Abstract:
PURPOSE:To evaluate the association between scleritis and systemic disease in a non-university, non-tertiary referral practice and to describe our experience with scleritis treatment. DESIGN:Retrospective chart review. METHODS:The medical records of patients with scleritis between 2001 and 2007 were reviewed for associated systemic disease. RESULTS:In our series of 86 patients with scleritis, 55 patients (64.0%) had isolated scleritis while 31 patients (36.0%) had associated systemic-disease. Twenty-six patients (83.9%) with systemic disease had diagnosed systemic disease at the time of initial scleritis presentation, while 5 patients (16.1%) were diagnosed following systemic work-up. Those diagnosed after systemic work-up were more likely to have systemic vasculitic disease as opposed to a rheumatic or infectious disease. Patients with and without associated systemic disease were likely to require systemic therapy at similar rates (93.5% and 92.7%, respectively). Five patients with steroid-refractory scleritis were treated with infliximab (Remicade; Centocor Inc, Horsham, Pennsylvania, USA) and all responded without evidence of adverse effect. Seven patients were treated with mycophenolate mofetil (CellCept; Roche Laboratories, Nutley, New Jersey, USA), of which three improved. CONCLUSIONS:The association between scleritis and systemic disease in a community-based referral practice may be lower than in tertiary referral or university-based centers. Although thorough systemic disease evaluation is warranted in scleritis patients, most patients with associated systemic disease will have such a diagnosis prior to the development of scleritis. The need to institute aggressive systemic therapy cannot be predicted by the presence of an associated systemic disease. Infliximab and mycophenolate mofetil are useful additions to the scleritis practitioner's armamentarium for steroid-refractory scleritis.
journal_name
Am J Ophthalmoljournal_title
American journal of ophthalmologyauthors
Raiji VR,Palestine AG,Parver DLdoi
10.1016/j.ajo.2009.07.021subject
Has Abstractpub_date
2009-12-01 00:00:00pages
946-50issue
6eissn
0002-9394issn
1879-1891pii
S0002-9394(09)00519-4journal_volume
148pub_type
杂志文章abstract:PURPOSE:To report a rare case of tuberculosis with facial abscess. METHODS:A 4 1/2-year-old girl had an acute left upper eyelid abscess and a large, spherical tumescence involving the right upper eyelid, eyebrow, and forehead. The left upper eyelid abscess was drained, and the mass involving the right eyelid, eyebrow,...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(14)70643-9
更新日期:1996-06-01 00:00:00
abstract:PURPOSE:To use micro-ribonucleic acid (microRNA) profiles in the vitreous for differential diagnosis of primary vitreoretinal lymphoma and uveitis. DESIGN:Prospective cross-sectional study. METHODS:This prospective cross-sectional study included 17 diffuse large B-cell primary vitreoretinal lymphoma and 12 uveitis pa...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2013.12.014
更新日期:2014-03-01 00:00:00
abstract:PURPOSE:Report incidence and risk of retinal detachment (RD)after coaxial phacoemulsification in high myopic patients. DESIGN:Retrospective consecutive interventional study. METHODS: SETTING:Vissum-Instituto Oftalmologico de Alicante, Spain. PATIENT OR STUDY POPULATION: A total of 439 eyes from 274 high myopic patie...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2007.03.043
更新日期:2007-07-01 00:00:00
abstract:PURPOSE:To study the tomographic and pathomorphologic features of dome-shaped maculas with swept-source optical coherence tomography (OCT). DESIGN:Prospective, cross-sectional study. METHODS:The macular area of 51 highly myopic eyes (35 patients) with dome-shaped maculas was studied with swept-source OCT at 1050 nm. ...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2012.08.007
更新日期:2013-02-01 00:00:00
abstract:PURPOSE:To describe the presentation and subsequent management of a case of severe gonococcal keratitis in a young man. DESIGN:Case report. METHODS:A young man presented with severe gonococcal keratitis. Topical and systemic antibiotics were given with no improvement, and progressive corneal melting was noted. Deep l...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2004.04.014
更新日期:2004-09-01 00:00:00
abstract:PURPOSE:To describe a modified laser technique for identification of bullous retinoschisis. DESIGN:Retrospective interventional case series collected over 10 years. METHODS:Forty-one eyes with presumed bullous retinoschisis and breaks in the inner layers underwent a low-energy argon green laser application at the sam...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(03)00485-9
更新日期:2003-11-01 00:00:00
abstract:PURPOSE:To evaluate the efficacy of hyperdry amniotic membrane (AM) patching attached using a tissue adhesive for corneal perforations and glaucoma filtering bleb leaks. DESIGN:Prospective, noncomparative, interventional case series. METHODS:Five eyes of 5 patients (glaucoma bleb leaks, 2 eyes; corneal perforations, ...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2009.03.030
更新日期:2009-09-01 00:00:00
abstract:PURPOSE:To determine a correlation between foveal morphologic changes and visual outcomes in patients with resolved central serous chorioretinopathy (CSC). DESIGN:Observational case series. METHODS:We measured the outer nuclear layer (ONL) thickness at the central fovea and evaluated the integrity of the photorecepto...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2009.01.018
更新日期:2009-07-01 00:00:00
abstract:PURPOSE:To investigate the impact on patient management of posterior segment echographic evaluation at an academic institution. DESIGN:Retrospective, noncomparative, consecutive case series. METHODS:Records were reviewed of all patients evaluated for the first time with ocular echography for posterior segment evaluat...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(03)00910-3
更新日期:2004-01-01 00:00:00
abstract:PURPOSE:To evaluate the relationship between rates of change on frequency doubling technology (FDT) perimetry and longitudinal changes in quality of life (QoL) of glaucoma patients. DESIGN:Prospective observational cohort study. METHODS:One hundred fifty-two subjects (127 glaucoma and 25 healthy) were followed for an...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2015.04.007
更新日期:2015-07-01 00:00:00
abstract:OBJECTIVE:To report clinicopathologic features, radiologic findings, and treatment outcomes of isolated, orbital aspergillosis. DESIGN:Multicenter, retrospective case series. METHODS:setting: Multicenter. PARTICIPANTS:There were 8 lesions in 8 eyes of 8 patients with isolated, orbital aspergillosis. PROCEDURE:Revie...
journal_title:American journal of ophthalmology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.ajo.2016.03.007
更新日期:2016-05-01 00:00:00
abstract:PURPOSE:To determine factors of uveal malignant melanoma that would help to predict prognosis in Japanese patients. METHODS:From 1969 to 1994, 23 eyes with uveal malignant melanoma were enucleated from 23 Japanese patients, and 16 of these patients were studied. In the 16 patients, enucleated eyes were evaluated for t...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(14)70275-2
更新日期:1996-03-01 00:00:00
abstract:PURPOSE:To provide a systematic classification of fundus autofluorescence (FAF) patterns in patients affected by Best vitelliform macular dystrophy. DESIGN:Cross-sectional prospective study. METHODS:Patients affected by Best vitelliform macular dystrophy at different stages of the disease were prospectively enrolled ...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2014.07.026
更新日期:2014-11-01 00:00:00
abstract:PURPOSE:To determine the spectrum of conjunctival flora and the antibiotic susceptibility profiles of patients undergoing cataract surgery at a Midwestern university. DESIGN:Prospective in vitro laboratory investigation of a patient cohort. METHODS:Conjunctival cultures were obtained from patients undergoing cataract...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2012.06.024
更新日期:2013-01-01 00:00:00
abstract::A 50-year-old man sustained severe head injury, including a brief loss of consciousness, in an automobile accident. Skull X-ray films disclosed a fracture of the right superior orbit. Computed tomography demonstrated pneumocephalus and extension of the fracture into the sella turcica. Perimetric testing disclosed a bi...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/0002-9394(81)90778-9
更新日期:1981-08-01 00:00:00
abstract:PURPOSE:To determine whether patients with primary open-angle glaucoma have an increase in size thresholds, prolongation of reaction times, and greater localization errors to random dot motion stimuli than normal subjects. METHODS:Motion perimetry, a computer graphics method of visual field testing, quantitates a subj...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(14)72205-6
更新日期:1995-11-01 00:00:00
abstract:PURPOSE:To compare visual outcomes among eyes that underwent pars plana vitrectomy (PPV) in combination with either anterior chamber intraocular lens implantation (ACIOL) or scleral suturing of posterior chamber lens (PCIOL). DESIGN:Retrospective comparative case series. METHODS:All eyes presented with aphakia or lux...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2016.05.006
更新日期:2016-08-01 00:00:00
abstract::We undertook an in vitro investigation of the role of the design of the eyedrop dispenser in bacterial contamination. The nozzle tips of pipette and squeeze bottles containing Fluress (pH 5.0) were inoculated with 10 microliter of an ocular isolate of Pseudomonas aeruginosa (5.5 X 10(5) bacteria/ml). Cultures of singl...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/0002-9394(84)90238-1
更新日期:1984-11-01 00:00:00
abstract:PURPOSE:We report a case of a submacular surgery complicated by a choroidal neovascular membrane at the retinotomy site. METHOD:The patient underwent submacular surgery for the removal of an idiopathic choroidal neovascular membrane. RESULT:Three weeks after surgery, the patient developed a choroidal neovascular memb...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(14)70499-4
更新日期:1996-11-01 00:00:00
abstract::In a prospective study of 415 consecutive eyes operated on for retinal detachment, there were no apparent retinal breaks in 41 eyes. Examination of the most likely site for breaks during, or shortly after, cryotherapy was helpful in detecting tiny breaks in several cases. All detachments without apparent breaks were o...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/0002-9394(76)90297-x
更新日期:1976-04-01 00:00:00
abstract:PURPOSE:To critically evaluate the potential impact of the coronavirus disease (COVID-19) pandemic on global ophthalmology and VISION 2020. DESIGN:Perspective supplemented with epidemiologic insights from available online databases. METHODS:We extracted data from the Global Vision Database (2017) and Global Burden of...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2020.11.016
更新日期:2020-12-09 00:00:00
abstract:PURPOSE:To present a case of congenital toxoplasmosis in a newborn whose mother had a 20-year history of a chorioretinal macular scar and positive serology for toxoplasmosis. DESIGN/METHODS:Case report. SETTING/RESULTS: A 38-year-old woman who had been treated for ocular toxoplasmosis 20 years earlier delivered a newb...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(03)00191-0
更新日期:2003-08-01 00:00:00
abstract::A retrospective study of 45 patients with low-tension glaucoma revealed the mean age at diagnosis to be 66 years. Seventeen patients had follow-up visual field examinations, the average follow-up period being 6.4 years. There was no significant difference in prognosis of the ocular course between patients with Po/C eq...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/0002-9394(76)90359-7
更新日期:1976-06-01 00:00:00
abstract:PURPOSE:To correlate visual acuity measured with the Optec 800 to the gold-standard Early Treatment Diabetic Retinopathy Study (ETDRS) chart. DESIGN:Prospective, cross-sectional study. METHODS:Forty patients of the Vanderbilt Eye Institute agreed to undergo visual acuity testing. Five patients were excluded because o...
journal_title:American journal of ophthalmology
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.ajo.2006.09.053
更新日期:2007-03-01 00:00:00
abstract:PURPOSE:To evaluate the ocular surface inflammatory response to the presence of preservatives in nonselective beta-blocker eyedrops. DESIGN:Prospective, crossover, single-masked, randomized clinical study. METHODS:study population: Twenty primary open-angle glaucoma or ocular hypertensive patients were divided in two...
journal_title:American journal of ophthalmology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/j.ajo.2004.08.028
更新日期:2005-01-01 00:00:00
abstract:PURPOSE:To investigate the magnitude, with-the-rule (WTR) or against-the-rule (ATR) orientation, and vector components (Jackson astigmatic vectors [J0 and J45] and blurring strength) of the anterior and posterior corneal astigmatism (ACA and PCA) in patients with keratoconus (KC) in a retrospective study, and to try to...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2016.03.051
更新日期:2016-07-01 00:00:00
abstract::Immunofluorescence, histological, and electron microscopic observations were made on rabbit corneas from animals with experimentally induced stromal keratitis following intracorneal injection with the RE strain of herpes simplex virus. Electron microscopic observations were also made on human corneas obtained from pat...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/0002-9394(76)90057-x
更新日期:1976-12-01 00:00:00
abstract::We investigated albumin and IgG concentrations in the aqueous humor of 41 patients before intracapsular cataract extraction (primary samples) and at the end of surgery (secondary samples). Albumin and IgG concentrations were determined in all samples by means of a quantitative fluoroimmunoassay. A short-term topical a...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(14)71914-2
更新日期:1983-12-01 00:00:00
abstract:PURPOSE:We hypothesized that major American dietary patterns are associated with risk for age-related macular degeneration (AMD). DESIGN:Cross-sectional study. METHODS:We classified 8103 eyes in 4088 eligible participants in the baseline Age-Related Eye Disease Study (AREDS). They were classified into control (n = 27...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2014.04.016
更新日期:2014-07-01 00:00:00
abstract:PURPOSE:To analyze the risk factors, clinical characteristics, management, and treatment outcomes of culture-proven cases of Moraxella keratitis at our center. DESIGN:Retrospective observational case series. METHODS:Thirty-nine culture-proven cases of Moraxella keratitis (39 eyes) diagnosed and treated between Januar...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2018.08.055
更新日期:2019-01-01 00:00:00