Abstract:
PURPOSE:The prediction of atherosclerosis using retinal fundus images and deep learning has not been shown possible. The purpose of this study was to develop a deep learning model which predicted atherosclerosis by using retinal fundus images and to verify its clinical implications by conducting a retrospective cohort analysis. DESIGN:Retrospective cohort study. METHODS:The database at the Health Promotion Center of Seoul National University Hospital (HPC-SNUH) was used. The deep learning model was trained using 15,408 images to predict carotid artery atherosclerosis, which was named the deep-learning funduscopic atherosclerosis score (DL-FAS). A retrospective cohort was constructed of participants 30-80 years old who had completed elective health examinations at HPC-SNUH. Using DL-FAS as the main exposure, participants were followed for the primary outcome of death due to CVD until Dec. 31, 2017. RESULTS:For predicting carotid artery atherosclerosis among subjects, the model achieved an area under receiver operating curve (AUROC) and area under the precision-recall curve (AUPRC), accuracy, sensitivity, specificity, positive and negative predictive values of 0.713, 0.569, 0.583, 0.891, 0.404, 0.465, and 0.865 respectively. The cohort consisted of 32,227 participants, 78 cardiovascular disease (CVD) deaths, and 7.6-year median follow-up visits. Those with DL-FAS greater than 0.66 had an increased risk of CVD deaths compared to those with DL-FAS <0.33 (hazard ratio: 8.33; 95% confidence interval [CI], 3.16-24.7). Risk association was significant among intermediate and high Framingham risk score (FRS) subgroups. The DL-FAS improved the concordance by 0.0266 (95% CI, 0.0043-0.0489) over the FRS-only model. The relative integrated discrimination index was 20.45% and net reclassification index was 29.5%. CONCLUSIONS:A deep learning model was developed which could predict atherosclerosis from retinal fundus images. The resulting DL-FAS was an independent predictor of CVD deaths when adjusted for FRS and added predictive value over FRS.
journal_name
Am J Ophthalmoljournal_title
American journal of ophthalmologyauthors
Chang J,Ko A,Park SM,Choi S,Kim K,Kim SM,Yun JM,Kang U,Shin IH,Shin JY,Ko T,Lee J,Oh BL,Park KHdoi
10.1016/j.ajo.2020.03.027subject
Has Abstractpub_date
2020-09-01 00:00:00pages
121-130eissn
0002-9394issn
1879-1891pii
S0002-9394(20)30127-6journal_volume
217pub_type
杂志文章abstract:PURPOSE:To compare the long-term efficacy and safety of 2 operation methods for late in-the-bag intraocular lens (IOL) dislocation. DESIGN:Prospective, randomized, parallel group surgical clinical trial. METHODS:During a 3-year period, 104 patients (104 eyes) were assigned one group for IOL repositioning by scleral s...
journal_title:American journal of ophthalmology
pub_type: 杂志文章,随机对照试验
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更新日期:2019-11-01 00:00:00
abstract::We evaluated the effect of a collagen shield on epithelial healing in keratectomy wounds in rabbit eyes. Superficial keratectomies 6 mm in diameter were created in 12 eyes of six rabbits. Six eyes received collagen shields every eight hours; six eyes received no treatment (control group). Epithelial healing was signif...
journal_title:American journal of ophthalmology
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doi:10.1016/0002-9394(89)90428-5
更新日期:1989-11-15 00:00:00
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journal_title:American journal of ophthalmology
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doi:10.1016/0002-9394(75)90464-x
更新日期:1975-01-01 00:00:00
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更新日期:2017-10-01 00:00:00
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journal_title:American journal of ophthalmology
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更新日期:2006-11-01 00:00:00
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journal_title:American journal of ophthalmology
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更新日期:1975-10-01 00:00:00
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journal_title:American journal of ophthalmology
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更新日期:1989-10-15 00:00:00
abstract::A microsurgical modification of the Rizzuti scleral fixation forceps for corneal and cataract surgery employs Bonn 0.12-mm teeth on an angled handle with an appropriate curve between the teeth to fix the tissue more adequately to allow accurate placement of sutures. ...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
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更新日期:1976-12-01 00:00:00
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journal_title:American journal of ophthalmology
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更新日期:2001-02-01 00:00:00
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journal_title:American journal of ophthalmology
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doi:
更新日期:1999-03-01 00:00:00
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journal_title:American journal of ophthalmology
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更新日期:2013-01-01 00:00:00
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journal_title:American journal of ophthalmology
pub_type: 杂志文章
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更新日期:2020-12-10 00:00:00
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journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(14)76090-8
更新日期:1984-02-01 00:00:00
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journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2006.12.024
更新日期:2007-05-01 00:00:00
abstract:PURPOSE:To review the current status of phakic intraocular lenses (IOLs), intraocular treatment of presbyopia, and IOLs that filter some blue light. DESIGN:Review of current information on the subject from numerous sources. METHODS:Medline search and Internet search engines on the topics of phakic IOLs, presbyopia or...
journal_title:American journal of ophthalmology
pub_type: 杂志文章,评审
doi:10.1016/j.ajo.2005.03.061
更新日期:2005-10-01 00:00:00
abstract::A consecutive group of 67 patients (70 eyes) with senile cataract underwent extracapsular cataract extraction and implantation of a Shearing posterior chamber intraocular lens. After two years of follow-up, there was an 11% +/- 2% decrease in central cell density (P less than .001), a 20% +/- 2% decrease in superior c...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/0002-9394(83)90068-5
更新日期:1983-06-01 00:00:00
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journal_title:American journal of ophthalmology
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.ajo.2008.12.017
更新日期:2009-05-01 00:00:00
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pub_type: 杂志文章
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更新日期:2001-07-01 00:00:00
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更新日期:2017-11-01 00:00:00
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更新日期:2003-05-01 00:00:00
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pub_type: 杂志文章
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更新日期:1981-11-01 00:00:00
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pub_type: 杂志文章
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更新日期:2000-08-01 00:00:00
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journal_title:American journal of ophthalmology
pub_type: 杂志文章
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更新日期:2017-06-01 00:00:00
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journal_title:American journal of ophthalmology
pub_type: 杂志文章
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更新日期:1986-01-15 00:00:00
abstract:PURPOSE:To evaluate the efficacy of reduced-fluence photodynamic therapy (PDT) for treating symptomatic subfoveal serous pigment epithelial detachments (PEDs) with hyperfluorescence on late-phase indocyanine green angiography (ICGA) without choroidal neovascularization (CNV). DESIGN:Retrospective, interventional case ...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
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更新日期:2012-11-01 00:00:00
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journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(14)72656-x
更新日期:1995-10-01 00:00:00
abstract:PURPOSE:To describe the minimum inhibitory concentration (MIC) of fungal isolates to natamycin and voriconazole, and to compare these MICs to previous ocular susceptibility studies. DESIGN:Experimental laboratory study using isolates from a randomized clinical trial. METHODS:The Mycotic Ulcer Treatment Trial I was a ...
journal_title:American journal of ophthalmology
pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2014-02-01 00:00:00
abstract:PURPOSE:To evaluate the efficacy of autologous plasmin (AP)-assisted vitrectomy for stage 5 retinopathy of prematurity (ROP). DESIGN:Interventional case series. METHODS:Six consecutive eyes of four children with stage 5 ROP were treated. The patients' ages at the surgery ranged from five to eight months after birth. ...
journal_title:American journal of ophthalmology
pub_type: 临床试验,杂志文章
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更新日期:2007-07-01 00:00:00