Abstract：
PURPOSE:To determine factors of uveal malignant melanoma that would help to predict prognosis in Japanese patients. METHODS:From 1969 to 1994, 23 eyes with uveal malignant melanoma were enucleated from 23 Japanese patients, and 16 of these patients were studied. In the 16 patients, enucleated eyes were evaluated for tumor characteristics, including cell type and microvascular architecture. Patient records were reviewed for follow-up therapy and outcome. Mortality rate was evaluated four years after enucleation. RESULTS:In Japanese patients with uveal malignant melanoma, the average tumor size was larger (average largest diameter, 11.36 mm; average increase, 6.25 mm) and the average patient age was younger (55.2 years old) than previously reported for white populations. Patients with spindle cell type melanoma tended to have a better prognosis than those with epithelioid cell type (four-year mortality rates: spindle cell type, 0%; mixed cell type, 43%; epithelioid cell type, 66%). Microvascular architecture patterns interpreted as either network or closed loop patterns were associated with a poorer prognosis (network pattern, P = .03; closed loop pattern, P = .005). CONCLUSIONS:The prognosis for Japanese patients with uveal malignant melanoma is poorer, and epithelioid cell-type melanoma is more common, than has been reported in white populations. Mitotic figures are well correlated with poor prognosis, as are two microvascular patterns, the network pattern and the closed loop pattern.
journal_name
Am J Ophthalmoljournal_title
American journal of ophthalmologyauthors
Sakamoto T,Sakamoto M,Yoshikawa H,Hata Y,Ishibashi T,Ohnishi Y,Inomata Hdoi
10.1016/s0002-9394(14)70275-2subject
Has Abstractpub_date
1996-03-01 00:00:00pages
276-83issue
3eissn
0002-9394issn
1879-1891pii
S0002-9394(14)70275-2journal_volume
121pub_type
杂志文章abstract：PURPOSE:To examine if myopia is a risk factor for age-related cataract. DESIGN:Systematic review and meta-analysis. METHODS:A systematic review of the literature was performed using PubMed and Embase from their inception to March 2013 for population-based studies with data on myopia and age-related cataract, includin...
journal_title：American journal of ophthalmology
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.ajo.2013.06.005
更新日期：2013-11-01 00:00:00
abstract：PURPOSE:To evaluate the outcomes of epiretinal membrane (ERM) surgery in highly myopic eyes without traction maculopathy, and to compare them with those from non-highly myopic eyes. DESIGN:Retrospective nested case-control study from a cohort of 509 consecutive patients (509 eyes) who underwent pars plana vitrectomy w...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2013.03.035
更新日期：2013-08-01 00:00:00
abstract：PURPOSE:To evaluate long-term outcomes after Ahmed valve implantation in patients with glaucoma when using adjunctive intraoperative mitomycin C (MMC) and postoperative 5-fluorouracil (5-FU). DESIGN:Retrospective, interventional, consecutive case series. METHODS:A consecutive series of eyes undergoing Ahmed valve imp...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2008.04.008
更新日期：2008-08-01 00:00:00
abstract：PURPOSE:To evaluate the incidence of adverse events (AEs) in patients who underwent refractive lens exchange. DESIGN:Retrospective case series. METHODS:Setting: Private refractive surgery clinics. Patients/Study Population: Patients who underwent refractive lens exchange between July 1, 2014, and June 30, 2016. Inter...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2019.08.025
更新日期：2019-12-01 00:00:00
abstract：PURPOSE:To determine the relationship between quantitative nerve fiber layer measurements and visual field testing in patients with large cup-to-disk ratios. METHODS:Seventy-six patients with vertical cup-to-disk ratios by contour of at least 0.8 on stereoscopic photographs and 50 normal subjects were included. One ey...
journal_title：American journal of ophthalmology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0002-9394(01)01107-2
更新日期：2001-10-01 00:00:00
abstract：PURPOSE:compare the results of vitrectomy with or without arteriovenous (AV) crossing sheathotomy for macular edema associated with branch retinal vein occlusion (BRVO). DESIGN:Interventional case series. METHODS:A retrospective study of 36 eyes with BRVO-associated macular edema. Twenty eyes underwent AV sheathotomy...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2004.06.061
更新日期：2004-12-01 00:00:00
abstract：:Cell loss and regeneration were investigated and compared in the retinal microvasculature of age- and sex-matched normal and streptozotocin diabetic rats. Selective pericyte loss in the diabetic rat was characterized by changes in the pericyte to endothelial cell ratio in retinal capillaries isolated for microscopy by...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)74982-7
更新日期：1985-07-15 00:00:00
abstract：PURPOSE:To present a case of choroidal neovascularization associated with sympathetic ophthalmia successfully treated with photocoagulation. DESIGN:Interventional case report. METHODS:A 41-year-old man with a history of penetrating injury right eye, as well as sympathetic ophthalmia left eye, developed a classic chor...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(01)01044-3
更新日期：2001-10-01 00:00:00
abstract：PURPOSE:To train a deep learning (DL) algorithm that quantifies glaucomatous neuroretinal damage on fundus photographs using the minimum rim width relative to Bruch membrane opening (BMO-MRW) from spectral-domain optical coherence tomography (SDOCT). DESIGN:Cross-sectional study. METHODS:A total of 9282 pairs of opti...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2019.01.011
更新日期：2019-05-01 00:00:00
abstract：PURPOSE:The aim of this study was to evaluate the baseline features associated with blindness in a cohort of children with primary congenital glaucoma (PCG) from a hospital registry. METHODS:Setting: Observational cohort study DESIGN: Retrospective clinical cohort study STUDY POPULATION: The registry included all chil...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2020.12.014
更新日期：2020-12-21 00:00:00
abstract：:Cryotherapy was an effective modality in the treatment of basal cell carcinoma in the eyelid and periorbital area and cured 93% of the 29 lesions in 25 patients. This method was especially advantageous in patients with blood clotting disorders; those with medical contraindications to, or who refused, classical surgery...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(76)90059-3
更新日期：1976-12-01 00:00:00
abstract：PURPOSE:To identify the frequency of recently acquired vs chronic systemic Toxoplasma gondii infections in patients with ocular toxoplasmosis. METHODS:Serum samples from 22 patients with primary ocular toxoplasmosis (not from scars) and 42 patients with recurrent ocular toxoplasmosis were tested for the presence of an...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(99)00266-4
更新日期：1999-10-01 00:00:00
abstract：:Topical ketoconazole (2% ointment three times per day for three weeks) markedly reduced the severity of keratitis produced with Candida albicans inoculation in the right eyes of 20 rabbits. Clinical scores of affected eyes were significantly lower in the treated eyes than in the controls, which consisted of the 20 ino...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(86)90084-x
更新日期：1986-10-15 00:00:00
abstract：PURPOSE:Photorefractive keratectomy has the potential to cause transient corneal haze. The purpose of this study was to evaluate the relationship between transient corneal haze as measured by an objective means and high and low contrast visual performance. METHODS:In a prospective study, 44 eyes of 28 patients were ex...
journal_title：American journal of ophthalmology
pub_type： 临床试验,杂志文章
doi：10.1016/s0002-9394(01)01003-0
更新日期：2001-08-01 00:00:00
abstract：PURPOSE:To evaluate changes in anterior chamber depth (ACD) and angle width after neodymium-yttrium-aluminum-garnet (Nd:YAG) laser capsulotomy. DESIGN:Prospective interventional case series. METHODS:In a single institution, 43 eyes of 43 consecutive pseudophakic patients with symptomatic posterior capsule opacificati...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2014.08.008
更新日期：2014-11-01 00:00:00
abstract：PURPOSE:To evaluate the relationship between β-zone parapapillary atrophy (βPPA) and corneal hysteresis (CH) in patients with glaucoma. DESIGN:Prospective, cross-sectional study. METHODS:Glaucoma patients aged 18 to 90 years with disc photographs within 12 months of the study visit were consecutively enrolled. Exclus...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2011.06.025
更新日期：2012-02-01 00:00:00
abstract：:There is no single method of perimetric examination which is applicable to all types of visual field defects. Perimetry is a subjective psychophysical sensory examination. It is not an exact science unless one includes the objective measurement of visual evoked response in the optic cortex. Until such a method becomes...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(75)90527-9
更新日期：1975-09-01 00:00:00
abstract：PURPOSE:To evaluate the relationship between rates of change on frequency doubling technology (FDT) perimetry and longitudinal changes in quality of life (QoL) of glaucoma patients. DESIGN:Prospective observational cohort study. METHODS:One hundred fifty-two subjects (127 glaucoma and 25 healthy) were followed for an...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2015.04.007
更新日期：2015-07-01 00:00:00
abstract：PURPOSE:To determine whether retinal arteriolar wall signs are associated with early age-related macular degeneration (AMD). DESIGN:Population-based cross-sectional study. METHODS:The Singapore Malay Eye Study (SiMES) is a population-based eye survey including 3,280 (78.7% response) persons aged 40 to 80 years. Retin...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2011.01.012
更新日期：2011-07-01 00:00:00
abstract：:Follow-up examinations, ranging from four to more than 20 years, were performed on 100 patients with chronic cyclitis whose ages at onset were from 4 to 58 years. Cataracts were found in 42% of eyes and macular disease secondary to macular edema in 28% of eyes. Band keratopathy, glaucoma, retinal detachment, retinosch...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(76)90434-7
更新日期：1976-08-01 00:00:00
abstract：PURPOSE:To investigate tear function and prevalence of dry eye disease (DED) in visual display terminal (VDT) users. DESIGN:Cross-sectional study. METHODS:Six hundred and seventy-two young and middle-aged Japanese office workers who used VDT completed questionnaires and underwent dry eye testing. We estimated the pre...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2013.05.040
更新日期：2013-10-01 00:00:00
abstract：PURPOSE:To compare the visual outcome after foveal translocation by scleral shortening and that after 360 degrees retinotomy with extraocular muscle surgery in a patient with bilateral myopic neovascular maculopathy. METHODS:Case report. RESULTS:A 52-year-old woman with bilateral myopic neovascular maculopathy underw...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(00)00582-1
更新日期：2000-10-01 00:00:00
abstract：PURPOSE:To report the occurrence of transient formed visual hallucinations following macular translocation. METHODS:Two case reports. RESULTS:Two white women aged 84 and 83 years with bilateral age-related macular degeneration and unilateral subfoveal choroidal neovascularization underwent macular translocation with ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(00)00934-x
更新日期：2001-05-01 00:00:00
abstract：PURPOSE:To report outcomes of Vogt-Koyanagi-Harada (VKH) disease from a clinical trial of antimetabolite therapies. DESIGN:Subanalysis from an observer-masked randomized clinical trial for noninfectious intermediate, posterior, and panuveitis. METHODS:setting: Clinical practice at Aravind Eye Hospitals, India. PATIE...
journal_title：American journal of ophthalmology
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.ajo.2016.06.004
更新日期：2016-08-01 00:00:00
abstract：PURPOSE:We investigated meetings of the Dermatologic and Ophthalmic Drug Advisory Committee (DODAC) and the Ophthalmic Devices Panel (ODP) of the Food and Drug Administration (FDA) to determine whether a relationship exists between receipt of industry payments by speakers of the Open Public Hearing (OPH) portion and th...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2020.09.043
更新日期：2020-11-06 00:00:00
abstract：PURPOSE:To report complications of cosmetic artificial iris implantation and explantation outcomes. SETTING:Stein Eye Institute DESIGN: : Retrospective case series METHODS: : Review of medical records of 12 patients (24 eyes) who presented to us after being implanted with cosmetic artificial irises elsewhere. Data col...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2021.01.005
更新日期：2021-01-22 00:00:00
abstract：:In a retrospective review from 1972 through 1987 of patients with microbial keratitis, fungal infection occurred in four (4%) of 90 cosmetic or aphakic contact lens wearers and in four (27%) of 15 patients using a therapeutic soft contact lens. Predisposing factors included improper lens care by the refractive lens we...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(88)90705-2
更新日期：1988-12-15 00:00:00
abstract：:Acetazolamide's usefulness in the treatment of the glaucomas is limited by the systemic side effects that often accompany its oral administration, and topical administration was initially thought to have no effect upon the intraocular pressures of human and rabbit eyes. Recent studies, however, have shown the usefulne...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(84)90190-9
更新日期：1984-07-15 00:00:00
abstract：:Although asymmetric or unilateral optic disk swelling is unusual in patients with increased intracranial pressure, we treated three such patients. Two (a 31-year-old man and a 31-year-old woman, both of whom were overweight) had benign intracranial hypertension. The third patient (a 64-year-old man) had a posterior fo...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)77912-7
更新日期：1983-10-01 00:00:00
abstract：:A 2,000-g infant boy had many features of the Smith-Lemli-Opitz syndrome (prenatal growth deficiency and developmental retardation, microcephaly with unusual facies, hypospadias, and feeding difficulties) as well as sclerocornea. The association of this rare eye finding with this rare congenital syndrome is unique. Su...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(77)90327-0
更新日期：1977-07-01 00:00:00
