The replica technique used to study superficial corneal epithelium in vivo.


:We used 2.15 to 2.3% collodion in amyl acetate to form a replica of the corneal surface epithelium in vivo in seven rabbit eyes and ten human eyes. When it was peeled off the replica removed superficial epithelial cells in patches. The corneal epithelium regenerated within one week. Repeated applications at weekly intervals for three months produced no harmful long-term effects in five rabbit corneas as evaluated with slit-lamp biomicroscopy, histological methods, and vital staining of the endothelium. In ten human eyes, the technique was harmless and chemically cauterized the dendritic herpetic ulcers. We studied the replicas and cells by conventional histological methods and electron microscopy. The preservation of cells was fairly good even for ultrastructural study.


Am J Ophthalmol


Missotten L,Maudgal PC




Has Abstract


1977-07-01 00:00:00














  • The incidence of Graves' ophthalmopathy in Olmsted County, Minnesota.

    abstract:PURPOSE:To determine the incidence of Graves' ophthalmopathy. METHODS:A population-based cohort of all Olmsted County, Minnesota, residents who had ophthalmopathy associated with autoimmune thyroid disease between Jan. 1, 1976, and Dec. 31, 1990, was identified through the medical diagnostic index of the Mayo Clinic a...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章


    authors: Bartley GB,Fatourechi V,Kadrmas EF,Jacobsen SJ,Ilstrup DM,Garrity JA,Gorman CA

    更新日期:1995-10-01 00:00:00

  • Histologic study of eyes with transsclerally sutured posterior chamber intraocular lenses.

    abstract::We studied the postmortem histologic characteristics of two eyes that had undergone penetrating keratoplasty and transscleral suturing of a posterior chamber intraocular lens for bullous keratopathy. The eyes were studied three days postoperatively in a 79-year-old man with pseudophakia and six months postoperatively ...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章


    authors: Lubniewski AJ,Holland EJ,Van Meter WS,Gussler D,Parelman J,Smith ME

    更新日期:1990-09-15 00:00:00

  • Treatment of infantile capillary hemangioma of the eyelid with systemic propranolol.

    abstract:PURPOSE:To assess the efficacy and safety of systemic propranolol for infantile capillary hemangiomas of the eyelid. DESIGN:Prospective, interventional cases series. METHODS:All patients with eyelid infantile capillary hemangiomas at risk of developing amblyopia seen between January 2009 and January 2012 at the Unive...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章


    authors: Vassallo P,Forte R,Di Mezza A,Magli A

    更新日期:2013-01-01 00:00:00

  • Long-term safety and functional outcome of combined pars plana vitrectomy and scleral-fixated sutured posterior chamber lens implantation.

    abstract:PURPOSE:To investigate the complication profile and the long-term functional outcome of combined pars plana vitrectomy and scleral-fixated sutured posterior chamber lens (PC IOL) implantation. DESIGN:Retrospective, consecutive, interventional case series. METHODS:The records of 63 patients (mean age, 67.5 years) were...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章


    authors: Bading G,Hillenkamp J,Sachs HG,Gabel VP,Framme C

    更新日期:2007-09-01 00:00:00

  • Trends in Prevalence of Diagnosed Ocular Disease and Utilization of Eye Care Services in American Veterans.

    abstract:PURPOSE:To assess trends in prevalence of diagnosed ocular disease and use of eye care services in the Veterans Affairs (VA) health care system. DESIGN:Prevalence study. METHODS:We performed a retrospective study of all eligible veterans in the VA Capitol Health Care Network from 2007 to 2011. The VA database was use...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章,多中心研究


    authors: Saeedi O,Ashraf H,Slade EP,Medoff DR,Li L,Friedman DS,Kreyenbuhl J

    更新日期:2017-01-01 00:00:00

  • Contact lens disinfection by ultraviolet light.

    abstract::A 253.7-nm ultraviolet light with an intensity of 1,100 microW/cm2 was tested for its germicidal activity against contact lenses and storage solutions contaminated with various corneal pathogens. The exposure time necessary to reduce a concentration of organisms from 10(6)/ml to less than 10/ml was 30 seconds for Stap...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章


    authors: Dolman PJ,Dobrogowski MJ

    更新日期:1989-12-15 00:00:00

  • Comparison of clinical characteristics between Korean and Western normal-tension glaucoma patients.

    abstract:PURPOSE:To detect potential differences in the phenotypes between Western normal-tension glaucoma (NTG) and Korean NTG. DESIGN:A retrospective, cross-sectional study. METHODS:One hundred eighty-four NTG eyes of 71 patients of the Jules Stein Eye Institute, University of California, Los Angeles, and 113 patients of th...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章,多中心研究


    authors: Kim JM,Jeoung JW,Bitrian E,Supawavej C,Mock D,Park KH,Caprioli J

    更新日期:2013-05-01 00:00:00

  • Iris color and intraocular pressure: the Blue Mountains Eye Study.

    abstract:PURPOSE:To assess the relationship between iris color and intraocular pressure (IOP). DESIGN:Population-based, cross-sectional study. METHODS:The Blue Mountains Eye Study examined 3,654 largely Caucasian participants, aged 49 to 97 years, from 1992 to 1994. Information was collected about glaucoma risk factors, and G...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章


    authors: Mitchell R,Rochtchina E,Lee A,Wang JJ,Mitchell P,Blue Mountains Eye Study.

    更新日期:2003-03-01 00:00:00

  • Contraction of a perifoveal epiretinal membrane simulating a macular hole.

    abstract::Four patients observed for a three- to four-year period had a hole in an epiretinal membrane overlying the macula that mimicked a macular hole. In two patients the clinical appearance remained essentially constant. In one, the epiretinal membrane contracted further, reducing the apparent macular hole to a slit and cau...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章


    authors: Allen AW Jr,Gass JD

    更新日期:1976-11-01 00:00:00

  • Evaluation of retinal and choroidal thickness by swept-source optical coherence tomography: repeatability and assessment of artifacts.

    abstract:PURPOSE:To determine the repeatability of automated retinal and choroidal thickness measurements with swept-source optical coherence tomography (SS OCT) and the frequency and type of scan artifacts. DESIGN:Prospective evaluation of new diagnostic technology. METHODS:Thirty healthy subjects were recruited prospectivel...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章


    authors: Mansouri K,Medeiros FA,Tatham AJ,Marchase N,Weinreb RN

    更新日期:2014-05-01 00:00:00

  • Subretinal neovascular membranes in Vogt-Koyanagi-Harada syndrome.

    abstract::Subretinal neovascular membranes cause late visual loss and are important determinants of final visual acuity in patients with Vogt-Koyanagi-Harada syndrome. The purpose of this study was to determine the prevalence and risk factors associated with the development of subretinal neovascular membranes in Vogt-Koyanagi-H...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章


    authors: Moorthy RS,Chong LP,Smith RE,Rao NA

    更新日期:1993-08-15 00:00:00

  • Severe vision loss and neovascular glaucoma complicating superior ophthalmic vein approach to carotid-cavernous sinus fistula.

    abstract:PURPOSE:To report a patient with unilateral vision loss and neovascular glaucoma after attempted superior ophthalmic vein embolization in the treatment of a carotid-cavernous sinus fistula. METHODS:A 69-year-old man with a history of a left dural carotid-cavernous sinus fistula underwent attempted treatment with super...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章


    authors: Gupta N,Kikkawa DO,Levi L,Weinreb RN

    更新日期:1997-12-01 00:00:00

  • Correlation between clinical suspicion and polymerase chain reaction verification of infectious vitritis.

    abstract:PURPOSE:To compare polymerase chain reaction (PCR) results to presumptive clinical diagnosis in patients with vitritis. DESIGN:Retrospective review of PCR laboratory records from vitreous samples. METHODS:Fifty consecutive laboratory records of vitreous samples sent for PCR testing were reviewed. Three reviewers with...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章


    authors: Acharya N,Lietman T,Cevallos V,Whitcher JP,Saidel M,Stone D,Duncan J,Margolis TP

    更新日期:2006-03-01 00:00:00

  • Proliferative diabetic retinopathy in patients with defects of platelet function.

    abstract::A 71-year-old woman had von Willebrand's disease, an inheritable abnormality of platelet activity, and developed diabetic retinal neovascularization. A 59-year-old man had a myeoloproliferative disorder with thrombocythemia but may have had retinal changes before the development of his platelet dysfunction. The occurr...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章


    authors: Ho PC,Feman SS,Stein RS,McKee LC

    更新日期:1979-07-01 00:00:00

  • Fundus flavimaculatus and Stargardt's disease.

    abstract::Of 42 patients studied who had fundus flavimaculatus and Stargardt's disease, most had reduced visual acuity due to an atrophic macular lesion. Family histories were consistent with autosomal-recessive inheritance. In some young patients, the yellow-white flecks developed with time, while in some older patients the fl...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章


    authors: Hadden OB,Gass JD

    更新日期:1976-10-01 00:00:00

  • Electromyographic studies of the reconstructed lower eyelid after a modified Hughes procedure.

    abstract:PURPOSE:We evaluated quantitatively, with electromyography, the function of orbicularis oculi muscle flaps in modified Hughes reconstructions of the lower eyelids. METHODS:A modified Hughes procedure with a bipedicle orbicularis oculi flap was used to reconstruct large left lower eyelid defects after tumor excision in...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章


    authors: Lowry JC,Bartley GB,Litchy WJ

    更新日期:1995-02-01 00:00:00

  • A controlled five-year follow-up study of laser trabeculoplasty as primary therapy for open-angle glaucoma.

    abstract::We followed up 32 eyes of 32 patients with early glaucoma (22 with capsular glaucoma and ten with simple glaucoma) who received laser trabeculoplasty as a primary therapy. These eyes were compared with a matched control group of 32 eyes treated with medication initially. The success rate (intraocular pressure below 22...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章


    authors: Tuulonen A,Niva AK,Alanko HI

    更新日期:1987-10-15 00:00:00

  • Scanning laser polarimetry with variable corneal compensation and optical coherence tomography in normal and glaucomatous eyes.

    abstract:PURPOSE:To evaluate the relationship between visual function and retinal nerve fiber layer (RNFL) measurements obtained with scanning laser polarimetry with variable corneal compensation (SLP-VCC) and optical coherence tomography (OCT). DESIGN:Cross-sectional analysis of normal and glaucomatous eyes in a tertiary care...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章


    authors: Bagga H,Greenfield DS,Feuer W,Knighton RW

    更新日期:2003-04-01 00:00:00

  • Neovasculogenic ability of prostaglandins, growth factors, and synthetic chemoattractants.

    abstract::Prostaglandins E1, E2, D2, A1, F1alpha, and F2alpha as well as synthetic chemoattractants and growth factors were tested for their ability to induce the proliferation of new blood vessels in the rabbit cornea. PGE1 showed the strongest neovasculogenic activity attracting new blood vessels in all of the cases. PGE2 was...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章


    authors: BenEzra D

    更新日期:1978-10-01 00:00:00

  • Identification of new pathogens in the intraocular fluid of patients with uveitis.

    abstract:PURPOSE:To determine infectious causes in patients with uveitis of unknown origin by intraocular fluids analysis. DESIGN:Case-control study. METHODS:Ocular fluids from 139 patients suspected of infectious uveitis, but negative for herpes simplex virus, varicella-zoster virus, cytomegalovirus, and Toxoplasma gondii by...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章


    authors: de Groot-Mijnes JD,de Visser L,Zuurveen S,Martinus RA,Völker R,ten Dam-van Loon NH,de Boer JH,Postma G,de Groot RJ,van Loon AM,Rothova A

    更新日期:2010-11-01 00:00:00

  • A fluidics comparison of Alcon Infiniti, Bausch & Lomb Stellaris, and Advanced Medical Optics Signature phacoemulsification machines.

    abstract:PURPOSE:To compare three phacoemulsification machines for measurement accuracy and postocclusion surge (POS) in human cadaver eyes. DESIGN:In vitro comparisons of machine accuracy and POS. METHODS:Tip vacuum and flow were compared with machine indicated vacuum and flow. All machines were placed in two human cadaver e...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章


    authors: Georgescu D,Kuo AF,Kinard KI,Olson RJ

    更新日期:2008-06-01 00:00:00

  • Herpetic stromal keratitis-evidence for cell-mediated immunopathogenesis.

    abstract::Immunofluorescence, histological, and electron microscopic observations were made on rabbit corneas from animals with experimentally induced stromal keratitis following intracorneal injection with the RE strain of herpes simplex virus. Electron microscopic observations were also made on human corneas obtained from pat...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章


    authors: Metcalf JF,Kaufman HE

    更新日期:1976-12-01 00:00:00

  • The Expanded Spectrum of Perifoveal Exudative Vascular Anomalous Complex.

    abstract:PURPOSE:To expand our understanding of the uncommon entity, referred to as perifoveal exudative vascular anomalous complex (PEVAC) by describing multimodal imaging findings, including optical coherence tomography angiography (OCT-A). DESIGN:Retrospective cohort study. METHODS:Patients diagnosed with PEVAC were identi...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章,多中心研究


    authors: Sacconi R,Freund KB,Yannuzzi LA,Dolz-Marco R,Souied E,Capuano V,Semoun O,Phasukkijwatana N,Sarraf D,Carnevali A,Querques L,Bandello F,Querques G

    更新日期:2017-12-01 00:00:00

  • Corneal toxicity with systemic cytarabine.

    abstract::Three patients with leukemia developed corneal toxicity while receiving high doses (3 g/m2) of systemic cytarabine. Symptoms began five to seven days after initiation of treatment with high doses of systemic cytarabine and consisted of ocular pain, tearing, foreign-body sensation, photophobia, and blurred vision. All ...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章


    authors: Hopen G,Mondino BJ,Johnson BL,Chervenick PA

    更新日期:1981-04-01 00:00:00

  • Disk drusen and angioid streaks in pseudoxanthoma elasticum.

    abstract::Visual field loss secondary to optic disk drusen became evident before the development of angioid streaks in a patient with pseudoxanthoma elasticum. The incidence of optic disk drusen in cases of pseudoxanthoma elasticum is 20 to 50 times greater than that in the healthy population. We postulate that the abnormal agg...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章


    authors: Coleman K,Ross MH,Mc Cabe M,Coleman R,Mooney D

    更新日期:1991-08-15 00:00:00

  • Autosomal recessive pericentral pigmentary retinopathy.

    abstract::A brother and sister, born to consanguineous parents, had pigmentary retinopathy in a pericentral distribution. The retinopathy was noted in infancy when the siblings were examined for strabismus. The optic disks, maculae, and retinal vessels were normal. There was mild reduction in amplitude of both scotopic and phot...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章


    authors: Traboulsi EI,O'Neill JF,Maumenee IH

    更新日期:1988-11-15 00:00:00

  • Long-Term Outcomes after Surgery for Late In-The-Bag Intraocular Lens Dislocation: A Randomized Clinical Trial.

    abstract:PURPOSE:To compare the long-term efficacy and safety of 2 operation methods for late in-the-bag intraocular lens (IOL) dislocation. DESIGN:Prospective, randomized, parallel group surgical clinical trial. METHODS:During a 3-year period, 104 patients (104 eyes) were assigned one group for IOL repositioning by scleral s...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章,随机对照试验


    authors: Dalby M,Kristianslund O,Drolsum L

    更新日期:2019-11-01 00:00:00

  • Sarcoidosis-related Uveitis: Clinical Presentation, Disease Course, and Rates of Systemic Disease Progression After Uveitis Diagnosis.

    abstract:OBJECTIVE:To document the clinical presentation, treatment, and visual outcome of sarcoid uveitis and to determine the timing and potential risk factors of sarcoidosis progression to symptomatic systemic disease from the time of sarcoid uveitis diagnosis. DESIGN:Retrospective, interventional case series. METHODS:Subj...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章


    authors: Ma SP,Rogers SL,Hall AJ,Hodgson L,Brennan J,Stawell RJ,Lim LL

    更新日期:2019-02-01 00:00:00

  • Safety and effectiveness of concomitant administration of dipivefrin and timolol maleate.

    abstract::Dipivefrin, an epinephrine prodromal drug, was used in conjunction with timolol maleate to evaluate the safety and effectiveness of combined therapy. Seventeen patients who had used timolol maleate for at least six months added dipivefrin (Group 1) and seven patients who had used dipivefrin for at least six months add...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章


    authors: Keates EU,Stone RA

    更新日期:1981-02-01 00:00:00

  • Leukemic involvement of the optic nerve.

    abstract::We studied five cases of leukemia with invasion of the optic disk and optic nerve. Two patients had acute lymphoblastic leukemia and three had acute myelogenous leukemia. All patients received intrathecal injections of chemotherapeutic drugs including methotrexate, cytarabine, and prednisolone. Three patients underwen...

    journal_title:American journal of ophthalmology

    pub_type: 杂志文章


    authors: Nikaido H,Mishima H,Ono H,Choshi K,Dohy H

    更新日期:1988-03-15 00:00:00