Abstract：
OBJECTIVE:To report clinicopathologic features, radiologic findings, and treatment outcomes of isolated, orbital aspergillosis. DESIGN:Multicenter, retrospective case series. METHODS:setting: Multicenter. PARTICIPANTS:There were 8 lesions in 8 eyes of 8 patients with isolated, orbital aspergillosis. PROCEDURE:Review of medical records and histopathology slides. MAIN OUTCOME MEASURES:Disease control. RESULTS:Of 34 patients with orbital aspergillosis, 8 (23.5%) had isolated orbital involvement at presentation. The mean age at presentation was 34.5 years (median, 43 years: range, 0.5-72 years). Gradually progressive proptosis and eyelid swelling were the most common presenting features (each 4/8). Proptosis ranged from 4 mm to 9 mm (median, 5.5 mm; mean, 5.75 mm). Restriction of ocular motility was seen in all 8 patients. Other examination findings included palpable mass (2/8), conjunctival chemosis (2/8), hyperglobus (1/8), hypoglobus (1/8), and resistance to retropulsion (1/8). Microbial culture results were available in 1 patient and showed Aspergillus fumigatus. Two patients were treated with complete surgical excision alone while 6 were treated with antifungal medications. Complete resolution of proptosis and restoration of ocular motility were seen in all patients following treatment. Visual disturbances present in 1 were corrected following treatment. Recurrence was observed in 1 patient. CONCLUSION:Isolated orbital aspergillosis, though rare, should be considered in the differential diagnosis of a patient presenting with a gradually progressive orbital mass, especially in Asian individuals. Early recognition will help reduce the morbidity and mortality associated with this disease.
journal_name
Am J Ophthalmoljournal_title
American journal of ophthalmologyauthors
Aggarwal E,Mulay K,Menon V,Sundar G,Honavar SG,Sharma Mdoi
10.1016/j.ajo.2016.03.007subject
Has Abstractpub_date
2016-05-01 00:00:00pages
125-32eissn
0002-9394issn
1879-1891pii
S0002-9394(16)30099-Xjournal_volume
165pub_type
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journal_title：American journal of ophthalmology
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更新日期：2011-05-01 00:00:00
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journal_title：American journal of ophthalmology
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