Abstract:
PURPOSE:To determine the efficacy of photodynamic therapy (PDT) and indocyanine green angiography (ICGA) findings for treating chronic central serous chorioretinopathy (CSC). DESIGN:Observational case series. METHODS:Thirty-two eyes of 27 patients with chronic CSC and symptoms for at least 6 months were recruited. The minimum follow-up was 1 year. The total PDT energy was reduced to about 36 to 42 mJ/cm(2). The baseline middle-phase ICGA findings were classified as intense, intermediate, or no hyperfluorescence depending on the degree of hyperfluorescence. The resolution of the subretinal fluid and recurrence rates were assessed in relation to each ICGA finding at baseline. RESULTS:ICGA before PDT showed intense hyperfluorescence in 23 eyes (72%), intermediate hyperfluorescence in 6 eyes (19%), and no hyperfluorescence in 3 eyes (9%). The subretinal fluid resolved completely 3 months after 1 application of PDT in 23 eyes (100%) with intense hyperfluorescence, 6 eyes (100%) with intermediate hyperfluorescence, and no eyes (0%) with no hyperfluorescence. In the last group, the subretinal fluid did not resolve throughout the follow-up period despite additional applications of PDT. The subretinal fluid recurred in 7 of 29 eyes (24%) in which the subretinal fluid resolved at 3 months; recurrence was frequent in eyes with intermediate hyperfluorescence (5 eyes; 83%). CONCLUSION:The PDT success rate in eyes with chronic CSC depends on the degree of hyperpermeability on ICGA. PDT is not effective or the recurrence rate is predicted to be high in eyes without intense hyperfluorescence.
journal_name
Am J Ophthalmoljournal_title
American journal of ophthalmologyauthors
Inoue R,Sawa M,Tsujikawa M,Gomi Fdoi
10.1016/j.ajo.2009.10.011subject
Has Abstractpub_date
2010-03-01 00:00:00pages
441-6.e1-2issue
3eissn
0002-9394issn
1879-1891pii
S0002-9394(09)00793-4journal_volume
149pub_type
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journal_title:American journal of ophthalmology
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更新日期:1975-06-01 00:00:00
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更新日期:2005-06-01 00:00:00
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journal_title:American journal of ophthalmology
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更新日期:1997-05-01 00:00:00
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journal_title:American journal of ophthalmology
pub_type: 杂志文章
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更新日期:1998-07-01 00:00:00
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journal_title:American journal of ophthalmology
pub_type: 杂志文章
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journal_title:American journal of ophthalmology
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journal_title:American journal of ophthalmology
pub_type: 杂志文章
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更新日期:2016-10-01 00:00:00
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journal_title:American journal of ophthalmology
pub_type: 杂志文章
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更新日期:2007-08-01 00:00:00
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journal_title:American journal of ophthalmology
pub_type: 杂志文章
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更新日期:2014-03-01 00:00:00
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journal_title:American journal of ophthalmology
pub_type: 杂志文章
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更新日期:2002-01-01 00:00:00
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journal_title:American journal of ophthalmology
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1993-11-15 00:00:00
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journal_title:American journal of ophthalmology
pub_type: 杂志文章
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更新日期:1983-11-01 00:00:00
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journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2016.04.008
更新日期:2016-07-01 00:00:00
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journal_title:American journal of ophthalmology
pub_type: 杂志文章,多中心研究
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更新日期:2017-01-01 00:00:00
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journal_title:American journal of ophthalmology
pub_type: 杂志文章
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更新日期:1998-01-01 00:00:00