Abstract：
PURPOSE:To investigate tear function and prevalence of dry eye disease (DED) in visual display terminal (VDT) users. DESIGN:Cross-sectional study. METHODS:Six hundred and seventy-two young and middle-aged Japanese office workers who used VDT completed questionnaires and underwent dry eye testing. We estimated the prevalence of DED using logistic regression analysis to examine associations between DED and possible risk factors. The ocular surface feature, prevalence of DED, and risk factors were evaluated. RESULTS:Of the 672 workers, 561 (83.5%, mean age: 43.3 ± 9.1 years) completed the questionnaire. The percentage of women with a composite outcome of definite DED or probable DED was 76.5%, which was higher than that among men (60.2%; odds ratio [OR] = 2.00; 95% confidence interval [CI], 1.29-3.10, P = .002). Workers over 30 years of age had a higher risk of DED (OR = 2.22; 95% CI, 1.06-4.66), as did workers using a VDT >8 hours per day (OR = 1.94; 95% CI, 1.22-3.09). Average Schirmer value was 18.7 ± 11.7 mm and tear break-up time (TBUT) was 4.0 ± 2.5 seconds (78.6% of study participants had TBUT ≤5 seconds). CONCLUSIONS:DED is prevalent among young to middle-aged Japanese VDT users. Ophthalmic findings revealed short TBUT and corneal staining accompanied by normal Schirmer test values. Increased risk for DED was noted for women aged over 30 years and prolonged VDT use. Measures to modify the adverse impact of VDT use on the ocular surface may provide a positive impact on public health and quality of life for office workers using VDTs.
journal_name
Am J Ophthalmoljournal_title
American journal of ophthalmologyauthors
Uchino M,Yokoi N,Uchino Y,Dogru M,Kawashima M,Komuro A,Sonomura Y,Kato H,Kinoshita S,Schaumberg DA,Tsubota Kdoi
10.1016/j.ajo.2013.05.040subject
Has Abstractpub_date
2013-10-01 00:00:00pages
759-66issue
4eissn
0002-9394issn
1879-1891pii
S0002-9394(13)00383-8journal_volume
156pub_type
杂志文章abstract：PURPOSE:To reexamine the role of the vitreous gel in ocular health and disease based on recent information in the ophthalmic literature. DESIGN:Perspective. METHODS:Review, analysis, and discussion of the implications of selected pertinent literature. RESULTS:A new understanding of the vitreous gel is emerging, plac...
journal_title：American journal of ophthalmology
pub_type： 杂志文章,评审
doi：10.1016/j.ajo.2009.07.036
更新日期：2010-01-01 00:00:00
abstract：PURPOSE:To evaluate the anatomic and visual outcomes in patients with initially closed macular holes after vitreoretinal surgery and with 1 to 7 years of follow-up. DESIGN:Retrospective, noncomparative, consecutive case series. METHODS:Eighty-seven consecutive eyes of 79 patients with previous closure of the macular ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2010.11.006
更新日期：2011-05-01 00:00:00
abstract：PURPOSE:To evaluate outcomes of patients treated with intensive intravitreal therapy and to describe the evolution of quantitative real-time polymerase chain reaction (qPCR) in patients treated for acute retinal necrosis (ARN) syndrome. DESIGN:Retrospective observational case series. METHODS:This study included 25 ey...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2019.08.007
更新日期：2019-12-01 00:00:00
abstract：PURPOSE:To examine the development and management of glaucoma in patients with ocular chemical burns. DESIGN:Retrospective, observational case series. METHODS:setting: University of Washington Eye Clinics. patient population: Twenty-nine eyes (18 patients) with ocular chemical burns seen between 1997 and 2010 with a ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2012.03.026
更新日期：2012-09-01 00:00:00
abstract：PURPOSE:To report a group of patients with symptoms of pain, strabismus, sensation of orbital fullness, and presence of a subconjunctival mass many years after successful scleral buckling surgery using hydrogel explants. DESIGN:We present an interventional consecutive case series of patients who underwent scleral buck...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(03)00873-0
更新日期：2004-01-01 00:00:00
abstract：PURPOSE:To describe the incidence of vision loss and of ocular complications attributable to birdshot retinochoroidopathy and to describe the association between therapy and the incidence thereof. DESIGN:Retrospective cohort study. METHODS: SETTING:Single-center, academic practice. STUDY POPULATION:Forty patients w...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2005.01.035
更新日期：2005-07-01 00:00:00
abstract：:A prospective study of 78 eyes with idiopathic preretinal macular gliosis disclosed that 74 of the 78 (95%) had posterior vitreous detachments at the time of the initial examination. A second prospective study of 34 eyes with acute posterior vitreous detachment showed preretinal macular gliosis in three eyes (9%) init...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(86)90144-3
更新日期：1986-08-15 00:00:00
abstract：PURPOSE:To investigate anatomic success after surgery for chronic retinal detachment. DESIGN:Retrospective, case series review. METHODS:The surgical outcomes of reattachment surgery for 36 eyes of 35 patients with chronic retinal detachments are reported and are compared with the outcomes for 129 fresh retinal detach...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2007.01.057
更新日期：2007-06-01 00:00:00
abstract：PURPOSE:To report the use of intravitreal injection of triamcinolone acetonide during the acute phase of Vogt-Koyanagi-Harada disease. DESIGN:Prospective interventional case series. METHODS:Three eyes from two patients at the acute phase of Vogt-Koyanagi-Harada disease with serous retinal detachments were treated wit...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2003.08.035
更新日期：2004-03-01 00:00:00
abstract：PURPOSE:To investigate the presence of the fibronectin isoform containing the extradomain B (B-FN), a marker-protein of angiogenesis, in surgically excised human choroidal neovascular membranes (CNVM) to evaluate whether B-FN could be used as a therapeutic target for specific antibody-photosensitizer immunoconjugates. ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(02)01839-1
更新日期：2003-01-01 00:00:00
abstract：PURPOSE:To evaluate the co-occurrence of acute ischemic stroke and acute retinal artery occlusion (RAO). DESIGN:Retrospective observational case series. METHODS:We included 33 consecutive patients with acute RAO who underwent diffusion-weighted magnetic resonance imaging within 7 days of the onset of visual symptoms....
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2014.01.033
更新日期：2014-06-01 00:00:00
abstract：:The in vivo sites of the blood-aqueous barrier were determined in five animal species, using acriflavine neutral (224 mol. wt.), ultrafreezing and drying, fluorescence microscopy, and fluorometry. Not toxic, acriflavine had specific in vivo affinity for nuclear DNA and RNA, produced intense fluorescence, and did not p...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(75)90405-5
更新日期：1975-10-01 00:00:00
abstract：:The extent of visual function loss from nuclear cataractous change can be estimated by observing the extinction of blue light compared to white light as a function of sagittal lens depth in standard slit lamps. Apparent extinction (loss of transmissivity) of 50% or more of the depth of the lens in blue light of maxima...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(81)90057-x
更新日期：1981-05-01 00:00:00
abstract：PURPOSE:To develop a near-real-time data warehouse (DW) in an academic ophthalmologic center to gain scientific use of increasing digital data from electronic medical records (EMR) and diagnostic devices. DESIGN:Database development. METHODS:Specific macular clinic user interfaces within the institutional hospital in...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2017.03.026
更新日期：2017-06-01 00:00:00
abstract：PURPOSE:To quantify, compare, and assess differences between retinal and choroidal hemodynamics in normal control subjects and patients with ocular hypertension, primary open-angle glaucoma, and normal-pressure glaucoma. METHODS:Video fluorescein angiograms were made in 20 normal subjects, 11 patients with ocular hype...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)71077-3
更新日期：1997-05-01 00:00:00
abstract：PURPOSE:To assesses the role of photodynamic therapy (PDT) with verteporfin in young patients with choroidal neovascularization (CNV) secondary to traumatic choroidal rupture. DESIGN:Retrospective case series. METHODS:Of 26 eyes with traumatic choroidal rupture followed since 1984 at the retina service of university ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2004.10.009
更新日期：2005-04-01 00:00:00
abstract：:Ten patients with Stargardt's disease and 14 with fundus flavimaculatus underwent thorough ophthalmic examinations, retinal photography, and, when possible, fluorescein angiography. Retinal function was also assessed by static and kinetic perimetry, the Farnsworth-Munsell 100-hue test, electro-oculography, and electro...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(83)90455-5
更新日期：1983-07-01 00:00:00
abstract：PURPOSE:To perform 11- and 2-year health care sector (ophthalmic) and societal cost perspective reference case, cost-utility analyses comparing bevacizumab, ranibizumab, and aflibercept monotherapies for neovascular age-related macular degeneration (NVAMD). DESIGN:Cost-utility analysis. METHODS:The authors performed ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2020.05.029
更新日期：2020-10-01 00:00:00
abstract：PURPOSE:To report outcomes of Vogt-Koyanagi-Harada (VKH) disease from a clinical trial of antimetabolite therapies. DESIGN:Subanalysis from an observer-masked randomized clinical trial for noninfectious intermediate, posterior, and panuveitis. METHODS:setting: Clinical practice at Aravind Eye Hospitals, India. PATIE...
journal_title：American journal of ophthalmology
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.ajo.2016.06.004
更新日期：2016-08-01 00:00:00
abstract：PURPOSE:To measure accurately the amount of cyclotorsion. METHODS:A horizontal light beam of the slit lamp is projected on the retina, crossing the fovea. The slit light will normally cross between the middle and lower thirds of the disk. Cyclotorsion of the eye will cause the horizontal slit-light beam to be projecte...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)70402-7
更新日期：1996-12-01 00:00:00
abstract：:A 14-year-old boy was stabbed above the left eye and had subsequent loss of both retinal and choroidal perfusion to the posterior segment. Ophthalmoscopic examination ten days after the injury disclosed intense nerve fiber layer edema, most prominent in the posterior pole, and absence of a cherry-red spot. Intravenous...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(79)90666-4
更新日期：1979-10-01 00:00:00
abstract：:We believe axoplasmic transport alteration is the anatomic substrate for formation of drusen of the optic disk. In familial cases the cause of axoplasmic transport alteration may be related to the presence of a genetically determined, small, crowded optic nerve head. We believe these congenitally elevated nerve heads ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)76658-9
更新日期：1978-01-01 00:00:00
abstract：PURPOSE:To describe the health literacy of subjects with open angle glaucoma and to investigate the hypothesis that low health literacy is associated with poor glaucoma medication adherence. DESIGN:Cross-sectional patient survey and concomitant chart review. METHODS:One hundred and ninety-seven subjects with open ang...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2006.03.018
更新日期：2006-08-01 00:00:00
abstract：PURPOSE:To determine whether the hepatocyte growth factor is increased in the vitreous of patients with proliferative vitreoretinopathy. METHODS:We assayed hepatocyte growth factor levels by enzyme-linked immunosorbent assay (ELISA) in vitreous samples from 65 consecutive eyes (65 patients) with proliferative vitreore...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(00)00360-3
更新日期：2000-05-01 00:00:00
abstract：PURPOSE:To determine the clinical differences between three-piece (3P) and single-piece (SP) truncated hydrophobic acrylic intraocular lenses (IOL). DESIGN:Retrospective cohort clinical study. METHODS:The setting was an academic clinical practice. The patient population consisted of subjects without confounding comor...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(03)00418-5
更新日期：2003-10-01 00:00:00
abstract：PURPOSE:To report a novel mutation of the CYP1B1 gene in a Japanese patient with primary infantile glaucoma. METHODS:DNA was extracted from leukocytes of six unrelated patients with primary infantile glaucoma. The coding regions of the CYP1B1 gene were amplified by polymerase chain reaction, examined by agarose gel se...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(99)00143-9
更新日期：1999-09-01 00:00:00
abstract：PURPOSE:To evaluate and comment on published peer-reviewed literature for evidence of effectiveness of treatments for metastatic uveal melanoma. DESIGN:Analytical nonexperimental study of published peer-reviewed data. METHODS:Literature search and analysis of pertinent articles published between January 1, 1980 and J...
journal_title：American journal of ophthalmology
pub_type： 杂志文章,meta分析
doi：10.1016/j.ajo.2009.01.023
更新日期：2009-07-01 00:00:00
abstract：:Cell loss and regeneration were investigated and compared in the retinal microvasculature of age- and sex-matched normal and streptozotocin diabetic rats. Selective pericyte loss in the diabetic rat was characterized by changes in the pericyte to endothelial cell ratio in retinal capillaries isolated for microscopy by...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)74982-7
更新日期：1985-07-15 00:00:00
abstract：:A 46-year-old woman had a hemangioma of the zygoma, which was excised flush with the normal bony contour. To the best of our knowledge, this is the second such case reported. ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)74865-2
更新日期：1980-08-01 00:00:00
abstract：PURPOSE:To evaluate whether the full-field flicker test, a psychophysical test employing full-field flickering stimuli to measure temporal contrast sensitivity, can detect glaucomatous optic nerve damage in patients with increased intraocular pressure and glaucomatous optic disk abnormalities but normal visual fields. ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)70126-6
更新日期：1997-03-01 00:00:00
