Abstract：
PURPOSE:To evaluate serum levels of triamcinolone acetonide after intravitreal high-dose injection. DESIGN:Prospective, interventional case series study. METHODS:For 20 consecutive patients, venous blood samples were taken before and 13 +/- 19 days (range 4 to 92) after an intravitreal injection of 20 to 25 mg triamcinolone acetonide as treatment of edematous macular diseases. RESULTS:Serum levels of triamcinolone acetonide did not differ significantly (P =.174; t test for paired matches) preoperatively (0 microg/l) and postoperatively (0.065 microg/l +/- 0.21 microg/l). In 18 eyes (90%), triamcinolone acetonide could not be detected in serum samples. For two patients (10%), serum samples taken 5 days and 7 days after the injection, respectively, contained 0.5 microg/l triamcinolone acetonide and 0.8 microg/l triamcinolone acetonide, respectively. CONCLUSION:After an intravitreal high-dose injection of 20 to 25 mg triamcinolone acetonide, triamcinolone acetonide is not, or only marginally, detectable in serum samples obtained within 4 to 92 days after the injection.
journal_name
Am J Ophthalmoljournal_title
American journal of ophthalmologyauthors
Degenring RF,Jonas JBdoi
10.1016/j.ajo.2004.01.008subject
Has Abstractpub_date
2004-06-01 00:00:00pages
1142-3issue
6eissn
0002-9394issn
1879-1891pii
S0002939404000091journal_volume
137pub_type
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journal_title：American journal of ophthalmology
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更新日期：2006-05-01 00:00:00
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更新日期：1998-03-01 00:00:00
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更新日期：2010-08-01 00:00:00
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pub_type： 杂志文章,多中心研究,随机对照试验
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更新日期：2005-12-01 00:00:00
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更新日期：2010-04-01 00:00:00
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journal_title：American journal of ophthalmology
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journal_title：American journal of ophthalmology
pub_type： 临床试验,杂志文章,随机对照试验
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journal_title：American journal of ophthalmology
pub_type： 杂志文章
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更新日期：1989-04-15 00:00:00
abstract：PURPOSE:Noninfectious uveitis has been treated historically with corticosteroid therapy in varying doses and routes. Triesence, a preservative-free sterile formulation of triamcinolone acetonide, has been used in a wide spectrum of ocular pathologies, but there have been few large studies validating its dosing or detai...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2018.07.003
更新日期：2018-10-01 00:00:00
