Treatment of fungal corneal ulcers with amphotericin B ointment.

Abstract:

PURPOSE:To report two patients with severe fungal corneal ulcers who were treated successfully with topical amphotericin B ointment. METHODS:Two eyes of two patients developed corneal ulcers and hypopyon after corneal foreign body removal. Aspergillus fumigatus and Fusarium solani were isolated in Patients 1 and 2, respectively. By antifungal susceptibility testing, amphotericin B was shown to have the lowest minimal inhibitory concentration. RESULT:Topical administration of amphotericin B ointment resulted in dramatic improvement in fungal corneal ulcers. CONCLUSIONS:Antifungal susceptibility tests may aid with selection of antifungal agents. Amphotericin B ointment is one of the promising therapies for keratomycosis caused by antimycotic-resistant fungi.

journal_name

Am J Ophthalmol

authors

Hirose H,Terasaki H,Awaya S,Yasuma T

doi

10.1016/s0002-9394(14)71701-5

subject

Has Abstract

pub_date

1997-12-01 00:00:00

pages

836-8

issue

6

eissn

0002-9394

issn

1879-1891

pii

S0002-9394(14)71701-5

journal_volume

124

pub_type

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