DESIGN:Cohort study. METHODS:Comparison of Age-related Macular Degeneration Treatment Trials participants were assigned randomly to ranibizumab or ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.ajo.2014.06.004
更新日期：2014-09-01 00:00:00
abstract：PURPOSE:To report two patients with severe fungal corneal ulcers who were treated successfully with topical amphotericin B ointment. METHODS:Two eyes of two patients developed corneal ulcers and hypopyon after corneal foreign body removal. Aspergillus fumigatus and Fusarium solani were isolated in Patients 1 and 2, re...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)71701-5
更新日期：1997-12-01 00:00:00
abstract：PURPOSE:To report hypertrichosis and increased pigmentation of vellus hairs of the malar region associated with topical bimatoprost usage. DESIGN:Interventional case report METHODS:In a female Hispanic patient with open-angle glaucoma, hypertrichosis, and increased pigmentation of the vellus hairs of the malar region...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2003.09.002
更新日期：2004-04-01 00:00:00
abstract：PURPOSE:We performed a histopathologic and immunohistologic study to determine the macromolecular and cellular components of subfoveal neovascular membranes removed at the time of submacular surgery. METHODS:Subfoveal neovascular membranes were surgically removed from ten patients (seven with age-related macular degen...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)72158-0
更新日期：1995-09-01 00:00:00
abstract：PURPOSE:To describe a Japanese patient with incomplete congenital stationary night blindness (iCSNB) with atypical retinal atrophy and kinetic visual field defects. METHODS:An ophthalmologic examination was performed, and the CACNA1F gene was analyzed by direct genomic sequencing. RESULTS:The patient had a hemizygous...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(02)01541-6
更新日期：2002-09-01 00:00:00
abstract：:The location of repository corticosteroid after subtenon injection was determined in 24 patients with macular edema associated with uveitis or anterior segment surgery. Standardized A-scan and B-scan echography were performed immediately before and after each injection. Localization was compared after subtenon injecti...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：
更新日期：1987-03-15 00:00:00
abstract：PURPOSE:To describe the clinical characteristics and course of optic disk edema (ODE) associated with isolated sudden-onset anterior uveitis. DESIGN:Interventional, noncomparative retrospective case series. METHODS:Review of patients with sudden-onset anterior uveitis and concomitant ODE seen in an academic uveitis r...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2005.03.062
更新日期：2005-10-01 00:00:00
abstract：:We used 2.15 to 2.3% collodion in amyl acetate to form a replica of the corneal surface epithelium in vivo in seven rabbit eyes and ten human eyes. When it was peeled off the replica removed superficial epithelial cells in patches. The corneal epithelium regenerated within one week. Repeated applications at weekly int...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(77)90333-6
更新日期：1977-07-01 00:00:00
abstract：PURPOSE:To evaluate complications and clinical outcomes of Descemet stripping automated endothelial keratoplasty in eyes with preexisting anterior chamber intraocular lenses. DESIGN:Retrospective review. METHODS:Thirty-one patients who underwent Descemet stripping automated endothelial keratoplasty and who had a pree...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2010.07.003
更新日期：2011-01-01 00:00:00
abstract：PURPOSE:To study the glistening formation in various hydrophobic-acrylic intraocular lens (IOL) models, and to evaluate the effect of glistenings on light scattering in these IOLs. DESIGN:Laboratory investigation. METHODS:The susceptibility of the hydrophobic-acrylic material to develop glistenings was evaluated in 6...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2018.08.032
更新日期：2018-12-01 00:00:00
abstract：:We performed 115 scleral-buckling procedures for primary rhegmatogenous retinal detachments in which the argon endolaser drained subretinal fluid. The laser was set at 0.80 to 1.25 W and 0.5 second; the endolaser probe was held adjacent to, but not touching, the choroid. The procedure was successful in 112 of 115 (97....
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)73643-8
更新日期：1993-06-15 00:00:00
abstract：PURPOSE:To determine the clinical differences between three-piece (3P) and single-piece (SP) truncated hydrophobic acrylic intraocular lenses (IOL). DESIGN:Retrospective cohort clinical study. METHODS:The setting was an academic clinical practice. The patient population consisted of subjects without confounding comor...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(03)00418-5
更新日期：2003-10-01 00:00:00
abstract：:I have modified a Maumenee-Park eyelid speculum to permit eyelid retraction in the direct plane of action of the lids and to avoid pressure on the globe from the speculum weight. A ball-joint at the end of the blade allows the blade to adjust with the eyelid. Increased angulation of the sidearm places the blade perpen...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(82)90711-5
更新日期：1982-01-01 00:00:00
abstract：:The Prospective Evaluation of Radial Keratotomy Study is a nine-center clinical trial of a standardized technique of radial keratotomy in 435 patients who had simple myopia with a preoperative refraction between -2.00 and -8.00 diopters. We studied the stability of the refractive error during four years after surgery ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)72250-0
更新日期：1991-02-15 00:00:00
abstract：PURPOSE:To assess baseline and follow-up characteristics of choroidal neovascularization (CNV) lesions in age-related macular degeneration in relation to the development of subfoveal subretinal fibrosis. DESIGN:Retrospective, observational case series. METHODS:settings and study population: One hundred ninety-seven t...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2013.02.012
更新日期：2013-07-01 00:00:00
abstract：PURPOSE:To determine whether spectral-domain optical coherence tomography (SD-OCT) disorganization of the retinal inner layers (DRIL) is predictive of best-corrected visual acuity (BCVA) in retinal vein occlusion macular edema (RVO-ME). DESIGN:Retrospective cohort study. METHODS:Setting: Two tertiary centers. PATIEN...
journal_title：American journal of ophthalmology
pub_type： 杂志文章,多中心研究
doi：10.1016/j.ajo.2017.08.005
更新日期：2017-10-01 00:00:00
abstract：PURPOSE:To report a patient with unilateral vision loss and neovascular glaucoma after attempted superior ophthalmic vein embolization in the treatment of a carotid-cavernous sinus fistula. METHODS:A 69-year-old man with a history of a left dural carotid-cavernous sinus fistula underwent attempted treatment with super...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)71711-8
更新日期：1997-12-01 00:00:00
abstract：PURPOSE:To evaluate the diagnostic performance characteristics of the Van Herick assessment (VHA) for identifying angle closure compared to gold-standard gonioscopy, as conducted by trained observers of varying expertise. DESIGN:Reliability analysis. METHODS:Patients (n = 131) from a glaucoma referral clinic aged ≥50...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2018.07.026
更新日期：2018-11-01 00:00:00
abstract：PURPOSE:To report endoscopic findings in the anterior chamber angle during injection of viscoelastic material in viscocanalostomy (VCS). DESIGN:Observational case reports. METHODS:Two cases of primary open-angle glaucoma were treated with VCS and cataract surgery. Immediately before and during injection of viscoelast...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2004.06.040
更新日期：2004-12-01 00:00:00
abstract：:We studied 20 patients with Vogt-Koyanagi-Harada syndrome. They represented 3.7% of referred patients with uveitis. American Indian ancestry appears to be the link to Oriental racial type. Five patients had a forme fruste retinal detachment. After extensive treatment with corticosteroids, detachments flattened within ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：
更新日期：1980-07-01 00:00:00
