Abstract：
:Cell loss and regeneration were investigated and compared in the retinal microvasculature of age- and sex-matched normal and streptozotocin diabetic rats. Selective pericyte loss in the diabetic rat was characterized by changes in the pericyte to endothelial cell ratio in retinal capillaries isolated for microscopy by the trypsin digest technique. A comparison of 3- and 9-month-old normal rats showed no significant change in the pericyte to endothelial cell ratio (1:2.7). In diabetic animals the ratio was reduced to 1:4.03, which was statistically significant (P less than .001). Premitotic retinal vascular cells in normal and diabetic rats were labelled with tritiated thymidine and the labelling indices calculated from cell counts of trypsin digest preparations. Methyl H3 thymidine was infused continuously over an eight-day period using osmotic mini pumps. The labelling index of endothelial cells (0.33%) in normal rats increased to 0.91% in diabetic animals (P less than .05). The labelling index of pericyte cells in normal animals (0.16%) did not increase significantly (P greater than .05) in diabetic animals (0.19%). A special stain was used to exclude labelled polymorphonuclear leukocytes from the cell counts.
journal_name
Am J Ophthalmoljournal_title
American journal of ophthalmologyauthors
Sharma NK,Gardiner TA,Archer DBdoi
10.1016/s0002-9394(14)74982-7subject
Has Abstractpub_date
1985-07-15 00:00:00pages
51-60issue
1eissn
0002-9394issn
1879-1891pii
S0002-9394(14)74982-7journal_volume
100pub_type
杂志文章abstract：PURPOSE:To highlight the possible role of indocyanine green angiography in predicting future exudative changes in eyes that are candidates for drusen laser treatment. METHODS:In a 56-year-old woman, fluorescein and indocyanine green angiography were performed before drusen laser treatment. RESULTS:The treated eye had...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)70875-x
更新日期：1997-10-01 00:00:00
abstract：PURPOSE:To determine the association between cystoid macular edema and vascular endothelial growth factor concentration in the aqueous humor and plasma of uveitis patients. METHODS:Cross-sectional study. Vascular endothelial growth factor concentrations were measured by enzyme-linked immunosorbent assay in the aqueous...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(01)01103-5
更新日期：2001-11-01 00:00:00
abstract：PURPOSE:This study sought to investigate retinal function in patients with noninfectious uveitis by using full-field electroretinography (ERG) and correlate the ERG to disease duration and severity of inflammation. DESIGN:Prospective cohort study. METHODS:Patients (n = 200) with noninfectious uveitis and a disease du...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2019.05.028
更新日期：2019-11-01 00:00:00
abstract：:Follow-up examinations, ranging from four to more than 20 years, were performed on 100 patients with chronic cyclitis whose ages at onset were from 4 to 58 years. Cataracts were found in 42% of eyes and macular disease secondary to macular edema in 28% of eyes. Band keratopathy, glaucoma, retinal detachment, retinosch...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(76)90434-7
更新日期：1976-08-01 00:00:00
abstract：PURPOSE:We evaluated quantitatively, with electromyography, the function of orbicularis oculi muscle flaps in modified Hughes reconstructions of the lower eyelids. METHODS:A modified Hughes procedure with a bipedicle orbicularis oculi flap was used to reconstruct large left lower eyelid defects after tumor excision in...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)73877-2
更新日期：1995-02-01 00:00:00
abstract：PURPOSE:To compare retinal nerve fiber layer (RNFL) thickness measurements between 3 different spectral-domain optical coherence tomography (SD-OCT) instruments (Spectralis; Heidelberg Engineering; Cirrus; Carl Zeiss Meditec; RTVue; Optovue, Inc) and one time-domain OCT (Stratus; Carl Zeiss Meditec). DESIGN:Prospectiv...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2010.06.024
更新日期：2010-12-01 00:00:00
abstract：PURPOSE:To report a minimally symptomatic patient with bilateral carcinoid tumors metastatic to the choroid who was followed up for 42 months without any treatment. METHOD:Case report. RESULTS:A 54-year-old white man with a history of bronchial carcinoid tumor had bilateral multiple carcinoid tumors metastatic to the...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(98)00053-1
更新日期：1998-06-01 00:00:00
abstract：:Of 42 patients studied who had fundus flavimaculatus and Stargardt's disease, most had reduced visual acuity due to an atrophic macular lesion. Family histories were consistent with autosomal-recessive inheritance. In some young patients, the yellow-white flecks developed with time, while in some older patients the fl...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(76)90539-0
更新日期：1976-10-01 00:00:00
abstract：:A 14-year-old boy was stabbed above the left eye and had subsequent loss of both retinal and choroidal perfusion to the posterior segment. Ophthalmoscopic examination ten days after the injury disclosed intense nerve fiber layer edema, most prominent in the posterior pole, and absence of a cherry-red spot. Intravenous...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(79)90666-4
更新日期：1979-10-01 00:00:00
abstract：PURPOSE:To correlate the anatomic features of the macula with functional parameters like location and stability of fixation in patients with neovascular age-related macular degeneration treated with intravitreal ranibizumab injections. DESIGN:Retrospective analysis. METHODS:The location and stability of fixation were...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2011.08.034
更新日期：2012-03-01 00:00:00
abstract：PURPOSE:To evaluate the correlation between tear film lipid layer thickness and other objective measurements such as tear film break-up time (TBUT), upper and lower meibomian gland losses, and Schirmer 1 test in patients with obstructive meibomian gland dysfunction (MGD) and normal controls. DESIGN:Cross-sectional stu...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2013.01.008
更新日期：2013-06-01 00:00:00
abstract：PURPOSE:To investigate the ocular manifestations of patients with severe acute respiratory syndrome (SARS) and to monitor the possible ocular complications arising from the treatment regimen with high-dose systemic corticosteroid drugs. DESIGN:Prospective, observational cohort case series. METHODS:Ninety eyes from 45...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2003.09.060
更新日期：2004-04-01 00:00:00
abstract：PURPOSE:To investigate cataract risk associated with the use of atypical antipsychotics. DESIGN:Retrospective, nested case-control study. METHODS:A large health claims database (The British Columbia Ministry of Health Databases) from British Columbia, Canada, was used from January 2000 through December 2007. Cases we...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2013.07.012
更新日期：2013-12-01 00:00:00
abstract：PURPOSE:We sought to understand better the efficacy and risks of local therapies (direct placement of drug into the eye) for the treatment of cytomegalovirus retinopathy. This understanding can be used to design rational treatment regimens, to formulate indications for use of local therapy, and to establish criteria fo...
journal_title：American journal of ophthalmology
pub_type： 杂志文章,评审
doi：10.1016/s0002-9394(14)72168-3
更新日期：1995-09-01 00:00:00
abstract：PURPOSE:beta-Adrenergic blocking drugs lower intraocular pressure. The question of whether these drugs also alter, either directly or indirectly, orbital hemodynamics is potentially of great importance for patients with normal-tension glaucoma who may have some degree of reversible vasospasm. METHODS:We compared the e...
journal_title：American journal of ophthalmology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0002-9394(14)72604-2
更新日期：1995-08-01 00:00:00
abstract：:We applied vitreous surgical techniques in the treatment of hemorrhagic and fibrous complications of choroidal neovascular membranes by removing subretinal scars or hemorrhage, or both, in four patients. The surgical goals were achieved in all patients. Visual acuity improved in three patients. The major complication ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(88)90116-x
更新日期：1988-01-15 00:00:00
abstract：PURPOSE:To look for associations of preoperative A-scan ultrasound ocular dimensions with complications during phacoemulsification in eyes with pseudoexfoliation. METHODS:A total of 174 eyes with pseudoexfoliation of 135 patients undergoing planned cataract surgery were included in a prognostic study based on the revi...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(99)00365-7
更新日期：2000-03-01 00:00:00
abstract：PURPOSE:To evaluate the effects of a dexamethasone intravitreous drug delivery system (dexamethasone DDS) in patients with persistent macular edema (ME) resulting from uveitis or Irvine-Gass syndrome. DESIGN:Randomized, prospective, single-masked, controlled trial. METHODS:Three hundred and fifteen patients with pers...
journal_title：American journal of ophthalmology
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.ajo.2008.12.033
更新日期：2009-06-01 00:00:00
abstract：PURPOSE:To evaluate the long-term intraocular pressure (IOP) control and to identify risk factors for failure of repeat trabeculectomy with mitomycin C (MMC) in patients with open-angle glaucoma. DESIGN:Retrospective case-control study. METHODS:Seventy-five eyes (67 patients) that had undergone repeat trabeculectomy ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2009.05.032
更新日期：2009-11-01 00:00:00
abstract：PURPOSE:To evaluate qualitatively the structural characteristics and the associated features that antedate the occurrence of a disk hemorrhage in patients with glaucoma. METHODS:Retrospective observational case series. A total of 4018 pairs of stereoscopic optic disk images obtained over 15 years were reviewed. All ey...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(01)01009-1
更新日期：2001-09-01 00:00:00
abstract：:In 29 experiments, vascular autologous retina from the contralateral rabbit eye was implanted into corneal pockets in New Zealand white rabbits. The implants induced a neovascular growth of limbal vessels that anastomosed with the vessels of the implant in 15 of the cases. Implantation of vascular autologous iris, cho...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(80)90116-6
更新日期：1980-02-01 00:00:00
abstract：:Abnormalities in neural crest cell migration may have a role in the pathogenesis of the congenital glaucomas, with or without changes in the gonioscopic appearance of the anterior chamber angle. Neural crest cells also contribute to the bones of the face, dental papilla, cartilage, bone, and meninges; this may explain...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(79)90643-3
更新日期：1979-09-01 00:00:00
abstract：:Fine-needle aspiration was used as a primary orbital diagnostic technique in 156 patients. A 20-mm syringe, a 22-gauge, 3.75-cm needle, and a plastic pistol grip were used. Local anesthetic was not necessary. When the needle is in the lesion, small to-and-fro movements with a minimum of angulation are helpful. The asp...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)77955-3
更新日期：1985-05-15 00:00:00
abstract：PURPOSE:To introduce a surgical approach for removing intruded scleral buckle resulting from Miragel's implant. DESIGN:Interventional case report. METHODS:After cutting and releasing scleral band externally, a pars plana Fragmatome was used to break up and aspirate pieces of the Miragel's implant that had grown into ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2004.07.032
更新日期：2005-01-01 00:00:00
abstract：PURPOSE:To report the occurrences of early rapid increases in intraocular (IOP) after intravitreal glucocorticoid injection. DESIGN:Observational case series. METHODS:We retrospectively reviewed the records of three patients seen and treated at Duke Eye Center. RESULTS:In all three cases, a significant rise in IOP o...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2004.03.001
更新日期：2004-08-01 00:00:00
abstract：:Eight patients were treated for Pseudomonas endophthalmitis associated with the implantation of contaminated intraocular lenses. All patients showed clinical signs of infection (loss of red reflex, diminished visual acuity, and intraocular lens coagulum) and P. aeruginosa was isolated from vitreous aspirates and unuse...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(79)90569-5
更新日期：1979-11-01 00:00:00
abstract：PURPOSE:To investigate the relationship of circulating levels of soluble form of LR11 (sLR11; also called SorLA or SORL1), with the progression of proliferative diabetic retinopathy (PDR) in patients with type 2 diabetes mellitus. DESIGN:Cross-sectional study. METHODS:Fifty-four patients with type 2 diabetes mellitus...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2012.01.035
更新日期：2012-07-01 00:00:00
abstract：:A study of ten patients (six girls and four boys ranging in age from 17 months to 9 1/2 years) with congenital third nerve palsies showed that not all cases are benign without other signs of focal neurologic damage. Six of the ten children showed some degree of pupillary involvement, five had signs of oculomotor synki...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(84)90629-9
更新日期：1984-03-01 00:00:00
abstract：PURPOSE:To compare retinal thickness (RT) measurements obtained by spectral-domain optical coherence tomography (SD-OCT) and time-domain OCT (TD-OCT) in eyes with and without posterior segment disease diagnoses. DESIGN:Retrospective, observational chart review. METHODS:Scans of 184 healthy and diseased eyes from 106 ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2008.11.019
更新日期：2009-05-01 00:00:00
abstract：:A retrospective study of 45 patients with low-tension glaucoma revealed the mean age at diagnosis to be 66 years. Seventeen patients had follow-up visual field examinations, the average follow-up period being 6.4 years. There was no significant difference in prognosis of the ocular course between patients with Po/C eq...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(76)90359-7
更新日期：1976-06-01 00:00:00
